WERAM Information

Tag Content
WERAM ID WERAM-Hos-0195
Ensembl Protein ID ENSP00000377748.2
Uniprot Accession Q8IUF8; MINA_HUMAN; D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q96C17; Q96KB0
Genbank Protein ID NP_001035998.1; NP_001248758.1; NP_116167.3; NP_694822.2; XP_005247895.1
Protein Name Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
Genbank Nucleotide ID NM_001042533.2; NM_001261829.1; NM_032778.5; NM_153182.3; XM_005247838.3
Gene Name MINA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170854.17 ENST00000394198.6 ENSP00000377748.2
ENSG00000170854.17 ENST00000333396.11 ENSP00000328251.6
ENSG00000170854.17 ENST00000360258.8 ENSP00000353395.4
ENSG00000170854.17 ENST00000514314.5 ENSP00000424955.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JmjC_only Jmjc H3K9 K 12091391
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JmjC_only 3.60e-41 142.6 136 271
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Domain Profile
  HDM JmjC_only
      JmjC_only.txt   4 dylvpktfsdqlwqlkeelsepfyclvgsnwfltGpassgfplHvddieaflvqveGrkrwrlyepsepaellklasdeqvkqedllltkft 95 
                        ++ +p++f+d+lw+++e+l+++f++lvgsn+++t++ s+g+p+H+dd+e f++q+eG+k+wrly+p+ p     la++++v++e+       
  ENSP00000377748.2 136 QFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVP-----LAREYSVEAEERIG---- 218
                        6889***************************************************************99.....**************.... PP
      JmjC_only.txt  96 liaprplletvlepgellyiprgtwHqa.......lsldvtlsvsqnfssetflenv 145
                            rp++e +l+pg+lly+prgt+Hqa       +s++vt+s++qn+s+++fl+++
  ENSP00000377748.2 219 ----RPVHEFMLKPGDLLYFPRGTIHQAdtpaglaHSTHVTISTYQNNSWGDFLLDT 271
                        ....5************************************************9876 PP
Protein Sequence
(Fasta)		MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK TETFFKEFWE 60
QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV NVCRCVNGKK KVLNKDGKAH 120
FLQLRKDFDQ KRATIQFHQP QRFKDELWRI QEKLECYFGS LVGSNVYITP AGSQGLPPHY 180
DDVEVFILQL EGEKHWRLYH PTVPLAREYS VEAEERIGRP VHEFMLKPGD LLYFPRGTIH 240
QADTPAGLAH STHVTISTYQ NNSWGDFLLD TISGLVFDTA KEDVELRTGI PRQLLLQVES 300
TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLP PYSAGDGAEL STPGGKLPRL 360
DSVVRLQFKD HIVLTVLPDQ DQSDEAQEKM VYIYHSLKNS RETHMMGNEE ETEFHGLRFP 420
LSHLDALKQI WNSPAISVKD LKLTTDEEKE SLVLSLWTEC LIQVV 465
Nucleotide Sequence
(Fasta)		ACGCTGCCCC GCCTCCAGCC GCTGCGCCGC AACGCAGTGG GCTCGCGGCC GCGAGCAACA 60
GGCCGTGCCG GGTTTGCATT TCCTTACTGC TTTGTCTTGA AGACAGAACG ATGCCAAAGA 120
AAGCAAAGCC TACAGGGAGT GGGAAGGAAG AGGGGCCGGC TCCCTGTAAG CAGATGAAGT 180
TAGAAGCAGC TGGGGGGCCT TCAGCTTTAA ACTTTGACAG TCCCAGTAGT CTCTTTGAAA 240
GTTTAATCTC GCCCATCAAG ACAGAGACTT TTTTCAAGGA ATTCTGGGAG CAGAAGCCCC 300
TTCTCATTCA GAGAGATGAC CCTGCACTGG CCACATACTA TGGGTCCCTG TTCAAGCTAA 360
CAGATCTGAA GAGTCTGTGC AGCCGGGGGA TGTACTATGG AAGAGATGTG AATGTCTGCC 420
GGTGTGTCAA TGGGAAGAAG AAGGTTTTAA ATAAAGATGG CAAAGCACAC TTTCTTCAGC 480
TGAGAAAAGA TTTTGATCAG AAAAGGGCAA CGATTCAGTT TCACCAACCT CAGAGATTTA 540
