WERAM Information

Tag Content
WERAM ID WERAM-Hos-0005
Ensembl Protein ID ENSP00000380692.2
Uniprot Accession Q6ZMT4; KDM7A_HUMAN; A4D1S9; C9JJH9; C9JQU2; Q6MZL8; Q9C0E5
Genbank Protein ID NP_085150.1
Protein Name Lysine-specific demethylase 7A
Genbank Nucleotide ID NM_030647.1
Gene Name KDM7A;KIAA1718;JHDM1D
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000006459.10 ENST00000397560.6 ENSP00000380692.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDM PHF2_PHF8 Jmjc H3K9me2; H3K27me2; H4K20 K 20194436
Me_Reader PHD PHD-type H3K4me3; H3K9me2; H3K27me2; H4K20 K 20194436
Status Reviewed
Classification
Type Family E-value Score Start End
HDM PHF2_PHF8 4.70e-94 314.7 230 386
Me_Reader PHD 2.50e-11 45.9 38 86
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Domain Profile
  HDM PHF2_PHF8
           PHF2.txt   1 fsdtklselveppdivkklslvenlwpdeavlekpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyeawesss 92 
                        fsdtk+selve+pdi+kkls+ven+wpd++v++kp+v+kycl+gv+dsytdfhidfgg+sv+yhvl+gekifyli+pt++nla+ye+w+ss+
  ENSP00000380692.2 230 FSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSV 321
                        79****************************************************************************************** PP
           PHF2.txt  93 dqsevffgdkvdkaykvvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157
                        +qsevffgdkvdk+yk+vvkqg+tl++p+gwihavlt++dc+afggnflh+lni+mqlr+ye+ek
  ENSP00000380692.2 322 TQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEK 386
                        ***************************************************************97 PP
  Me_Reader PHD
            PHD.txt  2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51
                        +C+ C+++++ +++m++Cd C+dwfH++Cv+++++++ + + ++Cp+C 
  ENSP00000380692.2 38 VYCV-CRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCA 86
                       69*9.*****************************666665558******6 PP
Protein Sequence
(Fasta)		MAGAAAAVAA GAAAGAAAAA VSVAAPGRAS APPPPPPVYC VCRQPYDVNR FMIECDICKD 60
WFHGSCVGVE EHHAVDIDLY HCPNCAVLHG SSLMKKRRNW HRHDYTEIDD GSKPVQAGTR 120
TFIKELRSRV FPSADEIIIK MHGSQLTQRY LEKHGFDVPI MVPKLDDLGL RLPSPTFSVM 180
DVERYVGGDK VIDVIDVARQ ADSKMTLHNY VKYFMNPNRP KVLNVISLEF SDTKMSELVE 240
VPDIAKKLSW VENYWPDDSV FPKPFVQKYC LMGVQDSYTD FHIDFGGTSV WYHVLWGEKI 300
