WERAM Information

Tag Content
WERAM ID WERAM-Hos-0032
Ensembl Protein ID ENSP00000446880.1
Uniprot Accession Q9UIF9; BAZ2A_HUMAN; B3KN66; O00536; O15030; Q68DI8; Q96H26
Genbank Protein ID NP_038477.2
Protein Name Bromodomain adjacent to zinc finger domain protein 2A
Genbank Nucleotide ID NM_013449.3
Gene Name BAZ2A;KIAA0314;TIP5;WALp3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000076108.11 ENST00000551812.5 ENSP00000446880.1
ENSG00000076108.11 ENST00000379441.7 ENSP00000368754.3
ENSG00000076108.11 ENST00000549884.5 ENSP00000447941.1
ENSG00000076108.11 ENST00000549787.5 ENSP00000448760.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 22464331
Me_Reader PHD PHD-type H3K4me0 K 26266342
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 2.40e-22 81 1811 1879
Me_Reader PHD 3.10e-09 39.1 1677 1724
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt    2 ehevsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71  
                         +h+ ++pF epv+p  ++  Y+ iik+Pmd+st++erl +g Y+s eef++D  l+f+N++++ne++s+v
  ENSP00000446880.1 1811 SHDAAWPFLEPVNP-RLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEV 1879
                         6999**********.6***************************************************987 PP
  Me_Reader PHD
            PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51  
                          +ClvC ++++++++++ Cd+Cd+  H++C+ ++++ +peg +w+C  C 
  ENSP00000446880.1 1677 VTCLVC-RKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEG-DWFCTVCL 1724
                         58****.66666679**************************.*******6 PP
Protein Sequence
(Fasta)		MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN GDVNVNGLST 60
VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS ANPGSNLKDP PLLSQFSGGQ 120
YPLNGILGGS RQPSSPSHNT NLRAGSQEFW ANGTQSPMGL NFDSQELYDS FPDQNFEVMP 180
NGPPSFFTSP QTSPMLGSSI QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL 240
EEEQPELKMC GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 300
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA FSLLADDSQT 360
STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ SSDFPPSLTQ PAPDQSSTIQ 420
LHPATSPAVS PTTSPAVSLV VSPAASPEIS PEVCPAASTV VSPAVFSVVS PASSAVLPAV 480
SLEVPLTASV TSPKASPVTS PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD 540
VMRRRIATPE EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 600
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG KRGRPRNTEK 660
AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE TLNEEDKAKI AKSKKKMRQK 720
VQRGECQTTI QGQARNKRKQ ETKSLKQKEA KKKSKAEKEK GKTKQEKLKE KVKREKKEKV 780
KMKEKEEVTK AKPACKADKT LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR 840
VPGLTLPSGA FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 900
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV EPALCDRLRT 960
QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS SYRKNKWIVE GRLRRLKTVL 1020
AKRTGRSEVE MEGPEECLGR RRSSRIMEET SGMEEEEEEE SIAAVPGRRG RRDGEVDATA 1080
SSIPELERQI EKLSKRQLFF RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE 1140
GNLVPEEVIK KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 1200
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ EGSPLSLGQS 1260
QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA PSQPPEEPEP DEAESSPDPQ 1320
ALWFNISAQM PCNAAPTPPP AVSEDQPTPS PQQLASSKPM NRPSAANPCS PVQFSSTPLA 1380
GLAPKRRAGD PGEMPQSPTG LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW 1440
WIRDPEMLDA MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG 1500
IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL AYCEHLSDSQ 1560
EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR YLREPLWPTH EVVLEKALLS 1620
TPNGAPEGTT TEISYEITPR IRVWRQTLER CRSAAQVCLC LGQLERSIAW EKSVNKVTCL 1680
VCRKGDNDEF LLLCDGCDRG CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK 1740
RGQKRKSGYS LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT 1800
FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG GYTSSEEFAA 1860
DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG KQANL 1905
Nucleotide Sequence
(Fasta)		AGTCTGTCAC ACAGGGACAT CACCCTACAG CAGTTCAGGC TGTGTGGTTC GCAGGAAGCA 60
TACACTGGCT TTTTGATTCT TGCTAGTTCC CAGCTCACAG TTTGGGAGGA TCCAACACCA 120
ACCTTTACGT GAAGTGGAGG CCCAAGGACA GTGAGGAGCT GGGTGGTCCC AGCCTGGAGC 180
TGTGCCAGCC TGACATGGAA ATGGAGGCAA ACGACCATTT TAACTTTACT GGCCTTCCCC 240
CTGCACCTGC TGCCTCAGGA CTGAAACCCT CTCCTTCCTC AGGGGAGGGC CTCTACACTA 300
ACGGGTCTCC CATGAACTTC CCCCAGCAAG GGAAAAGTTT GAATGGGGAT GTGAATGTTA 360
ATGGCTTATC TACTGTATCT CACACTACTA CTTCAGGGAT TTTGAACTCT GCTCCCCACT 420
CCTCCAGCAC CTCACACCTC CATCACCCCA GCGTGGCCTA CGACTGTCTC TGGAACTACT 480
CACAGTACCC ATCTGCCAAT CCTGGCAGCA ACCTCAAGGA CCCACCCCTT CTCTCCCAGT 540
TCTCGGGGGG ACAATACCCA CTCAACGGCA TCCTTGGGGG CAGCCGGCAA CCTTCATCCC 600
CAAGTCATAA CACTAACCTT CGGGCTGGGA GCCAAGAGTT CTGGGCCAAC GGTACCCAGA 660
GTCCCATGGG GCTTAACTTT GATTCACAAG AACTGTATGA TTCCTTTCCT GACCAGAATT 720
