Tag |
Content |
WERAM ID |
WERAM-Hos-0211 |
Ensembl Protein ID |
ENSP00000417980.1 |
Uniprot Accession |
Q9H9B1; EHMT1_HUMAN; B1AQ58; B1AQ59; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4 |
Genbank Protein ID |
NP_001138999.1; NP_079033.4 |
Protein Name |
Histone-lysine N-methyltransferase EHMT1 |
Genbank Nucleotide ID |
NM_001145527.1; NM_024757.4 |
Gene Name |
EHMT1;GLP;GLP1;KMT1D;FP13812;EUHMTASE1;Eu-HMTase1;bA188C12.1;GLP;KIAA1876 |
Ensembl Information |
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Details |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Me_Reader |
Ankyrin |
1.60e-148 |
494.8 |
737 |
967 |
HMT |
SUV39 |
3.10e-39 |
136.6 |
1127 |
1243 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. |
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.
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Domain Profile |
Me_Reader Ankyrin
ANKYRIN_REPEAT.txt 1 fhpkqlylsvkqgelqkvllmlldnldpnfkseqqskrsplhaaaekgsveichvllqaganidavdkdqrtplmeavvnnhlevvkylvk 91 fhpkqly+s++qgelqkvllml+d++dpnfk+e+q+krsplhaaae+g+v+ich+l+qaganid++++dqrtplmea++nnhle+vkyl+k ENSP00000417980.1 737 FHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK 827 9****************************************************************************************** PP ANKYRIN_REPEAT.txt 92 agalvdskeeegstclhlaakkgnlevvslllstgqvdvnaqddggwtpiiwaaeykhvelvklllskgadvtlrdneeniclhwaafsgs 182 agalvd+k++egstclhlaakkg++evv++lls+gq+dvn+qddggwtp+iwa+eykhv+lvklllskg+d+++rdneeniclhwaafsg+ ENSP00000417980.1 828 AGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGC 918 ******************************************************************************************* PP ANKYRIN_REPEAT.txt 183 vdiaevllaakcdlhavnihgdsplhiaaresrydcvllflsrdadvel 231 vdiae+llaakcdlhavnihgdsplhiaare+rydcv+lflsrd+dv+l ENSP00000417980.1 919 VDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTL 967 **********************************************997 PP
HMT SUV39