FYLIKPTDEN LARYESWSSS VTQSEVFFGD KVDKCYKCVV KQGHTLFVPT GWIHAVLTSQ 360
DCMAFGGNFL HNLNIGMQLR CYEMEKRLKT PDLFKFPFFE AICWFVAKNL LETLKELRED 420
GFQPQTYLVQ GVKALHTALK LWMKKELVSE HAFEIPDNVR PGHLIKELSK VIRAIEEENG 480
KPVKSQGIPI VCPVSRSSNE ATSPYHSRRK MRKLRDHNVR TPSNLDILEL HTREVLKRLE 540
MCPWEEDILS SKLNGKFNKH LQPSSTVPEW RAKDNDLRLL LTNGRIIKDE RQPFADQSLY 600
TADSENEEDK RRTKKAKMKI EESSGVEGVE HEESQKPLNG FFTRVKSELR SRSSGYSDIS 660
ESEDSGPECT ALKSIFTTEE SESSGDEKKQ EITSNFKEES NVMRNFLQKS QKPSRSEIPI 720
KRECPTSTST EEEAIQGMLS MAGLHYSTCL QRQIQSTDCS GERNSLQDPS SCHGSNHEVR 780
QLYRYDKPVE CGYHVKTEDP DLRTSSWIKQ FDTSRFHPQD LSRSQKCIRK EGSSEISQRV 840
QSRNYVDSSG SSLQNGKYMQ NSNLTSGACQ ISNGSLSPER PVGETSFSVP LHPTKRPASN 900
PPPISNQATK GKRPKKGMAT AKQRLGKILK LNRNGHARFF V 941
Nucleotide Sequence
(Fasta)		GCCGCCGCGG CTGCTGCAGG AGGCGGCGCT GGCTGGCGGC TGCGCTCGCT CCAGTCGGCG 60
AGCGGAGTAG CGAGCGAGCG TGTGTGTGTT TTTTAAAGAT GGCCGGAGCG GCGGCGGCGG 120
TGGCCGCGGG AGCAGCAGCT GGAGCCGCCG CGGCAGCCGT GTCGGTGGCG GCTCCCGGCC 180
GGGCCTCGGC GCCTCCGCCG CCCCCGCCCG TGTACTGTGT GTGCCGGCAG CCGTACGACG 240
TGAACCGCTT CATGATCGAG TGCGATATCT GCAAGGACTG GTTCCACGGC AGCTGTGTTG 300
GAGTAGAAGA ACATCATGCT GTTGACATTG ACCTGTATCA CTGTCCCAAC TGTGCAGTTT 360
TACATGGTTC CTCCTTGATG AAAAAAAGGA GGAACTGGCA CAGACATGAC TACACAGAAA 420
TTGATGATGG TTCCAAACCA GTGCAAGCTG GAACTAGAAC TTTCATTAAG GAATTACGCT 480
CTCGAGTCTT CCCAAGTGCC GATGAAATAA TTATAAAGAT GCATGGCAGC CAGCTGACAC 540
AAAGATATCT GGAGAAACAT GGATTTGATG TCCCTATTAT GGTCCCAAAA TTAGATGATC 600
TAGGACTCAG GCTCCCTTCA CCTACATTTT CTGTGATGGA TGTGGAACGT TATGTAGGTG 660
GTGACAAAGT GATAGATGTC ATTGATGTGG CGAGGCAGGC AGACAGCAAA ATGACACTTC 720
ACAATTATGT TAAATACTTC ATGAATCCTA ACAGACCAAA AGTGTTAAAT GTGATCAGCC 780
TTGAATTTTC AGATACAAAG ATGTCTGAAT TGGTGGAGGT CCCTGATATA GCCAAAAAAC 840
TTTCCTGGGT GGAAAATTAT TGGCCAGATG ATTCAGTCTT TCCCAAGCCA TTTGTTCAGA 900
AATATTGCTT AATGGGAGTT CAAGACAGCT ATACAGATTT CCACATTGAC TTCGGTGGAA 960
CTTCAGTCTG GTACCATGTC CTCTGGGGTG AGAAGATTTT TTATTTAATA AAGCCAACAG 1020
ATGAAAATTT GGCACGTTAT GAATCTTGGA GTTCATCTGT GACCCAGAGT GAGGTGTTCT 1080
TTGGAGATAA GGTGGATAAA TGCTACAAAT GTGTGGTAAA GCAGGGACAT ACCTTATTTG 1140
TTCCTACAGG GTGGATCCAT GCTGTGCTCA CTTCTCAGGA CTGTATGGCT TTTGGGGGGA 1200
ACTTCCTGCA CAACCTTAAC ATTGGCATGC AGCTCAGGTG TTATGAGATG GAGAAAAGGC 1260
TAAAAACACC AGATCTTTTC AAATTCCCTT TCTTTGAAGC CATATGTTGG TTTGTAGCCA 1320
