WERAM Information

Tag Content
WERAM ID WERAM-Hos-0036
Ensembl Protein ID ENSP00000381109.2
Uniprot Accession Q9H0M4; ZCPW1_HUMAN; A8MVF5; B4DUQ2; Q8NA98; Q9BUD0; Q9NWF7
Genbank Protein ID NP_001244937.1; NP_060454.3; XP_011514668.1
Protein Name Zinc finger CW-type PWWP domain protein 1
Genbank Nucleotide ID NM_001258008.1; NM_017984.4; XM_011516366.1
Gene Name ZCWPW1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078487.17 ENST00000398027.6 ENSP00000381109.2
ENSG00000078487.17 ENST00000360951.8 ENSP00000354210.4
ENSG00000078487.17 ENST00000471336.1 ENSP00000418351.1
ENSG00000078487.17 ENST00000490721.5 ENSP00000419187.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H3K4me2/3 K 21522130
Me_Reader ZF-CW CW-type H3K4me2/3 K 21522130
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader ZF-CW 1.70e-23 84.7 251 304
Me_Reader PWWP 1.90e-21 78.2 317 382
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Domain Profile
  Me_Reader ZF-CW
          ZF-CW.txt   2 geekvWvqCd..dClKWRrLpgevdasvlsekWiCinNsdvrynnCsvpeEslk 53 
                        g++ vWvqC+  +C KWRrL+g++d+svl+++W+C++N+dv+yn+C++peE+++
  ENSP00000381109.2 251 GQCLVWVQCSfpNCGKWRRLCGNIDPSVLPDNWSCDQNTDVQYNRCDIPEETWT 304
                        7899***********************************************985 PP
  Me_Reader PWWP
           PWWP.txt   1 agdLVwaKlkgYpwWPalvisppleakkl...ktqeaeenkylVlFFgnkherawvkrkklvpyse 63 
                        +g+++waK +gYpwWP+++ s+p+ ++++   ++ ++  +ky+V+FFg++ +raw+++++l++++e
  ENSP00000381109.2 317 PGSIIWAKQYGYPWWPGMIESDPDLGEYFlftSHLDSLPSKYHVTFFGETVSRAWIPVNMLKNFQE 382
                        699************************************************************987 PP
Protein Sequence
(Fasta)		MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE ARISLPKASL 60
KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT NAEFEEIVQI VLQKSLQECL 120
GMGSGLDFAE TSCAQPVVST QSDKEPGITA SATDTDNANG EEVPHTQEIS VSWEGEAAPE 180
IRTSKLGQPD PAPSKKKSNR LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR 240
DQQKGEISGF GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE 300
ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH LDSLPSKYHV 360
TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK LGVALMMAQE AEQISIQERV 420
NLFGFWSRFN GSNSNGERKD LQLSGLNSPG SCLEKKEKEE ELEKEEGEKT DPILPIRKRV 480
KIQTQKTKPR GLGGDAGTAD GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ 540
PGPKKKFKAP QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG 600
SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK 648
Nucleotide Sequence
(Fasta)		CGCCGTTTTC CCGGGGAGAT GCGCCGCCCG GTCTCCCTGC CAGCGGAGTG CTGGGCCGAG 60
GACAGGGCGG CAGGGGTGAC AGTGGGGTCC AGGAGAGTCT CAAAATCCTA AGCTTTCAGT 120
ATTTGTTATT GTGAAAGAAG TTAATTCACC TGAAACAGAG GAGGGGCAAC CTGAGTTATC 180
AGAAAGTGAC TTCCTGGCCT TCCCTTCTTT ACTGATCAGA GGCACACAAA GCGTAGTTTC 240
TAAGCTGAAT GATGACAACG TTGCAGAATA AAGAAGAATG TGGAAAGGGA CCAAAGAGAA 300
TCTTTGCCCC ACCTGCACAA AAATCTTACA GCCTGTTACC TTGTAGCCCT AACTCCCCTA 360
AGGAGGAGAC CCCGGGGATC AGTTCCCCAG AGACAGAGGC CAGGATAAGC CTGCCAAAGG 420
CCAGTTTAAA GAAGAAAGAG GAAAAAGCAA CCATGAAGAA TGTTCCAAGC AGGGAACAGG 480
AGAAAAAAAG AAAGGCACAA ATCAACAAGC AAGCAGAGAA GAAAGAAAAG GAAAAATCAA 540
GTCTTACCAA TGCAGAATTT GAGGAGATTG TCCAGATTGT TCTGCAGAAG TCCCTTCAGG 600
AGTGCTTGGG GATGGGATCT GGCCTTGATT TTGCAGAGAC TTCTTGTGCC CAGCCCGTAG 660
TATCTACCCA ATCAGACAAG GAGCCAGGAA TTACTGCTTC TGCTACTGAT ACTGATAATG 720
CTAATGGAGA GGAGGTACCA CATACTCAAG AGATTTCAGT GTCTTGGGAA GGTGAAGCTG 780
CCCCTGAGAT AAGGACATCT AAGTTAGGCC AGCCAGATCC TGCACCCTCT AAGAAGAAAT 840
CCAATAGACT CACCTTAAGC AAAAGAAAGA AGGAAGCTCA TGAGAAGGTG GAGAAAACTC 900
AAGGTGGACA TGAGCACAGA CAGGAAGACC GACTAAAGAA AACAGTTCAG GATCATTCTC 960
AGATCAGGGA CCAGCAAAAA GGAGAGATAA GTGGTTTTGG TCAATGTCTG GTCTGGGTCC 1020
AGTGTTCCTT CCCAAACTGT GGGAAATGGA GGCGGCTGTG TGGGAACATT GACCCCTCAG 1080
TTCTCCCAGA TAATTGGTCC TGTGATCAGA ACACAGATGT GCAGTATAAT CGCTGTGATA 1140
TTCCTGAGGA GACCTGGACA GGGCTTGAGA GTGATGTGGC CTATGCCTCC TACATCCCAG 1200
GATCCATCAT CTGGGCCAAG CAATACGGTT ACCCCTGGTG GCCAGGCATG ATAGAATCTG 1260
ATCCTGACTT AGGGGAATAT TTTCTTTTTA CTTCCCATCT TGATTCCCTG CCGTCTAAGT 1320
ACCATGTGAC GTTTTTTGGA GAAACAGTTT CTCGTGCATG GATCCCAGTC AACATGCTAA 1380
AGAACTTCCA GGAGCTGTCC CTGGAGCTAT CAGTCATGAA AAAGCGCAGA AATGACTGCA 1440
GCCAGAAACT GGGGGTGGCC CTGATGATGG CTCAAGAGGC AGAACAGATC AGCATTCAGG 1500
AACGGGTTAA CTTGTTTGGT TTCTGGAGCC GATTCAACGG ATCTAACAGT AATGGGGAAA 1560
GAAAAGACTT ACAGCTCTCT GGTTTGAACA GCCCAGGATC CTGCTTAGAG AAAAAGGAGA 1620
AAGAGGAAGA GTTGGAAAAG GAGGAAGGAG AGAAAACAGA CCCAATTTTG CCCATTCGTA 1680
AGCGAGTCAA AATACAGACC CAAAAAACCA AGCCAAGAGG GCTTGGGGGT GATGCAGGCA 1740
CAGCAGATGG CCGAGGCAGG ACACTGCAGA GGAAGATAAT GAAGAGATCT CTAGGCAGGA 1800
AATCCACAGC TCCTCCTGCA CCCAGAATGG GAAGGAAAGA AGGCCAAGGG AATTCAGATT 1860
CTGACCAGCC AGGCCCTAAG AAAAAATTTA AAGCTCCCCA GAGCAAGGCC TTGGCAGCCA 1920
GCTTTTCAGA GGGAAAAGAA GTTAGAACAG TGCCAAAGAA CCTGGGCCTA TCAGCGTGTA 1980