AGGATGAGCT TTGGAGGATC CAGGAGAAGC TGGAATGTTA CTTTGGCTCC TTGGTTGGCT 600
CGAATGTGTA CATAACTCCC GCAGGATCTC AGGGCCTGCC GCCCCATTAT GATGATGTCG 660
AGGTTTTCAT CCTGCAGCTG GAGGGAGAGA AACACTGGCG CCTCTACCAC CCCACTGTGC 720
CCCTGGCACG AGAGTACAGC GTGGAGGCCG AGGAAAGGAT CGGCAGGCCG GTGCATGAGT 780
TTATGCTGAA GCCGGGTGAT TTGTTGTACT TTCCCAGAGG AACCATTCAT CAAGCGGACA 840
CTCCTGCGGG GCTGGCCCAC TCTACTCACG TGACCATCAG CACCTACCAG AACAATTCAT 900
GGGGAGATTT CCTTTTGGAT ACCATCTCGG GGCTTGTATT TGATACTGCA AAGGAAGACG 960
TGGAGTTACG GACCGGCATA CCCCGGCAGC TGCTCCTGCA GGTGGAATCC ACAACTGTTG 1020
CTACAAGACG ATTAAGTGGC TTCCTGAGGA CACTTGCAGA CCGGCTGGAG GGCACCAAAG 1080
AACTGCTTTC CTCAGACATG AAGAAGGATT TTATTATGCA CAGACTCCCC CCTTACTCTG 1140
CGGGAGATGG GGCAGAGCTG TCAACACCAG GTGGAAAGTT ACCGAGGCTG GACAGTGTAG 1200
TGAGACTGCA GTTTAAAGAC CACATTGTCC TCACAGTACT GCCGGATCAA GATCAATCTG 1260
ATGAAGCTCA AGAAAAGATG GTGTACATCT ATCATTCCTT AAAGAATAGT AGAGAGACAC 1320
ACATGATGGG AAATGAGGAG GAAACAGAGT TTCATGGACT TCGCTTCCCT TTGTCACATT 1380
TGGATGCACT GAAGCAAATT TGGAATAGTC CAGCTATTTC TGTCAAGGAC CTGAAACTTA 1440
CTACAGATGA GGAAAAGGAA AGCCTGGTAT TATCCCTCTG GACAGAATGT TTAATTCAAG 1500
TAGTCTAGTG CCTTTGCAGA ATCAAATGCC TACTATTTTA TATGCATATA TTAAAAGAAA 1560
AGCAAAGACC TGAGCCGAGG AGAGGATGAA TTCAAGTTTC CTTACCTGCG TATCTACTAA 1620
CAAACATGAG ACCTCCCTGT TACAGGTGGT CAGTTGGCCA AATGTACTAA CGGGCACATG 1680
AAAGAAAGAA CAGCAAATTA CCAAGTGTCT CAGAAAATGA CAAAACCATA TTTTGACAAG 1740
TTTATTTAAT CCAGTGTGGT AGAAAAGGCA CAATTCCAAT GTATCATTTA GAATTGAATG 1800
TCATTAACCT GGCTTTGTTC TTTGGAAGAA ACAACTTCTT TAAAGAGCTT CTTTGGCTCT 1860
AGAAAAATTT CAAACAATTA AAATAAGAAA AAATTTTAAA CTGGTTTTTT ATAATGAAAA 1920
TATACATACC TTTGTGTATA GACAAGCCCA TGCCCATTAA AATAAAGTTA TCCTGTAACA 1980
TAAATTTTAT TAAATAATAC TTCCCCACAG ATGAGAGGCA CGCAACACCT ATGGACAAAA 2040
GGGAGTTACA GAGGCTGCTT AAAAGATGGA GAAAAGCCTG AGATTGAAGG AGGAAAAAAA 2100
CCCAGTATTT AAAGTCTATA AAAAATACTC AAAATAGTGG GTCTTCGAGT TTAAAATAGT 2160
CATTGTTATT TTACATTCTA AAGTGCATGT AGGTTGATAT TTTTTAAAAT ATCATTGGAG 2220
AATTTAATCT TTCTTTATAA AAATAGAGCA TTTTTCTGCT TTCTGGCAAA AGTTGGGGAT 2280
AAAAGGAAAA AAAGTTGTCA AAATGTAATT TTCAGTCCAA TTCACCAGGA AAACATGCTT 2340
G 2342
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam

PF08007--Cupin_4
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0051213--F:dioxygenase activity
GO:0046872--F:metal ion binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0042254--P:ribosome biogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0129 ENSPTRP00000026139.4 Pan troglodytes 99 0.0 959
WERAM-Gog-0179 ENSGGOP00000015830.2 Gorilla gorilla 99 0.0 956
WERAM-Mam-0169 ENSMMUP00000023497.2 Macaca mulatta 98 0.0 944
WERAM-Chs-0067 ENSCSAP00000002287.1 Chlorocebus sabaeus 98 0.0 943
WERAM-Nol-0020 ENSNLEP00000002560.1 Nomascus leucogenys 97 0.0 939
WERAM-Poa-0120 ENSPPYP00000015228.1 Pongo abelii 95 0.0 918
WERAM-Tub-0029 ENSTBEP00000003583.1 Tupaia belangeri 91 0.0 885
WERAM-Otg-0125 ENSOGAP00000010888.2 Otolemur garnettii 91 0.0 884
WERAM-Orc-0104 ENSOCUP00000008815.2 Oryctolagus cuniculus 90 0.0 876
WERAM-Tas-0037 ENSTSYP00000003567.1 Tarsius syrichta 89 0.0 872
WERAM-Tut-0134 ENSTTRP00000010872.1 Tursiops truncatus 89 0.0 867
WERAM-Eqc-0048 ENSECAP00000006585.1 Equus caballus 89 0.0 865
WERAM-Ocp-0138 ENSOPRP00000014391.1 Ochotona princeps 88 0.0 865
WERAM-Fec-0083 ENSFCAP00000006791.1 Felis catus 88 0.0 853
WERAM-Mup-0028 ENSMPUP00000002579.1 Mustela putorius furo 88 0.0 851
WERAM-Aim-0156 ENSAMEP00000014428.1 Ailuropoda melanoleuca 88 0.0 850
WERAM-Loa-0147 ENSLAFP00000013081.3 Loxodonta africana 88 0.0 847
WERAM-Dan-0186 ENSDNOP00000030790.1 Dasypus novemcinctus 87 0.0 845
WERAM-Paa-0063 ENSPANP00000010464.1 Papio anubis 96 0.0 843
WERAM-Cap-0125 ENSCPOP00000009959.2 Cavia porcellus 86 0.0 833
WERAM-Ict-0053 ENSSTOP00000004709.2 Ictidomys tridecemlineatus 84 0.0 821
WERAM-Bot-0144 ENSBTAP00000020656.2 Bos taurus 85 0.0 808
WERAM-Ova-0183 ENSOARP00000018879.1 Ovis aries 84 0.0 807
WERAM-Caf-0100 ENSCAFP00000033942.2 Canis familiaris 79 0.0 777
WERAM-Mim-0026 ENSMICP00000002734.1 Microcebus murinus 80 0.0 756
WERAM-Mum-0049 ENSMUSP00000023407.5 Mus musculus 77 0.0 754
WERAM-Ora-0075 ENSOANP00000012007.2 Ornithorhynchus anatinus 78 0.0 750
WERAM-Prc-0014 ENSPCAP00000000928.1 Procavia capensis 85 0.0 734
WERAM-Sah-0041 ENSSHAP00000004706.1 Sarcophilus harrisii 75 0.0 726
WERAM-Pes-0080 ENSPSIP00000009581.1 Pelodiscus sinensis 72 0.0 716
WERAM-Fia-0023 ENSFALP00000001689.1 Ficedula albicollis 71 0.0 712
WERAM-Anp-0038 ENSAPLP00000004239.1 Anas platyrhynchos 72 0.0 711
WERAM-Ran-0017 ENSRNOP00000002285.5 Rattus norvegicus 73 0.0 709
WERAM-Meg-0145 ENSMGAP00000015269.1 Meleagris gallopavo 70 0.0 699
WERAM-Gaga-0141 ENSGALP00000006145.4 Gallus gallus 70 0.0 692
WERAM-Mod-0149 ENSMODP00000021229.2 Monodelphis domestica 69 0.0 674
WERAM-Tag-0165 ENSTGUP00000013900.1 Taeniopygia guttata 68 0.0 665
WERAM-Anc-0095 ENSACAP00000009059.3 Anolis carolinensis 64 0.0 634
WERAM-Lac-0042 ENSLACP00000006514.1 Latimeria chalumnae 63 5e-176 614
WERAM-Leo-0041 ENSLOCP00000006118.1 Lepisosteus oculatus 61 9e-174 607
WERAM-Gam-0175 ENSGMOP00000017195.1 Gadus morhua 57 9e-154 540
WERAM-Asm-0088 ENSAMXP00000009176.1 Astyanax mexicanus 64 2e-133 473
WERAM-Dar-0152 ENSDARP00000088500.3 Danio rerio 33 5e-59 226
WERAM-Cis-0076 ENSCSAVP00000016284.1 Ciona savignyi 33 1e-57 221
WERAM-Myl-0199 ENSMLUP00000022681.1 Myotis lucifugus 34 6e-57 219
WERAM-Tar-0041 ENSTRUP00000009949.1 Takifugu rubripes 39 9e-56 215
WERAM-Xet-0179 ENSXETP00000062966.1 Xenopus tropicalis 35 5e-55 212
WERAM-Ten-0145 ENSTNIP00000000059.1 Tetraodon nigroviridis 34 7e-55 212
WERAM-Pof-0228 ENSPFOP00000018729.2 Poecilia formosa 35 4e-54 209
WERAM-Cii-0073 ENSCINP00000035005.1 Ciona intestinalis 32 6e-54 209
WERAM-Xim-0212 ENSXMAP00000017076.1 Xiphophorus maculatus 35 7e-54 209
WERAM-Orn-0065 ENSONIP00000007424.1 Oreochromis niloticus 33 1e-53 208
WERAM-Orla-0121 ENSORLP00000014519.1 Oryzias latipes 41 3e-49 193
WERAM-Pem-0031 ENSPMAP00000004327.1 Petromyzon marinus 29 2e-48 191
WERAM-Cae-0066 T28F2.4a Caenorhabditis elegans 31 1e-46 184
WERAM-Drm-0099 FBpp0070616 Drosophila melanogaster 35 2e-39 160
Created Date 25-Jun-2016