WERAM Information

Tag Content
WERAM ID WERAM-Hos-0215
Ensembl Protein ID ENSP00000384490.3
Uniprot Accession O95503; CBX6_HUMAN; A8KAH0; Q96EM5
Genbank Protein ID NP_001290423.1; NP_055107.3
Protein Name Chromobox protein homolog 6
Genbank Nucleotide ID NM_001303494.1; NM_014292.4
Gene Name CBX6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183741.11 ENST00000407418.7 ENSP00000384490.3
ENSG00000183741.11 ENST00000216083.6 ENSP00000216083.6
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K9me3; H3K27me3 K 23842000
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 7.20e-22 79.5 11 68
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Domain Profile
  Me_Reader Chromodomain
   Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59
                       F++e+i+ k+++rkg++eYlV+WkG+  +++tWepeen+l+++l+++fe+k+++++++g
  ENSP00000384490.3 11 FAAESII-KRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYG 68
                       99*****.**********************************************99876 PP
Protein Sequence
(Fasta)		MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD SRLIAAFEQK 60
ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK PSASASSPKL HSSAAVHRLK 120
KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI SPFSETVRII NRKVKPREPK RNRIILNLKV 180
IDKGAGGGGA GQGAGALARP KVPSRNRVIG KSKKFSESVL RTQIRHMKFG AFALYKPPPA 240
PLVAPSPGKA EASAPGPGLL LAAPAAPYDA RSSGSSGCPS PTPQSSDPDD TPPKLLPETV 300
SPSAPSWREP EVLDLSLPPE SAATSKRAPP EVTAAAGPAP PTAPEPAGAS SEPEAGDWRP 360
EMSPCSNVVV TDVTSNLLTV TIKEFCNPED FEKVAAGVAG AAGGGGSIGA SK 412
Nucleotide Sequence
(Fasta)		CGCGAGCGCG CGCCCCGCCG CGCTCCCGCC CGCCGGGGCC TGGGCGCTGC GGCGCGTGCG 60
CGAGCGGTGC CGCACCGGCC GCGGGCGCAG GGAGTATTAT GGGCTGTGGG TGCCGCTGAG 120
CAAGATGGAG CTGTCTGCAG TGGGCGAGCG GGTCTTCGCG GCCGAATCCA TCATCAAACG 180
GCGGATCCGA AAGGGACGCA TCGAGTACCT GGTGAAATGG AAGGGGTGGG CGATCAAGTA 240
CAGCACTTGG GAGCCCGAGG AGAACATCCT GGACTCGCGG CTCATTGCAG CCTTCGAACA 300
AAAGGAGAGG GAGCGTGAGC TGTATGGGCC CAAGAAGAGG GGACCCAAAC CCAAAACTTT 360
CCTCCTGAAG GCGCGGGCCC AGGCCGAGGC CCTCCGCATC AGTGATGTGC ATTTCTCTGT 420
