WERAM Information

Tag Content
WERAM ID WERAM-Hos-0127
Ensembl Protein ID ENSP00000398824.2
Uniprot Accession Q96BD5; PF21A_HUMAN; D3DQP5; Q6AWA2; Q9C0G7; Q9H8V9; Q9HAK6; Q9NZE9
Genbank Protein ID NP_001095272.1; NP_057705.3; XP_005253019.1; XP_005253022.1; XP_011518475.1; XP_011518476.1; XP_011518481.1
Protein Name PHD finger protein 21A
Genbank Nucleotide ID NM_001101802.1; NM_016621.3; XM_005252962.3; XM_005252965.3; XM_011520173.1; XM_011520174.1; XM_011520179.1
Gene Name PHF21A;BHC80;KIAA1696;BM-006
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135365.15 ENST00000418153.6 ENSP00000398824.2
ENSG00000135365.15 ENST00000323180.10 ENSP00000323152.6
ENSG00000135365.15 ENST00000530587.5 ENSP00000435984.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me0 K 26077434
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 1.40e-10 43.4 489 534
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Domain Profile
  Me_Reader PHD
            PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                        ++C vC +++ +   ++ Cd+C++ +Hl+C+++pl+++p+g  w+Cp+C+ 
  ENSP00000398824.2 489 DFCSVC-RKSGQ---LLMCDTCSRVYHLDCLDPPLKTIPKG-MWICPRCQD 534
                        69****.44444...8*************************.*******85 PP
Protein Sequence
(Fasta)		MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK 60
NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQSA AASPNLTASQ 120
KTVTTASMIT TKTLPLVLKA ATATMPASVV GQRPTIAMVT AINSQKAVLS TDVQNTPVNL 180
QTSSKVTGPG AEAVQIVAKN TVTLVQATPP QPIKVPQFIP PPRLTPRPNF LPQVRPKPVA 240
QNNIPIAPAP PPMLAAPQLI QRPVMLTKFT PTTLPTSQNS IHPVRVVNGQ TATIAKTFPM 300
AQLTSIVIAT PGTRLAGPQT VQLSKPSLEK QTVKSHTETD EKQTESRTIT PPAAPKPKRE 360
ENPQKLAFMV SLGLVTHDHL EEIQSKRQER KRRTTANPVY SGAVFEPERK KSAVTYLNST 420
MHPGTRKRGR PPKYNAVLGF GALTPTSPQS SHPDSPENEK TETTFTFPAP VQPVSLPSPT 480
STDGDIHEDF CSVCRKSGQL LMCDTCSRVY HLDCLDPPLK TIPKGMWICP RCQDQMLKKE 540
EAIPWPGTLA IVHSYIAYKA AKEEEKQKLL KWSSDLKQER EQLEQKVKQL SNSISKCMEM 600
KNTILARQKE MHSSLEKVKQ LIRLIHGIDL SKPVDSEATV GAISNGPDCT PPANAATSTP 660
APSPSSQSCT ANCNQGEETK
Nucleotide Sequence
(Fasta)		CCTCCTCCTC CTGCTTCTCC TGCTCAGAGT TCCTGCCTCC AGCTGCCAGG GGGGACAGCC 60
AGCCAGCAGC AGGAGGGGGG CTAGAGAGCT GAAGGAGAGC CAGTTTCCCC AAAATTGCTG 120
CAGTGAGAAG AGGAGTTTGT TACTTTAAAC AGAGGCTGAA GAAACTATAG AATTAGCAGA 180
GAAAGTGGAG AAGGTAGAGG ATGGAGTTGC AGACTCTACA GGAGGCTCTT AAAGTGGAAA 240
TTCAGGTTCA CCAGAAACTG GTTGCTCAAA TGAAGCAGGA TCCACAGAAT GCTGACTTAA 300
AGAAACAGCT TCATGAACTC CAAGCCAAAA TCACAGCTTT GAGTGAGAAA CAGAAAAGAG 360
