Tag |
Content |
WERAM ID |
WERAM-Hos-0045 |
Ensembl Protein ID |
ENSP00000366271.3 |
Uniprot Accession |
Q8NHM5; KDM2B_HUMAN; A8MRS1; Q1RLM7; Q8NCI2; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75 |
Genbank Protein ID |
NP_001005366.1; NP_115979.3 |
Protein Name |
Lysine-specific demethylase 2B |
Genbank Nucleotide ID |
NM_001005366.1; NM_032590.4 |
Gene Name |
KDM2B;FBXL10;JHDM1B;NDY1 |
Ensembl Information |
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Details |
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Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
JHDM1 |
1.80e-95 |
319.6 |
178 |
346 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
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Domain Profile |
HDM JHDM1
JHDM1.txt 1 fsktkleelvkkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPptek 92 fs+tkle+lvk+p+vv+ +d+vdn+Wp++lkekqte+tna++emkyPkv+kyclmsvk+c+tdfhidfgGtsv+yhv++G+k+fwliPpt + ENSP00000366271.3 178 FSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLH 269 8******************************************************************************************* PP JHDM1.txt 93 nlelyeewvlsgkqsdiflgdrvekcqrvelkagdtlliPsGwihavytPvdslvfgGnflhslniktqlkiyeied 169 nl+lyeewvlsgkqsdiflgdrve+cqr+elk+g+t++iPsGwihavytPvdslvfgGn+lhs+n+++ql+iyeied ENSP00000366271.3 270 NLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIED 346 ***************************************************************************97 PP
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Protein Sequence (Fasta) | MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE 60 EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD 120 PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH 180 TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD 240 FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 300 KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY 360 EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ 420 EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES 480 VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED 540 PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 600 RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA 660 VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP 720 KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE 780 HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS 840 LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA 900 PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR 960 TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP 1020 RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ 1080 DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ 1140 LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD 1200 NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT 1260 AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV 1320 SVQFGQVEEK LLQKLS 1336Protein Fasta Sequence
