WERAM Information

Tag Content
WERAM ID WERAM-Hos-0219
Ensembl Protein ID ENSP00000419184.2
Uniprot Accession Q9H7B4; SMYD3_HUMAN; A8K0P0; B1AN38; Q86TL8; Q8N5Z6; Q96AI5
Genbank Protein ID NP_001161212.1; NP_073580.1; XP_011542559.1
Protein Name Histone-lysine N-methyltransferase SMYD3
Genbank Nucleotide ID NM_001167740.1; NM_022743.2; XM_011544257.1
Gene Name SMYD3;KMT3E;ZMYND1;ZNFN3A1;bA74P14.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000185420.18 ENST00000490107.5 ENSP00000419184.2
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SMYD SET H3K4 K 25537518; 20951770; 26807165
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SMYD 1.00e-125 420.4 5 240
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
Domain Profile
  HMT SMYD
           SMYD.txt   2 kvekftaegkGrGlravkplragdllfasdayayvvtkssrgvvcdrclkrkeklsrcgqckvakycdakcqkeawpdhkrecsalksykkr 93 
                        kvekf+++++G+Glrav+plr+g+llf+sd++ay+v+k+srgvvcdrcl++kekl+rc+qc+vakyc+akcqk+awpdhkrec++lks+k+r
  ENSP00000419184.2   5 KVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPR 96 
                        8******************************************************************************************* PP
           SMYD.txt  94 yPsesvrllarilvkleiegersesekllsvkdleshveklteekkedlrsdvatlqhfyreeiq...qlpdqfdlveifakvncngftisd 182
                        yP++svrll+r+++kl ++g++sesekl+s++dles+++klte+kke+lr++v+t+qhf+reeiq   qlp++fdl+e+fakv+cn+fti++
  ENSP00000419184.2  97 YPPDSVRLLGRVVFKL-MDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQdasQLPPAFDLFEAFAKVICNSFTICN 187
                        ****************.*************************************************************************** PP
           SMYD.txt 183 eelqevGvgifPdlsllnhscdPnvsvvfnGthlelravreieeGeeltvsyi 235
                        +e+qevGvg++P++sllnhscdPn+s+vfnG+hl+lravr+ie+Geelt++y+
  ENSP00000419184.2 188 AEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL 240
                        ****************************************************7 PP
Protein Sequence
(Fasta)		MEPLKVEKFA TAKRGNGLRA VTPLRPGELL FRSDPLAYTV CKGSRGVVCD RCLLGKEKLM 60
RCSQCRVAKY CSAKCQKKAW PDHKRECKCL KSCKPRYPPD SVRLLGRVVF KLMDGAPSES 120
EKLYSFYDLE SNINKLTEDK KEGLRQLVMT FQHFMREEIQ DASQLPPAFD LFEAFAKVIC 180
NSFTICNAEM QEVGVGLYPS ISLLNHSCDP NCSIVFNGPH LLLRAVRDIE VGEELTICYL 240
DMLMTSEERR KQLRDQYCFE CDCFRCQTQD KDADMLTGDE QVWKEVQESL KKIEELKAHW 300
KWEQVLAMCQ AIISSNSERL PDINIYQLKV LDCAMDACIN LGLLEEALFY GTRTMEPYRI 360
FFPGSHPVRG VQVMKVGKLQ LHQGMFPQAM KNLRLAFDIM RVTHGREHSL IEDLILLLEE 420
CDANIRAS 428
Nucleotide Sequence
(Fasta)		GGACGCGGGT AGCCGTCTGA GGTGCCGGAG CTGCGGGAGG ATGGAGCCGC TGAAGGTGGA 60
AAAGTTCGCA ACCGCCAAGA GGGGAAACGG GCTGCGCGCC GTGACCCCGC TGCGCCCCGG 120
AGAGCTACTC TTCCGCTCGG ATCCCTTGGC GTACACGGTG TGCAAGGGGA GTCGTGGCGT 180
CGTCTGCGAC CGCTGCCTTC TCGGGAAGGA AAAGCTGATG CGATGCTCTC AGTGCCGCGT 240
CGCCAAATAC TGTAGTGCTA AGTGTCAGAA AAAAGCTTGG CCAGACCACA AGCGGGAATG 300
CAAATGCCTT AAAAGCTGCA AACCCAGATA TCCTCCAGAC TCCGTTCGAC TTCTTGGCAG 360
AGTTGTCTTC AAACTTATGG ATGGAGCACC TTCAGAATCA GAGAAGCTTT ACTCATTTTA 420
TGATCTGGAG TCAAATATTA ACAAACTGAC TGAAGATAAG AAAGAGGGCC TCAGGCAACT 480
CGTAATGACA TTTCAACATT TCATGAGAGA AGAAATACAG GATGCCTCTC AGCTGCCACC 540
TGCCTTTGAC CTTTTTGAAG CCTTTGCAAA AGTGATCTGC AACTCTTTCA CCATCTGTAA 600
TGCGGAGATG CAGGAAGTTG GTGTTGGCCT ATATCCCAGT ATCTCTTTGC TCAATCACAG 660
CTGTGACCCC AACTGTTCGA TTGTGTTCAA TGGGCCCCAC CTCTTACTGC GAGCAGTCCG 720
AGACATCGAG GTGGGAGAGG AGCTCACCAT CTGCTACCTG GATATGCTGA TGACCAGTGA 780
GGAGCGCCGG AAGCAGCTGA GGGACCAGTA CTGCTTTGAA TGTGACTGTT TCCGTTGCCA 840
AACCCAGGAC AAGGATGCTG ATATGCTAAC TGGTGATGAG CAAGTATGGA AGGAAGTTCA 900
AGAATCCCTG AAAAAAATTG AAGAACTGAA GGCACACTGG AAGTGGGAGC AGGTTCTGGC 960
CATGTGCCAG GCAATCATAA GCAGCAATTC TGAACGGCTT CCCGATATCA ACATCTACCA 1020
GCTGAAGGTG CTCGACTGCG CCATGGATGC CTGCATCAAC CTCGGCCTGT TGGAGGAAGC 1080
CTTGTTCTAT GGTACTCGGA CCATGGAGCC ATACAGGATT TTTTTCCCAG GAAGCCATCC 1140
CGTCAGAGGG GTTCAAGTGA TGAAAGTTGG CAAACTGCAG CTACATCAAG GCATGTTTCC 1200
CCAAGCAATG AAGAATCTGA GACTGGCTTT TGATATTATG AGAGTGACAC ATGGCAGAGA 1260
ACACAGCCTG ATTGAAGATT TGATTCTACT TTTAGAAGAA TGCGACGCCA ACATCAGAGC 1320
ATCCTAAGGG AACGCAGTCA GAGGGAAATA CGGCGTGTGT CTTTGTTGAA TGCCTTATTG 1380
AGGTCACACA CTCTATGCTT TGTTAGCTGT GTGAACCTCT CCTATTGGAA ATTCTGTTCC 1440
GTGTTTGTGT AGGTAAATAA AGGCAGACAT GGTTTGCAAA CCACAAGAAT CATTAGTTGT 1500
AGAGAAGCAC GATTATAATA AATTCAAAAC ATTTGGTTGA GGATGCCA 1549
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025805--Hist-Lys_N-MeTrfase_Smyd3
IPR001214--SET_dom
IPR002893--Znf_MYND
PROSITE