AGGGGGCCTG CCCCTCATCT GCGAAAGAAG AGCCCAGACA CCGGGAACCC CTGACCCAGG 2040
AGGCTGGAAG TGTCCCCCTT GAGGACGAAG CCTCCAGTGA CCTGGACCTG GAGCAACTCA 2100
TGGAAGATGT TGGGAGAGAG CTGGGGCAGA GCGGGGAGCT GCAGCACAGC AACAGTGATG 2160
GCGAGGACTT CCCCGTGGCG CTGTTTGGGA AGTAGCTGGT GCTCCTCTGC TCCCTCTTTT 2220
TCTCCCTTCT CTGGGGCGCA GGAGGGAGAA GTTGCTAAGT GCTGGGTCTG TTCATTGGCT 2280
ATGAGGTTCA AATGTGTGTG GTGCAGTTTC TGTGTTAATA AAGCAGGTTA CAGTCGACTG 2340
GGTTGGCTGG TCTCTA 2357
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR000313--PWWP_dom
IPR011124--Znf_CW
PROSITE

PS50812--PWWP
PS51050--ZF_CW
Pfam

PF00855--PWWP
PF07496--zf-CW
Gene Ontology

GO:0008270--F:zinc ion binding
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0058 ENSGGOP00000005254.2 Gorilla gorilla 100 0.0 1243
WERAM-Pat-0161 ENSPTRP00000056497.2 Pan troglodytes 99 0.0 1239
WERAM-Poa-0158 ENSPPYP00000019513.1 Pongo abelii 92 0.0 1115
WERAM-Chs-0210 ENSCSAP00000013911.1 Chlorocebus sabaeus 88 0.0 1079
WERAM-Nol-0123 ENSNLEP00000014257.1 Nomascus leucogenys 98 0.0 1015
WERAM-Paa-0123 ENSPANP00000011756.1 Papio anubis 92 0.0 954
WERAM-Otg-0112 ENSOGAP00000009858.2 Otolemur garnettii 72 0.0 839
WERAM-Caj-0158 ENSCJAP00000028289.2 Callithrix jacchus 87 0.0 834
WERAM-Mam-0108 ENSMMUP00000016699.2 Macaca mulatta 79 0.0 812
WERAM-Ict-0075 ENSSTOP00000006740.2 Ictidomys tridecemlineatus 69 0.0 790
WERAM-Aim-0168 ENSAMEP00000015870.1 Ailuropoda melanoleuca 68 0.0 775
WERAM-Orc-0141 ENSOCUP00000012373.2 Oryctolagus cuniculus 66 0.0 769
WERAM-Ptv-0131 ENSPVAP00000011305.1 Pteropus vampyrus 69 0.0 761
WERAM-Sus-0051 ENSSSCP00000008180.2 Sus scrofa 68 0.0 756
WERAM-Loa-0189 ENSLAFP00000028794.1 Loxodonta africana 66 0.0 756
WERAM-Eqc-0186 ENSECAP00000019855.1 Equus caballus 66 0.0 743
WERAM-Mup-0179 ENSMPUP00000015561.1 Mustela putorius furo 67 0.0 742
WERAM-Dan-0020 ENSDNOP00000002014.3 Dasypus novemcinctus 65 0.0 737
WERAM-Caf-0150 ENSCAFP00000021379.3 Canis familiaris 66 0.0 734
WERAM-Ova-0177 ENSOARP00000018230.1 Ovis aries 65 0.0 734
WERAM-Bot-0008 ENSBTAP00000001417.4 Bos taurus 66 0.0 734
WERAM-Vip-0003 ENSVPAP00000000200.1 Vicugna pacos 64 0.0 720
WERAM-Fec-0114 ENSFCAP00000010035.3 Felis catus 67 0.0 709
WERAM-Cap-0193 ENSCPOP00000015758.1 Cavia porcellus 62 0.0 698
WERAM-Mim-0033 ENSMICP00000003055.1 Microcebus murinus 72 0.0 678
WERAM-Ocp-0128 ENSOPRP00000013510.2 Ochotona princeps 58 0.0 662
WERAM-Myl-0107 ENSMLUP00000008794.2 Myotis lucifugus 71 0.0 652
WERAM-Mum-0145 ENSMUSP00000048730.7 Mus musculus 58 8e-178 621