>ENSP00000366271.3|KDM2B;FBXL10;JHDM1B;NDY1|Homo sapiens MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
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Nucleotide Sequence (Fasta) | AAAAGTTAGG CAGTCCTTAT AGGTATGGAA GCCGAGCTAA TTTCCTTCTG AGCCCCCCAA 60 ATGCCTCCTC CACATGGCGG GTCCGCAAAT GGGGGGATCT GCAGAGGATC ACCCCCCACG 120 AAAAAGACAT GCAGCAGAAA AGCAAAAAAA GAAAACAGTT ATATATACAA AATGCTTTGA 180 ATTTGAGTCG GCCACACAGC GCCCGATTGA CCGCCAGCGA TACGACGAGA ACGAGGACTT 240 GTCGGACGTG GAGGAGATCG TCAGCGTCCG CGGCTTCAGC CTGGAGGAGA AGCTTCGCAG 300 CCAGCTGTAC CAGGGGGACT TCGTGCACGC CATGGAGGGC AAAGATTTCA ACTATGAGTA 360 CGTACAGAGA GAAGCTCTCA GGGTTCCCCT GATATTTCGA GAAAAGGATG GACTGGGAAT 420 TAAGATGCCT GACCCTGATT TCACAGTCCG AGACGTCAAA CTCCTAGTGG GGAGCCGGCG 480 GCTTGTGGAC GTGATGGATG TGAACACCCA GAAGGGCACG GAGATGAGCA TGTCCCAGTT 540 TGTGCGTTAC TACGAGACGC CCGAGGCCCA GCGGGACAAG CTGTACAACG TCATCAGCCT 600 AGAGTTCAGC CACACCAAGC TGGAGCACTT GGTCAAGCGT CCGACTGTGG TAGACCTGGT 660 GGACTGGGTG GACAACATGT GGCCCCAGCA TCTGAAGGAG AAGCAGACAG AAGCCACGAA 720 CGCCATTGCA GAGATGAAGT ACCCGAAAGT GAAAAAGTAC TGTCTGATGA GCGTGAAAGG 780 TTGTTTCACC GACTTCCACA TCGACTTTGG AGGCACTTCC GTTTGGTACC ATGTTTTCCG 840 GGGTGGGAAG ATTTTTTGGC TGATTCCTCC AACGCTGCAC AATTTGGCGC TGTACGAGGA 900 GTGGGTGCTG TCAGGCAAAC AGAGTGACAT CTTTCTGGGA GACCGTGTGG AACGATGCCA 960 AAGAATTGAG CTGAAGCAGG GCTACACATT TTTCATCCCT TCCGGTTGGA TCCATGCCGT 1020 CTACACCCCT GTAGACTCTT TGGTGTTCGG CGGAAACATC CTGCACAGCT TTAACGTGCC 1080 CATGCAGCTG CGGATCTACG AGATCGAGGA CAGGACGCGG GTGCAGCCCA AATTCCGTTA 1140 CCCCTTCTAC TATGAGATGT GCTGGTATGT CCTGGAGAGA TACGTGTACT GTGTGACCCA 1200 GCGCTCCCAC CTCACTCAGG AATACCAGAG GGAGTCGATG CTTATTGATG CCCCGAGGAA 1260 GCCCAGCATA GACGGCTTCT CTTCGGATTC CTGGCTGGAG ATGGAGGAGG AGGCCTGTGA 1320 TCAGCAGCCT CAGGAGGAGG AGGAGAAGGA CGAGGAGGGC GAGGGCAGGG ACAGGGCACC 1380 CAAACCGCCC ACCGATGGCT CCACTTCACC CACCAGCACG CCCTCTGAGG ACCAGGAGGC 1440 CCTCGGGAAG AAGCCCAAAG CACCTGCCCT GCGATTCCTC AAAAGGACTT TGTCTAATGA 1500 GTCGGAGGAA AGTGTGAAGT CCACCACATT GGCCGTAGAC TACCCCAAGA CCCCCACCGG 1560 CTCTCCCGCC ACGGAGGTCT CTGCCAAATG GACCCATCTC ACTGAGTTTG AACTGAAGGG 1620 CCTGAAAGCT CTGGTGGAGA AACTGGAATC CCTCCCGGAG AACAAGAAGT GTGTCCCCGA 