TTGAGGTGAT GCCCAATGGA CCCCCTAGTT TTTTCACCTC CCCACAGACT TCTCCTATGT 780
TGGGATCTAG CATTCAAACC TTTGCACCCT CCCAGGAGGT AGGCAGTGGT ATCCATCCTG 840
ATGAGGCAGC AGAAAAGGAG ATGACTTCAG TTGTGGCAGA GAATGGCACT GGCTTGGTAG 900
GCAGCTTGGA GCTGGAAGAA GAGCAGCCAG AACTGAAGAT GTGTGGCTAC AATGGCTCTG 960
TCCCTTCTGT GGAATCGTTA CACCAAGAGG TCTCAGTCCT GGTCCCTGAC CCCACAGTGA 1020
GCTGTTTAGA TGATCCTTCA CATCTTCCTG ATCAACTGGA AGACACTCCA ATCCTCAGTG 1080
AAGACTCTCT GGAGCCCTTC AACTCTCTGG CACCAGAGCC AGTGAGTGGA GGACTATATG 1140
GTATTGATGA CACGGAGCTG ATGGGTGCAG AGGACAAGCT GCCTCTTGAG GACAGCCCTG 1200
TGATTTCTGC CCTTGATTGC CCTTCCCTCA ATAATGCTAC TGCCTTCAGT CTCCTGGCAG 1260
ATGATAGTCA AACATCAACC TCTATCTTTG CCAGTCCCAC CTCTCCACCT GTCCTAGGGG 1320
AGTCTGTCCT GCAAGATAAC AGCTTTGACC TGAATAATGG TAGTGACGCT GAACAGGAAG 1380
AAATGGAAAC TCAATCTTCA GACTTCCCAC CATCCCTGAC CCAGCCAGCT CCTGATCAGT 1440
CATCCACTAT TCAGCTACAT CCAGCAACCT CACCAGCAGT CTCGCCAACA ACCTCCCCAG 1500
CAGTCTCCCT AGTGGTTTCT CCAGCAGCCT CCCCAGAAAT CTCTCCAGAA GTTTGTCCCG 1560
CAGCTTCTAC AGTTGTCTCT CCAGCAGTCT TCTCAGTGGT CTCTCCAGCT TCCTCAGCAG 1620
TCCTCCCAGC AGTCTCCTTA GAAGTCCCGT TGACGGCTTC AGTGACATCC CCAAAAGCCT 1680
CTCCCGTAAC TTCCCCAGCA GCTGCCTTTC CAACAGCCTC CCCAGCAAAT AAGGATGTCA 1740
GCAGCTTTCT AGAAACCACT GCTGACGTGG AAGAGATCAC TGGAGAAGGA CTCACTGCTT 1800
CTGGTAGTGG TGATGTCATG AGGAGACGTA TTGCTACCCC AGAAGAAGTT CGTCTTCCCC 1860
TCCAACATGG GTGGCGGAGA GAGGTGCGCA TCAAGAAGGG CAGCCACCGA TGGCAGGGGG 1920
AGACCTGGTA TTATGGCCCC TGTGGGAAGA GGATGAAGCA ATTTCCAGAA GTGATCAAGT 1980
ACCTGAGCCG CAACGTGGTA CACAGTGTCC GCCGAGAGCA CTTCAGCTTC AGTCCCCGTA 2040
TGCCTGTTGG AGATTTCTTT GAAGAAAGAG ACACGCCAGA GGGCTTGCAG TGGGTGCAGC 2100
TCTCAGCAGA GGAGATCCCG TCGAGGATTC AGGCAATTAC TGGCAAACGG GGTCGACCTC 2160
GAAACACTGA GAAGGCTAAG ACTAAGGAAG TCCCCAAGGT GAAACGGGGT CGAGGTCGGC 2220
CACCTAAGGT CAAAATCACT GAGCTATTGA ACAAGACAGA CAACCGCCCC CTAAAGAAAC 2280
TGGAGGCCCA AGAAACATTG AATGAGGAGG ATAAAGCAAA GATTGCTAAA AGCAAGAAGA 2340
AGATGAGGCA GAAGGTTCAA CGGGGAGAGT GTCAGACTAC TATCCAAGGG CAGGCCAGAA 2400
ATAAGCGGAA ACAAGAGACC AAGAGCTTAA AGCAGAAGGA AGCTAAGAAG AAATCCAAGG 2460
CTGAGAAAGA AAAAGGAAAG ACAAAGCAGG AAAAACTGAA GGAAAAAGTC AAGAGGGAAA 2520
AGAAGGAGAA GGTAAAAATG AAGGAAAAGG AGGAGGTGAC CAAAGCCAAG CCAGCCTGTA 2580
AAGCAGATAA GACCCTGGCC ACACAGAGGC GCTTGGAGGA ACGGCAGAGG CAGCAGATGA 2640
TCTTGGAGGA AATGAAGAAG CCGACAGAGG ATATGTGTCT GACTGACCAC CAGCCCCTGC 2700
CTGACTTCTC ACGAGTCCCT GGTCTGACAT TGCCCAGTGG AGCCTTCTCA GACTGCTTGA 2760
