| Tag |
Content |
| WERAM ID |
WERAM-Hos-0220 |
| Ensembl Protein ID |
ENSP00000362227.3 |
| Uniprot Accession |
Q9Y468; LMBL1_HUMAN; B4DRC9; E1P5W7; Q5H8Y8; Q5H8Y9; Q8IUV7; Q9H1E6; Q9H1G5; Q9UG06; Q9UJB9; Q9Y4C9
|
| Genbank Protein ID |
NP_056293.4; NP_115479.4
|
| Protein Name |
Lethal(3)malignant brain tumor-like protein 1 |
| Genbank Nucleotide ID |
NM_015478.6; NM_032107.4
|
| Gene Name |
L3MBTL1;KIAA0681;L3MBTL |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
MBT |
MBT1 |
H4K20me1/2 |
K |
24309976
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
MBT |
6.40e-100 |
316.3 |
206 |
306 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
|
| Domain Profile |
Me_Reader MBT
MBT-1.txt 1 fsWesyleeeksiavPveaFkeaqtvtvned.vkegvklEvvdkdnakvywiatvikvagyrvllrydGadskaDFWlnidssdihpvgwce 91
+sWesylee+k+i++Pv++F+++q+vt+n++ +k g+klE++d++++++y+i+tv++v+gyr++l++dG+++++DFW+n++s+dihp gw+e
ENSP00000362227.3 206 WSWESYLEEQKAITAPVSLFQDSQAVTHNKNgFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFE 297
89****************************************************************************************** PP
MBT-1.txt 92 ksgkklepp 100
k+g+kl+pp
ENSP00000362227.3 298 KTGHKLQPP 306
*******98 PP
MBT-1.txt 1 fsWesyleeeksiavPveaFkeaqtvtvnedvkegvklEvvdkdnakvywiatvikvagyrvllrydGadskaDFWlnidssdihpvgwcek 92
fsW +yl +++++a+P ++F ++ + +++g+klE+vd+ n++ +++a+v +v+++r l+++d d+++D+W++ +s+ ihpvgwc+k
ENSP00000362227.3 314 FSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQK 405
89******************88877777666************************************************************* PP
MBT-1.txt 93 sgkklepp 100
+gk l+pp
ENSP00000362227.3 406 QGKPLTPP 413
*****998 PP
MBT-1.txt 1 fsWesyleeeksiavPveaFkeaqtvtvnedvkegvklEvvdkdnakvywiatvikvagyrvllrydGadskaDFWlnidssdihpvgwcek 92
f+We+ylee++++avP+ aFk + ++ +++klE+vd++n+ + +a+v++v + r+++++dG ++ +DFW+++d +dihp gwc k
ENSP00000362227.3 422 FCWEKYLEETGASAVPTWAFKVRPPH----SFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSK 509
89******************977654....3778********************************************************** PP
MBT-1.txt 93 sgkklepp 100
+g+ l+pp
ENSP00000362227.3 510 TGHPLQPP 517
******98 PP
|
Protein Sequence
(Fasta) | MRRREGHGTD SEMGQGPVRE SQSSDPPALQ FRISEYKPLN MAGVEQPPSP ELRQEGVTEY 60
EDGGAPAGDG EAGPQQAEDH PQNPPEDPNQ DPPEDDSTCQ CQACGPHQAA GPDLGSSNDG 120
CPQLFQERSV IVENSSGSTS ASELLKPMKK RKRREYQSPS EEESEPEAME KQEEGKDPEG 180
QPTASTPESE EWSSSQPATG EKKECWSWES YLEEQKAITA PVSLFQDSQA VTHNKNGFKL 240
GMKLEGIDPQ HPSMYFILTV AEVCGYRLRL HFDGYSECHD FWVNANSPDI HPAGWFEKTG 300
HKLQPPKGYK EEEFSWSQYL RSTRAQAAPK HLFVSQSHSP PPLGFQVGMK LEAVDRMNPS 360
LVCVASVTDV VDSRFLVHFD NWDDTYDYWC DPSSPYIHPV GWCQKQGKPL TPPQDYPDPD 420
NFCWEKYLEE TGASAVPTWA FKVRPPHSFL VNMKLEAVDR RNPALIRVAS VEDVEDHRIK 480
IHFDGWSHGY DFWIDADHPD IHPAGWCSKT GHPLQPPLGP REPSSASPGG CPPLSYRSLP 540
HTRTSKYSFH HRKCPTPGCD GSGHVTGKFT AHHCLSGCPL AERNQSRLKA ELSDSEASAR 600
KKNLSGFSPR KKPRHHGRIG RPPKYRKIPQ EDFQTLTPDV VHQSLFMSAL SAHPDRSLSV 660
CWEQHCKLLP GVAGISASTV AKWTIDEVFG FVQTLTGCED QARLFKDEAR IVRVTHVSGK 720
TLVWTVAQLG DLVCSDHLQE GKGILETGVH SLLCSLPTHL LAKLSFASDS QY 772Protein Fasta Sequence
>ENSP00000362227.3|L3MBTL1;KIAA0681;L3MBTL|Homo sapiens
MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY |
Nucleotide Sequence
(Fasta) | AGAGTGGGGC ACCCTGGGAC TGGACCCCGC AGGTGCTTGG GGGCGTAGCC TGGAGTGAGG 60
GTTTGGCTGG TGTAGCTTGG AGTGAGGCCC CCTGGCGTGG AGTCTTGAGG CCTGCTGAGG 120
GCGTGAGCTG GCATGAGGCG AAGAGAGGGC CATGGCACCG ACTCCGAGAT GGGTCAAGGA 180
CCCGTACGGG AGTCGCAATC CTCAGACCCT CCCGCGCTCC AGTTCCGGAT AAGCGAGTAT 240
AAGCCGCTGA ACATGGCGGG AGTGGAGCAG CCCCCGAGCC CCGAGCTGCG GCAGGAAGGC 300
GTGACCGAAT ACGAAGATGG CGGGGCCCCG GCGGGAGATG GCGAGGCGGG CCCCCAACAG 360
GCGGAGGACC ACCCCCAGAA TCCTCCAGAA GATCCCAATC AGGACCCCCC AGAGGATGAT 420
AGCACCTGTC AGTGCCAGGC GTGCGGGCCT CACCAAGCCG CGGGTCCAGA TCTTGGTTCC 480
TCTAATGATG GCTGCCCTCA GCTGTTCCAG GAGCGGTCAG TCATAGTGGA GAACTCCTCA 540
GGCTCTACCA GCGCTTCTGA GCTCCTCAAA CCCATGAAGA AGAGGAAGCG CAGGGAATAC 600
CAGAGCCCAT CAGAGGAGGA GTCGGAGCCA GAGGCCATGG AGAAGCAAGA AGAAGGAAAG 660
GACCCAGAGG GACAACCCAC TGCTAGCACC CCAGAGAGTG AGGAGTGGAG CAGCAGCCAG 720
CCTGCAACAG GTGAGAAGAA GGAATGCTGG TCGTGGGAGT CCTACCTAGA GGAGCAGAAG 780
GCCATTACTG CTCCAGTCAG CCTCTTCCAG GACTCCCAGG CAGTCACTCA CAACAAGAAT 840
GGCTTCAAAC TGGGCATGAA GTTGGAAGGC ATTGACCCTC AACACCCGTC CATGTACTTC 900
ATCCTCACCG TGGCTGAGGT ATGTGGCTAT CGCCTACGCC TGCACTTTGA TGGGTATTCT 960
GAGTGCCATG ACTTCTGGGT CAATGCCAAC TCCCCTGACA TTCACCCTGC TGGCTGGTTC 1020
GAGAAGACGG GCCACAAGCT GCAGCCTCCC AAAGGTTACA AGGAGGAGGA GTTCAGCTGG 1080
AGCCAGTACC TGCGCAGCAC AAGAGCTCAG GCTGCCCCCA AGCACCTGTT TGTGAGCCAG 1140
AGCCACAGTC CCCCACCCCT GGGCTTCCAG GTGGGCATGA AGCTGGAGGC TGTTGACCGC 1200
ATGAACCCGT CCCTTGTCTG CGTGGCCAGT GTGACCGATG TGGTGGACAG CCGCTTCCTG 1260
GTGCACTTTG ACAACTGGGA TGATACTTAT GACTACTGGT GTGATCCCAG CAGCCCCTAC 1320
ATCCACCCAG TGGGCTGGTG CCAGAAGCAA GGAAAGCCCC TCACCCCTCC ACAAGACTAC 1380
CCAGACCCTG ATAACTTCTG TTGGGAGAAA TATCTGGAAG AAACTGGGGC CTCTGCTGTC 1440
CCCACCTGGG CCTTCAAGGT GCGACCCCCT CACAGCTTCC TGGTCAATAT GAAGCTGGAG 1500
GCTGTGGACC GCAGGAACCC AGCCCTGATT CGCGTGGCCA GCGTGGAGGA TGTGGAGGAC 1560
CATCGGATAA AGATCCACTT TGATGGCTGG AGTCATGGCT ATGATTTCTG GATCGACGCT 1620
GACCACCCAG ACATCCACCC TGCCGGCTGG TGCTCCAAGA CAGGACATCC CCTGCAGCCT 1680
CCTCTCGGAC CCAGAGAGCC CAGCTCTGCC TCCCCTGGGG GCTGTCCCCC TCTCAGCTAT 1740
AGGAGCCTGC CCCACACTAG GACCTCCAAA TACAGCTTTC ACCACCGGAA GTGCCCCACT 1800
CCTGGTTGCG ACGGCTCTGG CCATGTCACA GGCAAGTTCA CAGCTCACCA TTGCCTCTCA 1860
GGCTGCCCAC TGGCTGAGAG GAACCAGAGC CGGCTGAAAG CGGAGCTGTC TGACTCGGAG 1920
GCCTCAGCCC GCAAGAAGAA CCTCTCAGGC TTCTCCCCAA GGAAGAAGCC TCGCCATCAC 1980
GGCCGAATTG GACGCCCTCC GAAGTATCGA AAGATTCCGC AGGAAGATTT CCAGACCCTC 2040
ACGCCCGATG TCGTGCACCA GTCCCTCTTC ATGTCAGCCC TGTCGGCCCA CCCTGACCGC 2100
TCACTCTCAG TGTGCTGGGA GCAGCACTGC AAGCTCCTGC CAGGAGTAGC GGGCATCTCA 2160
GCCTCGACAG TCGCCAAGTG GACCATCGAT GAGGTCTTCG GCTTTGTTCA GACCCTGACA 2220
GGTTGTGAGG ACCAAGCACG CCTCTTCAAA GACGAGGCAA GAATAGTCAG AGTGACCCAT 2280
GTATCTGGGA AGACTCTAGT CTGGACTGTG GCCCAGCTTG GGGACCTTGT GTGCTCAGAT 2340
CATCTTCAGG AAGGAAAAGG CATCCTGGAG ACAGGAGTCC ATTCACTCCT CTGCTCTCTA 2400
CCCACTCATT TGCTTGCCAA ACTTAGCTTT GCCAGTGATA GTCAATATTA AAGTGTACTT 2460
TTTTCCCCTT TAATCCAATA TAGTTGATAA TTAAAGTGTA TTTTGAATGA CACAGATATT 2520
GTGATTTACT GCAAGGATCC TAACACACAC TTAAAATCAA GAGCCAAGGA GTAGTGAGTT 2580
GTAGATAAAA AAAGAATGTC AGCTTTGGAG ACAGTCTGGG TTTAAATCCC AGTTCTGTCA 2640
ATTTGAGCTG TTTACTGTCT CTGAGCCTAC ATCTTCTTGT CTGTAAAATG GAGATAAAAT 2700
GGGTTTAATG AGGTCTACCT TGCAGAGCCA TTGTGAGCAT TGGAAATGAT GAATGAATCA 2760
TACCAGAACG TCTAGTATAA TTACAGTCAT GCATTGCTTA ACGATGGGGA TACATTCTTA 2820
GAAATGTGTC ACTAGGCAAT TCTGTCATTG TGTAAACATT ATAGAATGTA CTTACACAAA 2880
CCTAGATGTT ATATGTATTT TTATTTACAT GTATATTTTC ACATGAAATA CCAAATGTCA 2940
CAGCATTATT ACTGAATGTC AGTCATTTCC CCTACTTGAT CTGCAATGCC AATATCAAGG 3000
GCCATGTATC AGGTTTCTGT ATATGTTCCA CTATAATCTT ATGGGACCAT GGTTTTAAAT 3060
GTGGAATCAT TGACAGAAAT GTCTTTATGT AGCATATGGC TGTGTATCAC TAGTATATAA 3120
TAGAGCAATA TTATGGAGGA ATATGTAGAT CCAATCACTT TACCTATACA AAATGACTGC 3180
TATGGTGGGA ACACAATAAA CACCAGTTTT GACTTTTA
3219Nucleotide Fasta Sequence
>ENSP00000362227.3|MBT|Homo sapiens
AGAGTGGGGCACCCTGGGACTGGACCCCGCAGGTGCTTGGGGGCGTAGCCTGGAGTGAGGGTTTGGCTGGTGTAGCTTGGAGTGAGGCCCCCTGGCGTGGAGTCTTGAGGCCTGCTGAGGGCGTGAGCTGGCATGAGGCGAAGAGAGGGCCATGGCACCGACTCCGAGATGGGTCAAGGACCCGTACGGGAGTCGCAATCCTCAGACCCTCCCGCGCTCCAGTTCCGGATAAGCGAGTATAAGCCGCTGAACATGGCGGGAGTGGAGCAGCCCCCGAGCCCCGAGCTGCGGCAGGAAGGCGTGACCGAATACGAAGATGGCGGGGCCCCGGCGGGAGATGGCGAGGCGGGCCCCCAACAGGCGGAGGACCACCCCCAGAATCCTCCAGAAGATCCCAATCAGGACCCCCCAGAGGATGATAGCACCTGTCAGTGCCAGGCGTGCGGGCCTCACCAAGCCGCGGGTCCAGATCTTGGTTCCTCTAATGATGGCTGCCCTCAGCTGTTCCAGGAGCGGTCAGTCATAGTGGAGAACTCCTCAGGCTCTACCAGCGCTTCTGAGCTCCTCAAACCCATGAAGAAGAGGAAGCGCAGGGAATACCAGAGCCCATCAGAGGAGGAGTCGGAGCCAGAGGCCATGGAGAAGCAAGAAGAAGGAAAGGACCCAGAGGGACAACCCACTGCTAGCACCCCAGAGAGTGAGGAGTGGAGCAGCAGCCAGCCTGCAACAGGTGAGAAGAAGGAATGCTGGTCGTGGGAGTCCTACCTAGAGGAGCAGAAGGCCATTACTGCTCCAGTCAGCCTCTTCCAGGACTCCCAGGCAGTCACTCACAACAAGAATGGCTTCAAACTGGGCATGAAGTTGGAAGGCATTGACCCTCAACACCCGTCCATGTACTTCATCCTCACCGTGGCTGAGGTATGTGGCTATCGCCTACGCCTGCACTTTGATGGGTATTCTGAGTGCCATGACTTCTGGGTCAATGCCAACTCCCCTGACATTCACCCTGCTGGCTGGTTCGAGAAGACGGGCCACAAGCTGCAGCCTCCCAAAGGTTACAAGGAGGAGGAGTTCAGCTGGAGCCAGTACCTGCGCAGCACAAGAGCTCAGGCTGCCCCCAAGCACCTGTTTGTGAGCCAGAGCCACAGTCCCCCACCCCTGGGCTTCCAGGTGGGCATGAAGCTGGAGGCTGTTGACCGCATGAACCCGTCCCTTGTCTGCGTGGCCAGTGTGACCGATGTGGTGGACAGCCGCTTCCTGGTGCACTTTGACAACTGGGATGATACTTATGACTACTGGTGTGATCCCAGCAGCCCCTACATCCACCCAGTGGGCTGGTGCCAGAAGCAAGGAAAGCCCCTCACCCCTCCACAAGACTACCCAGACCCTGATAACTTCTGTTGGGAGAAATATCTGGAAGAAACTGGGGCCTCTGCTGTCCCCACCTGGGCCTTCAAGGTGCGACCCCCTCACAGCTTCCTGGTCAATATGAAGCTGGAGGCTGTGGACCGCAGGAACCCAGCCCTGATTCGCGTGGCCAGCGTGGAGGATGTGGAGGACCATCGGATAAAGATCCACTTTGATGGCTGGAGTCATGGCTATGATTTCTGGATCGACGCTGACCACCCAGACATCCACCCTGCCGGCTGGTGCTCCAAGACAGGACATCCCCTGCAGCCTCCTCTCGGACCCAGAGAGCCCAGCTCTGCCTCCCCTGGGGGCTGTCCCCCTCTCAGCTATAGGAGCCTGCCCCACACTAGGACCTCCAAATACAGCTTTCACCACCGGAAGTGCCCCACTCCTGGTTGCGACGGCTCTGGCCATGTCACAGGCAAGTTCACAGCTCACCATTGCCTCTCAGGCTGCCCACTGGCTGAGAGGAACCAGAGCCGGCTGAAAGCGGAGCTGTCTGACTCGGAGGCCTCAGCCCGCAAGAAGAACCTCTCAGGCTTCTCCCCAAGGAAGAAGCCTCGCCATCACGGCCGAATTGGACGCCCTCCGAAGTATCGAAAGATTCCGCAGGAAGATTTCCAGACCCTCACGCCCGATGTCGTGCACCAGTCCCTCTTCATGTCAGCCCTGTCGGCCCACCCTGACCGCTCACTCTCAGTGTGCTGGGAGCAGCACTGCAAGCTCCTGCCAGGAGTAGCGGGCATCTCAGCCTCGACAGTCGCCAAGTGGACCATCGATGAGGTCTTCGGCTTTGTTCAGACCCTGACAGGTTGTGAGGACCAAGCACGCCTCTTCAAAGACGAGGCAAGAATAGTCAGAGTGACCCATGTATCTGGGAAGACTCTAGTCTGGACTGTGGCCCAGCTTGGGGACCTTGTGTGCTCAGATCATCTTCAGGAAGGAAAAGGCATCCTGGAGACAGGAGTCCATTCACTCCTCTGCTCTCTACCCACTCATTTGCTTGCCAAACTTAGCTTTGCCAGTGATAGTCAATATTAAAGTGTACTTTTTTCCCCTTTAATCCAATATAGTTGATAATTAAAGTGTATTTTGAATGACACAGATATTGTGATTTACTGCAAGGATCCTAACACACACTTAAAATCAAGAGCCAAGGAGTAGTGAGTTGTAGATAAAAAAAGAATGTCAGCTTTGGAGACAGTCTGGGTTTAAATCCCAGTTCTGTCAATTTGAGCTGTTTACTGTCTCTGAGCCTACATCTTCTTGTCTGTAAAATGGAGATAAAATGGGTTTAATGAGGTCTACCTTGCAGAGCCATTGTGAGCATTGGAAATGATGAATGAATCATACCAGAACGTCTAGTATAATTACAGTCATGCATTGCTTAACGATGGGGATACATTCTTAGAAATGTGTCACTAGGCAATTCTGTCATTGTGTAAACATTATAGAATGTACTTACACAAACCTAGATGTTATATGTATTTTTATTTACATGTATATTTTCACATGAAATACCAAATGTCACAGCATTATTACTGAATGTCAGTCATTTCCCCTACTTGATCTGCAATGCCAATATCAAGGGCCATGTATCAGGTTTCTGTATATGTTCCACTATAATCTTATGGGACCATGGTTTTAAATGTGGAATCATTGACAGAAATGTCTTTATGTAGCATATGGCTGTGTATCACTAGTATATAATAGAGCAATATTATGGAGGAATATGTAGATCCAATCACTTTACCTATACAAAATGACTGCTATGGTGGGAACACAATAAACACCAGTTTTGACTTTTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR004092--Mbt
IPR001660--SAM
IPR013761--SAM/pointed
IPR002515--Znf_C2HC
|
| PROSITE |
PS51079--MBT
PS50105--SAM_DOMAIN
|
| Pfam |
PF02820--MBT
PF00536--SAM_1
PF01530--zf-C2HC
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0000793--C:condensed chromosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0042802--F:identical protein binding
GO:0035064--F:methylated histone binding
GO:0031493--F:nucleosomal histone binding
GO:0031491--F:nucleosome binding
GO:0032093--F:SAM domain binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0030097--P:hemopoiesis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0051726--P:regulation of cell cycle
GO:0045652--P:regulation of megakaryocyte differentiation
GO:0007088--P:regulation of mitotic nuclear division
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
