WERAM Information

Tag Content
WERAM ID WERAM-Hos-0037
Ensembl Protein ID ENSP00000375899.3
Uniprot Accession Q13342; SP140_HUMAN; E7ESH9; E7EUR5; E9PFJ6; Q0VGE5; Q13341; Q3KR17; Q4ZG66; Q53TG1; Q6NSG4; Q92881; Q96TG3
Genbank Protein ID NP_001005176.1; NP_001265380.1; NP_001265381.1; NP_001265382.1; NP_009168.4
Protein Name Nuclear body protein SP140
Genbank Nucleotide ID NM_001005176.2; NM_001278451.1; NM_001278452.1; NM_001278453.1; NM_007237.4
Gene Name SP140;LOC93349;LYSP100;SP140L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000079263.18 ENST00000392045.7 ENSP00000375899.3
ENSG00000079263.18 ENST00000343805.10 ENSP00000342096.6
ENSG00000079263.18 ENST00000417495.7 ENSP00000393618.3
ENSG00000079263.18 ENST00000420434.7 ENSP00000398210.3
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.80e-19 71.9 771 841
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt   1 kehevsepFrepvdpqleipdYydi......ikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 
                        +++++s++F       ++ip+Yy+i      +kePm+L++ik+rl+e+ Y ++e fv+D+rlif+N++a +++k+++q
  ENSP00000375899.3 771 YCCSESSFF-------AKIPYYYYIreacqgLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQ 841
                        566666666.......4677******************************************************9986 PP
Protein Sequence
(Fasta)		MAQQGQQGQM ASGDSNLNFR MVAEIQNVEG QNLQEQVCPE PIFRFFRENK VEIASAITRP 60
FPFLMGLRDR SFISEQMYEH FQEAFRNLVP VTRVMYCVLS ELEKTFGWSH LEALFSRINL 120
MAYPDLNEIY RSFQNVCYEH SPLQMNNVND LEDRPRLLPY GKQENSNACH EMDDIAVPQE 180
ALSSSPRCEP GFSSESCEQL ALPKAGGGDA EDAPSLLPGG GVSCKLAIQI DEGESEEMPK 240
LLPYDTEVLE SNGMIDAART YSTAPGEKQG EEEGRNSPRK RNQDKEKYQE SPEGRDKETF 300
DLKTPQVTNE GEPEKGLCLL PGEGEEGSDD CSEMCDGEEP QEASSSLARC GSVSCLSAET 360
FDLKTPQVTN EGEPEKELSL LPGEGEEGSD DCSEMCDGEE RQEASSSLAR RGSVSSELEN 420
HPMNEEGESE ELASSLLYDN VPGAEQSAYE NEKCSCVMCF SEEVPGSPEA RTESDQACGT 480
MDTVDIANNS TLGKPKRKRR KKRGHGWSRM RMRRQENSQQ NDNSKADGQV VSSEKKANVN 540
LKDLSKIRGR KRGKPGTRFT QSDRAAQKRV RSRASRKHKD ETVDFKAPLL PVTCGGVKGI 600
LHKKKLQQGI LVKCIQTEDG KWFTPTEFEI KGGHARSKNW RLSVRCGGWP LRWLMENGFL 660
PDPPRIRYRK KKRILKSQNN SSVDPCMRNL DECEVCRDGG ELFCCDTCSR VFHEDCHIPP 720
VEAERTPWNC IFCRMKESPG SQQCCQESEV LERQMCPEEQ LKCEFLLLKV YCCSESSFFA 780
KIPYYYYIRE ACQGLKEPMW LDKIKKRLNE HGYPQVEGFV QDMRLIFQNH RASYKYKDFG 840
QMGFRLEAEF EKNFKEVFAI QETNGNN 867
Nucleotide Sequence
(Fasta)		CTTTTCTTTT CCTCTTTGAC TGAGCACCGA GGGGCAGTTG GCAGCTTCAC CTCAGAGCTG 60
CAGGAAGGAA CGGGGCAGTG AAAATCGAAT CGGGTGTGAT CCTAGGCCAA GCTCATGGCC 120
CAGCAGGGCC AGCAGGGGCA GATGGCAAGT GGAGACAGCA ATCTCAACTT CAGGATGGTC 180
GCAGAGATCC AGAACGTAGA GGGTCAGAAC CTGCAGGAGC AGGTTTGCCC TGAGCCCATT 240
TTCAGGTTCT TCAGAGAAAA CAAGGTGGAG ATTGCAAGTG CAATAACAAG GCCATTTCCT 300
