| Tag |
Content |
| WERAM ID |
WERAM-Hos-0241 |
| Ensembl Protein ID |
ENSP00000450518.1 |
| Uniprot Accession |
Q92784; DPF3_HUMAN; A8MSI3; B7Z276; F5H575; Q32UJ0; Q6P9E6; Q6ZT41; Q9H7Y5
|
| Genbank Protein ID |
NP_001267471.1; NP_001267472.1; NP_001267473.1; NP_036206.3
|
| Protein Name |
Zinc finger protein DPF3 |
| Genbank Nucleotide ID |
NM_001280542.1; NM_001280543.1; NM_001280544.1; NM_012074.4
|
| Gene Name |
DPF3;BAF45C;CERD4 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Tandem-PHD |
PHD1;PHD2 |
H3K9; H3K14; H4K5; H4K8; H4K12; H4K16 |
K |
26266342; 18765789
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
1.70e-14 |
56 |
198 |
364 |
| Ac_Reader |
Tandem-PHD |
1.10e-44 |
137.8 |
259 |
319 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. |
Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 2 tiClvCgkdde 12
+C +Cgk+++
ENSP00000450518.1 198 YVCDICGKRYK 208
45666666655 PP
PHD.txt 2 tiClvC.gkddegeke.....mvqCdeCddwfHlkCvklp..lsslpegkswyCpsCk 51
++C +C g ++ ++k +v C C + H +C++++ ++++ + +w C +Ck
ENSP00000450518.1 260 NYCDFClGGSNMNKKSgrpeeLVSCADCGRSGHPTCLQFTlnMTEAVKTYKWQCIECK 317
79****666666655567777*******************44444445589******8 PP
PHD.txt 3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51
+C++Cg++++++ +++ Cd Cd+ +H++C+++p + peg sw C C
ENSP00000450518.1 318 SCILCGTSENDD-QLLFCDDCDRGYHMYCLNPPVAEPPEG-SWSCHLCW 364
7****6555555.5**************************.*******5 PP
Ac_Reader Tandem-PHD
PHD1.txt 1 inicdfclGtkesnkkk.kPeelvscadcGrsGhPsclkftlelteavkalkWqciecksc 60
+n+cdfclG++++nkk+ +PeelvscadcGrsGhP+cl+ftl++teavk++kWqciecksc
ENSP00000450518.1 259 NNYCDFCLGGSNMNKKSgRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSC 319
79*********************************************************** PP
PHD1.txt 20 eelvscadcGrsGhPsclk 38
++l+ c dc r h cl+
ENSP00000450518.1 329 DQLLFCDDCDRGYHMYCLN 347
6899*************96 PP
|
Protein Sequence
(Fasta) | MATVIHNPLK ALGDQFYKEA IEHCRSYNSR LCAERSVRLP FLDSQTGVAQ NNCYIWMEKR 60
HRGPGLAPGQ LYTYPARCWR KKRRLHPPED PKLRLLEIKP EVELPLKKDG FTSESTTLEA 120
LLRGEGVEKK VDAREEESIQ EIQRVLENDE NVEEGNEEED LEEDIPKRKN RTRGRARGSA 180
GGRRRHDAAS QEDHDKPYVC DICGKRYKNR PGLSYHYAHT HLASEEGDEA QDQETRSPPN 240
HRNENHRPQK GPDGTVIPNN YCDFCLGGSN MNKKSGRPEE LVSCADCGRS GHPTCLQFTL 300
NMTEAVKTYK WQCIECKSCI LCGTSENDDQ LLFCDDCDRG YHMYCLNPPV AEPPEGSWSC 360
HLCWELLKEK ASAFGCQA 378Protein Fasta Sequence
>ENSP00000450518.1|DPF3;BAF45C;CERD4|Homo sapiens
MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA |
Nucleotide Sequence
(Fasta) | ATGGCGACTG TCATTCACAA CCCCCTGAAA GCGCTCGGGG ACCAGTTCTA CAAGGAAGCC 60
ATTGAGCACT GCCGGAGTTA CAACTCACGG CTGTGTGCAG AGCGCAGCGT GCGTCTTCCC 120
TTCCTGGACT CACAGACTGG GGTGGCCCAG AACAACTGCT ACATCTGGAT GGAGAAGAGG 180
CACCGAGGCC CAGGCCTTGC CCCGGGCCAG CTGTATACAT ACCCTGCCCG CTGCTGGCGC 240