1680 GGGCATCGAG GACCCCCAGG CACTCCTGGA GGGTGTGAAG AACGTCCTGA AGGAGCACGC 1740 AGATGATGAC CCTAGTCTGG CCATCACTGG GGTCCCTGTG GTGACTTGGC CAAAGAAGAC 1800 TCCAAAGAAC CGGGCTGTGG GTCGGCCCAA GGGGAAGCTG GGCCCGGCCT CCGCGGTGAA 1860 GTTGGCCGCC AACCGGACAA CGGCAGGAGC TCGGCGGCGC CGGACGCGAT GCCGCAAGTG 1920 CGAGGCCTGC CTGCGGACCG AGTGCGGAGA GTGCCACTTC TGCAAGGACA TGAAGAAGTT 1980 CGGGGGCCCC GGGCGCATGA AGCAGAGCTG CATCATGCGG CAGTGCATCG CGCCAGTGCT 2040 GCCCCACACC GCCGTGTGCC TTGTGTGTGG CGAGGCGGGG AAGGAAGACA CGGTGGAAGA 2100 GGAGGAAGGC AAGTTTAACC TCATGCTCAT GGAGTGCTCC ATCTGCAATG AAATCATCCA 2160 CCCTGGATGC CTTAAGATTA AGGAGTCAGA GGGTGTGGTC AACGACGAGC TTCCAAACTG 2220 CTGGGAGTGT CCGAAGTGTA ACCACGCCGG CAAGACCGGG AAACAAAAGC GTGGCCCTGG 2280 CTTTAAGTAC GCCTCCAACC TGCCCGGCTC CCTGCTCAAG GAGCAGAAGA TGAACCGGGA 2340 CAACAAGGAA GGGCAGGAAC CTGCCAAGCG GAGGAGTGAG TGTGAGGAGG CGCCCCGGCG 2400 CAGGTCGGAT GAGCACTCGA AGAAGGTGCC GCCGGACGGC CTTCTGCGCA GAAAGTCTGA 2460 CGACGTGCAC CTGAGGAAGA AGCGGAAATA CGAGAAGCCC CAGGAGCTGA GTGGACGCAA 2520 GCGGGCCTCA TCGCTTCAAA CGTCCCCCGG TTCCTCCTCT CACCTCTCGC CGAGGCCCCC 2580 TCTAGGCAGC AGCCTCAGCC CCTGGTGGAG ATCCAGTCTC ACTTACTTCC AGCAGCAGCT 2640 CAAACCTGGC AAAGAAGATA AGCTTTTCAG GAAAAAGCGG CGGTCCTGGA AGAACGCCGA 2700 GGACCGCATG GCGCTGGCCA ACAAGCCCCT CCGGCGCTTC AAGCAGGAAC CCGAGGACGA 2760 ACTGCCCGAG GCGCCCCCCA AGACCAGGGA GAGCGACCAC TCCCGCTCCA GCTCCCCCAC 2820 CGCGGGACCC AGCACCGAAG GGGCCGAGGG CCCGGAGGAG AAGAAGAAGG TGAAGATGCG 2880 CCGGAAGCGG CGGCTTCCCA ACAAGGAGCT GAGCAGGGAG CTGAGCAAGG AGCTCAACCA 2940 CGAGATCCAG AGGACGGAGA ACAGCCTGGC CAACGAGAAC CAGCAGCCCA TCAAGTCGGA 3000 GCCTGAGAGC GAGGGCGAGG AGCCCAAGCG GCCCCCGGGC ATCTGCGAGC GTCCCCACCG 3060 CTTCAGCAAG GGGCTCAACG GCACCCCCCG GGAGCTGCGG CACCAGCTGG GGCCCAGCCT 3120 GCGCAGCCCG CCCCGTGTCA TCTCCCGGCC CCCACCCTCC GTGTCCCCGC CCAAGTGTAT 3180 CCAGATGGAG CGCCATGTGA TCCGGCCACC CCCCATCAGC CCCCCGCCTG ACTCGCTACC 3240 CCTGGACGAT GGGGCAGCCC ACGTCATGCA CAGGGAGGTG TGGATGGCCG TCTTCAGCTA 3300 CCTCAGCCAC CAAGACCTGT GTGTGTGCAT GCGGGTCTGC AGGACCTGGA ACCGCTGGTG 3360 CTGCGATAAG CGGTTGTGGA CCCGCATTGA CCTGAACCAC TGCAAGTCTA TCACACCCCT 3420 GATGCTGAGT GGCATCATCC GGCGACAGCC CGTCTCCCTC GACCTCAGCT GGACCAATAT 3480 CTCCAAGAAG CAGCTGAGCT GGCTCATCAA CCGGCTGCCT GGGCTCCGGG ACTTGGTGCT 3540 GTCAGGCTGC TCATGGATCG CGGTCTCGGC CCTTTGCAGC TCCAGTTGTC CGCTGCTCCG 3600 GACCCTGGAT GTCCAGTGGG TGGAGGGACT AAAGGATGCC CAGATGCGGG ATCTCCTGTC 3660 CCCGCCCACA GACAACAGGC CAGGTCAGAT GGACAATCGG AGCAAGCTCC GGAACATCGT 3720 GGAGCTGCGC CTGGCAGGCC TGGACATCAC AGATGCCTCC CTGCGGCTCA TCATCCGCCA 3780 CATGCCCCTG CTCTCCAAGC TCCACCTCAG