SUV39.txt 2 rLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegleegdeyladldske 59 rLq+++t++ GwGvr+l+di+ g+Fvc+y+Ge+++d+ea+ + e+d+yl+dld+k+ ENSP00000417980.1 1127 RLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVR---EEDSYLFDLDNKD 1181 8***************************************98...9*********986 PP SUV39.txt 87 keeseyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdYg 150 k+ ++y+ida+ +gnv+rf+nH+c+pNl+ +vf+ ++dlrfpr+afF+++ i+ag++L +dYg ENSP00000417980.1 1180 KDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYG 1243 67899**********************************************************6 PP
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Protein Sequence (Fasta) | MAAADAEAVP ARGEPQQDCC VKTELLGEET PMAADEGSAE KQAGEAHMAA DGETNGSCEN 60 SDASSHANAA KHTQDSARVN PQDGTNTLTR IAENGVSERD SEAAKQNHVT ADDFVQTSVI 120 GSNGYILNKP ALQAQPLRTT STLASSLPGH AAKTLPGGAG KGRTPSAFPQ TPAAPPATLG 180 EGSADTEDRK LPAPGADVKV HRARKTMPKS VVGLHAASKD PREVREARDH KEPKEEINKN 240 ISDFGRQQLL PPFPSLHQSL PQNQCYMATT KSQTACLPFV LAAAVSRKKK RRMGTYSLVP 300 KKKTKVLKQR TVIEMFKSIT HSTVGSKGEK DLGASSLHVN GESLEMDSDE DDSEELEEDD 360 GHGAEQAAAF PTEDSRTSKE SMSEADRAQK MDGESEEEQE SVDTGEEEEG GDESDLSSES 420 SIKKKFLKRK GKTDSPWIKP ARKRRRRSRK KPSGALGSES YKSSAGSAEQ TAPGDSTGYM 480 EVSLDSLDLR VKGILSSQAE GLANGPDVLE TDGLQEVPLC SCRMETPKSR EITTLANNQC 540 MATESVDHEL GRCTNSVVKY ELMRPSNKAP LLVLCEDHRG RMVKHQCCPG CGYFCTAGNF 600 MECQPESSIS HRFHKDCASR VNNASYCPHC GEESSKAKEV TIAKADTTST VTPVPGQEKG 660 SALEGRADTT TGSAAGPPLS EDDKLQGAAS HVPEGFDPTG PAGLGRPTPG LSQGPGKETL 720 ESALIALDSE KPKKLRFHPK QLYFSARQGE LQKVLLMLVD GIDPNFKMEH QNKRSPLHAA 780 AEAGHVDICH MLVQAGANID TCSEDQRTPL MEAAENNHLE AVKYLIKAGA LVDPKDAEGS 840 TCLHLAAKKG HYEVVQYLLS NGQMDVNCQD DGGWTPMIWA TEYKHVDLVK LLLSKGSDIN 900 IRDNEENICL HWAAFSGCVD IAEILLAAKC DLHAVNIHGD SPLHIAAREN RYDCVVLFLS 960 RDSDVTLKNK EGETPLQCAS LNSQVWSALQ MSKALQDSAP DRPSPVERIV SRDIARGYER 1020 IPIPCVNAVD SEPCPSNYKY VSQNCVTSPM NIDRNITHLQ YCVCIDDCSS SNCMCGQLSM 1080 RCWYDKDGRL LPEFNMAEPP LIFECNHACS CWRNCRNRVV QNGLRARLQL YRTRDMGWGV 1140 RSLQDIPPGT FVCEYVGELI SDSEADVREE DSYLFDLDNK DGEVYCIDAR FYGNVSRFIN 1200 HHCEPNLVPV RVFMAHQDLR FPRIAFFSTR LIEAGEQLGF DYGERFWDIK GKLFSCRCGS 1260 PKCRHSSAAL AQRQASAAQE AQEDGLPDTS SAAAADPL 1298Protein Fasta Sequence
>ENSP00000417980.1|EHMT1;GLP;GLP1;KMT1D;FP13812;EUHMTASE1;Eu-HMTase1;bA188C12.1;GLP;KIAA1876|Homo sapiens MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL
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Nucleotide Sequence (Fasta) | GGGCCGCGAG GCGCGGGCGG GGCGATGGCG CGCGGGAGGG GCGGGGCCAC GCTGCGGGCC 60 CGGGCCATGG CCGCCGCCGA TGCCGAGGCA GTTCCGGCGA GGGGGGAGCC TCAGCAGGAT 120 TGCTGTGTGA AAACCGAGCT GCTGGGAGAA GAGACACCTA TGGCTGCCGA TGAAGGCTCA 180 GCAGAGAAAC AGGCAGGAGA GGCCCACATG GCTGCGGACG GTGAGACCAA TGGGTCTTGT 240 GAAAACAGCG ATGCCAGCAG TCATGCAAAT GCTGCAAAGC ACACTCAGGA CAGCGCAAGG 300 GTCAACCCCC AGGATGGCAC CAACACACTA ACTCGGATAG CGGAAAATGG GGTTTCAGAA 360 AGAGACTCAG AAGCGGCGAA GCAAAACCAC GTCACTGCCG ACGACTTTGT GCAGACTTCT 420 GTCATCGGCA GCAACGGATA CATCTTAAAT AAGCCGGCCC TACAGGCACA GCCCTTGAGG 480 ACTACCAGCA CTCTGGCCTC TTCGCTGCCT GGCCATGCTG CAAAAACCCT TCCTGGAGGG 540 GCTGGCAAAG GCAGGACTCC AAGCGCTTTT CCCCAGACGC CAGCCGCCCC ACCAGCCACC 600 CTTGGGGAGG GGAGTGCTGA CACAGAGGAC AGGAAGCTCC CGGCCCCTGG CGCCGACGTC 660 AAGGTCCACA GGGCACGCAA GACCATGCCG AAGTCCGTCG TGGGCCTGCA TGCAGCCAGT 720 AAAGATCCCA GAGAAGTTCG AGAAGCTAGA GATCATAAGG AACCAAAAGA GGAGATCAAC 780 AAAAACATTT CTGACTTTGG ACGACAGCAG CTTTTACCCC CCTTCCCATC CCTTCATCAG 840 TCGCTACCTC AGAACCAGTG CTACATGGCC ACCACAAAAT CACAGACAGC TTGCTTGCCT 900 TTTGTTTTAG CAGCTGCAGT ATCTCGGAAG AAAAAACGAA GAATGGGAAC CTATAGCCTG 960 GTTCCTAAGA AAAAGACCAA AGTATTAAAA CAGAGGACGG TGATTGAGAT GTTTAAGAGC 1020 ATAACTCATT CCACTGTGGG TTCCAAGGGG GAGAAGGACC TGGGCGCCAG CAGCCTGCAC 1080 GTGAATGGGG AGAGCCTGGA GATGGACTCG GATGAGGACG ACTCAGAGGA GCTCGAGGAG 1140 GACGACGGCC ATGGTGCAGA GCAGGCGGCC GCGTTCCCCA CAGAGGACAG CAGGACTTCC 1200 AAGGAGAGCA TGTCGGAGGC TGATCGCGCC CAGAAGATGG ACGGGGAGTC CGAGGAGGAG 1260 CAGGAGTCCG TGGACACCGG GGAGGAGGAG GAAGGCGGTG ACGAGTCTGA CCTGAGTTCG 1320 GAATCCAGCA TTAAGAAGAA ATTTCTCAAG AGGAAAGGAA AGACCGACAG TCCCTGGATC 1380 AAGCCAGCCA GGAAAAGGAG GCGGAGAAGT AGAAAGAAGC CCAGCGGTGC CCTCGGTTCT 1440 GAGTCGTATA AGTCATCTGC AGGAAGCGCT GAGCAGACGG CACCAGGAGA CAGCACAGGG 1500 TACATGGAAG TTTCTCTGGA CTCCCTGGAT CTCCGAGTCA AAGGAATTCT GTCTTCACAA 1560 GCAGAAGGGT TGGCCAACGG TCCAGATGTG CTGGAGACAG ACGGCCTCCA GGAAGTGCCT 1620 CTCTGCAGCT GCCGGATGGA AACACCGAAG AGTCGAGAGA TCACCACACT GGCCAACAAC 1680 CAGTGCATGG CTACAGAGAG CGTGGACCAT GAATTGGGCC GGTGCACAAA CAGCGTGGTC 1740 AAGTATGAGC TGATGCGCCC CTCCAACAAG GCCCCGCTCC TCGTGCTGTG TGAAGACCAC 1800 CGGGGCCGCA TGGTGAAGCA CCAGTGCTGT CCTGGCTGTG GCTACTTCTG CACAGCGGGT 