TAGTTGAACA GCTACGGAAG AACCTGATAG TAAAGCAAGA ACAACCGGAC AAGTTCCAAA 420
TACAGCCATT GCCACAATCT GAAAACAAAC TACAAACAGC ACAGCAGCAA CCACTACAGC 480
AACTACAACA ACAGCAGCAG TACCACCACC ACCACGCCCA GCAGTCAGCT GCAGCCTCTC 540
CCAACCTGAC TGCTTCACAG AAGACTGTAA CTACAGCTTC TATGATTACC ACAAAGACAC 600
TACCTCTCGT CTTGAAAGCA GCAACTGCGA CCATGCCTGC CTCTGTGGTG GGCCAGAGAC 660
CTACCATTGC TATGGTGACC GCCATCAACA GTCAGAAGGC TGTGCTCAGC ACTGATGTGC 720
AGAACACACC AGTCAACCTC CAGACGTCTA GTAAGGTCAC TGGGCCTGGG GCAGAGGCTG 780
TCCAAATTGT GGCAAAAAAC ACAGTCACTC TGGTTCAGGC AACACCTCCT CAGCCCATCA 840
AAGTACCACA GTTTATCCCC CCTCCTAGAC TCACTCCACG TCCAAACTTT CTTCCACAGG 900
TTCGACCCAA GCCTGTGGCC CAGAATAACA TTCCTATTGC CCCAGCACCA CCTCCCATGC 960
TCGCAGCTCC TCAGCTTATC CAGAGGCCCG TCATGCTGAC CAAGTTCACC CCCACAACCC 1020
TTCCCACATC CCAGAATTCC ATCCACCCCG TCCGTGTCGT CAATGGGCAG ACTGCAACCA 1080
TAGCCAAAAC GTTCCCCATG GCCCAGCTCA CCAGCATTGT GATAGCTACT CCAGGGACCA 1140
GACTCGCTGG ACCTCAAACT GTACAGCTTA GCAAGCCAAG TCTTGAAAAA CAGACAGTTA 1200
AATCTCACAC AGAAACAGAT GAGAAACAAA CAGAGAGCCG CACCATCACC CCACCTGCTG 1260
CACCCAAACC AAAACGGGAG GAGAACCCTC AGAAACTTGC CTTCATGGTG TCTCTAGGGT 1320
TGGTAACACA TGACCATCTA GAAGAAATCC AAAGCAAGAG GCAAGAGCGA AAAAGAAGAA 1380
CAACAGCAAA TCCGGTCTAC AGTGGAGCAG TCTTTGAGCC AGAGCGTAAG AAGAGTGCAG 1440
TGACATACCT AAACAGCACA ATGCACCCTG GGACCCGGAA GAGAGGTCGT CCTCCAAAAT 1500
ACAATGCAGT GCTGGGGTTT GGAGCCCTTA CCCCAACATC CCCCCAATCC AGTCATCCTG 1560
ACTCCCCTGA AAATGAAAAG ACAGAGACCA CATTCACTTT CCCTGCACCT GTTCAGCCTG 1620
TGTCCCTGCC CAGCCCCACC TCCACAGACG GTGATATTCA TGAGGATTTT TGCAGCGTTT 1680
GCAGAAAAAG TGGCCAGTTA CTGATGTGCG ACACATGTTC CCGTGTATAT CATTTGGACT 1740
GCTTAGACCC CCCTCTGAAA ACAATTCCCA AGGGCATGTG GATCTGTCCC AGATGTCAGG 1800
ACCAGATGCT GAAGAAGGAA GAAGCAATTC CATGGCCTGG AACTTTAGCA ATTGTTCATT 1860
CCTATATTGC CTACAAAGCA GCAAAAGAAG AAGAGAAACA GAAGTTACTT AAATGGAGTT 1920
CAGATTTAAA ACAAGAACGA GAACAACTAG AGCAAAAGGT GAAACAGCTC AGCAATTCCA 1980
TAAGTAAATG CATGGAAATG AAGAACACCA TCCTGGCCCG GCAGAAGGAG ATGCACAGCT 2040
CCCTGGAGAA GGTAAAACAG CTGATTCGCC TCATCCACGG CATCGACCTC TCCAAACCTG 2100
TAGACTCTGA GGCCACTGTG GGGGCCATCT CCAATGGCCC GGACTGCACC CCCCCTGCCA 2160
ATGCCGCCAC CTCCACGCCG GCCCCTTCCC CCTCCTCCCA GAGCTGCACA GCGAACTGTA 2220
ACCAGGGGGA AGAGACTAAA TAACAGAGCC CCTCTAGGAG AAGCCACGGG ATCCCGGCGG 2280
CAAGGAGAAC AGAACACTGA AGACTCTAGA AAAGCAAAGC CGGATTTCTG GAAAGTGCAG 2340
AATTCTTTTG GTTCTTTGGT TCCAGAGAGA GAGAAGATGC TTGTGCCAGG TGGCACCAGA 2400
GTTTGCCAAT TGATCCTTCT TATTCTGTGT GTACATGCAA AGATTGGACC ATGTTACATG 2460