CCATTGTGGA GTTCCTGCAT AGCTTTGGCA AGGTGCTGGG CTTTGATCCT GCCAAAGATG 2820
TGCCTAGCCT GGGGGTCCTG CAGGAGGGAC TCCTGTGTCA AGGTGACAGC TTGGGTGAGG 2880
TGCAAGACCT GCTGGTCAGG CTGCTGAAGG CTGCACTCCA TGATCCTGGC TTTCCCTCCT 2940
ACTGTCAGTC CCTAAAGATC TTGGGGGAGA AGGTGTCTGA GATCCCACTG ACAAGAGACA 3000
ATGTGTCAGA GATCCTGCGC TGCTTCCTTA TGGCATATGG AGTAGAGCCA GCCCTCTGTG 3060
ACCGCCTGCG CACCCAGCCT TTTCAGGCCC AGCCACCCCA GCAGAAGGCT GCTGTCCTGG 3120
CCTTCCTTGT GCATGAGCTC AATGGCTCCA CCCTCATCAT CAATGAGATT GACAAGACTC 3180
TGGAGAGTAT GTCCAGCTAC AGGAAAAACA AGTGGATTGT TGAAGGCCGG CTCCGGAGGC 3240
TGAAAACTGT TCTGGCCAAG CGAACTGGGC GGTCTGAAGT AGAGATGGAA GGGCCAGAGG 3300
AATGCCTGGG ACGGAGGCGC AGTTCTCGGA TCATGGAGGA GACCAGTGGC ATGGAAGAAG 3360
AGGAAGAAGA GGAGTCTATA GCAGCTGTCC CTGGCCGCAG GGGTCGAAGA GATGGAGAGG 3420
TTGATGCCAC AGCATCTAGC ATCCCAGAGC TAGAGCGCCA GATAGAAAAA CTCAGCAAGC 3480
GTCAGCTTTT CTTTCGCAAA AAGCTGCTTC ACTCATCCCA GATGCTTCGG GCGGTCTCCC 3540
TGGGTCAGGA CCGCTACAGA CGTCGCTACT GGGTATTGCC GTATTTGGCT GGTATCTTTG 3600
TAGAAGGAAC AGAGGGGAAC TTAGTTCCTG AGGAGGTGAT AAAGAAGGAA ACTGACTCCT 3660
TAAAAGTGGC AGCCCATGCG TCACTCAACC CTGCCCTCTT CTCTATGAAG ATGGAGTTAG 3720
CTGGCTCCAA CACCACTGCC AGTTCTCCTG CCCGGGCCCG AGGCCGACCT CGAAAAACTA 3780
AGCCCGGGTC TATGCAACCT AGGCATCTTA AGTCCCCTGT CAGGGGTCAG GATTCAGAAC 3840
AGCCCCAGGC CCAGCTTCAG CCTGAGGCTC AGCTTCATGC TCCTGCCCAG CCCCAGCCTC 3900
AGCTTCAGCT TCAGCTTCAG TCCCATAAGG GGTTCCTGGA GCAAGAAGGC TCCCCTTTGT 3960
CACTGGGTCA GAGCCAGCAT GACCTCAGCC AGTCAGCCTT CCTGTCTTGG CTGAGCCAGA 4020
CTCAGAGCCA TAGCTCCCTG TTGAGCAGCT CAGTCCTCAC ACCTGATAGC AGTCCGGGAA 4080
AACTAGACCC AGCTCCATCA CAACCCCCGG AGGAGCCAGA GCCTGATGAG GCAGAATCCA 4140
GCCCTGATCC TCAAGCACTC TGGTTTAACA TCTCAGCCCA GATGCCCTGC AATGCTGCCC 4200
CCACACCGCC CCCTGCAGTT TCTGAGGACC AACCCACTCC CTCCCCTCAG CAGCTTGCCT 4260
CCTCCAAGCC AATGAATAGA CCTAGTGCTG CCAACCCTTG TTCTCCAGTG CAGTTCTCTT 4320
CCACGCCCTT GGCTGGGTTG GCCCCTAAGA GGCGAGCAGG AGACCCTGGA GAAATGCCAC 4380
AGAGTCCCAC AGGGCTGGGA CAGCCCAAAC GGAGAGGGAG ACCTCCCAGT AAGTTCTTCA 4440
AACAGATGGA ACAGCGTTAC CTAACCCAGC TGACAGCCCA GCCTGTCCCA CCTGAGATGT 4500
GCTCAGGCTG GTGGTGGATA CGAGATCCTG AGATGTTGGA TGCCATGCTC AAGGCCCTAC 4560
ACCCCCGAGG TATCCGGGAG AAGGCACTTC ACAAACACCT TAACAAGCAC AGGGACTTCT 4620
TGCAGGAAGT CTGCCTGCGG CCCTCAGCTG ACCCCATCTT TGAGCCCAGG CAACTACCTG 4680
CCTTTCAAGA AGGGATTATG AGCTGGTCCC CCAAAGAGAA GACATACGAG ACAGACCTAG 4740
CAGTGCTTCA ATGGGTAGAG GAGCTGGAGC AGCGGGTTAT CATGTCTGAT CTGCAGATTC 4800
GGGGCTGGAC ATGTCCTAGC CCAGACTCTA CCCGTGAAGA CTTGGCCTAC TGTGAGCACC 4860
