| Tag |
Content |
| WERAM ID |
WERAM-Hos-0048 |
| Ensembl Protein ID |
ENSP00000449207.1 |
| Uniprot Accession |
P45973; CBX5_HUMAN; B2R8T9
|
| Genbank Protein ID |
NP_001120793.1; NP_001120794.1; NP_036249.1
|
| Protein Name |
Chromobox protein homolog 5 |
| Genbank Nucleotide ID |
NM_001127321.1; NM_001127322.1; NM_012117.2
|
| Gene Name |
Cbx5 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
DCD |
Chromo1 |
H3K9me3 |
K |
22514736
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
DCD |
7.60e-35 |
105.9 |
22 |
73 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
|
| Domain Profile |
Me_Reader DCD
Chromo-2.txt 3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresm 57
ve++++ kG+++yL+kWk+ +we+++ n ++p+l+ +f + + m
ENSP00000449207.1 22 VEKVLDRR-VVKGQVEYLLKWKGFSEEHNTWEPEK--NLDCPELISEFMKKYKKM 73
77888877.689***********988888898875..99*******997766555 PP
Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
++e+Ii+++ d++G+l++L+kWkd+ dea+++ a+++n k+pq+v++fyeer++++ ++
ENSP00000449207.1 122 EPEKIIGAT-DSCGDLMFLMKWKDT--DEADLVLAKEANVKCPQIVIAFYEERLTWHAYP 178
79*******.***************..******************************986 PP
|
Protein Sequence
(Fasta) | MGKKTKRTAD SSSSEDEEEY VVEKVLDRRV VKGQVEYLLK WKGFSEEHNT WEPEKNLDCP 60
ELISEFMKKY KKMKEGENNK PREKSESNKR KSNFSNSADD IKSKKKREQS NDIARGFERG 120
LEPEKIIGAT DSCGDLMFLM KWKDTDEADL VLAKEANVKC PQIVIAFYEE RLTWHAYPED 180
AENKEKETAK S 191Protein Fasta Sequence
>ENSP00000449207.1|Cbx5|Homo sapiens
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS |
Nucleotide Sequence
(Fasta) | GTTAGCCCAG AGGGAAAGAA AGAACTGGGG CGATCCGGTA GGTAAAGGAG GGAACCCCCA 60
TTCATTTTCT ACCTTTGGGG CTCCTCTTCT GCATGAAGGT ATAAAGGGAG ATTTTCCTTG 120
TCTCTCCCTC AAAATGAAGA ACACATGTAA ATCCTTGTTT TTCCTGGTGA GGCAGGGGAG 180
GCCATAGCCA CAATGCTTAA CTGCATGCAT CTAACATGGG GCTGGTTTTA ACCCCAGCGC 240
TCTGACCTAA ACTGCTCAGC TCCCGGAAAT TCCAAGGGAC CTGGTGGCCT TAGTCTTTCA 300
GGTGGAACGG TGTGCGACAT GGGAAAGAAA ACCAAGCGGA CAGCTGACAG TTCTTCTTCA 360
GAGGATGAGG AGGAGTATGT TGTGGAGAAG GTGCTAGACA GGCGCGTGGT TAAGGGACAA 420
GTGGAATATC TACTGAAGTG GAAAGGCTTT TCTGAGGAGC ACAATACTTG GGAACCTGAG 480
AAAAACTTGG ATTGCCCTGA GCTAATTTCT GAATTTATGA AAAAGTATAA GAAGATGAAG 540
GAGGGTGAAA ATAATAAACC CAGGGAGAAG TCAGAAAGTA ACAAGAGGAA ATCCAATTTC 600
TCAAACAGTG CCGATGACAT CAAATCTAAA AAAAAGAGAG AGCAGAGCAA TGATATCGCT 660
CGGGGCTTTG AGAGAGGACT GGAACCAGAA AAGATCATTG GGGCAACAGA TTCCTGTGGT 720
GATTTAATGT TCCTAATGAA ATGGAAAGAC ACAGATGAAG CTGACCTGGT TCTTGCAAAA 780
GAAGCTAATG TGAAATGTCC ACAAATTGTG ATAGCATTTT ATGAAGAGAG ACTGACATGG 840
CATGCATATC CTGAGGATGC GGAAAACAAA GAGAAAGAAA CAGCAAAGAG CTAA
895Nucleotide Fasta Sequence
>ENSP00000449207.1|DCD|Homo sapiens
GTTAGCCCAGAGGGAAAGAAAGAACTGGGGCGATCCGGTAGGTAAAGGAGGGAACCCCCATTCATTTTCTACCTTTGGGGCTCCTCTTCTGCATGAAGGTATAAAGGGAGATTTTCCTTGTCTCTCCCTCAAAATGAAGAACACATGTAAATCCTTGTTTTTCCTGGTGAGGCAGGGGAGGCCATAGCCACAATGCTTAACTGCATGCATCTAACATGGGGCTGGTTTTAACCCCAGCGCTCTGACCTAAACTGCTCAGCTCCCGGAAATTCCAAGGGACCTGGTGGCCTTAGTCTTTCAGGTGGAACGGTGTGCGACATGGGAAAGAAAACCAAGCGGACAGCTGACAGTTCTTCTTCAGAGGATGAGGAGGAGTATGTTGTGGAGAAGGTGCTAGACAGGCGCGTGGTTAAGGGACAAGTGGAATATCTACTGAAGTGGAAAGGCTTTTCTGAGGAGCACAATACTTGGGAACCTGAGAAAAACTTGGATTGCCCTGAGCTAATTTCTGAATTTATGAAAAAGTATAAGAAGATGAAGGAGGGTGAAAATAATAAACCCAGGGAGAAGTCAGAAAGTAACAAGAGGAAATCCAATTTCTCAAACAGTGCCGATGACATCAAATCTAAAAAAAAGAGAGAGCAGAGCAATGATATCGCTCGGGGCTTTGAGAGAGGACTGGAACCAGAAAAGATCATTGGGGCAACAGATTCCTGTGGTGATTTAATGTTCCTAATGAAATGGAAAGACACAGATGAAGCTGACCTGGTTCTTGCAAAAGAAGCTAATGTGAAATGTCCACAAATTGTGATAGCATTTTATGAAGAGAGACTGACATGGCATGCATATCCTGAGGATGCGGAAAACAAAGAGAAAGAAACAGCAAAGAGCTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
|
| Pfam |
PF00385--Chromo
PF01393--Chromo_shadow
|
| Gene Ontology |
GO:0010369--C:chromocenter
GO:0000118--C:histone deacetylase complex
GO:0035097--C:histone methyltransferase complex
GO:0000776--C:kinetochore
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005635--C:nuclear envelope
GO:0005720--C:nuclear heterochromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0030674--F:protein binding, bridging
GO:0070491--F:repressing transcription factor binding
GO:0007596--P:blood coagulation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016032--P:viral process
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