TTCCTTATGG GCCTCCGAGA CCGCTCCTTC ATCTCCGAGC AGATGTATGA ACATTTTCAA 360
GAAGCTTTTA GAAACCTGGT CCCAGTGACA AGAGTGATGT ATTGTGTACT CAGTGAACTG 420
GAGAAGACAT TTGGCTGGTC ACATCTGGAA GCATTGTTCA GCAGGATTAA CCTGATGGCC 480
TATCCTGATT TAAACGAGAT TTACAGAAGC TTCCAGAATG TATGCTATGA ACACTCACCT 540
CTCCAAATGA ATAATGTAAA CGATTTAGAA GATAGACCCA GATTACTACC ATATGGTAAA 600
CAAGAGAACA GCAATGCCTG TCATGAAATG GATGATATAG CAGTGCCTCA GGAAGCCTTG 660
AGCTCCTCGC CAAGGTGTGA GCCAGGTTTC TCTTCAGAGT CTTGTGAGCA GTTAGCTCTC 720
CCAAAGGCTG GTGGAGGAGA TGCTGAAGAT GCACCCAGCC TACTACCAGG TGGGGGAGTG 780
TCCTGTAAAC TTGCTATACA AATAGATGAA GGAGAATCAG AAGAAATGCC CAAGTTACTG 840
CCTTATGATA CAGAAGTTCT AGAAAGCAAC GGGATGATAG ATGCGGCAAG GACATACAGC 900
ACAGCACCAG GGGAGAAACA GGGAGAGGAG GAAGGCAGGA ACAGTCCCAG AAAAAGAAAC 960
CAAGACAAGG AGAAGTACCA AGAGAGTCCA GAGGGAAGAG ACAAAGAGAC CTTTGATCTA 1020
AAAACTCCCC AAGTCACTAA TGAAGGAGAA CCAGAGAAGG GGCTCTGTCT ACTACCAGGT 1080
GAAGGAGAAG AGGGCAGTGA TGACTGTTCA GAAATGTGTG ATGGAGAAGA GCCCCAGGAA 1140
GCCTCTAGCT CCCTAGCAAG ATGTGGGTCA GTTTCTTGTT TATCTGCAGA GACCTTTGAT 1200
CTAAAGACTC CCCAAGTCAC TAATGAAGGA GAACCAGAGA AGGAGCTCAG TCTACTACCA 1260
GGTGAAGGAG AAGAGGGCAG TGATGACTGT TCGGAAATGT GTGATGGAGA AGAGCGCCAG 1320
GAAGCCTCTA GCTCCCTAGC AAGACGTGGG TCAGTGTCTA GTGAACTAGA AAATCACCCA 1380
ATGAATGAAG AAGGAGAATC AGAAGAGCTT GCTTCTAGCC TGCTATATGA TAATGTACCA 1440
GGAGCGGAGC AATCAGCATA TGAAAATGAG AAGTGTTCCT GTGTCATGTG TTTCTCAGAA 1500
GAGGTGCCAG GAAGCCCAGA AGCAAGGACG GAAAGTGATC AAGCGTGTGG CACAATGGAT 1560
ACTGTGGATA TTGCAAACAA CTCCACTTTG GGAAAACCCA AGAGGAAAAG AAGAAAAAAG 1620
AGGGGGCATG GCTGGAGCAG AATGAGAATG AGAAGGCAGG AAAACAGCCA ACAAAATGAT 1680
AATAGCAAAG CCGACGGCCA GGTGGTCTCC AGTGAAAAGA AGGCGAACGT GAATCTGAAA 1740
GACCTTTCCA AGATTAGGGG GAGAAAGAGA GGCAAACCTG GAACCCGCTT CACTCAGAGT 1800
GACAGAGCTG CACAGAAAAG AGTCCGATCA AGAGCTTCAA GAAAGCACAA AGATGAAACT 1860
GTGGATTTTA AGGCTCCTTT GCTTCCAGTG ACCTGTGGTG GGGTGAAGGG AATTTTACAT 1920
AAGAAGAAAT TGCAGCAAGG AATCTTGGTG AAGTGTATAC AGACTGAGGA TGGAAAATGG 1980
TTCACCCCCA CGGAATTTGA AATCAAAGGA GGCCATGCAA GATCAAAGAA CTGGAGGCTG 2040
AGTGTGCGCT GTGGCGGGTG GCCCCTACGA TGGCTGATGG AGAATGGATT TCTGCCTGAT 2100
CCTCCAAGAA TACGTTACAG GAAAAAAAAG AGAATACTGA AGTCTCAAAA CAATAGCTCA 2160
GTTGACCCTT GTATGAGAAA CCTGGATGAG TGTGAGGTGT GCCGGGACGG AGGGGAGCTG 2220
TTCTGTTGCG ACACTTGTTC AAGAGTCTTC CATGAGGACT GTCACATCCC GCCTGTGGAA 2280
GCTGAGAGGA CCCCGTGGAA TTGCATCTTC TGCAGGATGA AGGAGTCTCC GGGAAGCCAA 2340
CAGTGTTGTC AGGAATCTGA GGTCCTGGAG AGGCAGATGT GTCCTGAGGA ACAGTTGAAA 2400
TGTGAGTTCC TCCTCTTGAA AGTCTATTGC TGTTCTGAGA GCTCCTTTTT TGCCAAGATT 2460
CCATACTATT ATTATATTAG AGAGGCGTGT CAAGGCCTGA AGGAGCCCAT GTGGTTGGAT 2520
AAAATCAAGA AAAGGCTGAA TGAGCACGGT TACCCCCAAG TGGAGGGGTT TGTACAAGAC 2580
ATGCGCCTCA TCTTCCAGAA CCACAGGGCC TCTTACAAGT ACAAGGATTT TGGCCAAATG 2640
