WERAM Information
| Tag | Content | ||||||||||||||||||
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| WERAM ID | WERAM-Hos-0040 | ||||||||||||||||||
| Ensembl Protein ID | ENSP00000440190.1 | ||||||||||||||||||
| Uniprot Accession | Q9H7E2; TDRD3_HUMAN; B2MWP9; Q53XA6; Q6P992 | ||||||||||||||||||
| Genbank Protein ID | NP_001139542.1; NP_001139543.1; NP_110421.1; XP_011533550.1 | ||||||||||||||||||
| Protein Name | Tudor domain-containing protein 3 | ||||||||||||||||||
| Genbank Nucleotide ID | NM_001146070.1; NM_001146071.1; NM_030794.2; XM_011535248.1 | ||||||||||||||||||
| Gene Name | TDRD3 | ||||||||||||||||||
| Ensembl Information |
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| Details |
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| Status | Reviewed | ||||||||||||||||||
| Classification |
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| Organism | Homo sapiens | ||||||||||||||||||
| NCBI Taxa ID | 9606 | ||||||||||||||||||
| Functional Description (View) |
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. | ||||||||||||||||||
| Domain Profile | Me_Reader Tudor Tudor.txt 2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqy 62 |
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| Protein Sequence (Fasta) | MAQVAGAALS QAGWYLSDEG IEACTSSPDK VNVNDIILIA LNTDLRTIGK KFLPSDINSG 60 KVEKLEGPCV LQIQKIRNVA APKDNEESQA APRMLRLQMT DGHISCTAVE FSYMSKISLN 120 TPPGTKVKLS GIVDIKNGFL LLNDSNTTVL GGEVEHLIEK WELQRSLSKH NRSNIGTEGG 180 PPPFVPFGQK CVSHVQVDSR ELDRRKTLQV TMPVKPTNDN DEFEKQRTAA IAEVAKSKET 240 KTFGGGGGGA RSNLNMNAAG NRNREVLQKE KSTKSEGKHE GVYRELVDEK ALKHITEMGF 300 SKEASRQALM DNGNNLEAAL NVLLTSNKQK PVMGPPLRGR GKGRGRIRSE DEEDLGNARP 360 SAPSTLFDFL ESKMGTLNVE EPKSQPQQLH QGQYRSSNTE QNGVKDNNHL RHPPRNDTRQ 420 PRNEKPPRFQ RDSQNSKSVL EGSGLPRNRG SERPSTSSVS EVWAEDRIKC DRPYSRYDRT 480 KDTSYPLGSQ HSDGAFKKRD NSMQSRSGKG PSFAEAKENP LPQGSVDYNN QKRGKRESQT 540 SIPDYFYDRK SQTINNEAFS GIKIEKHFNV NTDYQNPVRS NSFIGVPNGE VEMPLKGRRI 600 GPIKPAGPVT AVPCDDKIFY NSGPKRRSGP IKPEKILESS IPMEYAKMWK PGDECFALYW 660 EDNKFYRAEV EALHSSGMTA VVKFIDYGNY EEVLLSNIKP IQTEAWEEEG TYDQTLEFRR 720 GGDGQPRRST RPTQQFYQPP RARN 744 |
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| Nucleotide Sequence (Fasta) | GGGGTCTCAA GTAGGAGGCC TCCCCATCAC CCCCACCCCA GCCCCCCACC ACCCCCGGCC 60 TAAGCAGCTA CCATGGCCCA GGTGGCCGGC GCGGCGTTGT CCCAGGCGGG TTGGTATCTT 120 TCAGATGAAG GCATTGAAGC TTGCACAAGC TCTCCAGACA AAGTCAATGT AAATGACATC 180 ATCCTGATTG CTCTCAATAC AGATCTGAGA ACAATTGGCA AGAAATTCCT CCCCAGTGAC 240 ATCAATAGTG GAAAGGTAGA AAAGCTCGAA GGTCCATGTG TTTTGCAAAT TCAAAAAATT 300 CGCAATGTTG CTGCACCAAA GGATAATGAA GAATCTCAGG CTGCACCAAG GATGCTGCGA 360 TTACAGATGA CTGATGGTCA TATAAGTTGC ACAGCAGTAG AATTTAGTTA TATGTCAAAA 420 ATAAGCCTGA ACACACCACC TGGAACTAAA GTTAAGCTCT CAGGCATTGT TGACATAAAA 480 AATGGATTCC TGCTCTTGAA TGACTCTAAC ACCACAGTTC TTGGTGGTGA AGTGGAACAC 540 CTTATTGAGA AATGGGAGTT ACAGAGAAGC TTATCAAAAC