CAAGCCGAGC GCCAGTGCCT CCTCGCCCAA GCTGCACTCC AGCGCAGCCG TGCACCGGCT 480
CAAGAAGGAC ATCCGCCGCT GCCACCGTAT GTCCCGCCGT CCCCTGCCCC GCCCGGACCC 540
GCAGGGGGGC AGCCCCGGAC TGCGCCCGCC CATTTCGCCC TTCTCGGAGA CGGTGCGCAT 600
CATCAACCGC AAGGTGAAGC CGCGGGAGCC CAAGCGGAAC CGCATCATCC TGAACCTGAA 660
GGTGATCGAC AAGGGCGCTG GCGGCGGGGG CGCCGGGCAG GGGGCCGGGG CGCTGGCCCG 720
CCCCAAAGTC CCCTCGCGGA ACCGCGTTAT AGGCAAGAGC AAGAAGTTCA GCGAGAGCGT 780
CCTGCGTACA CAGATCCGCC ACATGAAGTT CGGCGCCTTT GCGCTGTACA AGCCTCCGCC 840
CGCCCCCCTG GTAGCCCCGT CCCCCGGCAA GGCTGAGGCC TCAGCCCCGG GCCCTGGGCT 900
ACTTCTGGCC GCCCCCGCCG CCCCCTACGA CGCCCGCAGC TCTGGCTCCT CCGGCTGCCC 960
CTCGCCTACA CCACAGTCCT CTGACCCCGA CGACACGCCC CCCAAGCTCC TCCCCGAGAC 1020
CGTGAGCCCA TCCGCCCCCA GCTGGCGCGA GCCGGAGGTG CTCGACCTGT CCCTCCCTCC 1080
CGAGTCGGCA GCCACCAGCA AGCGGGCACC GCCTGAGGTC ACAGCTGCTG CCGGCCCGGC 1140
ACCTCCCACG GCCCCTGAGC CCGCCGGTGC CTCCTCCGAG CCCGAGGCTG GGGACTGGCG 1200
CCCCGAGATG TCACCCTGCT CCAATGTGGT CGTCACCGAT GTCACCAGCA ACCTCCTGAC 1260
GGTCACAATC AAGGAATTCT GCAACCCTGA GGATTTCGAG AAGGTGGCTG CTGGGGTAGC 1320
AGGCGCCGCT GGGGGCGGTG GCAGCATTGG GGCGAGCAAG TGAGGGGGCT CCACCAAGGA 1380
GGGGGGCTTG GGGGGGCCCT CCTGCCCGAA GTCATACTCT TGCTCCCACC CCACCCTTGC 1440
CCCCAGCCCT CTCTCCCTGT GCTTTGCTTG TCTCAAATGG CTCGGTGTTG ACCCAGGGAT 1500
GGGGCTGGGT AGTTGGGGTC CCAGAAAGCC GGGGGTAGGG GCCACCCTGG AATGGGGCAG 1560
GGGAAGGGCA CACCCCCTGC CCATGCATGG TAGCCCACTG GGTGGTTTCT GGAAAGCCCT 1620
AGAAACTAGG GTTCCTCTGC CCCTTCCACA TCCCACCTGT CTCTCTAGCT TGCTTCCTGC 1680
TCTCCTGTGC GGCGTCTGAT TTCTCGGTGC TAACCTGGCA GCTGTGGGGC CCTTAGGAGC 1740
CCCCCACCGA GGGTGGACAC AGTCCCTTTC CTTCCTGCAG ATGCCTAGGC AGGAGGAGGG 1800
CTTCCTGCCT GTTTGGCAAA GTCCCAGGCA GAGGCCAAGG ATGAGGCCTG ACTCGGCTCC 1860
TCCCTCCACA TCAGCCAGGG CATCAGAAGT TGGGCCAGGG CGGGGTCTTC CCTGCTCGAT 1920
TTTGGACGAG GCCTAAGTAG ACCCCCTATG CCCTGCCCCA GCCCTGGCTC TTTCCTAACC 1980
CCCTCAACGG TGGGAGGAAC TGGCAGAGGG TGCGCCTGGC CACAGCCTCC CCGCATCTAA 2040
AGGCCCCTTC AGTTCTTGAC CAAAGGTGCT ACGAGAACCT GCCGTGGAAA CTTCCAGTTG 2100
TGCGTCTGCC CCACTCGCTG TGTTTGTCCG TGGGTTCATA CATGCATTGG GTGCTAGGCC 2160
CCAGGCTGCC GGGTGGCACC CTTTACAGTT CCTTTGAACA GGGGCATTGA AGGCCTGGAC 2220