PS51574--SAM_MT43_2
PS50280--SET
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2
Pfam

PF00856--SET
PF01753--zf-MYND
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0046872--F:metal ion binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0001162--F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0045184--P:establishment of protein localization
GO:0014904--P:myotube cell development
GO:0006469--P:negative regulation of protein kinase activity
GO:0006334--P:nucleosome assembly
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0001 ENSPPYP00000000044.2 Pongo abelii 100 0.0 860
WERAM-Mam-0040 ENSMMUP00000007626.2 Macaca mulatta 99 0.0 854
WERAM-Gog-0225 ENSGGOP00000028735.1 Gorilla gorilla 97 0.0 835
WERAM-Ptv-0002 ENSPVAP00000000324.1 Pteropus vampyrus 96 0.0 830
WERAM-Mum-0199 ENSMUSP00000117410.1 Mus musculus 94 0.0 823
WERAM-Cap-0029 ENSCPOP00000002413.2 Cavia porcellus 94 0.0 813
WERAM-Dio-0005 ENSDORP00000000968.1 Dipodomys ordii 91 0.0 755
WERAM-Bot-0204 ENSBTAP00000044365.2 Bos taurus 85 0.0 723
WERAM-Paa-0169 ENSPANP00000006663.1 Papio anubis 31 8e-57 218
WERAM-Chs-0198 ENSCSAP00000012439.1 Chlorocebus sabaeus 31 9e-57 218
WERAM-Pat-0098 ENSPTRP00000020870.2 Pan troglodytes 32 9e-53 205
WERAM-Caj-0205 ENSCJAP00000035935.2 Callithrix jacchus 29 3e-47 186
WERAM-Ora-0016 ENSOANP00000002495.2 Ornithorhynchus anatinus 31 6e-06 49.3
Created Date 25-Jun-2016