AAGAAGAGAC GATTGCACCC ACCTGAAGAT CCAAAACTGC GGCTGCTGGA GATAAAACCT 300
GAAGTGGAGC TTCCCCTGAA GAAGGATGGG TTCACCTCAG AGAGCACCAC GCTGGAAGCC 360
TTGCTCCGTG GCGAGGGGGT TGAGAAGAAG GTGGATGCCA GGGAGGAGGA AAGCATCCAG 420
GAAATACAGA GGGTTTTGGA AAATGATGAA AATGTAGAAG AAGGGAATGA AGAAGAGGAT 480
TTGGAAGAGG ATATTCCCAA GCGAAAGAAC AGGACTAGAG GACGGGCTCG CGGCTCTGCA 540
GGGGGCAGGA GGAGGCACGA CGCCGCCTCT CAGGAAGACC ACGACAAACC TTACGTCTGT 600
GACATCTGTG GCAAGCGCTA CAAGAACCGA CCGGGGCTCA GCTACCACTA TGCTCACACT 660
CACCTGGCCA GCGAGGAGGG GGATGAAGCT CAAGACCAGG AGACTCGGTC CCCACCCAAC 720
CACAGAAATG AGAACCACAG GCCCCAGAAA GGACCGGATG GAACAGTCAT TCCCAATAAC 780
TACTGTGACT TCTGCTTGGG GGGCTCCAAC ATGAACAAGA AGAGTGGGCG GCCTGAAGAG 840
CTGGTGTCCT GCGCAGACTG TGGACGCTCT GGTCACCCAA CCTGCCTGCA GTTTACCCTG 900
AACATGACCG AGGCTGTCAA GACCTACAAG TGGCAGTGCA TAGAGTGCAA ATCCTGTATC 960
CTCTGTGGGA CCTCAGAGAA TGATGACCAG CTACTCTTCT GCGATGACTG TGACCGAGGC 1020
TATCACATGT ACTGTTTAAA TCCCCCGGTG GCTGAGCCCC CAGAAGGAAG CTGGAGCTGC 1080
CACTTATGCT GGGAACTGCT CAAAGAGAAA GCCTCAGCCT TTGGCTGCCA GGCCTAGG
1139Nucleotide Fasta Sequence
>ENSP00000450518.1|Tandem-PHD|Homo sapiens
ATGGCGACTGTCATTCACAACCCCCTGAAAGCGCTCGGGGACCAGTTCTACAAGGAAGCCATTGAGCACTGCCGGAGTTACAACTCACGGCTGTGTGCAGAGCGCAGCGTGCGTCTTCCCTTCCTGGACTCACAGACTGGGGTGGCCCAGAACAACTGCTACATCTGGATGGAGAAGAGGCACCGAGGCCCAGGCCTTGCCCCGGGCCAGCTGTATACATACCCTGCCCGCTGCTGGCGCAAGAAGAGACGATTGCACCCACCTGAAGATCCAAAACTGCGGCTGCTGGAGATAAAACCTGAAGTGGAGCTTCCCCTGAAGAAGGATGGGTTCACCTCAGAGAGCACCACGCTGGAAGCCTTGCTCCGTGGCGAGGGGGTTGAGAAGAAGGTGGATGCCAGGGAGGAGGAAAGCATCCAGGAAATACAGAGGGTTTTGGAAAATGATGAAAATGTAGAAGAAGGGAATGAAGAAGAGGATTTGGAAGAGGATATTCCCAAGCGAAAGAACAGGACTAGAGGACGGGCTCGCGGCTCTGCAGGGGGCAGGAGGAGGCACGACGCCGCCTCTCAGGAAGACCACGACAAACCTTACGTCTGTGACATCTGTGGCAAGCGCTACAAGAACCGACCGGGGCTCAGCTACCACTATGCTCACACTCACCTGGCCAGCGAGGAGGGGGATGAAGCTCAAGACCAGGAGACTCGGTCCCCACCCAACCACAGAAATGAGAACCACAGGCCCCAGAAAGGACCGGATGGAACAGTCATTCCCAATAACTACTGTGACTTCTGCTTGGGGGGCTCCAACATGAACAAGAAGAGTGGGCGGCCTGAAGAGCTGGTGTCCTGCGCAGACTGTGGACGCTCTGGTCACCCAACCTGCCTGCAGTTTACCCTGAACATGACCGAGGCTGTCAAGACCTACAAGTGGCAGTGCATAGAGTGCAAATCCTGTATCCTCTGTGGGACCTCAGAGAATGATGACCAGCTACTCTTCTGCGATGACTGTGACCGAGGCTATCACATGTACTGTTTAAATCCCCCGGTGGCTGAGCCCCCAGAAGGAAGCTGGAGCTGCCACTTATGCTGGGAACTGCTCAAAGAGAAAGCCTCAGCCTTTGGCTGCCAGGCCTAGG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR025750--Requiem/DPF_N_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
PF00628--PHD
PF14051--Requiem_N
|
| Gene Ontology |
GO:0071565--C:nBAF complex
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0007399--P:nervous system development
GO:0002230--P:positive regulation of defense response to virus by host
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0098792--P:xenophagy
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