TGCCTCTCGC CTCAGTAGGC CTGGGGACCA GGCTTGGGTC TGGAGGTTTG CTGTGGAAGT 2280
CACCAGGCCT CCCCTCCTGG CCCAGGTGTG CTGGGGGCAC CGTGCCCCCC ACCCCCCTGC 2340
CCTCCTCAGG GTGGTCAGCC CAACCTGTCG GACCTTCACT TCACATCATG GTGGGGACCG 2400
AGATAGAGAG GGAGACCCCA TTCCAAGCTC CCTCTTCCTC CGGGTGTTTG GGGAGGATGC 2460
TGAAGAATCC ATTCCCGAGG GCCTCCCGGC TTGTCCCAGC CCCTCTTTTG CTTCTGACCA 2520
CGGAGGCTTT CTCACAGCCC AGCCTGCCTG AAGCAAAGGA GGCTCCCGTG TCCTGGGCAG 2580
CTTCTGTTTC CCTCTGCTGC CTGGGAGCTG AGGCACCCGT GCCAGTGGCA GAGGCCACAG 2640
CCCCAGCCTT AGGCCAGGCC CTGGGAGGGC AGGCAGGCAA AGGGGAGACC AGAGGGTCTG 2700
TGTTCTCCAG GAGAATGAGG GTGTTGGTCC CAGAATTGGG ACCGGGGCCC CGCTGGCCAG 2760
CCCTGGGCCA CTTCCCGGGT CTCCATTGTG CGTGGGTGGC GTGTTCCAGG CGTGGCTGGA 2820
GCTGGCTTCC TGGCTGTGCT GCCATGGGCC CCTCCCTCAG AAGCACGTTG GCAGGAGGCC 2880
GATCAGAACC CTAGCGCCTT TGGTCCTAAG AATGGGAGGC TGCCTTCCTT CCCAATCTCC 2940
CTGCCAGGGC CCACAGCGTG GCCCTAGCCC TCCCCTCCCC GGGATGTAGA ACGGGGACCC 3000
TCGCAGGGTT GGGGCGGGGG CTGATACTCC TCGGCCCCTC CCTACCCTGC CCTGTGTGTT 3060
GGCTTTGTGG CCGTCCAAGT GCCAATTGGC TTTTCGCCCA AATAAGGGCT GGTATTTCTC 3120
CTCTGTCCTT GGAGGTGATT TCCCCCTGAC CCCCTCCCCC AGGTGAGTGA CCACCTGGGT 3180
GCCAGTTACA GGTGTTTCCA GAGACCATAG AAATGTGTTT TCCTGAGAGT TCGTGTCATT 3240
CGTGACTTTT TTGTAAAGAA GTTGTGTTTT CAGAGGTGAT TTTATGACAG GAAAGTGAAA 3300
GAATTAGTTT TGCAAAAAAA CAAAAACAAA AAAAGAGGAA AAAAAAAAGA AATAGAAAAA 3360
AATATTGTGG GATTCCTATG GGGGGGTGGC GGGGGAGAAA GAGCTATTTA AGAAAAAATA 3420
GTAACGCAGT GATTGCACAG GTGAGGTGGC AATGTCAGGA TGGGGCGGAG GCCTGGGCCC 3480
AGCTGGCAGG TCCCCTGGCA TCGCAGGCAC TGTGGAGAGG GCCTGGACCC AGATCTCCAC 3540
ACCCGTGCTT GCTCAAAGGG AAGGACAACA GCGGGCCCCC GGGAGCTAAC CCAAGCTGCA 3600
GGTCCCGGCA AGCTGAGGTT TGGGAGGGTG GGGGTTGTCA CTGGTGATTT TCTCCAGGGG 3660
GCTGGTGAGT GGGCAGTTTG GTTTCTTGCC CCCTTCTGTT CCTTTCCCAG TTGTTGGGCC 3720
ATCTGGTCCC CACCACCGCC ACCCTATGGG GGAGACCTCC CTCCCCACGG GTCACCCTAA 3780
AGCCCACAAC CTCTCTGAGC CTCCCTGGCC TGAAAGGGGA TGCAGGCTTC AGGAGGCAAG 3840
AAGCTGGGCC CCTGGGGGTG GCTGGGGAGA GGGAATGCAT TTCCCTTGCC ACAGGTGGTC 3900
TGCTTCTGCT GGCCTGAGCT CCAAGTGGAG CAGCCCGGGC CAGCCTTGGT GCATGAAGAG 3960