TCTCCGACTC CCAGGAGGAT ATCACCTGGC GAGGTCGGGG CAGGGAGGGA CTGGCACCTC 4920
AGCGTAAAAC TACCAACCCT TTGGACCTGG CTGTGATGCG GCTGGCTGCC CTGGAACAGA 4980
ATGTAGAACG GCGGTACCTG CGGGAGCCCC TCTGGCCAAC TCATGAGGTT GTGCTGGAGA 5040
AGGCCCTGCT TAGCACACCT AATGGTGCCC CTGAGGGCAC CACTACAGAG ATATCATATG 5100
AGATCACCCC TCGCATTCGT GTCTGGCGCC AGACCCTCGA GCGGTGCCGG AGCGCAGCCC 5160
AGGTGTGCTT GTGCCTGGGC CAGCTGGAGA GGTCCATTGC CTGGGAGAAG TCTGTCAACA 5220
AAGTGACATG TCTAGTCTGC CGGAAGGGTG ACAATGATGA GTTTCTTCTG CTTTGTGATG 5280
GGTGTGACCG TGGCTGCCAC ATTTACTGCC ATCGTCCCAA GATGGAGGCT GTCCCAGAAG 5340
GAGATTGGTT CTGTACTGTC TGTTTGGCTC AGCAGGTGGA GGGAGAATTC ACTCAGAAGC 5400
CTGGTTTCCC AAAGCGTGGC CAGAAGCGGA AAAGTGGTTA TTCGCTGAAC TTCTCAGAGG 5460
GTGATGGCCG CCGACGCCGG GTACTGTTGA GGGGCCGAGA AAGCCCAGCA GCAGGGCCTC 5520
GGTACTCGGA AGAAGGGCTC TCCCCCTCCA AGCGGCGGCG ACTCTCTATG CGGAACCACC 5580
ACAGTGATCT CACATTTTGC GAGATTATCC TGATGGAGAT GGAGTCCCAT GATGCAGCCT 5640
GGCCTTTCCT AGAGCCTGTG AACCCACGTT TGGTGAGTGG GTACCGGCGC ATCATCAAAA 5700
ATCCTATGGA TTTTTCCACC ATGCGGGAGC GGCTGCTCAG GGGAGGGTAC ACCAGCTCAG 5760
AGGAGTTTGC GGCTGATGCC CTCCTGGTAT TTGACAACTG CCAGACTTTC AACGAGGATG 5820
ACTCTGAAGT AGGCAAGGCT GGGCACATCA TGCGCCGCTT CTTCGAGAGC CGCTGGGAGG 5880
AGTTTTATCA GGGAAAACAG GCCAATCTGT GAGGCAAGGG AGGTGGGGAG TCACCTTGTG 5940
GCATCTCCCC CCACCTTCCA AACAAAAACC TGCCATTTTC ACCTGCTGAT GCTGCCCTGG 6000
GTCCAGACTC AAGTCAGATA CAACCCTGAT TTTTGACCTT GCCCTTGGCA GTGCCCCACA 6060
TCCTCTTATT CCTACATCCC TTTCTCCCTT CCCTCCTCTT GCTCCTCAAG TAAGAGGTGC 6120
AGAGATGAGG TCCTTCTGGA CTAAAAGCCA AAAAAAGAAA GAAAAAAATA ATTTTTCTTT 6180
TCTGTTTTAT TTGCTAATTA AAAATGGGGA GGGGGAAAGT CGTCCCTACT TCCTCCTCCC 6240
TGCTTCCTCT CCTCCCCTGT ACGTGCCCCA GCATTCTGGG GTTATTTAAC AATAGCAATA 6300
GTTCTAGTGA ATGTGTGAAA CCAAGAAACA CTCTGTACTG TGTGCGGACC CGCAGTGACG 6360
GCCAGTAAAG TGGACTTAAC TCCCAAGTGT GTCGCGCCGG ACACCGGGCC CTGGACATGC 6420
TGCTTCCATG TTCAGTCCCT TCCCTGCTTC TCGCTGTCTT TCTTTTCCCA CCTCCCACCC 6480
CCCAGTTTTC AGATTTTCTC TCATCCAATA ATGTAAAACT ATCGTGTACG GGTTCCTCCC 6540
TCCTTTTCTC TTCTCCCAAA TCTTTTCCCT TCAAAGGAAA AAAAAATGTT CAGAGGTCCC 6600
TGTCTTCTGT CCCCATCTTC CTGCCGATAG CTATCCCCTG TATGATGTTG GATGCTCCTC 6660
ACATGCTGAG TTTCCAGCCT TTTCTGAAAC TCAGTAGCTG GGGAGAGGGC AGGGAGGCTT 6720
CCTGGGCCTT CCAGCCTCCT TCCCCACCTC CTTCCCAAAC CCTCTTGGGA ACTCCTCAGG 6780
GACAACTACT GCTGAGTTTG GGTGCACCCT AAGATGGAGG CCAGGTAGCA ATGGGGCCGG 6840
CCTCAGAGAG AGCGCTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTCGGCCTCA 6900