WERAM-Ran-0152 ENSRNOP00000032071.6 Rattus norvegicus 57 4e-169 592
WERAM-Ect-0127 ENSETEP00000014588.1 Echinops telfairi 65 8e-164 574
WERAM-Soa-0029 ENSSARP00000002907.1 Sorex araneus 62 3e-149 526
WERAM-Prc-0018 ENSPCAP00000001501.1 Procavia capensis 50 2e-133 473
WERAM-Ere-0046 ENSEEUP00000003988.1 Erinaceus europaeus 61 1e-113 407
WERAM-Mae-0015 ENSMEUP00000001250.1 Macropus eugenii 42 6e-93 339
WERAM-Sah-0006 ENSSHAP00000000215.1 Sarcophilus harrisii 72 2e-84 311
WERAM-Anc-0121 ENSACAP00000011361.3 Anolis carolinensis 61 4e-66 249
WERAM-Lac-0195 ENSLACP00000022745.1 Latimeria chalumnae 44 4e-60 230
WERAM-Leo-0137 ENSLOCP00000016746.1 Lepisosteus oculatus 33 2e-44 178
WERAM-Asm-0212 ENSAMXP00000020465.1 Astyanax mexicanus 37 2e-40 164
WERAM-Pem-0067 ENSPMAP00000007319.1 Petromyzon marinus 46 4e-37 153
WERAM-Mod-0200 ENSMODP00000032422.2 Monodelphis domestica 37 2e-14 78.2
WERAM-Tas-0002 ENSTSYP00000000260.1 Tarsius syrichta 32 4e-14 77.4
WERAM-Dio-0135 ENSDORP00000012704.1 Dipodomys ordii 32 9e-13 73.2
WERAM-Dar-0064 ENSDARP00000002944.8 Danio rerio 31 2e-11 68.6
WERAM-Pes-0051 ENSPSIP00000007311.1 Pelodiscus sinensis 40 8e-11 66.6
WERAM-Anp-0029 ENSAPLP00000003282.1 Anas platyrhynchos 39 2e-10 65.5
WERAM-Fia-0121 ENSFALP00000010353.1 Ficedula albicollis 39 2e-10 65.5
WERAM-Xim-0090 ENSXMAP00000008149.1 Xiphophorus maculatus 27 2e-10 65.1
WERAM-Tut-0152 ENSTTRP00000013007.1 Tursiops truncatus 30 2e-10 65.1
WERAM-Pof-0045 ENSPFOP00000003632.2 Poecilia formosa 26 3e-10 64.7
WERAM-Tag-0131 ENSTGUP00000010895.1 Taeniopygia guttata 38 5e-10 63.9
WERAM-Ten-0149 ENSTNIP00000015371.1 Tetraodon nigroviridis 30 6e-10 63.5
WERAM-Gaga-0142 ENSGALP00000025281.4 Gallus gallus 41 9e-10 63.2
WERAM-Tub-0107 ENSTBEP00000012130.1 Tupaia belangeri 42 1e-09 62.8
WERAM-Meg-0126 ENSMGAP00000013772.1 Meleagris gallopavo 41 1e-09 62.8
WERAM-Orn-0148 ENSONIP00000015592.1 Oreochromis niloticus 29 2e-09 62.0
WERAM-Gaa-0041 ENSGACP00000006025.1 Gasterosteus aculeatus 28 2e-09 62.0
WERAM-Xet-0165 ENSXETP00000005100.3 Xenopus tropicalis 43 6e-09 60.5
WERAM-Orla-0025 ENSORLP00000003502.1 Oryzias latipes 29 7e-09 60.1
WERAM-Chh-0042 ENSCHOP00000004990.1 Choloepus hoffmanni 40 1e-08 59.7
WERAM-Tar-0201 ENSTRUP00000042261.1 Takifugu rubripes 28 1e-08 59.3
WERAM-Gam-0146 ENSGMOP00000014567.1 Gadus morhua 27 2e-08 58.2
WERAM-Ora-0032 ENSOANP00000005155.1 Ornithorhynchus anatinus 26 6e-08 57.0
Created Date 25-Jun-2016