AAATAGTGCC AGCTGGAGGT TCTTTGCCAG CACCATGCCA AGTGAAATAA TATATTTACT 2520
CTCTCTATTA TACACCAGTG TGTGCCTGCA GCAGCCTCCA CAGCCACGAT GGGTTTGTTT 2580
CTGTTTTCTT GGGTGGGGAG CAGGGACGGG CGGAGGGAGG AGAGCAGGTT TCAGATCCTT 2640
ACTTGCCGAG CCGTTTGTTT AGGTAGAGAA GACAAGTCCA AAGAGTGTGT GGGCTTTCCT 2700
GTTTCTAAAC TTTCGCTACT ATAAAACCAA 2731
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
Gene Ontology

GO:1990391--C:DNA repair complex
GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0004407--F:histone deacetylase activity
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0007596--P:blood coagulation
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0026 ENSPTRP00000006148.5 Pan troglodytes 100 0.0 1183
WERAM-Gog-0024 ENSGGOP00000002265.2 Gorilla gorilla 100 0.0 1178
WERAM-Poa-0032 ENSPPYP00000003818.2 Pongo abelii 100 0.0 1177
WERAM-Nol-0160 ENSNLEP00000016998.1 Nomascus leucogenys 100 0.0 1175
WERAM-Otg-0130 ENSOGAP00000011255.2 Otolemur garnettii 99 0.0 1139
WERAM-Caf-0103 ENSCAFP00000013745.3 Canis familiaris 97 0.0 1137
WERAM-Ptv-0027 ENSPVAP00000003342.1 Pteropus vampyrus 97 0.0 1136
WERAM-Myl-0165 ENSMLUP00000013444.2 Myotis lucifugus 98 0.0 1136
WERAM-Dio-0156 ENSDORP00000014596.1 Dipodomys ordii 96 0.0 1133
WERAM-Tut-0012 ENSTTRP00000000983.1 Tursiops truncatus 95 0.0 1130
WERAM-Fec-0181 ENSFCAP00000019146.1 Felis catus 96 0.0 1127
WERAM-Mup-0064 ENSMPUP00000005601.1 Mustela putorius furo 96 0.0 1127
WERAM-Cap-0008 ENSCPOP00000001178.2 Cavia porcellus 97 0.0 1125
WERAM-Ova-0022 ENSOARP00000003228.1 Ovis aries 94 0.0 1121
WERAM-Orc-0013 ENSOCUP00000001434.2 Oryctolagus cuniculus 95 0.0 1112
WERAM-Ran-0037 ENSRNOP00000061099.3 Rattus norvegicus 94 0.0 1108
WERAM-Vip-0070 ENSVPAP00000006550.1 Vicugna pacos 89 0.0 1084
WERAM-Mod-0184 ENSMODP00000034189.2 Monodelphis domestica 89 0.0 1084
WERAM-Tag-0134 ENSTGUP00000011014.1 Taeniopygia guttata 88 0.0 1081
WERAM-Fia-0081 ENSFALP00000006511.1 Ficedula albicollis 88 0.0 1072
WERAM-Sah-0157 ENSSHAP00000016521.1 Sarcophilus harrisii 92 0.0 1065
WERAM-Caj-0120 ENSCJAP00000021488.2 Callithrix jacchus 94 0.0 1059
WERAM-Chs-0061 ENSCSAP00000001965.1 Chlorocebus sabaeus 100 0.0 1052
WERAM-Aim-0011 ENSAMEP00000000630.1 Ailuropoda melanoleuca 97 0.0 1042
WERAM-Mam-0018 ENSMMUP00000003518.2 Macaca mulatta 92 0.0 1038
WERAM-Loa-0043 ENSLAFP00000002984.4 Loxodonta africana 98 0.0 1038
WERAM-Mim-0128 ENSMICP00000013003.1 Microcebus murinus 92 0.0 1024
WERAM-Gaga-0085 ENSGALP00000013674.5 Gallus gallus 89 0.0 1022
WERAM-Anp-0010 ENSAPLP00000001908.1 Anas platyrhynchos 88 0.0 1022