GGATTTAGAC TGGAGGCTGA GTTTGAGAAG AATTTCAAGG AAGTGTTTGC TATTCAGGAA 2700
ACAAATGGGA ACAATTGACT GGATTAGTGG ATGCTGAAAG CATTCAGCAA ATGGCACCCT 2760
AAAATATGCC GCTGGTTTGC CACTGACTTC AAAATGAGGT CACTTGGGCA CAGCACATGC 2820
AGGGAGGGGC TTTTCTCTGA GCCTCCTTCA TCTGCCCAAA GACAAATCCT CAAAAGGAAA 2880
TTCAATCATC ATGAATCACA ACCCCAAGTA TCTCATCAGC CAGGGAAGAG TAAGTGGGAT 2940
CACAGGGAAG GATGTTGGCA GCGACACCAT CCCATACAGG CTCTTACCTC TTCTCCTGAG 3000
GGCTGCTCCA GACAACATTT ATTACCCAGA AGACCTTTTG TCTGAAAACC AGCCAAGCTT 3060
TATTCAGGAC ACACTTCTTG CCTTCACTTT CCCACTTCCG TGGCCACCTC CATGCAGAAG 3120
CCCTAAGCCC ACATTCTTTC GATAGCTCAC GGTGGTGCAT GAGTGTCCAT CATCTGACTC 3180
TTCTCGGAGT CTCATATTTT GTGGGACTCC TGTGCAAACA TATGTTATTA AAATTTTTTT 3240
CCTCCT 3247
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001487--Bromodomain
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50014--BROMODOMAIN_2
PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF01342--SAND
PF03172--Sp100
Gene Ontology

GO:0005739--C:mitochondrion
GO:0005635--C:nuclear envelope
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006952--P:defense response
GO:0006355--P:regulation of transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0101 ENSPTRP00000022247.5 Pan troglodytes 89 0.0 1393
WERAM-Chs-0083 ENSCSAP00000003185.1 Chlorocebus sabaeus 85 0.0 1377
WERAM-Paa-0172 ENSPANP00000006222.1 Papio anubis 84 0.0 1326
WERAM-Poa-0114 ENSPPYP00000014816.1 Pongo abelii 77 0.0 1196
WERAM-Gog-0082 ENSGGOP00000006798.2 Gorilla gorilla 91 0.0 1145
WERAM-Caj-0133 ENSCJAP00000024422.2 Callithrix jacchus 73 0.0 1125
WERAM-Aim-0187 ENSAMEP00000017451.1 Ailuropoda melanoleuca 59 0.0 834
WERAM-Mim-0141 ENSMICP00000014357.1 Microcebus murinus 59 0.0 827
WERAM-Tut-0106 ENSTTRP00000008817.1 Tursiops truncatus 56 0.0 803
WERAM-Mam-0102 ENSMMUP00000015993.2 Macaca mulatta 88 0.0 796
WERAM-Sus-0120 ENSSSCP00000017226.2 Sus scrofa 55 0.0 784
WERAM-Otg-0206 ENSOGAP00000020888.1 Otolemur garnettii 54 0.0 775
WERAM-Myl-0020 ENSMLUP00000001755.2 Myotis lucifugus 56 0.0 712
WERAM-Ict-0054 ENSSTOP00000004707.2 Ictidomys tridecemlineatus 53 0.0 705
WERAM-Fec-0029 ENSFCAP00000002319.3 Felis catus 58 0.0 684
WERAM-Loa-0030 ENSLAFP00000001920.4 Loxodonta africana 50 0.0 682
WERAM-Caf-0118 ENSCAFP00000015760.3 Canis familiaris 66 6e-148 522
WERAM-Mup-0049 ENSMPUP00000004382.1 Mustela putorius furo 62 2e-133 474
WERAM-Cap-0119 ENSCPOP00000009466.2 Cavia porcellus 58 7e-133 472
WERAM-Ptv-0050 ENSPVAP00000005420.1 Pteropus vampyrus 58 2e-130 464
WERAM-Ova-0216 ENSOARP00000022188.1 Ovis aries 61 1e-122 438
WERAM-Eqc-0184 ENSECAP00000019711.1 Equus caballus 72 2e-122 437
WERAM-Prc-0057 ENSPCAP00000005387.1 Procavia capensis 67 2e-118 424