GCACCAGGCA CACCGCCTTG AGGTGGGCAG TGCCCATGGG GGCCCGAGTG GATGGGACCG 4020
AGGGTGAGTG GAGCCTCCTT CCTCCCCTCT CTAGTACCCC CGCCTCCCAC ACACTTGCAC 4080
GGATCGGCCT CCCTTGGGAG ATCAGCCTCC ATGGGCCCCT CGTCCACCCT TGCTGCTTTC 4140
CATTTGCCTA ATTACCAAGC AGAAGTTGCA ATCTGGTTTG CTTTATTTTT GTATGTGAAA 4200
TAACCCCCAA AGCCCAATCT CCTCCTACGT TCAATATTGG TTGGGGCATC CGTCATCTCC 4260
CCTTAAGTGC GCCCCCTCCC CACCCAAGTA TCATAGGAAA CCGGTGAGGT CTGGTGTCTC 4320
TGGTTTGAGA CGGTAAGTTG GGACCCATCC CTGTCTGGGT GCCCACTCTG ACCTTTAGTT 4380
TGCCCTTCTG TGAAATGGGT GTATTGGGTA GCAAGCCCTC TTCAGAAAGC GCTGCTGGTG 4440
TCAGAGCAGC TGCCCAGTAC CAGGTGGGGG GTCAAGGTTG CTGGTACTGG GGCCCCCAGC 4500
TGCCCACAAC CCCTCTTTGT TCTCACCCTG CAAAGGGGTC AAGGTCAAAA TGAGCCTCAT 4560
CCTTCCTATG ATCTGGGAAG AGGTGATGAT CAAGTCCCCA ACTTCAGTGT GAGGTGGACA 4620
GAGTTGGGGG GATGGCCCCT TTTTGAAGAG GTGAAAATGG TTTTGGAGAA GCGCAGCTGC 4680
TTCACTGGGG GAATGCGGCA GGGACTGGGG CCCAGGATGC TTTGGCCTAT GGGGAAAAGC 4740
CCTTTAAAAG GCAGGGCCCA GGCCCTGGAG CCAGCACAAG ACTGGCCTCG AGCCCCTGAG 4800
CCAGGAGGTC CTGGAGGAGA GCCAGGCCGG TGGGCCCGCC CAAGGCTGGA GGGTCAGCCC 4860
CAACAGGGAG CTGGGTTGGC CAGGGGGCTG GACTGCTACC AGCCTCTCTG GCCTATGGGG 4920
ACCCAAGAGG ACACATCCCC CTTTTGCCCA CTCTTCTGTG TCATTTTGTT GTTTTGGTTT 4980
GTGGTGGTTT TTCTTTTTTC TTTTGTTTTT CTTTTTTCTT TCTTTCTTTT TTTTTTTTTT 5040
TTTTTTTTTT TTTGCACTTC GCCCACACAG GACAGTGGAG CCCCACCTGG TCAGTTCCAC 5100
TTCCGGGCTC CCATGCACTT GCCCAAGGCG GCCTCTTTGG GACGGGGATG GTTTGAGGAA 5160
ACACTTTTAA AGAAAAAAGG AAGACATTGA AAGGTTTTAG TTTCTTCCCT ATCTGCATGT 5220
CCTCTCATAT AGAAAGCCCA GAATTAGGGG CTAGAACTCC AGGAGAGGGT CTCCCCGACT 5280
CATCTCTTGC TGACGGTCAC CAGGATGCAG AAATAGGGAG ATGGTTAGTG GGGGCCAAAG 5340
ATGCCCCCTC CCAGGCCTTC GTGGTTCCCT CCTCCGCCCC CTGCAATCTT TGGAGGAGTC 5400
AGTGCCTCAC TCCAGCAGTG AGTGCCTACT GTATGCAGGT AGTCAGCCAG GCAAAGAGAG 5460
ACTAACGGTC TCATGGGGGA ACCCTCTTGC GGGAGGCCGG GTAGCTGGAG CGAAGCGTTC 5520
CGGCTGCCCT TGCTGCTGGG TGGAGTGGAG AGGGAGACTT CTTTTTGTTG GTTTTAATTT 5580
AAAAACACAA AGGCCTAAAG AAATACGTAT CTTATAATTT TTTTAATTTT TGAGACGTTC 5640
ATTTAATGAA TTGTGCACGA ATGAATTCTA TATATATAAA ATATACATAT ATAGCTCTAT 5700
ATTTGGGGAG GGGCACTGTC TCTTTTTTCT CTCATTTTTA AAATGAAGTG TTGTTGCCTT 5760
TGTATGTGGT TCAACCATCC AGCTCCCAGC TGGCTAAACT TTGCCTCCAG TGGTCAAAGA 5820
TGGGAAAAGA GTGGGGTTGG CAGGAGATGG AAAACGGAGG TGCCGCCCCA GCATGGGGGG 5880
CAGGTCCCCC AGTCCACCCT GCCCCTCCCC CTGTGGAGAA GACGCTTAGT TGGGGGTGTG 5940
GGTTTGGGCT CCATTCTGGA TTCGGCGGTT CCGGGGGAGG GGTGGGTCTG TGCCGATTAC 6000
TCTGTCTTGT ACGTTTGTTC TGCTGCTCTT CAATATTGTA TCAACGCCAG GAAAGGGGGG 6060
TGAAAAGCCT CTTTTACCCC CCAAATAAAT TGTCACATTC CGAAGCTGAG GCCTAGCCCC 6120
TA 6123
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
Gene Ontology

GO:0000792--C:heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0003727--F:single-stranded RNA binding
GO:0016568--P:chromatin modification
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0165 ENSNLEP00000018459.1 Nomascus leucogenys 98 4e-143 505
WERAM-Paa-0058 ENSPANP00000013346.1 Papio anubis 96 3e-142 502
WERAM-Chs-0074 ENSCSAP00000002741.1 Chlorocebus sabaeus 96 1e-141 500
WERAM-Gog-0051 ENSGGOP00000004565.2 Gorilla gorilla 95 3e-141 498
WERAM-Ict-0163 ENSSTOP00000018543.1 Ictidomys tridecemlineatus 92 6e-138 488
WERAM-Poa-0099 ENSPPYP00000013197.2 Pongo abelii 97 9e-138 487
WERAM-Tut-0107 ENSTTRP00000008922.2 Tursiops truncatus 90 1e-137 487
WERAM-Bot-0218 ENSBTAP00000055457.1 Bos taurus 90 1e-137 487
WERAM-Caf-0018 ENSCAFP00000001953.4 Canis familiaris 90 5e-137 484
WERAM-Otg-0197 ENSOGAP00000016360.1 Otolemur garnettii 89 7e-137 484
WERAM-Ptv-0108 ENSPVAP00000009576.2 Pteropus vampyrus 87 1e-135 479
WERAM-Mup-0150 ENSMPUP00000013100.1 Mustela putorius furo 89 3e-135 479
WERAM-Eqc-0147 ENSECAP00000016028.1 Equus caballus 91 9e-135 477
WERAM-Ect-0139 ENSETEP00000015740.1 Echinops telfairi 87 4e-133 472
WERAM-Ran-0199 ENSRNOP00000061325.1 Rattus norvegicus 80 3e-125 445
WERAM-Anc-0081 ENSACAP00000007710.2 Anolis carolinensis 75 1e-124 443
WERAM-Pes-0118 ENSPSIP00000014005.1 Pelodiscus sinensis 76 3e-124 442
WERAM-Lac-0008 ENSLACP00000001305.1 Latimeria chalumnae 66 1e-116 417
WERAM-Cap-0215 ENSCPOP00000020733.1 Cavia porcellus 78 2e-116 416
WERAM-Xet-0045 ENSXETP00000015103.3 Xenopus tropicalis 65 3e-116 415
WERAM-Mod-0074 ENSMODP00000011965.2 Monodelphis domestica 73 8e-110 394
WERAM-Fec-0115 ENSFCAP00000010125.3 Felis catus 97 2e-102 370
WERAM-Asm-0035 ENSAMXP00000004721.1 Astyanax mexicanus 65 6e-65 245
WERAM-Dar-0197 ENSDARP00000127727.1 Danio rerio 56 7e-61 232
WERAM-Orla-0109 ENSORLP00000013159.1 Oryzias latipes 60 2e-60 230
WERAM-Orn-0161 ENSONIP00000016483.1 Oreochromis niloticus 64 7e-57 218
WERAM-Ten-0218 ENSTNIP00000022027.1 Tetraodon nigroviridis 64 1e-56 217
WERAM-Tar-0039 ENSTRUP00000009617.1 Takifugu rubripes 57 5e-56 215
WERAM-Pof-0253 ENSPFOP00000026056.1 Poecilia formosa 60 7e-56 215
WERAM-Gaa-0211 ENSGACP00000026232.1 Gasterosteus aculeatus 58 4e-51 199
WERAM-Dio-0159 ENSDORP00000014864.2 Dipodomys ordii 69 1e-50 197
WERAM-Mum-0231 ENSMUSP00000105252.1 Mus musculus 98 6e-50 195
WERAM-Loa-0177 ENSLAFP00000016274.2 Loxodonta africana 59 3e-46 183
WERAM-Gam-0102 ENSGMOP00000010469.1 Gadus morhua 60 2e-45 180
WERAM-Xim-0220 ENSXMAP00000017956.1 Xiphophorus maculatus 90 1e-33 141
WERAM-Caj-0234 ENSCJAP00000048058.1 Callithrix jacchus 90 1e-33 141
WERAM-Tub-0039 ENSTBEP00000004995.1 Tupaia belangeri 87 9e-31 132
WERAM-Myl-0216 ENSMLUP00000018435.1 Myotis lucifugus 87 2e-30 131
WERAM-Aim-0169 ENSAMEP00000015919.1 Ailuropoda melanoleuca 86 2e-30 130
WERAM-Pat-0081 ENSPTRP00000016554.4 Pan troglodytes 86 3e-30 130
WERAM-Sus-0128 ENSSSCP00000018184.2 Sus scrofa 86 3e-30 130
WERAM-Dan-0132 ENSDNOP00000034654.1 Dasypus novemcinctus 86 3e-30 130
WERAM-Sah-0110 ENSSHAP00000011795.1 Sarcophilus harrisii 85 6e-30 129
WERAM-Mam-0152 ENSMMUP00000021562.2 Macaca mulatta 86 8e-30 129
WERAM-Ova-0016 ENSOARP00000002822.1 Ovis aries 85 5e-27 119
WERAM-Leo-0139 ENSLOCP00000017078.1 Lepisosteus oculatus 88 1e-25 115
WERAM-Gaga-0164 ENSGALP00000037077.2 Gallus gallus 65 3e-19 94.0
WERAM-Prc-0153 ENSPCAP00000014543.1 Procavia capensis 66 1e-18 91.7
WERAM-Ere-0051 ENSEEUP00000004327.1 Erinaceus europaeus 85 3e-18 90.5
WERAM-Tag-0129 ENSTGUP00000010594.1 Taeniopygia guttata 64 2e-14 77.8
WERAM-Ora-0048 ENSOANP00000007669.2 Ornithorhynchus anatinus 61 2e-11 67.4
Created Date 25-Jun-2016