AAAACTTGCT GGAAACCCTG AAAGAACTGA GAGAAGATGG TTTCCAGCCT CAAACTTACC 1380
TAGTACAGGG AGTGAAAGCA CTGCATACTG CTTTAAAATT ATGGATGAAA AAAGAACTTG 1440
TATCTGAACA TGCCTTTGAA ATTCCAGACA ATGTTAGACC TGGACACCTT ATTAAAGAAC 1500
TTTCTAAAGT AATTCGAGCA ATAGAGGAGG AAAACGGCAA ACCAGTTAAA TCTCAGGGAA 1560
TTCCTATTGT GTGTCCAGTT TCACGATCCT CAAATGAAGC AACTTCCCCA TACCATTCCC 1620
GAAGAAAGAT GAGGAAACTT CGAGATCATA ATGTCCGAAC TCCTTCTAAC CTAGACATCC 1680
TAGAGCTCCA CACAAGGGAG GTCCTCAAAA GATTAGAGAT GTGTCCATGG GAAGAGGACA 1740
TCTTGAGCTC TAAACTGAAT GGAAAATTCA ACAAACATCT CCAACCATCC TCCACAGTAC 1800
CTGAATGGAG AGCGAAAGAT AATGATCTAC GATTACTGCT GACAAATGGA AGAATAATTA 1860
AAGATGAAAG GCAGCCCTTT GCAGATCAAA GTCTTTATAC AGCAGATAGT GAAAATGAAG 1920
AGGATAAAAG AAGGACAAAA AAGGCAAAAA TGAAGATAGA AGAGAGTTCA GGAGTAGAGG 1980
GAGTGGAACA TGAAGAATCT CAAAAACCAC TGAATGGGTT TTTTACACGT GTGAAATCAG 2040
AACTCAGGAG TAGATCATCA GGATATTCTG ATATTTCTGA GTCAGAAGAC TCCGGACCCG 2100
AGTGCACTGC ACTGAAAAGT ATCTTTACCA CTGAAGAGTC TGAAAGTTCA GGTGATGAAA 2160
AGAAACAAGA AATAACATCC AACTTTAAGG AGGAATCTAA TGTGATGAGG AACTTCCTTC 2220
AAAAGAGCCA GAAGCCATCT AGAAGTGAAA TTCCAATTAA AAGGGAATGT CCTACCTCGA 2280
CGAGCACAGA GGAAGAAGCT ATTCAGGGCA TGCTGTCTAT GGCAGGGTTG CACTATTCCA 2340
CGTGTTTACA AAGGCAAATA CAAAGCACAG ACTGCAGTGG TGAAAGAAAC TCTCTCCAGG 2400
ATCCCAGCAG CTGCCATGGC AGTAACCATG AGGTTAGGCA GTTGTATCGC TATGATAAAC 2460
CAGTGGAATG TGGATACCAT GTCAAGACTG AAGATCCAGA CTTGAGGACT TCCTCCTGGA 2520
TTAAACAGTT TGATACTTCC AGATTTCATC CTCAGGATCT AAGTAGAAGC CAGAAATGCA 2580
TCAGAAAGGA AGGTTCATCA GAAATTAGTC AGAGGGTACA AAGTAGGAAT TATGTGGACA 2640
GCAGCGGCTC AAGCCTTCAG AATGGAAAGT ATATGCAGAA TTCAAACCTG ACTTCGGGGG 2700
CGTGCCAGAT AAGTAATGGC AGTCTAAGCC CAGAAAGGCC AGTTGGTGAA ACTTCCTTCT 2760
CGGTGCCCCT TCACCCCACC AAGAGACCGG CATCAAATCC ACCACCTATC AGCAACCAGG 2820
CAACAAAAGG TAAACGTCCA AAAAAAGGAA TGGCAACAGC CAAACAACGT CTTGGGAAGA 2880
TCCTTAAGTT GAACAGAAAT GGCCATGCAC GTTTCTTTGT GTGACAGAGC TGCTGTTGCA 2940
GCCATTCTTC CCTTTGGAGA CCAGTCTAGG GGTGCAGGAG CCTGGAGCTT CCGCTGTCCC 3000
CCTGCCTGGA GCAGTTTGTG TGTATAGTAA GAACACTGCC CGAAGAACAG AATGAACCTG 3060
ATGCTGCATT TTCACTGTGC CACACCCACT CAGCAATAAC CATTTTGGAC CTGGTGGGGG 3120
AGAGGAAGAA GGAGGGTAGA ACCTTAAAAA GAGACCTTGA ACTGGAAAGG GTCTCTTGTC 3180
AGGGCTTGAA TTTTATTTTG TTGTTGGTAG TGTCTTGATG TATTTTCAGT GGTAGGGTAA 3240
AGAATTATCA ATAATTTATT TAACAGATTT TTTTTTAAAG TTAACAGCTT TTAAATTCTT 3300
TTTTTAAAGC TATTTATTTG GAAGATTTCT GGAGAAATAT CTCACTAATT TAGATGTAAG 3360
AATGTGAAGG TTTTTAAATT ATTTTTGATA GTGTGTGTGT TACATGTGGG GAAGGGCCAC 3420
AGTAACAGTA ACTAGTCTGG ACTCTTAAAT TTGATATTCA GGTTAAAGTC TTAAACAGGG 3480
ATTTGATGCA TTAATTATTT TAAATTAAGA TGTATATGAA AATCATTTTA TTTTATATAT 3540
TTCATGTGTT TTTTATAAGC TATTAGCTTC GCTTTTGCTA ACATCCAAGG TGCATACTGT 3600
TATCCAGGTT GATTACCTTA TATCCCACCT TCCCTCTGCA CTCCCCATCA TTTTGTGATG 3660
ACCCAGTAAG ACTCTTCTCT TTGCAGGGAA ACACTTTCGT AGCCAATGTG TAAGAACTCC 3720
ATGAAAGATC CCTCATTTCT CATTTCGTTT GACATTGTGA TTTTCTTCTC AACATTAAAA 3780
AAAATAGGCT TTTGCATTTT CATTTCTGCT GATGATATCT GGGTCCCAAA GAGAGCAGCT 3840
TTAATATATT TTTCCTACTT GTGGGAAAAG TATTATAAGT TTGGTTAAAT TGTCATGTTT 3900
ATAGTTTTTC CAAGTACATT TGTAACTACA GCAGGCCTTC TTCGTACTGC TGCTGTTGGA 3960
CAACAGGACT GGCACCTGCT GCAGAGGTTA TACCTTATGA TACTTTTATG CTCCATACCT 4020
GATTTGTTGG GAAATGTTAT TTAGGATATT CAAATCTGCA TCATAAGCCG TAATATAATA 4080
GGATTAATAC TACATTAAGT TGTATAGAAG CAAGCATGTT GGAATAGATC TTTTGTGTGT 4140
ATTTACTTTT TTTATTTCTT AATTTTCTAA AGAATTACTT AAGATATGGA TTTGGAGTAA 4200
AATGGGTGCT TTTGGCAGTT TCTTCCATCT ATCCTAACCT GACCAGTACA TATTGAGGTT 4260
AAGTATCTGG TTAAACTTTA AGGTATTCAT TTATCTCCTT TATGTATGAT TTTTACTAAA 4320
TGCCAGTTTT CATTTGCTTA TAGTAGCTTC TATTTTCCCT TTTTTCCATC CATGGCATAA 4380
AAATAAGTGA TTTCTGGGGG TGGGGCAGAA ATGTTCCCAA GTCTGACAAT AGAGCATTTT 4440
ACAAATTCCT ACAAAGAAAA TATAGGCAAA TAGATAAAAT TTATTTTTAT GGAGAAGAAA 4500
TATGGCCATA TTATGGATTT GTCTTTTTTT TACTCAGCAA GATAGCAGGA CTTACCCTTC 4560
TCTATTAAGT ATCACTTGAA TTGCTAAGAA GAAAAAAGTC TGTACCATCA TCTTTCATGG 4620
TTGCATTCAA ATGTATATTT TCAAAGAGAA ATACTTCTTG TGTCCCCATT CCAAAATGTC 4680
ATGGGATAAA TATGAAATAG TTTATGAAGT AGCCTTTCTG GTTCAGAGTG ACTGGACCAA 4740
AGTCTGAATC TTATCTGGGT ATCAGGAAAA AGAATTTTTA TGGAAATCCT TAGTGTCTAT 4800
AAACAACCCG TGTAAACCCT GTCTACACTA TGCCAAAACC AGTGGAAAGA TGGGTAGAGT 4860
CATCTTATCT CAGGATGTCA AAAATCTGGG TTTGACTGAT TCCCCTACCT TCCCACACAG 4920
TATATTCTTG TGATTTTTGC TTTTCTGTAG ATCCTGAGTC GGTGTTACAA TAGTCATGTT 4980
TTTATTTTGG GTTAAGAAAT ACGAGGTGTA AGAGCTATAA TTTCCTTTTC GTGTTATATC 5040
ATGATCTGGG TTTTCTTTTT TCCTTTACGT TTTTCACAGC TCTTGAGTAT TTTCTATTTT 5100
TTTCTTTAGT CACAAAAATT AAAATTAAAC TTTATTTTTA TGAATTAAAA TGAAATTTAA 5160
TTTATTTTTA TGAATTAAAA TTGTGGCCAG TATCCACTGT GTCCTTAGGC TGAGAAGTAC 5220
TAATTTGGAG TAGCCCGTGT GTGGAATTCT AAAGTGAAGG TACTGTGGAT TCATTTTTAG 5280
TAGTTTTAGC CCCTTAATAA GTGGCTAAGT TAGAAAACTT TCAGCGAGGT AATAGAACCA 5340
CTTGAATAGA ATCCATGTGT CTTTTTCTGA ATTGGTGAAA ATTCGGCCAC TGATCCAGTG 5400
ACTCCTGGTC AAACGTCTTA TAACATTACT GGCCATAATG CATCCCTTTA TCTCATGGAA 5460
ATGGCTGAAC TTTGTGGTAG CTGCTGCGAG TACCTGGGCT TAACAGTAAT AGAGAACCTC 5520
ATTTATACCA TACAGACACA GCAACTTAGG AAGACAGCAC TGATAGCATT TAGCTAGTTG 5580
TAACCAAATA CAAATATGTA AAATTGAGAA TTATGATTAA CATATGCAAC TTTAGTAATA 5640
GGAATAGATG ATAATTTTCC TGTATTGTTT CAAATAAGTG ACTGTTCAGC TGGGATCCAT 5700
TGGATTATAA TTTACAATGT CACATAATAT TATGCTTTTC AATATTGATG AGTGATGTAA 5760
ACAATATAAA GTTGGCAGTT TGTAGTAGTT CAGTATCCTA GAAATACATT GAACTTCATA 5820
AGTATCAGTT CATTTTTAAG CATACAGAAT TGAAGATTCT GACTGAAATC ATAAACTCAG 5880
AGGAAACAAG CCCATCTTTA TCACTAATTA CTTAGCTTGA ATACTTTTCT ATTTTTAAAT 5940
AATCCTAATT ATTGCCTTTT CAATTATAGT CTACTGTATT TATTTATATG GGATCAACAG 6000
GTATTTATCA AACATCTACT GTGTGCCCAG CACTACCTAG TACTGTTGGG GAACATCAAT 6060
TTGCAGTTGT GGTCTCTGCC CTTGAAGGTA TCTTCTCCAG GAAATTAGCA GTATTATTTT 6120
CACTTCTAAG CAAACATGAG CAAAAGAGGA CCTGTTCATT AAAAAACATG CTGACTTTTT 6180
TAGTTTCAAC TGAGATATGC CACTGTAGAA GTGAAAGTAA TTTCACAATT AAAGAAATGC 6240
TTCAACTTGG TAATTAATAT GGTCATACAG GGACTTGGTG TAGCATGCAA GGAAGCAGAA 6300
GACCTGGGCT TTTGTCGAAG TTCTGCCATT TAGGTATCAG CTGTGTAACC TTGAATAAGT 6360
CACTTAACTC TTTCTCTTAG TTTTCTCATT TGTAAATTTG GATTAAAGTG TTTATTATGA 6420
TAATCAATTA AGAAAATCTC TTAACACTTC ATACATACAG AGAACTTATC ATTAAGTTAA 6480
AACTGGCAAT TAATGCACCT TTATATATAT TTTTAAATGA AAACTAATAC TATTCATGAT 6540
GTTTATTTTA TATCAAATAT ATGCCCAGGG CATGCTACTT TAAAAATCCG AGGAATCTCC 6600
AACAAGGTGC TGGATTAAAA TCAGATTTCG TGCTTGAAGT GGAAGAAAAA TGAAGTTGTT 6660
TATGGATAAG AGAGTGAGAA TGTGTATCCT CAAGTACGTT AAGATGATTT AACTGAAAGA 6720
TGGCTTTAGG TTTTTCTTGA AGAATTAGGA AAGTACCATC CCCACAGATT CAGCATACTC 6780
TTCAGGTACT AGATAAAGGT GAAGGAAGTC ATGGAATTAA AATGACTTAG CAACTCCCCA 6840
GGGAACTTGT GGGGAGAATG AGGTGGTTAG AAAGGTGAGA ATGCACAAAG ACAGCTCTGG 6900
GTTGGGTACC AACAGTTTGC TTGGTAGAAA GAAACCAGTG TAGGAAAGGA GACGCCACCA 6960
GACATCTTCA ACAGACAAGA TTCTTTCTGC CTTTTTCAAA AGATGCTCTC TGCAGCAGTA 7020
AGACTATAGA TAGAGTTGAT TGGAATATCA TGTGACCCAG TATGCTACTG CTAGGCATAA 7080
TTATCAAAAA TTCATTTTTC TCATTAAATA TTGTTAATTG CTCGCCACAT AAAGAGAAGC 7140
TAGAGCTCAC CAGTCTTGGT GGTGTCCTAG ACCTTCCTCT AAAGCAGTCT TGGGAAGCTG 7200
GATCATCAGA TCTTTAGCCT AGACAGAGTG TCGCTGGTAA ATAAAGGAGA CACAGGTAAC 7260
CCAGAGTGGA CAGTGATTTG CGTGGGGAGA CACAGTGGAT CTGGGGCCTC TGATACTTTG 7320
CTTCCTAAAA CAGCCCCCAG TTTTCGGCTT GCCCTATGAG ATGATGTTCA TGTGCTTCCT 7380
TGAAACCAGG TGGAAAGAAA GGGGAAGAAT TAATTTTCTC ATTCTGTTGC TGTTGAACGT 7440
AATGTAATCT TAATACTGTA GCCTTCCTAG AAGCCCTTCC CTCTTTTTCA TGCTGTAAAG 7500
TCAAATATTT GATATCCTTA ACATAAATTT TAAAAATTAA GGTCATTAGG AAGCAAATGT 7560
CTATTTCCAA AGCAATGAGC TTGTTGTGAC TGTGATTTTA TTCTTCTATA GTATTTTTTT 7620
CCTCATTTTA ACTGAGAGGA GAAAATAATA CTCTTTTGCA ATATCCTTAG GTTCTCCCCT 7680
TCCCCCTGGT GCCCCTTCTA GTGTCTTAAG ACTTTGTCTT AACAAGTATA ACATTACATT 7740
TTGTTGTTAA AACCTTTCGA AACTGTATTC AGTGATTCTT CCAAGTTTAT CTGCTCTGCA 7800
CTATTTCACT AATAAACCCT GGCTACCACG TAGCCCTTGA TCTCCAAGTA GTTTACCTAT 7860
GCAAGACCTG TGACACTCTG AATTCACTTC TCTTTCTTTC AGAAAGTAGT CATAAATGGA 7920
GCTTAATTAT AAAGGTAAAA CTTGTCTCCA ACCAGTTTCA TTTTGGCCAT TTCTTTTTCA 7980
AAATGTCAGC TGTTTTCCTC CAAGATTTTT CACCAAAACA ATGATCATAA GTGCTGGAAT 8040
ATATAATACT TTGCAGGCAT AAAATAACCC AGACATACTC TCATATTTCT TTGGTGTATT 8100
TTGGTTGGTA AAACTTACCA GCATTAAATG TAAAATATAA TGAGGAGTTA ATTCCTTACC 8160
TAGAACTATT TCTTCCTTTT AAGATTCATA AGTAACCTTT TATTTTTACA GAGCTACGTA 8220
TAACTTCCAC ATTACAGTCA GGGACCTGAG GTGTAACTTA CTAAGTGAAC CCCAAGGTTA 8280
TTTTATCTTG CAAAAGAAAC CTAAACCAAA CTAAGGGCCT TACAGTTTAT GGTTAGACTG 8340
AATCAAAAGC TATAACCTCA ATTTTTCCAA AAACAGCTTC TGACTGCAAA AGCAAGTCAT 8400
ACAGTTGTTA GGTATGAAAT AGCACTGATC AGGAAATGCA TCTTCGCAGA TGGTATTTCC 8460
TTCAGAAAAG ACTTTTCTAC TTTTAATATA AATTAAGCCA TAACAGTTTC ATGCTGTGGA 8520
AAGAGGGTGA AAAGGTTCAT TTTAAGAGAT TATATAATAT GAACTTTCAC ATTTACTGTG 8580
AAATGTCTAA CTTTGCCAGT GCTTCAGCAA GTTTTTTTGG GGGGTGATGG GGAGGGGTAG 8640
TATTGGTTTT AGAGGTTTCA AATCTGTGAA CTTTGGAGAG GGGACAGTTG TTGGCTCTGG 8700
TATTTACTAG TTTTGTAGTA ACGTTTTGCT AGCCTGACTG ACTTTTCTTA CTGGTTTTTA 8760
TGCCCACGGT CCGAGGGGAC TGTTCTTCTT GTTGGGGGTG TCTGCGGAAT AGCGTCTCGT 8820
CTTGTTTGTA TAGGCAGTCA ATGTGTGTGA CATGTGTGTC CTTTCAGTCC GGAAGCCCAC 8880
TGTGTGACAA TGGCGTGGGG TGTGGCTGGG AGGTGGGGTG CTGAAGCTTG AAGAGCATTT 8940
CTTTGCTGAT TCATAACAGT ATTTCCCATC TTTTGCCTGC AGGCAGGGAA AGTGTACAGT 9000
ATTTATTTTG TTTCTGTTTT ACTTTAAATT TGTAAGTCTT TAAGTAGCTT ACATTGATTA 9060
TTATAGGGGA GGACAAGTGA CTTGTTTAAA GTTGTATTTA GTATTCTTTC CAATTTCTGT 9120
ATTTTAAAAT ATTGAAATTA AAATTGTATT ACTTCTGTTT TGATTTTTTT AGCACTTAGT 9180
GTATTTTTTG CTCATTTTGT TTGAAAGTAT AAATGTTGAA AATTGTATAA AATGCGTCCT 9240
TGAAAGAAAA AGAATCTGAA TTCTATATCC AA 9273
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032452--F:histone demethylase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0030901--P:midbrain development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0166 ENSPTRP00000033854.5 Pan troglodytes 100 0.0 1794
WERAM-Mam-0063 ENSMMUP00000010640.2 Macaca mulatta 98 0.0 1764
WERAM-Chs-0095 ENSCSAP00000004529.1 Chlorocebus sabaeus 98 0.0 1763
WERAM-Paa-0084 ENSPANP00000012302.1 Papio anubis 98 0.0 1761
WERAM-Gog-0038 ENSGGOP00000003778.2 Gorilla gorilla 99 0.0 1726
WERAM-Nol-0019 ENSNLEP00000002239.1 Nomascus leucogenys 99 0.0 1711
WERAM-Poa-0168 ENSPPYP00000020257.1 Pongo abelii 99 0.0 1706
WERAM-Dan-0075 ENSDNOP00000007530.3 Dasypus novemcinctus 94 0.0 1689
WERAM-Caj-0137 ENSCJAP00000024642.1 Callithrix jacchus 95 0.0 1674
WERAM-Sus-0122 ENSSSCP00000017483.2 Sus scrofa 93 0.0 1662
WERAM-Ptv-0024 ENSPVAP00000002984.1 Pteropus vampyrus 95 0.0 1655
WERAM-Tut-0109 ENSTTRP00000009023.1 Tursiops truncatus 92 0.0 1650
WERAM-Otg-0087 ENSOGAP00000006873.2 Otolemur garnettii 96 0.0 1645
WERAM-Eqc-0012 ENSECAP00000002654.1 Equus caballus 94 0.0 1636
WERAM-Caf-0047 ENSCAFP00000005920.3 Canis familiaris 94 0.0 1633
WERAM-Ova-0130 ENSOARP00000013436.1 Ovis aries 94 0.0 1630
WERAM-Aim-0207 ENSAMEP00000018869.1 Ailuropoda melanoleuca 93 0.0 1622
WERAM-Mum-0175 ENSMUSP00000002305.8 Mus musculus 90 0.0 1622
WERAM-Bot-0042 ENSBTAP00000033407.3 Bos taurus 93 0.0 1620
WERAM-Mup-0034 ENSMPUP00000003537.1 Mustela putorius furo 93 0.0 1619
WERAM-Vip-0043 ENSVPAP00000003846.1 Vicugna pacos 93 0.0 1601
WERAM-Cap-0126 ENSCPOP00000010087.2 Cavia porcellus 90 0.0 1597
WERAM-Tas-0064 ENSTSYP00000005800.1 Tarsius syrichta 95 0.0 1583
WERAM-Orc-0027 ENSOCUP00000002799.2 Oryctolagus cuniculus 91 0.0 1577
WERAM-Fec-0205 ENSFCAP00000018769.1 Felis catus 94 0.0 1573
WERAM-Myl-0042 ENSMLUP00000003826.2 Myotis lucifugus 91 0.0 1571
WERAM-Mod-0119 ENSMODP00000017143.3 Monodelphis domestica 86 0.0 1551
WERAM-Loa-0066 ENSLAFP00000004797.3 Loxodonta africana 89 0.0 1517
WERAM-Prc-0011 ENSPCAP00000000805.1 Procavia capensis 83 0.0 1438
WERAM-Sah-0159 ENSSHAP00000016739.1 Sarcophilus harrisii 85 0.0 1435
WERAM-Gaga-0121 ENSGALP00000020923.4 Gallus gallus 80 0.0 1374
WERAM-Meg-0130 ENSMGAP00000013930.2 Meleagris gallopavo 80 0.0 1371
WERAM-Pes-0093 ENSPSIP00000011413.1 Pelodiscus sinensis 79 0.0 1367
WERAM-Anp-0159 ENSAPLP00000016291.1 Anas platyrhynchos 79 0.0 1360
WERAM-Tag-0142 ENSTGUP00000012053.1 Taeniopygia guttata 79 0.0 1353
WERAM-Fia-0054 ENSFALP00000003840.1 Ficedula albicollis 79 0.0 1301
WERAM-Ora-0038 ENSOANP00000006010.2 Ornithorhynchus anatinus 79 0.0 1244
WERAM-Anc-0136 ENSACAP00000012669.2 Anolis carolinensis 70 0.0 1214
WERAM-Soa-0069 ENSSARP00000006883.1 Sorex araneus 74 0.0 1194
WERAM-Dio-0129 ENSDORP00000012102.1 Dipodomys ordii 83 0.0 1184
WERAM-Ect-0009 ENSETEP00000000482.1 Echinops telfairi 77 0.0 1184
WERAM-Mae-0053 ENSMEUP00000005244.1 Macropus eugenii 67 0.0 1126
WERAM-Lac-0177 ENSLACP00000020635.1 Latimeria chalumnae 67 0.0 1106
WERAM-Xet-0019 ENSXETP00000005738.3 Xenopus tropicalis 70 0.0 1035
WERAM-Leo-0174 ENSLOCP00000020601.1 Lepisosteus oculatus 62 0.0 1011
WERAM-Asm-0142 ENSAMXP00000013545.1 Astyanax mexicanus 57 0.0 885
WERAM-Dar-0044 ENSDARP00000050378.6 Danio rerio 56 0.0 880
WERAM-Orn-0001 ENSONIP00000000115.1 Oreochromis niloticus 56 0.0 860
WERAM-Orla-0169 ENSORLP00000019966.2 Oryzias latipes 62 0.0 806
WERAM-Pof-0199 ENSPFOP00000016475.2 Poecilia formosa 62 0.0 796
WERAM-Gaa-0214 ENSGACP00000026389.1 Gasterosteus aculeatus 61 0.0 793
WERAM-Tar-0195 ENSTRUP00000040079.1 Takifugu rubripes 62 0.0 784
WERAM-Gam-0031 ENSGMOP00000003440.1 Gadus morhua 68 0.0 726
WERAM-Ten-0137 ENSTNIP00000014336.1 Tetraodon nigroviridis 80 0.0 706
WERAM-Xim-0053 ENSXMAP00000004655.1 Xiphophorus maculatus 79 0.0 701
WERAM-Ere-0005 ENSEEUP00000000200.1 Erinaceus europaeus 87 0.0 696
WERAM-Ict-0112 ENSSTOP00000011474.2 Ictidomys tridecemlineatus 97 0.0 674
WERAM-Ran-0022 ENSRNOP00000040672.4 Rattus norvegicus 62 3e-162 570
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 64 1e-159 561
WERAM-Tub-0093 ENSTBEP00000010730.1 Tupaia belangeri 61 4e-118 423
WERAM-Mim-0110 ENSMICP00000010445.1 Microcebus murinus 45 2e-89 328
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 42 1e-67 255
WERAM-Cis-0003 ENSCSAVP00000000437.1 Ciona savignyi 36 2e-64 244
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 41 4e-63 240
Created Date 25-Jun-2016