1860 AATTTTATGG AGTGTCAGCC CGAGAGCAGC ATCTCTCACC GTTTCCACAA AGACTGTGCC 1920 TCTCGAGTCA ATAACGCCAG CTATTGTCCC CACTGTGGGG AGGAGAGCTC CAAGGCCAAA 1980 GAGGTGACGA TAGCTAAAGC AGACACCACC TCGACCGTGA CACCAGTCCC CGGGCAGGAG 2040 AAGGGCTCGG CCCTGGAGGG CAGGGCCGAC ACCACAACGG GCAGTGCTGC CGGGCCACCA 2100 CTCTCGGAGG ACGACAAGCT GCAGGGTGCA GCCTCCCACG TGCCCGAGGG CTTTGATCCA 2160 ACGGGACCTG CTGGGCTTGG GAGGCCAACT CCCGGCCTTT CCCAGGGACC AGGGAAGGAA 2220 ACCTTGGAGA GCGCTCTCAT CGCCCTCGAC TCGGAAAAAC CCAAGAAGCT TCGCTTCCAC 2280 CCAAAGCAGC TGTACTTCTC CGCCAGGCAA GGGGAGCTTC AGAAGGTGCT CCTCATGCTG 2340 GTGGACGGAA TTGACCCCAA CTTCAAAATG GAGCACCAGA ATAAGCGCTC TCCACTGCAC 2400 GCCGCGGCAG AGGCTGGACA CGTGGACATC TGCCACATGC TGGTTCAGGC GGGCGCTAAT 2460 ATTGACACCT GCTCAGAAGA CCAGAGGACC CCGTTGATGG AAGCAGCCGA AAACAACCAT 2520 CTGGAAGCAG TGAAGTACCT CATCAAGGCT GGGGCCCTGG TGGATCCCAA GGACGCAGAG 2580 GGCTCTACGT GTTTGCACCT GGCTGCCAAG AAAGGCCACT ACGAAGTGGT CCAGTACCTG 2640 CTTTCAAATG GACAGATGGA CGTCAACTGT CAGGATGACG GAGGCTGGAC ACCCATGATC 2700 TGGGCCACAG AGTACAAGCA CGTGGACCTC GTGAAGCTGC TGCTGTCCAA GGGCTCTGAC 2760 ATCAACATCC GAGACAACGA GGAGAACATT TGCCTGCACT GGGCGGCGTT CTCCGGCTGC 2820 GTGGACATAG CCGAGATCCT GCTGGCTGCC AAGTGCGACC TCCACGCCGT GAACATCCAC 2880 GGAGACTCGC CACTGCACAT TGCCGCCCGG GAGAACCGCT ACGACTGTGT CGTCCTCTTT 2940 CTTTCTCGGG ATTCAGATGT CACCTTAAAG AACAAGGAAG GAGAGACGCC CCTGCAGTGT 3000 GCGAGCCTCA ACTCTCAGGT GTGGAGCGCT CTGCAGATGA GCAAGGCTCT GCAGGACTCG 3060 GCCCCCGACA GGCCCAGCCC CGTGGAGAGG ATAGTGAGCA GGGACATCGC TCGAGGCTAC 3120 GAGCGCATCC CCATCCCCTG TGTCAACGCC GTGGACAGCG AGCCATGCCC CAGCAACTAC 3180 AAGTACGTCT CTCAGAACTG CGTGACGTCC CCCATGAACA TCGACAGAAA TATCACTCAT 3240 CTGCAGTACT GCGTGTGCAT CGACGACTGC TCCTCCAGCA ACTGCATGTG CGGCCAGCTC 3300 AGCATGCGCT GCTGGTACGA CAAGGATGGC CGGCTCCTGC CAGAGTTCAA CATGGCGGAG 3360 CCTCCCTTGA TCTTCGAATG CAACCACGCG TGCTCCTGCT GGAGGAACTG CCGAAATCGC 3420 GTCGTACAGA ATGGTCTCAG GGCAAGGCTG CAGCTCTACC GGACGCGGGA CATGGGCTGG 3480 GGCGTGCGGT CCCTGCAGGA CATCCCACCA GGCACCTTTG TCTGCGAGTA TGTTGGGGAG 3540 CTGATTTCAG ACTCAGAAGC CGACGTTCGA GAGGAAGATT CTTACCTCTT TGATCTCGAC 3600 AATAAGGACG GGGAGGTTTA CTGCATCGAC GCGCGGTTCT ACGGGAACGT CAGCCGGTTC 3660 ATCAACCACC ACTGCGAGCC CAACCTGGTG CCCGTGCGCG TGTTCATGGC