WERAM-Ran-0148 ENSRNOP00000031057.6 Rattus norvegicus 48 6e-117 419
WERAM-Nol-0155 ENSNLEP00000016673.1 Nomascus leucogenys 54 2e-113 407
WERAM-Mum-0221 ENSMUSP00000079095.4 Mus musculus 51 1e-110 399
WERAM-Tas-0089 ENSTSYP00000009104.1 Tarsius syrichta 49 1e-106 385
WERAM-Dan-0044 ENSDNOP00000004457.3 Dasypus novemcinctus 50 2e-104 378
WERAM-Tub-0049 ENSTBEP00000005765.1 Tupaia belangeri 44 1e-91 335
WERAM-Bot-0222 ENSBTAP00000054823.1 Bos taurus 73 1e-82 305
WERAM-Vip-0071 ENSVPAP00000006559.1 Vicugna pacos 41 6e-75 280
WERAM-Ere-0052 ENSEEUP00000004410.1 Erinaceus europaeus 39 1e-74 278
WERAM-Ocp-0089 ENSOPRP00000007990.1 Ochotona princeps 52 6e-67 253
WERAM-Sah-0029 ENSSHAP00000003206.1 Sarcophilus harrisii 46 6e-56 216
WERAM-Lac-0066 ENSLACP00000008975.1 Latimeria chalumnae 40 4e-48 191
WERAM-Mod-0208 ENSMODP00000038934.1 Monodelphis domestica 38 6e-42 170
WERAM-Ora-0139 ENSOANP00000030270.1 Ornithorhynchus anatinus 49 7e-37 153
WERAM-Soa-0030 ENSSARP00000003044.1 Sorex araneus 46 7e-36 150
WERAM-Dar-0193 ENSDARP00000108373.1 Danio rerio 34 5e-34 144
WERAM-Leo-0114 ENSLOCP00000014415.1 Lepisosteus oculatus 36 3e-30 131
WERAM-Pof-0069 ENSPFOP00000006195.2 Poecilia formosa 33 3e-29 128
WERAM-Ect-0021 ENSETEP00000001537.1 Echinops telfairi 56 3e-26 118
WERAM-Orn-0097 ENSONIP00000010786.1 Oreochromis niloticus 30 8e-25 113
WERAM-Tar-0059 ENSTRUP00000012635.1 Takifugu rubripes 39 5e-24 110
WERAM-Ten-0081 ENSTNIP00000009576.1 Tetraodon nigroviridis 37 2e-23 108
WERAM-Gaa-0050 ENSGACP00000006576.1 Gasterosteus aculeatus 39 7e-23 107
WERAM-Xim-0010 ENSXMAP00000001247.1 Xiphophorus maculatus 30 1e-22 106
WERAM-Dio-0037 ENSDORP00000004316.1 Dipodomys ordii 38 1e-22 106
WERAM-Meg-0128 ENSMGAP00000013880.2 Meleagris gallopavo 39 1e-22 106
WERAM-Pes-0149 ENSPSIP00000017710.1 Pelodiscus sinensis 40 2e-22 105
WERAM-Tag-0017 ENSTGUP00000001056.1 Taeniopygia guttata 36 2e-22 105
WERAM-Xet-0078 ENSXETP00000025313.3 Xenopus tropicalis 35 4e-22 104
WERAM-Orc-0070 ENSOCUP00000006290.2 Oryctolagus cuniculus 38 5e-22 104
WERAM-Gaga-0120 ENSGALP00000020886.4 Gallus gallus 38 8e-22 103
WERAM-Asm-0192 ENSAMXP00000018335.1 Astyanax mexicanus 35 8e-22 103
WERAM-Gam-0174 ENSGMOP00000017205.1 Gadus morhua 35 9e-22 103
WERAM-Fia-0053 ENSFALP00000003821.1 Ficedula albicollis 37 8e-21 100
WERAM-Anp-0085 ENSAPLP00000010241.1 Anas platyrhynchos 39 1e-20 99.8
WERAM-Orla-0118 ENSORLP00000014098.1 Oryzias latipes 35 6e-20 97.4
WERAM-Anc-0023 ENSACAP00000002604.2 Anolis carolinensis 37 8e-20 97.1
WERAM-Cii-0027 ENSCINP00000010542.3 Ciona intestinalis 38 6e-18 90.5
WERAM-Drm-0020 FBpp0083320 Drosophila melanogaster 35 8e-18 90.1
WERAM-Chh-0017 ENSCHOP00000001525.1 Choloepus hoffmanni 37 2e-17 89.4
Created Date 25-Jun-2016