ACAATAGAAG CAATATTGGA 600 ACTGAAGGTG GACCACCGCC TTTTGTGCCT TTTGGACAGA AGTGTGTATC TCATGTCCAA 660 GTGGATAGCA GAGAACTTGA TCGAAGAAAA ACATTGCAAG TTACAATGCC TGTCAAACCT 720 ACAAATGATA ATGATGAATT TGAAAAGCAA AGGACGGCTG CTATTGCTGA AGTTGCAAAG 780 AGCAAGGAAA CCAAGACATT TGGAGGAGGT GGTGGTGGTG CTAGAAGTAA TCTCAATATG 840 AATGCTGCTG GTAACCGAAA TAGGGAAGTT TTACAGAAAG AAAAGTCAAC CAAATCAGAG 900 GGAAAACATG AAGGTGTCTA TAGAGAACTG GTTGATGAGA AAGCTCTGAA GCACATAACG 960 GAAATGGGCT TCAGTAAGGA AGCATCGAGG CAAGCTCTTA TGGATAATGG CAACAACTTA 1020 GAAGCAGCAC TGAACGTACT TCTTACAAGC AATAAACAGA AACCTGTTAT GGGTCCTCCT 1080 CTGAGAGGTA GAGGAAAAGG CAGGGGGCGA ATAAGATCTG AAGATGAAGA GGACCTGGGA 1140 AATGCAAGGC CATCAGCACC AAGCACATTA TTTGATTTCT TGGAATCTAA AATGGGAACT 1200 TTGAATGTGG AAGAACCTAA ATCACAGCCA CAGCAGCTTC ATCAGGGACA ATACAGATCA 1260 TCAAATACTG AGCAAAATGG AGTAAAAGAT AATAATCATC TGAGACATCC TCCTCGAAAT 1320 GATACCAGGC AGCCAAGAAA TGAAAAACCG CCTCGTTTTC AAAGAGACTC CCAAAATTCA 1380 AAGTCAGTTT TAGAAGGCAG TGGATTACCT AGAAATAGAG GTTCTGAAAG ACCAAGTACT 1440 TCTTCAGTAT CTGAAGTATG GGCTGAAGAC AGAATCAAAT GTGATAGACC GTATTCTAGA 1500 TATGACAGAA CTAAAGATAC TTCATATCCT TTAGGTTCTC AGCATAGTGA TGGTGCTTTT 1560 AAAAAAAGAG ATAACTCTAT GCAAAGCAGA TCAGGAAAAG GTCCCTCCTT TGCAGAGGCA 1620 AAAGAAAATC CACTTCCTCA AGGATCTGTA GATTATAATA ATCAAAAACG TGGAAAAAGA 1680 GAAAGCCAAA CATCTATTCC TGATTATTTT TATGACAGGA AATCACAAAC AATAAATAAT 1740 GAAGCTTTCA GTGGTATAAA AATTGAAAAA CATTTTAATG TAAATACTGA TTATCAGAAT 1800 CCAGTTCGAA GTAATAGTTT CATTGGTGTT CCAAATGGAG AAGTAGAAAT GCCACTGAAA 1860 GGAAGACGAA TAGGACCTAT TAAGCCAGCA GGACCTGTCA CAGCTGTACC CTGTGATGAT 1920 AAAATATTTT ACAATAGTGG GCCCAAACGA AGATCTGGGC CAATTAAGCC AGAAAAAATA 1980 CTAGAATCAT CTATTCCTAT GGAGTATGCA AAAATGTGGA AACCTGGAGA TGAATGTTTT 2040 GCACTTTATT GGGAAGACAA CAAGTTTTAC CGGGCAGAAG TTGAAGCCCT CCATTCTTCG 2100 GGTATGACAG CAGTTGTTAA ATTCATTGAC TACGGAAACT ATGAAGAGGT GCTACTGAGC 2160 AATATCAAGC CCATTCAAAC AGAGGCATGG GAGGAAGAAG GCACCTACGA TCAAACTCTG 2220 GAGTTCCGTA GGGGAGGTGA TGGCCAGCCA AGACGATCCA CTCGGCCAAC CCAACAGTTT 2280 TACCAACCAC CCCGGGCTCG GAACTAATAG GAAAAGACTC TTTGTGAAGA AACGAGCCAG 2340 TGACTGAAAC ACCCTGGTGG AAACCTGTTG ACAGACCTTC CACTTTCTCT TCAGAATAAG 2400 TAGCTGTGGT GGATATTATT ATTTGAAGAA AGAAAAAACA GATTTTAGGG TGGAAAAAAC 2460 AGTCAACTCA CACAAAGAAT GGAAAAAAAT ACTGAGTTAA ATTAAGCAAA TACCTTTTAC 2520 AAGTGAAAGG AAGAATTTTT CTTCTGCCGT CAATAAAACC ATTGTGCTAT TATTGTTTT 2580 |
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| Sequence Source | Ensembl | ||||||||||||||||||
| Keyword | KW-0002--3D-structure |
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| Interpro | IPR013894--RMI1_N |
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| PROSITE | |||||||||||||||||||
| Pfam | PF08585--RMI1_N |
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| Gene Ontology | GO:0005737--C:cytoplasm |
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| Orthology | |||||||||||||||||||
| Created Date | 25-Jun-2016 |