GAGCGCGCTG TGTGTGTGTG TGTGTGTGTC AGCCTCAGAG CGCGCGCTGT GTGTGTGTGT 6960
GTGTGTGCGT GCTTGTGACC CTGTATTGTT TGATAGGATC CATTCAGTTT CCCCAAGTAC 7020
CTGTTTTCAT TCCCATTTTT CCCATTGTTT AAAACCATCA CTTTTTTGTC TTTGGGAAAC 7080
CACAGGAACA ATTTCTCTGG AGACAAGGCT GTGTCTCTCT CCTGGTCATT TTTGTTCCAG 7140
CCTCTTCAGA CTGTGCAATC TTTCAGCAGG AACTCCCTCT CTTCTCGGTA GCTTTGAATC 7200
TTAAGCTTCT ACGGGAGAGT GGTAGAACTG GATCATTTCC TAATCCCATT TAGTTGTGCT 7260
TTTCTTCATT TACTTCATAC CCCAGGACCC CTTCCCCAGC AGCAGAGACC CTGGAGCACA 7320
GGAGAGTAGG GAGGAGGGGT TCTGGGTCCA TCACTGCCCT ACATGTGACT ATGTCCAAGT 7380
TAAGCCCCCA ACACGAGAGG AAAGCTGCTG ACTCCCAGCT ATAGCCATGG GCACTTGGCC 7440
CCCTGCTTTT CCTGCTCAGC AGAGCCCCTC CCTTCAGAGA TTACGGGTAC TTGCACTGGG 7500
GAGGTGGCTG CTGGCTGGCC CAAGCAGAGA GCTGAGGCAT CCAAGAAATG TTCCATTGGG 7560
GGGTGGGGGT GCCAGGTGAG GTGGAGCATT CCTTGTATTC TGGCAGCACT GAAGAGCCAC 7620
TGAAGGGGGT AGGGGCAGTG TAGGTCCTGG GGCAGCCCCT TTATTCCTTT ATGCCCCTTC 7680
TCCCTCATAG CCTATTTCTA AAGTCGCCTT TTCTGTCAGA TAAACCTCAA AACTTTTAAT 7740
TTTATTTGAG ATTTTTTTTT GCTTTTAAGA GGTGGATTGA AGAATATTTG AATTGACTTT 7800
ATATTATGCA TAAATATTTA TATTTTATCT AAATAACTGC GCTGTAACAA ACTTTGTGTT 7860
AGACAGTTGA AACTGTTAGA GTTGGGGGCT CTGCTTTTTC CCCCTGGCAA TTTTCCCCTG 7920
GTATAAGATG TGCTAGATTA ATTTCATTGT GAGGTGGATG GGGGAGTGAA ATTGTGAGGT 7980
GGATGGGGGA GTGAAATCTC CATGGTTCCT GCTTTGTGTT CCTCTCCCAG CTCCATCTCT 8040
TTCCCTAGGG ACCAGGCACT CATATGGCGG GGTGGGGTCC TAGCCTCAGT TTGAAGAAGT 8100
GGGGGCTGGA GCGGGGTTGG GGGTGGTAGG GATAGGGCAT GATCAAAGGG GCCATTTCTT 8160
GCTTTTCTTT CCTCATCTTC ACTGCCCCCT TGAGCTAGGT GGATTTTCTC TTCATGACAA 8220
GAGTATTTGG TAGGGAAAGC AGGTTTAAAA TAAAAAGACA ACCCACCCCC TGCCCTTTTG 8280
CTTCCCTCCC ATCAGTCTGG TTGACAGGAA GAAACCACAC CATCAACACC AACAAGTTTC 8340
TGTGTTCCTT TTACAGCAAA AGGGACTTTT TATATAACCA AATGTGGTGT TTTAGTGACT 8400
TTTTGATAAT GTACAGTTTT TTGTGAATTT AAATTTATTT CTTTCTATAT TTTTAGGACC 8460
AATCTCATTT TTAATAAGGT TAAAAAGAAA AAAAAAGTCT AGCGAAAAAA CTCCTGTTTT 8520
TGCCATGTGA TGTTCCACAA GTGCAGCTGT AGAAAAGTGC TTGTCAGTTG TTGAATAAAA 8580
AAAACCACAT TTGATAGAGA 8601
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR017956--AT_hook_DNA-bd_motif
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR016177--DNA-bd_dom
IPR001739--Methyl_CpG_DNA-bd
IPR028940--TIP5
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS50982--MBD
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF02791--DDT
PF01429--MBD
PF00628--PHD
PF15612--WHIM1
PF15613--WSD
Gene Ontology