TTACTGTAAC CACGTCACCG ACCAGTCTAT 3840 CAACCTGCTC ACTGCTGTTG GCACCACCAC CCGAGACTCC TTAACCGAGA TCAACCTGTC 3900 TGACTGCAAT AAGGTCACTG ATCAGTGCCT GTCCTTCTTC AAACGCTGTG GAAACATCTG 3960 TCATATTGAC CTGAGGTACT GCAAGCAAGT CACCAAGGAA GGCTGTGAGC AGTTCATAGC 4020 CGAGATGTCT GTGAGTGTCC AGTTTGGGCA AGTAGAAGAA AAACTCCTGC AAAAACTGAG 4080 TTAGTCCAAG GATAAGTATG TAAATACGGG GCGGGCTCTG GGAGGGGAGA GACTTTACAA 4140 AAATGAGGGC TTTTATTTTC CATTTGGAAC GTGGGACAAC AGACCACAAC GCAATTCCAT 4200 TTTGCAAGTC TTTCCAAGGG AGAAGCTGTT CAACCACCCG TTTGGGGGAT GAGTGAGCCG 4260 ACACTTTCCT TTGGTCTTTC TGAATCGTAA CTGCACTGCT TTCTGGACCA TTTCTAAGGC 4320 GGCCTTTACA AGAAGACATT CCTGTCGGAG AGGAGGGTGG ACTTCGGAGA AATTCTCATA 4380 CTGAAGCATG AGCTTAGGAG TTTCTGTTAG TGGTAGTGGT GTTTTGGACA CTTCATTCCT 4440 TGCAACACCG AGGTTTTGGG TGTTGACATA AAGTGGACCA CACACCACAT CTGCTGCCGT 4500 CTTGACACTT TTTTTTGTTT GGTTGGTTTT GTTACATCTT ACATTATGCA GAACTATTTT 4560 TGTACAAATT GTTTAAAAGT TATTTATGCA AGGTT
4596Nucleotide Fasta Sequence
>ENSP00000366271.3|JHDM1|Homo sapiens AAAAGTTAGGCAGTCCTTATAGGTATGGAAGCCGAGCTAATTTCCTTCTGAGCCCCCCAAATGCCTCCTCCACATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACGAAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATATATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGACCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAGCCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGATTTCAACTATGAGTACGTACAGAGAGAAGCTCTCAGGGTTCCCCTGATATTTCGAGAAAAGGATGGACTGGGAATTAAGATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTGGGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACGCCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTGGTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAACGCCATTGCAGAGATGAAGTACCCGAAAGTGAAAAAGTACTGTCTGATGAGCGTGAAAGGTTGTTTCACCGACTTCCACATCGACTTTGGAGGCACTTCCGTTTGGTACCATGTTTTCCGGGGTGGGAAGATTTTTTGGCTGATTCCTCCAACGCTGCACAATTTGGCGCTGTACGAGGAGTGGGTGCTGTCAGGCAAACAGAGTGACATCTTTCTGGGAGACCGTGTGGAACGATGCCAAAGAATTGAGCTGAAGCAGGGCTACACATTTTTCATCCCTTCCGGTTGGATCCATGCCGTCTACACCCCTGTAGACTCTTTGGTGTTCGGCGGAAACATCCTGCACAGCTTTAACGTGCCCATGCAGCTGCGGATCTACGAGATCGAGGACAGGACGCGGGTGCAGCCCAAATTCCGTTACCCCTTCTACTATGAGATGTGCTGGTATGTCCTGGAGAGATACGTGTACTGTGTGACCCAGCGCTCCCACCTCACTCAGGAATACCAGAGGGAGTCGATGCTTATTGATGCCCCGAGGAAGCCCAGCATAGACGGCTTCTCTTCGGATTCCTGGCTGGAGATGGAGGAGGAGGCCTGTGATCAGCAGCCTCAGGAGGAGGAGGAGAAGGACGAGGAGGGCGAGGGCAGGGACAGGGCACCCAAACCGCCCACCGATGGCTCCACTTCACCCACCAGCACGCCCTCTGAGGACCAGGAGGCCCTCGGGAAGAAGCCCAAAGCACCTGCCCTGCGATTCCTCAAAAGGACTTTGTCTAATGAGTCGGAGGAAAGTGTGAAGTCCACCACATTGGCCGTAGACTACCCCAAGACCCCCACCGGCTCTCCCGCCACGGAGGTCTCTGCCAAATGGACCCATCTCACTGAGTTTGAACTGAAGGGCCTGAAAGCTCTGGTGGAGAAACTGGAATCCCTCCCGGAGAACAAGAAGTGTGTCCCCGAGGGCATCGAGGACCCCCAGGCACTCCTGGAGGGTGTGAAGAACGTCCTGAAGGAGCACGCAGATGATGACCCTAGTCTGGCCATCACTGGGGTCCCTGTGGTGACTTGGCCAAAGAAGACTCCAAAGAACCGGGCTGTGGGTCGGCCCAAGGGGAAGCTGGGCCCGGCCTCCGCGGTGAAGTTGGCCGCCAACCGGACAACGGCAGGAGCTCGGCGGCGCCGGACGCGATGCCGCAAGTGCGAGGCCTGCCTGCGGACCGAGTGCGGAGAGTGCCACTTCTGCAAGGACATGAAGAAGTTCGGGGGCCCCGGGCGCATGAAGCAGAGCTGCATCATGCGGCAGTGCATCGCGCCAGTGCTGCCCCACACCGCCGTGTGCCTTGTGTGTGGCGAGGCGGGGAAGGAAGACACGGTGGAAGAGGAGGAAGGCAAGTTTAACCTCATGCTCATGGAGTGCTCCATCTGCAATGAAATCATCCACCCTGGATGCCTTAAGATTAAGGAGTCAGAGGGTGTGGTCAACGACGAGCTTCCAAACTGCTGGGAGTGTCCGAAGTGTAACCACGCCGGCAAGACCGGGAAACAAAAGCGTGGCCCTGGCTTTAAGTACGCCTCCAACCTGCCCGGCTCCCTGCTCAAGGAGCAGAAGATGAACCGGGACAACAAGGAAGGGCAGGAACCTGCCAAGCGGAGGAGTGAGTGTGAGGAGGCGCCCCGGCGCAGGTCGGATGAGCACTCGAAGAAGGTGCCGCCGGACGGCCTTCTGCGCAGAAAGTCTGACGACGTGCACCTGAGGAAGAAGCGGAAATACGAGAAGCCCCAGGAGCTGAGTGGACGCAAGCGGGCCTCATCGCTTCAAACGTCCCCCGGTTCCTCCTCTCACCTCTCGCCGAGGCCCCCTCTAGGCAGCAGCCTCAGCCCCTGGTGGAGATCCAGTCTCACTTACTTCCAGCAGCAGCTCAAACCTGGCAAAGAAGATAAGCTTTTCAGGAAAAAGCGGCGGTCCTGGAAGAACGCCGAGGACCGCATGGCGCTGGCCAACAAGCCCCTCCGGCGCTTCAAGCAGGAACCCGAGGACGAACTGCCCGAGGCGCCCCCCAAGACCAGGGAGAGCGACCACTCCCGCTCCAGCTCCCCCACCGCGGGACCCAGCACCGAAGGGGCCGAGGGCCCGGAGGAGAAGAAGAAGGTGAAGATGCGCCGGAAGCGGCGGCTTCCCAACAAGGAGCTGAGCAGGGAGCTGAGCAAGGAGCTCAACCACGAGATCCAGAGGACGGAGAACAGCCTGGCCAACGAGAACCAGCAGCCCATCAAGTCGGAGCCTGAGAGCGAGGGCGAGGAGCCCAAGCGGCCCCCGGGCATCTGCGAGCGTCCCCACCGCTTCAGCAAGGGGCTCAACGGCACCCCCCGGGAGCTGCGGCACCAGCTGGGGCCCAGCCTGCGCAGCCCGCCCCGTGTCATCTCCCGGCCCCCACCCTCCGTGTCCCCGCCCAAGTGTATCCAGATGGAGCGCCATGTGATCCGGCCACCCCCCATCAGCCCCCCGCCTGACTCGCTACCCCTGGACGATGGGGCAGCCCACGTCATGCACAGGGAGGTGTGGATGGCCGTCTTCAGCTACCTCAGCCACCAAGACCTGTGTGTGTGCATGCGGGTCTGCAGGACCTGGAACCGCTGGTGCTGCGATAAGCGGTTGTGGACCCGCATTGACCTGAACCACTGCAAGTCTATCACACCCCTGATGCTGAGTGGCATCATCCGGCGACAGCCCGTCTCCCTCGACCTCAGCTGGACCAATATCTCCAAGAAGCAGCTGAGCTGGCTCATCAACCGGCTGCCTGGGCTCCGGGACTTGGTGCTGTCAGGCTGCTCATGGATCGCGGTCTCGGCCCTTTGCAGCTCCAGTTGTCCGCTGCTCCGGACCCTGGATGTCCAGTGGGTGGAGGGACTAAAGGATGCCCAGATGCGGGATCTCCTGTCCCCGCCCACAGACAACAGGCCAGGTCAGATGGACAATCGGAGCAAGCTCCGGAACATCGTGGAGCTGCGCCTGGCAGGCCTGGACATCACAGATGCCTCCCTGCGGCTCATCATCCGCCACATGCCCCTGCTCTCCAAGCTCCACCTCAGTTACTGTAACCACGTCACCGACCAGTCTATCAACCTGCTCACTGCTGTTGGCACCACCACCCGAGACTCCTTAACCGAGATCAACCTGTCTGACTGCAATAAGGTCACTGATCAGTGCCTGTCCTTCTTCAAACGCTGTGGAAACATCTGTCATATTGACCTGAGGTACTGCAAGCAAGTCACCAAGGAAGGCTGTGAGCAGTTCATAGCCGAGATGTCTGTGAGTGTCCAGTTTGGGCAAGTAGAAGAAAAACTCCTGCAAAAACTGAGTTAGTCCAAGGATAAGTATGTAAATACGGGGCGGGCTCTGGGAGGGGAGAGACTTTACAAAAATGAGGGCTTTTATTTTCCATTTGGAACGTGGGACAACAGACCACAACGCAATTCCATTTTGCAAGTCTTTCCAAGGGAGAAGCTGTTCAACCACCCGTTTGGGGGATGAGTGAGCCGACACTTTCCTTTGGTCTTTCTGAATCGTAACTGCACTGCTTTCTGGACCATTTCTAAGGCGGCCTTTACAAGAAGACATTCCTGTCGGAGAGGAGGGTGGACTTCGGAGAAATTCTCATACTGAAGCATGAGCTTAGGAGTTTCTGTTAGTGGTAGTGGTGTTTTGGACACTTCATTCCTTGCAACACCGAGGTTTTGGGTGTTGACATAAAGTGGACCACACACCACATCTGCTGCCGTCTTGACACTTTTTTTTGTTTGGTTGGTTTTGTTACATCTTACATTATGCAGAACTATTTTTGTACAAATTGTTTAAAAGTTATTTATGCAAGGTT
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0175--Coiled coil KW-0181--Complete proteome KW-0223--Dioxygenase KW-0408--Iron KW-1017--Isopeptide bond KW-0433--Leucine-rich repeat KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0694--RNA-binding KW-0699--rRNA-binding KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0833--Ubl conjugation pathway KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR001810--F-box_dom IPR003347--JmjC_dom IPR032675--L_dom-like IPR006553--Leu-rich_rpt_Cys-con_subtyp IPR002857--Znf_CXXC IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR019787--Znf_PHD-finger
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PROSITE |
PS51184--JMJC PS51058--ZF_CXXC PS50016--ZF_PHD_2
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Pfam |
PF00646--F-box PF16866--PHD_4 PF02008--zf-CXXC
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Gene Ontology |
GO:0005730--C:nucleolus GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0003677--F:DNA binding GO:0032452--F:histone demethylase activity GO:0051864--F:histone demethylase activity (H3-K36 specific) GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding GO:0019843--F:rRNA binding GO:0008270--F:zinc ion binding GO:0048596--P:embryonic camera-type eye morphogenesis GO:0030900--P:forebrain development GO:0021592--P:fourth ventricle development GO:0030902--P:hindbrain development GO:0035518--P:histone H2A monoubiquitination GO:0021993--P:initiation of neural tube closure GO:0021670--P:lateral ventricle development GO:0030901--P:midbrain development GO:0021555--P:midbrain-hindbrain boundary morphogenesis GO:2000178--P:negative regulation of neural precursor cell proliferation GO:0043524--P:negative regulation of neuron apoptotic process GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0030307--P:positive regulation of cell growth GO:1902459--P:positive regulation of stem cell population maintenance GO:0007283--P:spermatogenesis GO:0021678--P:third ventricle development GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |