WERAM Information

Tag Content
WERAM ID WERAM-Hos-0154
Ensembl Protein ID ENSP00000362895.4
Uniprot Accession P21675; TAF1_HUMAN; A5CVC8; A5CVC9; A5CVD0; A5CVD1; B1Q2X3; Q59FZ3; Q6IUZ1; Q70Q86; Q70Q87; Q70T00; Q70T01; Q70T02; Q70T03
Genbank Protein ID NP_001273003.1; NP_004597.2; NP_620278.1; XP_005262354.1
Protein Name Transcription initiation factor TFIID subunit 1
Genbank Nucleotide ID NM_001286074.1; NM_004606.4; NM_138923.3; XM_005262297.3
Gene Name TAF1;BA2R;CCG1;CCGS;TAF2A;TAFII250
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000147133.15 ENST00000373790.8 ENSP00000362895.4
ENSG00000147133.15 ENST00000276072.7 ENSP00000276072.3
ENSG00000147133.15 ENST00000373775.8 ENSP00000362880.4
ENSG00000147133.15 ENST00000437147.7 ENSP00000406517.3
ENSG00000147133.15 ENST00000423759.5 ENSP00000406549.1
ENSG00000147133.15 ENST00000463163.5 ENSP00000421611.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H3K9; H3K14; H4K5; H4K8; H4K12; H4K16 K 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 7.10e-42 143.6 1402 1589
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt    6 sepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkss 70  
                           pF+ pv++ + ++dYy+ii +PmdL+t +e+++++ Y s eef ++++li++N+ +yn++k+s
  ENSP00000362895.4 1402 TYPFHTPVNA-KVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHS 1465
                         579*******.7***************************************************97 PP
          BROMO.txt    4 evsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71  
                         ++s+pF++pv++ + +pdYy++i +PmdL+ti++++ +++Y+s e f++Dv+li+ N+ +yn+++s++
  ENSP00000362895.4 1523 PDSWPFHHPVNK-KFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQY 1589
                         79**********.7**************************************************9987 PP
Protein Sequence
(Fasta)		MGPGCDLLLR TAATITAAAI MSDTDSDEDS AGGGPFSLAG FLFGNINGAG QLEGESVLDD 60
ECKKHLAGLG ALGLGSLITE LTANEELTGT DGALVNDEGW VRSTEDAVDY SDINEVAEDE 120
SRRYQQTMGS LQPLCHSDYD EDDYDADCED IDCKLMPPPP PPPGPMKKDK DQDSITGEKV 180
DFSSSSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF PEFRPGKVLR 240
FLRLFGPGKN VPSVWRSARR KRKKKHRELI QEEQIQEVEC SVESEVSQKS LWNYDYAPPP 300
PPEQCLSDDE ITMMAPVESK FSQSTGDIDK VTDTKPRVAE WRYGPARLWY DMLGVPEDGS 360
GFDYGFKLRK TEHEPVIKSR MIEEFRKLEE NNGTDLLADE NFLMVTQLHW EDDIIWDGED 420
VKHKGTKPQR ASLAGWLPSS MTRNAMAYNV QQGFAATLDD DKPWYSIFPI DNEDLVYGRW 480
EDNIIWDAQA MPRLLEPPVL TLDPNDENLI LEIPDEKEEA TSNSPSKESK KESSLKKSRI 540
LLGKTGVIKE EPQQNMSQPE VKDPWNLSND EYYYPKQQGL RGTFGGNIIQ HSIPAVELRQ 600
PFFPTHMGPI KLRQFHRPPL KKYSFGALSQ PGPHSVQPLL KHIKKKAKMR EQERQASGGG 660
EMFFMRTPQD LTGKDGDLIL AEYSEENGPL MMQVGMATKI KNYYKRKPGK DPGAPDCKYG 720
ETVYCHTSPF LGSLHPGQLL QAFENNLFRA PIYLHKMPET DFLIIRTRQG YYIRELVDIF 780
VVGQQCPLFE VPGPNSKRAN THIRDFLQVF IYRLFWKSKD RPRRIRMEDI KKAFPSHSES 840
SIRKRLKLCA DFKRTGMDSN WWVLKSDFRL PTEEEIRAMV SPEQCCAYYS MIAAEQRLKD 900
AGYGEKSFFA PEEENEEDFQ MKIDDEVRTA PWNTTRAFIA AMKGKCLLEV TGVADPTGCG 960
EGFSYVKIPN KPTQQKDDKE PQPVKKTVTG TDADLRRLSL KNAKQLLRKF GVPEEEIKKL 1020
SRWEVIDVVR TMSTEQARSG EGPMSKFARG SRFSVAEHQE RYKEECQRIF DLQNKVLSST 1080
EVLSTDTDSS SAEDSDFEEM GKNIENMLQN KKTSSQLSRE REEQERKELQ RMLLAAGSAA 1140
SGNNHRDDDT ASVTSLNSSA TGRCLKIYRT FRDEEGKEYV RCETVRKPAV IDAYVRIRTT 1200
KDEEFIRKFA LFDEQHREEM RKERRRIQEQ LRRLKRNQEK EKLKGPPEKK PKKMKERPDL 1260
KLKCGACGAI GHMRTNKFCP LYYQTNAPPS NPVAMTEEQE EELEKTVIHN DNEELIKVEG 1320
TKIVLGKQLI ESADEVRRKS LVLKFPKQQL PPKKKRRVGT TVHCDYLNRP HKSIHRRRTD 1380
PMVTLSSILE SIINDMRDLP NTYPFHTPVN AKVVKDYYKI ITRPMDLQTL RENVRKRLYP 1440
SREEFREHLE LIVKNSATYN GPKHSLTQIS QSMLDLCDEK LKEKEDKLAR LEKAINPLLD 1500
DDDQVAFSFI LDNIVTQKMM AVPDSWPFHH PVNKKFVPDY YKVIVNPMDL ETIRKNISKH 1560
KYQSRESFLD DVNLILANSV KYNGPESQYT KTAQEIVNVC YQTLTEYDEH LTQLEKDICT 1620
AKEAALEEAE LESLDPMTPG PYTPQPPDLY DTNTSLSMSR DASVFQDESN MSVLDIPSAT 1680
PEKQVTQEGE DGDGDLADEE EGTVQQPQAS VLYEDLLMSE GEDDEEDAGS DEEGDNPFSA 1740
IQLSESGSDS DVGSGGIRPK QPRMLQENTR MDMENEESMM SYEGDGGEAS HGLEDSNISY 1800
GSYEEPDPKS NTQDTSFSSI GGYEVSEEEE DEEEEEQRSG PSVLSQVHLS EDEEDSEDFH 1860
SIAGDSDLDS DE 1872
Nucleotide Sequence
(Fasta)		AAGGGAGCTC AGTAAGTCAC TTCTGGGCGA CTGTTGTTTT ATTTCCGGTC TATGGGACCC 60
GGCTGCGATT TGCTGCTGCG GACAGCAGCT ACCATCACTG CTGCCGCCAT CATGTCAGAC 120
ACGGACAGCG ACGAAGATTC CGCTGGAGGC GGCCCATTTT CTTTAGCGGG TTTCCTTTTC 180
GGCAACATCA ATGGAGCCGG GCAGCTGGAG GGGGAAAGCG TCTTGGATGA TGAATGTAAG 240
AAGCACTTGG CAGGCTTGGG GGCTTTGGGG CTGGGCAGCC TGATCACTGA ACTCACGGCA 300
AATGAAGAAT TGACCGGGAC TGACGGTGCC TTGGTAAATG ATGAAGGGTG GGTTAGGAGT 360
ACAGAAGATG CTGTGGACTA TTCAGACATC AATGAGGTGG CAGAAGATGA AAGCCGAAGA 420
TACCAGCAGA CGATGGGGAG CTTGCAGCCC CTTTGCCACT CAGATTATGA TGAAGATGAC 480
TATGATGCTG ATTGTGAAGA CATTGATTGC AAGTTGATGC CTCCTCCACC TCCACCCCCG 540
GGACCAATGA AGAAGGATAA GGACCAGGAT TCTATTACTG GTGAGAAAGT GGACTTCAGT 600
AGTTCCTCTG ACTCAGAATC TGAGATGGGA CCTCAGGAAG CAACACAGGC AGAATCTGAA 660
GATGGAAAGC TGACCCTTCC ATTGGCTGGG ATTATGCAGC ATGATGCCAC CAAGCTGTTG 720
CCAAGTGTCA CAGAACTTTT TCCAGAATTT CGACCTGGAA AGGTGTTACG TTTTCTACGT 780
CTTTTTGGAC CAGGGAAGAA TGTCCCATCT GTTTGGCGGA GTGCTCGGAG AAAGAGGAAG 840
AAGAAGCACC GTGAGCTGAT ACAGGAAGAG CAGATCCAGG AGGTGGAGTG CTCAGTAGAA 900
TCAGAAGTCA GCCAGAAGTC TTTGTGGAAC TACGACTACG CTCCACCACC ACCTCCAGAG 960
CAGTGTCTCT CTGATGATGA AATCACGATG ATGGCTCCTG TGGAGTCCAA ATTTTCCCAA 1020
TCAACTGGAG ATATAGATAA AGTGACAGAT ACCAAACCAA GAGTGGCTGA GTGGCGTTAT 1080
GGGCCTGCCC GACTGTGGTA TGATATGCTG GGTGTCCCTG AAGATGGCAG TGGGTTTGAC 1140
TATGGCTTCA AACTGAGAAA GACAGAACAT GAACCTGTGA TAAAATCTAG AATGATAGAG 1200
GAATTTAGGA AACTTGAGGA AAACAATGGC ACTGATCTTC TGGCTGATGA AAACTTCCTG 1260
ATGGTGACAC AGCTGCATTG GGAGGATGAT ATCATCTGGG ATGGGGAGGA TGTCAAACAC 1320
AAAGGGACAA AACCTCAGCG TGCAAGCCTG GCAGGCTGGC TTCCTTCTAG CATGACTAGG 1380
AATGCGATGG CTTACAATGT TCAGCAAGGT TTTGCAGCCA CTCTTGATGA TGACAAACCT 1440
TGGTACTCCA TTTTTCCCAT TGACAATGAG GATCTGGTAT ATGGACGCTG GGAGGACAAT 1500
ATCATTTGGG ATGCTCAGGC CATGCCCCGG CTGTTGGAAC CTCCTGTTTT GACACTTGAT 1560
CCCAATGATG AGAACCTCAT TTTGGAAATT CCTGATGAGA AGGAAGAGGC CACCTCTAAC 1620
TCCCCCTCCA AGGAGAGTAA GAAGGAATCA TCTCTGAAGA AGAGTCGAAT TCTCTTAGGG 1680
AAAACAGGAG TCATCAAGGA GGAACCACAG CAGAACATGT CTCAGCCAGA AGTGAAAGAT 1740
CCATGGAATC TCTCCAATGA TGAGTATTAT TATCCCAAGC AACAGGGTCT TCGAGGCACC 1800
TTTGGAGGGA ATATTATCCA GCATTCAATT CCTGCTGTGG AATTACGGCA GCCCTTCTTT 1860
CCCACCCACA TGGGGCCCAT CAAACTCCGG CAGTTCCATC GCCCACCTCT GAAAAAGTAC 1920
TCATTTGGTG CACTTTCTCA GCCAGGTCCC CACTCAGTCC AACCTTTGCT AAAGCACATC 1980
AAAAAAAAGG CCAAGATGAG AGAACAAGAG AGGCAAGCTT CAGGTGGTGG AGAGATGTTT 2040
TTTATGCGCA CACCTCAGGA CCTCACAGGC AAAGATGGTG ATCTTATTCT TGCAGAATAT 2100
AGTGAGGAAA ATGGACCCTT AATGATGCAG GTTGGCATGG CAACCAAGAT AAAGAACTAT 2160
TATAAACGGA AACCTGGAAA AGATCCTGGA GCACCAGATT GTAAATATGG GGAAACTGTT 2220
TACTGCCATA CATCTCCTTT CCTGGGTTCT CTCCATCCTG GCCAATTGCT GCAAGCATTT 2280
GAGAACAACC TTTTTCGTGC TCCAATTTAT CTTCATAAGA TGCCAGAAAC TGATTTCTTG 2340
ATCATTCGGA CAAGACAGGG TTACTATATT CGGGAATTAG TGGATATTTT TGTGGTTGGC 2400
CAGCAGTGTC CCTTGTTTGA AGTTCCTGGG CCTAACTCCA AAAGGGCCAA TACGCATATT 2460
CGAGACTTTC TACAGGTTTT TATTTACCGC CTTTTCTGGA AAAGTAAAGA TCGGCCACGG 2520
AGGATACGAA TGGAAGATAT AAAAAAAGCC TTTCCTTCCC ATTCAGAAAG CAGCATCCGG 2580
AAGAGGCTAA AGCTCTGCGC TGACTTCAAA CGCACAGGGA TGGACTCAAA CTGGTGGGTG 2640
CTTAAGTCTG ATTTTCGTTT ACCAACGGAA GAAGAGATCA GAGCTATGGT GTCACCAGAG 2700
CAGTGCTGTG CTTATTATAG CATGATAGCT GCAGAGCAAC GACTGAAGGA TGCTGGCTAT 2760
GGTGAGAAAT CCTTTTTTGC TCCAGAAGAA GAAAATGAGG AAGATTTCCA GATGAAGATT 2820
GATGATGAAG TTCGCACTGC CCCTTGGAAC ACCACAAGGG CCTTCATTGC TGCCATGAAG 2880
GGCAAGTGTC TGCTAGAGGT GACTGGGGTG GCAGATCCCA CGGGGTGTGG TGAAGGATTC 2940
TCCTATGTGA AGATTCCAAA CAAACCAACA CAGCAGAAGG ATGATAAAGA ACCGCAGCCA 3000
GTGAAGAAGA CAGTGACAGG AACAGATGCA GACCTTCGTC GCCTTTCCCT GAAAAATGCC 3060
AAGCAACTTC TACGTAAATT TGGTGTGCCT GAGGAAGAGA TTAAAAAGTT GTCCCGCTGG 3120
GAAGTGATTG ATGTGGTGCG CACAATGTCA ACAGAACAGG CTCGTTCTGG AGAGGGGCCC 3180
ATGAGTAAAT TTGCCCGTGG ATCAAGGTTT TCTGTGGCTG AGCATCAAGA GCGTTACAAA 3240
GAGGAATGTC AGCGCATCTT TGACCTACAG AACAAGGTTC TGTCATCAAC TGAAGTCTTA 3300
TCAACTGACA CAGACAGCAG CTCAGCTGAA GATAGTGACT TTGAAGAAAT GGGAAAGAAC 3360
ATTGAGAACA TGTTGCAGAA CAAGAAAACC AGCTCTCAGC TTTCACGTGA ACGGGAGGAA 3420
CAGGAGCGGA AGGAACTACA GCGAATGCTA CTGGCAGCAG GCTCAGCAGC ATCCGGAAAC 3480
AATCACAGAG ATGATGACAC AGCTTCCGTG ACTAGCCTTA ACTCTTCTGC CACTGGACGC 3540
TGTCTCAAGA TTTATCGCAC GTTTCGAGAT GAAGAGGGGA AAGAGTATGT TCGCTGTGAG 3600
ACAGTCCGAA AACCAGCTGT CATTGATGCC TATGTGCGCA TACGGACTAC AAAAGATGAG 3660
GAATTCATTC GAAAATTTGC CCTTTTTGAT GAACAACATC GGGAAGAGAT GCGAAAAGAA 3720
CGGCGGAGGA TTCAAGAGCA ACTGAGGCGG CTTAAGAGGA ACCAGGAAAA GGAGAAGCTT 3780
AAGGGTCCTC CTGAGAAGAA GCCCAAGAAA ATGAAGGAGC GTCCTGACCT AAAACTGAAA 3840
TGTGGGGCAT GTGGTGCCAT TGGACACATG AGGACTAACA AATTCTGCCC CCTCTATTAT 3900
CAAACAAATG CGCCACCTTC CAACCCTGTT GCCATGACAG AAGAACAGGA GGAGGAGTTG 3960
GAAAAGACAG TCATTCATAA TGATAATGAA GAACTTATCA AGGTTGAAGG GACCAAAATT 4020
GTCTTGGGGA AACAGCTAAT TGAGAGTGCG GATGAGGTTC GCAGAAAATC TCTGGTTCTC 4080
AAGTTTCCTA AACAGCAGCT TCCTCCAAAG AAGAAACGGC GAGTTGGAAC CACTGTTCAC 4140
TGTGACTATT TGAATAGACC TCATAAGTCC ATCCACCGGC GCCGCACAGA CCCTATGGTG 4200
ACGCTGTCGT CCATCTTGGA GTCTATCATC AATGACATGA GAGATCTTCC AAATACATAC 4260
CCTTTCCACA CTCCAGTCAA TGCAAAGGTT GTAAAGGACT ACTACAAAAT CATCACTCGG 4320
CCAATGGACC TACAAACACT CCGCGAAAAC GTGCGTAAAC GCCTCTACCC ATCTCGGGAA 4380
GAGTTCAGAG AGCATCTGGA GCTAATTGTG AAAAATAGTG CAACCTACAA TGGGCCAAAA 4440
CACTCATTGA CTCAGATCTC TCAATCCATG CTGGATCTCT GTGATGAAAA ACTCAAAGAG 4500
AAAGAAGACA AATTAGCTCG CTTAGAGAAA GCTATCAACC CCTTGCTGGA TGATGATGAC 4560
CAAGTGGCGT TTTCTTTCAT TCTGGACAAC ATTGTCACCC AGAAAATGAT GGCAGTTCCA 4620
GATTCTTGGC CATTTCATCA CCCAGTTAAT AAGAAATTTG TTCCAGATTA TTACAAAGTG 4680
ATTGTCAATC CAATGGATTT AGAGACCATA CGTAAGAACA TCTCCAAGCA CAAGTATCAG 4740
AGTCGGGAGA GCTTTCTGGA TGATGTAAAC CTTATTCTGG CCAACAGTGT TAAGTATAAT 4800
GGACCTGAGA GTCAGTATAC TAAGACTGCC CAGGAGATTG TGAACGTCTG TTACCAGACA 4860
TTGACTGAGT ATGATGAACA TTTGACTCAA CTTGAGAAGG ATATTTGTAC TGCTAAAGAA 4920
GCAGCTTTGG AGGAAGCAGA ATTAGAAAGC CTGGACCCAA TGACCCCAGG GCCCTACACG 4980
CCTCAGCCTC CTGATTTGTA TGATACCAAC ACATCCCTCA GTATGTCTCG AGATGCCTCT 5040
GTATTTCAAG ATGAGAGCAA TATGTCTGTC TTGGATATTC CCAGTGCCAC TCCAGAAAAG 5100
CAGGTAACAC AGGAAGGTGA AGATGGAGAT GGTGATCTTG CAGATGAAGA GGAAGGAACT 5160
GTACAACAGC CTCAAGCCAG TGTCCTGTAT GAGGATTTGC TTATGTCTGA AGGAGAAGAT 5220
GATGAGGAAG ATGCTGGGAG TGATGAAGAA GGAGACAATC CTTTCTCTGC TATCCAGCTG 5280
AGTGAAAGTG GAAGTGACTC TGATGTGGGA TCTGGTGGAA TAAGACCCAA ACAACCCCGC 5340
ATGCTTCAGG AGAACACAAG GATGGACATG GAAAATGAAG AAAGCATGAT GTCCTATGAG 5400
GGAGACGGTG GGGAGGCTTC CCATGGTTTG GAGGATAGCA ACATCAGTTA TGGGAGCTAT 5460
GAGGAGCCTG ATCCCAAGTC GAACACCCAA GACACAAGCT TCAGCAGCAT CGGTGGGTAT 5520
GAGGTATCAG AGGAGGAAGA AGATGAGGAG GAGGAAGAGC AGCGCTCTGG GCCGAGCGTA 5580
CTAAGCCAGG TCCACCTGTC AGAGGACGAG GAGGACAGTG AGGATTTCCA CTCCATTGCT 5640
GGGGACAGTG ACTTGGACTC TGATGAATGA GGCTTCCTTT GGGCCTCCTT GGTCAGCCTT 5700
CCCTGTTCTC CAGCCTAGGT GGTTCACCTT TCCCCAATTT GTTCATATTT GTACAGTATC 5760
TGATCCTGAA ATCATGAAAT TAACTAACAC CTTAGCCTTT TTAAAAGTAG TAAGTAAATG 5820
ATAATAAATC ACCTCTCCTA ATCTTCCTGG GGCAATGTCA CCCTTTGATT TAAAACAAAG 5880
CAACCCCCTT TCCCCTACCA CTACGGAAAA GAGCAAGCTC ATTTTTCCGT GTCCTCCTTT 5940
ATTTAACTCC ATTTATTGCT TTTGGTATAA TTTTTCCCTG GGGAAGGAGG GGAAATTATG 6000
AAAGAACTAG TAACTTTATG TCCTCTTGAT GTATTAGGAA ATTTCCGGCC AGGCGTGGTG 6060
GCTCACACCT GTAATCTCAG CACTCTGGGA GGCCGAGGCG GGCAGATCAC CTGAGGTCAG 6120
AAGTTCGAGA CCAGCTTGGC CAACATGGCG AAACCGCATC TCTACTAAAA ATACAAAAAT 6180
TAGCCAGGTG TGGTGGCGTA TGCCTGTTAA TCCTAGCTAC TCGGGAGGCT GAGGCAGGAG 6240
AATTACTTGA ACCCGGGAGG CAGAGGTTGC AGTGAGTGGA GGTCACGCCA CTGCACTCCA 6300
GCCTGGGCGA AAGAGTGAGA TTCAGTCTCA AAAAAAAAAA AATTTCCAAG CATGGTATCA 6360
TCTCACTTTT CTAATTTACA GGCTGGAGCA GATGAGAGCC CTCCTGCTGG GACAGAGAAT 6420
TGGGTTCTAG TGGACTCTGT GCTACACTTA AACCTGTGAG ACAAACCGCC CATTATTTTA 6480
TTATTTAATT ATGCAATGCC TAGTTCCTAA ATGGATTGGA GGCAAATTAC CGTAAATTTT 6540
GAAACAGCCT ATATGTCAGA AATGATAATG TTGCCACCTA AATGTTTTCT GTCCCCCCCA 6600
CCCTCCCCAG GGGAAATGGT AGGAAAATGG TAAGTTTCTT AGGGCAAAGA CTGTGTCTTC 6660
TGTTTCTTTT CATGCTTAGG ATATGGTTCT GTGCATAGTA GGTACTCAGT AAATGTTCCT 6720
AGAATCATAA AATCCTCAAC AGATATGTTA CTGAGCATCT GCTTTTCATG ATAAGCACTC 6780
TATCAGATCC TTGGGATGCA AAGGTAAATA AGACAAATCC CTTTTACCCA AAGAGCTCAC 6840
CATCAAGTTG GGGGAGGGAA AGTGGAATTC AAAACATGTT AATAAATCAT CATAGTACTG 6900
TGAGATAAGT GCAATTAAGA AGCTAGTTAT AAAGTATAGG GGAAATAGAG GAGTAATCAT 6960
GTCTGAAAAG TCAGGAAAGT CTTCCTAGAG GTAATTTTTA AGCTGATTGT TTTAGAATTA 7020
GTAGAAGCTT GCCAGATGGA AAAGTCCAGG CAAAGTGTAA CATGAATGGG AAAGGCCACA 7080
GTCTAGAAAT GGCAGAGTGT GTTCCTAGTT TGTTTGTTTG TTTGTTTGTA CCTGCCTTGT 7140
TCCAGGAAGG ATTTAATGTG GTTTATATTC CAGTCCTTTA ATGCTGGAAG GGCTGAGATG 7200
AGACTGAAAG ATGGGCAGGA AGTATATCAT CACAAGCTTT GTGTTTGATG TTAATGTGTA 7260
TGATTTTTAT ATTATGGGAA ATAAGCTCTT AGAGGAGTGA TATAATCAGG TTTGTGTTTT 7320
AGAAATCTGT GTAATGAATG AATGAAGAAA GAAATTGAAG AATCATGTAA CATATGTGAT 7380
CGCATTTTTG TAAAAGAACC ATGTGTGTTT ATATGTGTTT ATATATATAC TTGTGTATGC 7440
AAAGGTAAAA GTCTGAAAGG ATATATGCTA ACTGTTCACA ATGATAACCC CCCAGGAATG 7500
GGATTGGAGG GGAGGGGGCT TCTGTGTTTG TTATGTATGC TGGGTGGGAT ATTGTGCTTT 7560
TATTTCTATA TTGTTTGAAT TTTTTTACAG TATGTATTAT TTTTGTAATA AAAATTTTAA 7620
AAAATTCCA
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1023--Dystonia
KW-0945--Host-virus interaction
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0908--Parkinsonism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR011177--TAF1_animal
IPR009067--TAF_II_230-bd
IPR022591--TFIID_sub1_DUF3591
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
Pfam

PF00439--Bromodomain
PF12157--DUF3591
PF09247--TBP-binding
Gene Ontology

GO:0071339--C:MLL1 complex
GO:0005654--C:nucleoplasm
GO:0005669--C:transcription factor TFIID complex
GO:0005524--F:ATP binding
GO:0004402--F:histone acetyltransferase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0043565--F:sequence-specific DNA binding
GO:0017025--F:TBP-class protein binding
GO:0003713--F:transcription coactivator activity
GO:0008134--F:transcription factor binding
GO:0007049--P:cell cycle
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006352--P:DNA-templated transcription, initiation
GO:0016573--P:histone acetylation
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060261--P:positive regulation of transcription initiation from RNA polymerase II promoter
GO:0046777--P:protein autophosphorylation
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0051123--P:RNA polymerase II transcriptional preinitiation complex assembly
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Chs-0141 ENSCSAP00000007455.1 Chlorocebus sabaeus 98 0.0 3124
WERAM-Ict-0137 ENSSTOP00000014223.2 Ictidomys tridecemlineatus 97 0.0 3093
WERAM-Caf-0181 ENSCAFP00000025204.3 Canis familiaris 97 0.0 3084
WERAM-Mup-0057 ENSMPUP00000005037.1 Mustela putorius furo 96 0.0 3076
WERAM-Aim-0179 ENSAMEP00000017043.1 Ailuropoda melanoleuca 97 0.0 3075
WERAM-Orc-0155 ENSOCUP00000013470.2 Oryctolagus cuniculus 98 0.0 3075
WERAM-Eqc-0028 ENSECAP00000005777.1 Equus caballus 95 0.0 3072
WERAM-Bot-0071 ENSBTAP00000053806.2 Bos taurus 97 0.0 3064
WERAM-Ova-0178 ENSOARP00000018395.1 Ovis aries 97 0.0 3059
WERAM-Dan-0084 ENSDNOP00000008297.3 Dasypus novemcinctus 95 0.0 3055
WERAM-Tut-0126 ENSTTRP00000010206.1 Tursiops truncatus 96 0.0 3040
WERAM-Mum-0117 ENSMUSP00000098895.2 Mus musculus 94 0.0 3003
WERAM-Loa-0017 ENSLAFP00000001072.3 Loxodonta africana 95 0.0 2993
WERAM-Caj-0136 ENSCJAP00000024653.2 Callithrix jacchus 94 0.0 2991
WERAM-Paa-0189 ENSPANP00000008327.1 Papio anubis 93 0.0 2974
WERAM-Myl-0097 ENSMLUP00000007938.2 Myotis lucifugus 94 0.0 2933
WERAM-Gog-0169 ENSGGOP00000015303.2 Gorilla gorilla 94 0.0 2922
WERAM-Otg-0129 ENSOGAP00000011203.2 Otolemur garnettii 93 0.0 2918
WERAM-Fec-0147 ENSFCAP00000013737.3 Felis catus 96 0.0 2916
WERAM-Poa-0203 ENSPPYP00000022899.2 Pongo abelii 99 0.0 2913
WERAM-Nol-0009 ENSNLEP00000001213.1 Nomascus leucogenys 93 0.0 2843
WERAM-Mam-0039 ENSMMUP00000007484.2 Macaca mulatta 94 0.0 2840
WERAM-Ptv-0178 ENSPVAP00000015575.1 Pteropus vampyrus 92 0.0 2830
WERAM-Soa-0079 ENSSARP00000007616.1 Sorex araneus 94 0.0 2796
WERAM-Gaga-0058 ENSGALP00000008763.4 Gallus gallus 86 0.0 2756
WERAM-Mod-0037 ENSMODP00000005636.4 Monodelphis domestica 87 0.0 2746
WERAM-Tag-0103 ENSTGUP00000007224.1 Taeniopygia guttata 87 0.0 2736
WERAM-Pes-0010 ENSPSIP00000002836.1 Pelodiscus sinensis 89 0.0 2731
WERAM-Vip-0023 ENSVPAP00000002111.1 Vicugna pacos 90 0.0 2713
WERAM-Sah-0104 ENSSHAP00000011347.1 Sarcophilus harrisii 90 0.0 2711
WERAM-Fia-0145 ENSFALP00000012270.1 Ficedula albicollis 83 0.0 2653
WERAM-Sus-0187 ENSSSCP00000025903.1 Sus scrofa 97 0.0 2621
WERAM-Xet-0153 ENSXETP00000050061.3 Xenopus tropicalis 84 0.0 2563
WERAM-Meg-0096 ENSMGAP00000009261.2 Meleagris gallopavo 88 0.0 2557
WERAM-Anc-0157 ENSACAP00000014677.3 Anolis carolinensis 84 0.0 2508
WERAM-Orla-0084 ENSORLP00000010572.2 Oryzias latipes 78 0.0 2466
WERAM-Gaa-0218 ENSGACP00000026935.2 Gasterosteus aculeatus 78 0.0 2461
WERAM-Anp-0016 ENSAPLP00000002714.1 Anas platyrhynchos 87 0.0 2448
WERAM-Tar-0191 ENSTRUP00000039887.1 Takifugu rubripes 80 0.0 2447
WERAM-Leo-0153 ENSLOCP00000018291.1 Lepisosteus oculatus 81 0.0 2398
WERAM-Ten-0141 ENSTNIP00000001793.1 Tetraodon nigroviridis 80 0.0 2359
WERAM-Asm-0072 ENSAMXP00000007802.1 Astyanax mexicanus 80 0.0 2331
WERAM-Dar-0075 ENSDARP00000051195.3 Danio rerio 81 0.0 2325
WERAM-Gam-0177 ENSGMOP00000017484.1 Gadus morhua 79 0.0 2251
WERAM-Orn-0047 ENSONIP00000005424.1 Oreochromis niloticus 76 0.0 2250
WERAM-Xim-0140 ENSXMAP00000011463.1 Xiphophorus maculatus 82 0.0 2239
WERAM-Pof-0035 ENSPFOP00000003440.2 Poecilia formosa 82 0.0 2195
WERAM-Lac-0109 ENSLACP00000013555.1 Latimeria chalumnae 78 0.0 2011
WERAM-Drm-0014 FBpp0089369 Drosophila melanogaster 52 0.0 1364
WERAM-Cis-0047 ENSCSAVP00000010606.1 Ciona savignyi 63 0.0 1246
WERAM-Prc-0112 ENSPCAP00000010168.1 Procavia capensis 91 0.0 1201
WERAM-Tas-0038 ENSTSYP00000003813.1 Tarsius syrichta 99 0.0 847
WERAM-Dio-0149 ENSDORP00000013710.1 Dipodomys ordii 95 0.0 817
WERAM-Cae-0027 W04A8.7 Caenorhabditis elegans 40 0.0 734
WERAM-Mim-0154 ENSMICP00000015906.1 Microcebus murinus 82 0.0 716
WERAM-Mae-0077 ENSMEUP00000007728.1 Macropus eugenii 98 0.0 713
WERAM-Cii-0011 ENSCINP00000003774.3 Ciona intestinalis 57 3e-111 401
WERAM-Sol-0088 Solyc07g006820.2.1 Solanum lycopersicum 40 3e-79 295
WERAM-Php-0136 PP1S95_40V6.1 Physcomitrella patens 38 2e-76 286
WERAM-Sob-0136 Sb10g025390.1 Sorghum bicolor 39 2e-76 286
WERAM-Tra-0320 Traes_7DL_8317D3365.2 Triticum aestivum 39 4e-76 285
WERAM-Orbr-0075 OB06G30330.1 Oryza brachyantha 38 7e-76 284
WERAM-Brd-0018 BRADI1G30648.1 Brachypodium distachyon 38 2e-75 282
WERAM-Viv-0073 VIT_12s0028g03940.t01 Vitis vinifera 39 3e-75 282
WERAM-Amt-0079 ERN03830 Amborella trichopoda 37 7e-75 281
WERAM-Mua-0045 GSMUA_Achr2P11610_001 Musa acuminata 37 1e-74 280
WERAM-Lep-0067 LPERR06G18820.1 Leersia perrieri 38 1e-73 276
WERAM-Aet-0010 EMT07791 Aegilops tauschii 37 3e-73 275
WERAM-Tru-0057 TRIUR3_23361-P1 Triticum urartu 31 9e-73 273
WERAM-Sei-0076 Si020960m Setaria italica 37 1e-72 273
WERAM-Sem-0077 EFJ24900 Selaginella moellendorffii 37 2e-72 273
WERAM-Glm-0106 GLYMA09G34820.1 Glycine max 38 3e-71 269
WERAM-Prp-0005 EMJ26687 Prunus persica 37 6e-71 268
WERAM-Met-0127 AES95544 Medicago truncatula 38 1e-69 263
WERAM-Thc-0050 EOY04724 Theobroma cacao 36 4e-69 261
WERAM-Pot-0162 POPTR_0017s07490.1 Populus trichocarpa 37 9e-69 260
WERAM-Orp-0065 OPUNC06G20420.1 Oryza punctata 37 1e-68 260
WERAM-Orgl-0065 OGLUM06G23920.1 Oryza glumaepatula 37 1e-68 259
WERAM-Orni-0066 ONIVA06G26610.1 Oryza nivara 37 1e-68 259
WERAM-Orr-0069 ORUFI06G24340.1 Oryza rufipogon 37 1e-68 259
WERAM-Orb-0067 OBART06G22700.1 Oryza barthii 36 4e-67 254
WERAM-Ori-0064 BGIOSGA020788-PA Oryza indica 36 4e-67 254
WERAM-Orm-0064 OMERI06G22620.1 Oryza meridionalis 36 5e-67 254
WERAM-Bro-0143 Bo8g028930.1 Brassica oleracea 34 3e-66 252
WERAM-Brr-0176 Bra035499.1-P Brassica rapa 34 3e-66 252
WERAM-Orl-0023 KN538731.1_FGP008 Oryza longistaminata 35 8e-65 247
WERAM-Org-0063 ORGLA06G0189300.1 Oryza glaberrima 35 1e-64 247
WERAM-Art-0017 AT1G32750.1 Arabidopsis thaliana 33 2e-63 242
WERAM-Arl-0032 fgenesh1_pm.C_scaffold_1002616 Arabidopsis lyrata 31 6e-57 221
WERAM-Osl-0013 ABO97954 Ostreococcus lucimarinus 30 1e-39 163
WERAM-Cym-0013 CMH262CT Cyanidioschyzon merolae 27 7e-17 88.6
WERAM-Ran-0073 ENSRNOP00000015499.5 Rattus norvegicus 34 8e-15 81.3
WERAM-Pug-0010 EFP80056 Puccinia graminis 38 3e-14 79.3
WERAM-Pat-0116 ENSPTRP00000024168.4 Pan troglodytes 33 4e-14 79.3
WERAM-Ect-0125 ENSETEP00000014449.1 Echinops telfairi 33 5e-14 79.0
WERAM-Ocp-0047 ENSOPRP00000004188.2 Ochotona princeps 33 6e-14 78.6
WERAM-Chh-0096 ENSCHOP00000011245.1 Choloepus hoffmanni 36 8e-14 78.2
WERAM-Ere-0081 ENSEEUP00000007356.1 Erinaceus europaeus 33 9e-14 78.2
WERAM-Crn-0009 AAW41608 Cryptococcus neoformans 40 1e-13 77.4
WERAM-Mao-0032 MGG_11716T0 Magnaporthe oryzae 40 2e-13 77.0
WERAM-Scj-0018 EEB07672 Schizosaccharomyces japonicus 41 7e-13 75.1
WERAM-Pem-0007 ENSPMAP00000000651.1 Petromyzon marinus 41 1e-12 73.9
WERAM-Zem-0032 GRMZM2G044044_P01 Zea mays 36 2e-12 73.9
WERAM-Ora-0100 ENSOANP00000019048.3 Ornithorhynchus anatinus 38 3e-12 73.2
WERAM-Put-0007 PTTG_04942P0 Puccinia triticina 36 3e-12 73.2
WERAM-Tum-0005 CAZ80037 Tuber melanosporum 42 4e-12 72.8
Created Date 25-Jun-2016