GO:0005677--C:chromatin silencing complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0033553--C:rDNA heterochromatin
GO:0042393--F:histone binding
GO:0016922--F:ligand-dependent nuclear receptor binding
GO:0070577--F:lysine-acetylated histone binding
GO:0003723--F:RNA binding
GO:0001164--F:RNA polymerase I CORE element sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0000183--P:chromatin silencing at rDNA
GO:0006306--P:DNA methylation
GO:0016575--P:histone deacetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0043 ENSPTRP00000008685.5 Pan troglodytes 100 0.0 3230
WERAM-Gog-0130 ENSGGOP00000011304.2 Gorilla gorilla 100 0.0 3225
WERAM-Nol-0188 ENSNLEP00000021198.2 Nomascus leucogenys 98 0.0 3214
WERAM-Poa-0045 ENSPPYP00000005316.1 Pongo abelii 98 0.0 3207
WERAM-Paa-0152 ENSPANP00000011547.1 Papio anubis 97 0.0 3180
WERAM-Chs-0052 ENSCSAP00000001354.1 Chlorocebus sabaeus 97 0.0 3180
WERAM-Mam-0178 ENSMMUP00000025402.2 Macaca mulatta 96 0.0 3139
WERAM-Caj-0113 ENSCJAP00000019888.2 Callithrix jacchus 95 0.0 3093
WERAM-Ict-0121 ENSSTOP00000012070.2 Ictidomys tridecemlineatus 90 0.0 2976
WERAM-Fec-0120 ENSFCAP00000011161.3 Felis catus 92 0.0 2966
WERAM-Aim-0053 ENSAMEP00000004353.1 Ailuropoda melanoleuca 91 0.0 2952
WERAM-Caf-0001 ENSCAFP00000000198.4 Canis familiaris 91 0.0 2950
WERAM-Sus-0007 ENSSSCP00000000430.2 Sus scrofa 90 0.0 2938
WERAM-Otg-0046 ENSOGAP00000003155.2 Otolemur garnettii 91 0.0 2932
WERAM-Bot-0161 ENSBTAP00000038030.4 Bos taurus 91 0.0 2924
WERAM-Ova-0086 ENSOARP00000009023.1 Ovis aries 90 0.0 2921
WERAM-Dan-0086 ENSDNOP00000008734.3 Dasypus novemcinctus 88 0.0 2915
WERAM-Eqc-0145 ENSECAP00000016353.1 Equus caballus 91 0.0 2905
WERAM-Mup-0014 ENSMPUP00000001481.1 Mustela putorius furo 88 0.0 2875
WERAM-Loa-0089 ENSLAFP00000006928.4 Loxodonta africana 89 0.0 2837
WERAM-Orc-0057 ENSOCUP00000005267.2 Oryctolagus cuniculus 85 0.0 2781
WERAM-Cap-0080 ENSCPOP00000005771.2 Cavia porcellus 82 0.0 2744
WERAM-Mum-0166 ENSMUSP00000044359.8 Mus musculus 82 0.0 2730
WERAM-Ocp-0013 ENSOPRP00000001588.2 Ochotona princeps 84 0.0 2685
WERAM-Tub-0012 ENSTBEP00000001298.1 Tupaia belangeri 89 0.0 2283
WERAM-Sah-0003 ENSSHAP00000000140.1 Sarcophilus harrisii 75 0.0 1726
WERAM-Mim-0011 ENSMICP00000000984.1 Microcebus murinus 85 0.0 1627
WERAM-Chh-0056 ENSCHOP00000006516.1 Choloepus hoffmanni 86 0.0 1570
WERAM-Ptv-0076 ENSPVAP00000007198.1 Pteropus vampyrus 88 0.0 1519