CCACCAGGAC 3720 CTGCGGTTCC CCCGGATCGC CTTCTTCAGC ACCCGCCTGA TCGAGGCCGG CGAGCAGCTC 3780 GGGTTTGACT ATGGAGAGCG CTTCTGGGAC ATCAAAGGCA AGCTCTTCAG CTGCCGCTGC 3840 GGCTCCCCCA AGTGCCGGCA CTCGAGCGCG GCCCTGGCCC AGCGTCAGGC CAGCGCGGCC 3900 CAGGAGGCCC AGGAGGACGG CTTGCCCGAC ACCAGCTCCG CGGCTGCCGC CGACCCCCTA 3960 TGAGACGCCG CCGGCCAGCG GGGCGCTCGG GAGCCAGGGA CCGCCGCGTC GCCGATTAGA 4020 GGACGAGGAG GAGAGATTCC GCACGCAACC GAAAGGGTCC TTCGGGGCTG CGCCGCCGGC 4080 TTCCTGGAGG GGTCGGAGGT GAGGCTGCAG CCCCTGCGGG CGGGTGTGGA TGCCTCCCAG 4140 CCACCTTCCC AGACCTGCGG CCTCACCGCG GGCCCAGTGC CCAGGCTGGA GCGCACACTT 4200 TGGTCCGCGC GCCAGAGACG CTGGGAGTCC GCACTGGCAT CACCTTCTGA GTTTCTGATG 4260 CTGATTTGTC GTTGCGAAGT TTCTCGTTTC TTCCTCTGAC CTCCGAGGTC CCCGCTGCAC 4320 CACGGGGTTG CTCTGTTCTC CTGTCCGGCC CAGACTCTTC TGTGTGGCGC CGCCGAAGCC 4380 ACCGTTAGCG CGAGCTGCTC CGTTCGCCCT GCCCACGGCC TGCGTGGCTG GGGCCGAGTC 4440 CCAGGGGCCG CACGGAGGGC ACAGTCTCCT GTCAGGCTCG GAGAGGTCAG GAGACCGACC 4500 CCACCACTAA CTTTGGAGAA AATGTGGGTT TGCTTTTTAA AGGAATCCTA TATCTAGTCC 4560 TATATATCAA ACCTCTAACT GACGTTTCTT TTCGAGGAAG TGGCTTGGTG GGTGCAGCCC 4620 CCGCCGGTTC CGTTGACGCT GGCACCTTCT GTTGATTTTT TAAGCCACAT GCTATGATGA 4680 ATAAACTGAT TTATTTTCTA CCATTACTGA ACATTAGGAC AAACACAAAA TAAAAAACAA 4740 AACACAGACA ACGGTGCTGA TTCTGGTGTG GTTTCTACTC ACCACGTGAA ATAAACTATC 4800 AACTGTATAA AGAGAACAAA GTGATTTTAG AATAAAATGC AGGAAAAACT TTTTTAAAGA 4860 TGTTAGTCTT GTAGCGTGAA TAAATTTGCC ATCACCTTTT GTGTGGTGGC CTGGCAGGTC 4920 ATATACTTTT TTTTGGCATA TACCTTTTTA AAGACTGTAA TTAGTGCAGT AACAGTGGGG 4980 TTTTTTTTGT GCAACTCTTC TAAAAACATT CATAATGCAG TCATGTTTAT TTTTTTCTGT 5040 TAAAATGTTT TTGACAGTTT TAAGAGCAGT CTTTTGGCTC TGACCATTTC TTGTTCTGTT 5100 TCCAATGAAA TCAATAAAAA AAAAGAAGTA CTTTAAA
5138Nucleotide Fasta Sequence
>ENSP00000417980.1|SUV39|Homo sapiens GGGCCGCGAGGCGCGGGCGGGGCGATGGCGCGCGGGAGGGGCGGGGCCACGCTGCGGGCCCGGGCCATGGCCGCCGCCGATGCCGAGGCAGTTCCGGCGAGGGGGGAGCCTCAGCAGGATTGCTGTGTGAAAACCGAGCTGCTGGGAGAAGAGACACCTATGGCTGCCGATGAAGGCTCAGCAGAGAAACAGGCAGGAGAGGCCCACATGGCTGCGGACGGTGAGACCAATGGGTCTTGTGAAAACAGCGATGCCAGCAGTCATGCAAATGCTGCAAAGCACACTCAGGACAGCGCAAGGGTCAACCCCCAGGATGGCACCAACACACTAACTCGGATAGCGGAAAATGGGGTTTCAGAAAGAGACTCAGAAGCGGCGAAGCAAAACCACGTCACTGCCGACGACTTTGTGCAGACTTCTGTCATCGGCAGCAACGGATACATCTTAAATAAGCCGGCCCTACAGGCACAGCCCTTGAGGACTACCAGCACTCTGGCCTCTTCGCTGCCTGGCCATGCTGCAAAAACCCTTCCTGGAGGGGCTGGCAAAGGCAGGACTCCAAGCGCTTTTCCCCAGACGCCAGCCGCCCCACCAGCCACCCTTGGGGAGGGGAGTGCTGACACAGAGGACAGGAAGCTCCCGGCCCCTGGCGCCGACGTCAAGGTCCACAGGGCACGCAAGACCATGCCGAAGTCCGTCGTGGGCCTGCATGCAGCCAGTAAAGATCCCAGAGAAGTTCGAGAAGCTAGAGATCATAAGGAACCAAAAGAGGAGATCAACAAAAACATTTCTGACTTTGGACGACAGCAGCTTTTACCCCCCTTCCCATCCCTTCATCAGTCGCTACCTCAGAACCAGTGCTACATGGCCACCACAAAATCACAGACAGCTTGCTTGCCTTTTGTTTTAGCAGCTGCAGTATCTCGGAAGAAAAAACGAAGAATGGGAACCTATAGCCTGGTTCCTAAGAAAAAGACCAAAGTATTAAAACAGAGGACGGTGATTGAGATGTTTAAGAGCATAACTCATTCCACTGTGGGTTCCAAGGGGGAGAAGGACCTGGGCGCCAGCAGCCTGCACGTGAATGGGGAGAGCCTGGAGATGGACTCGGATGAGGACGACTCAGAGGAGCTCGAGGAGGACGACGGCCATGGTGCAGAGCAGGCGGCCGCGTTCCCCACAGAGGACAGCAGGACTTCCAAGGAGAGCATGTCGGAGGCTGATCGCGCCCAGAAGATGGACGGGGAGTCCGAGGAGGAGCAGGAGTCCGTGGACACCGGGGAGGAGGAGGAAGGCGGTGACGAGTCTGACCTGAGTTCGGAATCCAGCATTAAGAAGAAATTTCTCAAGAGGAAAGGAAAGACCGACAGTCCCTGGATCAAGCCAGCCAGGAAAAGGAGGCGGAGAAGTAGAAAGAAGCCCAGCGGTGCCCTCGGTTCTGAGTCGTATAAGTCATCTGCAGGAAGCGCTGAGCAGACGGCACCAGGAGACAGCACAGGGTACATGGAAGTTTCTCTGGACTCCCTGGATCTCCGAGTCAAAGGAATTCTGTCTTCACAAGCAGAAGGGTTGGCCAACGGTCCAGATGTGCTGGAGACAGACGGCCTCCAGGAAGTGCCTCTCTGCAGCTGCCGGATGGAAACACCGAAGAGTCGAGAGATCACCACACTGGCCAACAACCAGTGCATGGCTACAGAGAGCGTGGACCATGAATTGGGCCGGTGCACAAACAGCGTGGTCAAGTATGAGCTGATGCGCCCCTCCAACAAGGCCCCGCTCCTCGTGCTGTGTGAAGACCACCGGGGCCGCATGGTGAAGCACCAGTGCTGTCCTGGCTGTGGCTACTTCTGCACAGCGGGTAATTTTATGGAGTGTCAGCCCGAGAGCAGCATCTCTCACCGTTTCCACAAAGACTGTGCCTCTCGAGTCAATAACGCCAGCTATTGTCCCCACTGTGGGGAGGAGAGCTCCAAGGCCAAAGAGGTGACGATAGCTAAAGCAGACACCACCTCGACCGTGACACCAGTCCCCGGGCAGGAGAAGGGCTCGGCCCTGGAGGGCAGGGCCGACACCACAACGGGCAGTGCTGCCGGGCCACCACTCTCGGAGGACGACAAGCTGCAGGGTGCAGCCTCCCACGTGCCCGAGGGCTTTGATCCAACGGGACCTGCTGGGCTTGGGAGGCCAACTCCCGGCCTTTCCCAGGGACCAGGGAAGGAAACCTTGGAGAGCGCTCTCATCGCCCTCGACTCGGAAAAACCCAAGAAGCTTCGCTTCCACCCAAAGCAGCTGTACTTCTCCGCCAGGCAAGGGGAGCTTCAGAAGGTGCTCCTCATGCTGGTGGACGGAATTGACCCCAACTTCAAAATGGAGCACCAGAATAAGCGCTCTCCACTGCACGCCGCGGCAGAGGCTGGACACGTGGACATCTGCCACATGCTGGTTCAGGCGGGCGCTAATATTGACACCTGCTCAGAAGACCAGAGGACCCCGTTGATGGAAGCAGCCGAAAACAACCATCTGGAAGCAGTGAAGTACCTCATCAAGGCTGGGGCCCTGGTGGATCCCAAGGACGCAGAGGGCTCTACGTGTTTGCACCTGGCTGCCAAGAAAGGCCACTACGAAGTGGTCCAGTACCTGCTTTCAAATGGACAGATGGACGTCAACTGTCAGGATGACGGAGGCTGGACACCCATGATCTGGGCCACAGAGTACAAGCACGTGGACCTCGTGAAGCTGCTGCTGTCCAAGGGCTCTGACATCAACATCCGAGACAACGAGGAGAACATTTGCCTGCACTGGGCGGCGTTCTCCGGCTGCGTGGACATAGCCGAGATCCTGCTGGCTGCCAAGTGCGACCTCCACGCCGTGAACATCCACGGAGACTCGCCACTGCACATTGCCGCCCGGGAGAACCGCTACGACTGTGTCGTCCTCTTTCTTTCTCGGGATTCAGATGTCACCTTAAAGAACAAGGAAGGAGAGACGCCCCTGCAGTGTGCGAGCCTCAACTCTCAGGTGTGGAGCGCTCTGCAGATGAGCAAGGCTCTGCAGGACTCGGCCCCCGACAGGCCCAGCCCCGTGGAGAGGATAGTGAGCAGGGACATCGCTCGAGGCTACGAGCGCATCCCCATCCCCTGTGTCAACGCCGTGGACAGCGAGCCATGCCCCAGCAACTACAAGTACGTCTCTCAGAACTGCGTGACGTCCCCCATGAACATCGACAGAAATATCACTCATCTGCAGTACTGCGTGTGCATCGACGACTGCTCCTCCAGCAACTGCATGTGCGGCCAGCTCAGCATGCGCTGCTGGTACGACAAGGATGGCCGGCTCCTGCCAGAGTTCAACATGGCGGAGCCTCCCTTGATCTTCGAATGCAACCACGCGTGCTCCTGCTGGAGGAACTGCCGAAATCGCGTCGTACAGAATGGTCTCAGGGCAAGGCTGCAGCTCTACCGGACGCGGGACATGGGCTGGGGCGTGCGGTCCCTGCAGGACATCCCACCAGGCACCTTTGTCTGCGAGTATGTTGGGGAGCTGATTTCAGACTCAGAAGCCGACGTTCGAGAGGAAGATTCTTACCTCTTTGATCTCGACAATAAGGACGGGGAGGTTTACTGCATCGACGCGCGGTTCTACGGGAACGTCAGCCGGTTCATCAACCACCACTGCGAGCCCAACCTGGTGCCCGTGCGCGTGTTCATGGCCCACCAGGACCTGCGGTTCCCCCGGATCGCCTTCTTCAGCACCCGCCTGATCGAGGCCGGCGAGCAGCTCGGGTTTGACTATGGAGAGCGCTTCTGGGACATCAAAGGCAAGCTCTTCAGCTGCCGCTGCGGCTCCCCCAAGTGCCGGCACTCGAGCGCGGCCCTGGCCCAGCGTCAGGCCAGCGCGGCCCAGGAGGCCCAGGAGGACGGCTTGCCCGACACCAGCTCCGCGGCTGCCGCCGACCCCCTATGAGACGCCGCCGGCCAGCGGGGCGCTCGGGAGCCAGGGACCGCCGCGTCGCCGATTAGAGGACGAGGAGGAGAGATTCCGCACGCAACCGAAAGGGTCCTTCGGGGCTGCGCCGCCGGCTTCCTGGAGGGGTCGGAGGTGAGGCTGCAGCCCCTGCGGGCGGGTGTGGATGCCTCCCAGCCACCTTCCCAGACCTGCGGCCTCACCGCGGGCCCAGTGCCCAGGCTGGAGCGCACACTTTGGTCCGCGCGCCAGAGACGCTGGGAGTCCGCACTGGCATCACCTTCTGAGTTTCTGATGCTGATTTGTCGTTGCGAAGTTTCTCGTTTCTTCCTCTGACCTCCGAGGTCCCCGCTGCACCACGGGGTTGCTCTGTTCTCCTGTCCGGCCCAGACTCTTCTGTGTGGCGCCGCCGAAGCCACCGTTAGCGCGAGCTGCTCCGTTCGCCCTGCCCACGGCCTGCGTGGCTGGGGCCGAGTCCCAGGGGCCGCACGGAGGGCACAGTCTCCTGTCAGGCTCGGAGAGGTCAGGAGACCGACCCCACCACTAACTTTGGAGAAAATGTGGGTTTGCTTTTTAAAGGAATCCTATATCTAGTCCTATATATCAAACCTCTAACTGACGTTTCTTTTCGAGGAAGTGGCTTGGTGGGTGCAGCCCCCGCCGGTTCCGTTGACGCTGGCACCTTCTGTTGATTTTTTAAGCCACATGCTATGATGAATAAACTGATTTATTTTCTACCATTACTGAACATTAGGACAAACACAAAATAAAAAACAAAACACAGACAACGGTGCTGATTCTGGTGTGGTTTCTACTCACCACGTGAAATAAACTATCAACTGTATAAAGAGAACAAAGTGATTTTAGAATAAAATGCAGGAAAAACTTTTTTAAAGATGTTAGTCTTGTAGCGTGAATAAATTTGCCATCACCTTTTGTGTGGTGGCCTGGCAGGTCATATACTTTTTTTTGGCATATACCTTTTTAAAGACTGTAATTAGTGCAGTAACAGTGGGGTTTTTTTTGTGCAACTCTTCTAAAAACATTCATAATGCAGTCATGTTTATTTTTTTCTGTTAAAATGTTTTTGACAGTTTTAAGAGCAGTCTTTTGGCTCTGACCATTTCTTGTTCTGTTTCCAATGAAATCAATAAAAAAAAAGAAGTACTTTAAA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0025--Alternative splicing KW-0040--ANK repeat KW-0156--Chromatin regulator KW-0158--Chromosome KW-0181--Complete proteome KW-0225--Disease mutation KW-1017--Isopeptide bond KW-0991--Mental retardation KW-0479--Metal-binding KW-0489--Methyltransferase KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0677--Repeat KW-0949--S-adenosyl-L-methionine KW-0808--Transferase KW-0832--Ubl conjugation KW-0862--Zinc --
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Interpro |
IPR002110--Ankyrin_rpt IPR020683--Ankyrin_rpt-contain_dom IPR007728--Pre-SET_dom IPR001214--SET_dom
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PROSITE |
PS50297--ANK_REP_REGION PS50088--ANK_REPEAT PS50867--PRE_SET PS50280--SET
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Pfam |
PF12796--Ank_2 PF05033--Pre-SET PF00856--SET
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Gene Ontology |
GO:0005694--C:chromosome GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0046976--F:histone methyltransferase activity (H3-K27 specific) GO:0046974--F:histone methyltransferase activity (H3-K9 specific) GO:0018024--F:histone-lysine N-methyltransferase activity GO:0008168--F:methyltransferase activity GO:0002039--F:p53 binding GO:0016279--F:protein-lysine N-methyltransferase activity GO:0008270--F:zinc ion binding GO:0016568--P:chromatin modification GO:0006306--P:DNA methylation GO:0009790--P:embryo development GO:0016571--P:histone methylation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0018027--P:peptidyl-lysine dimethylation GO:0018026--P:peptidyl-lysine monomethylation GO:1901796--P:regulation of signal transduction by p53 class mediator GO:0060992--P:response to fungicide
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Orthology |
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Created Date |
25-Jun-2016 |