WERAM-Bot-0093 ENSBTAP00000012652.4 Bos taurus 94 0.0 1020
WERAM-Eqc-0131 ENSECAP00000014828.1 Equus caballus 95 0.0 1018
WERAM-Mae-0134 ENSMEUP00000013413.1 Macropus eugenii 82 0.0 1004
WERAM-Sus-0164 ENSSSCP00000022039.1 Sus scrofa 96 0.0 969
WERAM-Ora-0055 ENSOANP00000008522.3 Ornithorhynchus anatinus 94 0.0 963
WERAM-Dan-0008 ENSDNOP00000000927.3 Dasypus novemcinctus 96 0.0 961
WERAM-Meg-0114 ENSMGAP00000011531.2 Meleagris gallopavo 83 0.0 946
WERAM-Pes-0127 ENSPSIP00000015001.1 Pelodiscus sinensis 90 0.0 927
WERAM-Ect-0104 ENSETEP00000011849.1 Echinops telfairi 83 0.0 903
WERAM-Lac-0184 ENSLACP00000021179.1 Latimeria chalumnae 75 0.0 855
WERAM-Ocp-0098 ENSOPRP00000009049.2 Ochotona princeps 88 0.0 840
WERAM-Mum-0205 ENSMUSP00000038497.8 Mus musculus 94 0.0 791
WERAM-Xet-0004 ENSXETP00000002259.3 Xenopus tropicalis 75 0.0 774
WERAM-Leo-0049 ENSLOCP00000006781.1 Lepisosteus oculatus 70 0.0 773
WERAM-Soa-0124 ENSSARP00000011924.1 Sorex araneus 99 0.0 753
WERAM-Anc-0158 ENSACAP00000014715.2 Anolis carolinensis 87 0.0 711
WERAM-Ict-0101 ENSSTOP00000015864.1 Ictidomys tridecemlineatus 95 0.0 672
WERAM-Gaa-0077 ENSGACP00000010464.1 Gasterosteus aculeatus 62 0.0 637
WERAM-Ten-0169 ENSTNIP00000016757.1 Tetraodon nigroviridis 60 1e-180 630
WERAM-Orla-0154 ENSORLP00000017902.1 Oryzias latipes 64 1e-178 624
WERAM-Xim-0074 ENSXMAP00000006896.1 Xiphophorus maculatus 61 1e-177 620
WERAM-Tas-0116 ENSTSYP00000011950.1 Tarsius syrichta 99 2e-177 620
WERAM-Orn-0220 ENSONIP00000022945.1 Oreochromis niloticus 61 5e-176 615
WERAM-Dar-0053 ENSDARP00000019987.9 Danio rerio 57 3e-174 609
WERAM-Asm-0189 ENSAMXP00000018222.1 Astyanax mexicanus 61 4e-174 609
WERAM-Pof-0151 ENSPFOP00000012381.2 Poecilia formosa 57 4e-167 585
WERAM-Gam-0100 ENSGMOP00000010189.1 Gadus morhua 56 2e-156 550
WERAM-Tar-0163 ENSTRUP00000034720.1 Takifugu rubripes 62 8e-153 538
WERAM-Pem-0052 ENSPMAP00000006082.1 Petromyzon marinus 65 3e-100 363
WERAM-Paa-0100 ENSPANP00000013535.1 Papio anubis 44 2e-55 214
WERAM-Prc-0044 ENSPCAP00000004137.1 Procavia capensis 31 1e-28 125
WERAM-Php-0082 PP1S33_329V6.1 Physcomitrella patens 55 1e-16 85.9
WERAM-Sem-0049 EFJ08442 Selaginella moellendorffii 57 2e-16 85.1
WERAM-Drm-0021 FBpp0074766 Drosophila melanogaster 53 9e-15 79.7
WERAM-Chh-0003 ENSCHOP00000000249.1 Choloepus hoffmanni 58 2e-14 79.0
WERAM-Ere-0102 ENSEEUP00000010821.1 Erinaceus europaeus 58 2e-14 78.6
WERAM-Bro-0176 Bo9g068090.1 Brassica oleracea 37 3e-14 78.2
Created Date 25-Jun-2016