WERAM-Ect-0075 ENSETEP00000008287.1 Echinops telfairi 87 0.0 1501
WERAM-Prc-0110 ENSPCAP00000009860.1 Procavia capensis 89 0.0 1456
WERAM-Vip-0041 ENSVPAP00000003739.1 Vicugna pacos 94 0.0 1396
WERAM-Mae-0033 ENSMEUP00000002624.1 Macropus eugenii 74 0.0 1375
WERAM-Tut-0026 ENSTTRP00000002006.1 Tursiops truncatus 89 0.0 1256
WERAM-Myl-0206 ENSMLUP00000020807.1 Myotis lucifugus 93 0.0 1044
WERAM-Dio-0087 ENSDORP00000008680.1 Dipodomys ordii 80 0.0 798
WERAM-Tas-0081 ENSTSYP00000008083.1 Tarsius syrichta 96 0.0 786
WERAM-Anc-0175 ENSACAP00000016468.3 Anolis carolinensis 62 0.0 744
WERAM-Lac-0185 ENSLACP00000021251.1 Latimeria chalumnae 60 0.0 709
WERAM-Xet-0136 ENSXETP00000047091.3 Xenopus tropicalis 59 6e-176 616
WERAM-Leo-0069 ENSLOCP00000008820.1 Lepisosteus oculatus 56 7e-171 600
WERAM-Asm-0016 ENSAMXP00000002046.1 Astyanax mexicanus 52 2e-159 561
WERAM-Pof-0142 ENSPFOP00000011949.1 Poecilia formosa 56 5e-159 560
WERAM-Orn-0205 ENSONIP00000021515.1 Oreochromis niloticus 52 3e-158 557
WERAM-Ten-0152 ENSTNIP00000015568.1 Tetraodon nigroviridis 52 5e-158 556
WERAM-Tar-0030 ENSTRUP00000007135.1 Takifugu rubripes 54 6e-157 553
WERAM-Xim-0215 ENSXMAP00000017489.1 Xiphophorus maculatus 51 1e-155 549
WERAM-Gam-0011 ENSGMOP00000001206.1 Gadus morhua 54 4e-153 541
WERAM-Orla-0127 ENSORLP00000015292.1 Oryzias latipes 50 5e-151 533
WERAM-Gaa-0160 ENSGACP00000020092.2 Gasterosteus aculeatus 55 7e-149 526
WERAM-Ere-0002 ENSEEUP00000000141.1 Erinaceus europaeus 89 8e-144 509
WERAM-Ora-0045 ENSOANP00000007088.2 Ornithorhynchus anatinus 72 3e-136 484
WERAM-Dar-0224 ENSDARP00000130087.1 Danio rerio 54 1e-133 476
WERAM-Meg-0125 ENSMGAP00000013670.2 Meleagris gallopavo 45 6e-124 444
WERAM-Anp-0149 ENSAPLP00000015693.1 Anas platyrhynchos 45 1e-123 442
WERAM-Gaga-0116 ENSGALP00000020513.1 Gallus gallus 45 2e-123 442
WERAM-Tag-0148 ENSTGUP00000012613.1 Taeniopygia guttata 45 8e-122 437
WERAM-Ran-0242 ENSRNOP00000071727.1 Rattus norvegicus 46 3e-120 431
WERAM-Mod-0044 ENSMODP00000006157.3 Monodelphis domestica 45 1e-119 429
WERAM-Pes-0123 ENSPSIP00000014751.1 Pelodiscus sinensis 44 1e-116 420
WERAM-Fia-0004 ENSFALP00000000459.1 Ficedula albicollis 70 2e-112 405
WERAM-Soa-0038 ENSSARP00000003789.1 Sorex araneus 40 9e-101 367
WERAM-Cae-0003 ZK783.4 Caenorhabditis elegans 24 5e-31 135
WERAM-Drm-0051 FBpp0087193 Drosophila melanogaster 54 2e-28 126
WERAM-Cii-0051 ENSCINP00000020063.3 Ciona intestinalis 48 4e-25 115
Created Date 25-Jun-2016