| Tag |
Content |
| WERAM ID |
WERAM-Hos-0235 |
| Ensembl Protein ID |
ENSP00000359095.1 |
| Uniprot Accession |
Q96LA8; ANM6_HUMAN; A3KME1; B4DID8; Q5T5Y5; Q6DKI4; Q9NVR8
|
| Genbank Protein ID |
NP_060607.2
|
| Protein Name |
Protein arginine N-methyltransferase 6 |
| Genbank Nucleotide ID |
NM_018137.2
|
| Gene Name |
PRMT6;ANM6 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
PRMT |
PRMT-type |
H2AR3; H3R2; H4R3 |
R |
18079182; 23557020
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
PRMT |
7.60e-111 |
372.6 |
45 |
357 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). |
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).
|
| Domain Profile |
HMT PRMT
PRMT.txt 2 qqylqslselLesgvyeemlkDevrtdaYreailknktllkdkvvldvGaGtGiLslfaakagarkvyavekspmakvarkvvkvnglkdrv 93
q y++++s++ +v+eem++D+vrtdaYr +il+n+++l+ k+vldvGaGtGiLs+f+a+agar+vyave+s+++++ar+vv++ngl+drv
ENSP00000359095.1 45 QLYYECYSDV---SVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRV 133
89********...******************************************************************************* PP
PRMT.txt 94 tvikgkveelelpkekvDiivSEllgsfllnEsllpsvlhardkfLkddglslPdkatlyvapiedtklykeekaefw...ksvygvdlscl 182
+v++g ve++elp e+vD+ivSE++g+ ll+Es+l+svlhar+k+Lk++gl+lP++a+l++api+d+ + e++ fw k++ygvd+scl
ENSP00000359095.1 134 HVLPGPVETVELP-EQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQ--MLEWRLGFWsqvKQHYGVDMSCL 222
*************.*****************************************************..799******9999********** PP
PRMT.txt 183 ekaaikeqfesp..lVdtldkekllsepkkiftfdiskakesd..ee.relslelevkrnaslhglaayFdvqft...sektvvlStaPetk 266
e++a+++++ ++ +V+ l+ e++l++p++++++++s+a ++ e+ + +++++++ +a +hg+a++F+v+f+ sek +vlSt+P
ENSP00000359095.1 223 EGFATRCLMGHSeiVVQGLSGEDVLARPQRFAQLELSRAGLEQelEAgVGGRFRCSCYGSAPMHGFAIWFQVTFPggeSEKPLVLSTSP--F 312
*********998889************************99886545799************************9999***********..* PP
PRMT.txt 267 spathWkqavlyledpltvkegekis..illlarkknsrdvdyel 309
+pathWkqa+lyl++p++v++++++s i+ll++++n+r++++ l
ENSP00000359095.1 313 HPATHWKQALLYLNEPVQVEQDTDVSgeITLLPSRDNPRRLRVLL 357
****************************************99876 PP
|
Protein Sequence
(Fasta) | MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC YSDVSVHEEM 60
IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC AQAGARRVYA VEASAIWQQA 120
REVVRFNGLE DRVHVLPGPV ETVELPEQVD AIVSEWMGYG LLHESMLSSV LHARTKWLKE 180
GGLLLPASAE LFIAPISDQM LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG 240
LSGEDVLARP QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE 300
SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP RRLRVLLRYK 360
VGDQEEKTKD FAMED 375Protein Fasta Sequence
>ENSP00000359095.1|PRMT6;ANM6|Homo sapiens
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED |
Nucleotide Sequence
(Fasta) | GCGCTACGCC CGCCGGGAGC CGGGCAGAGC GGCCAAGATG TCGCAGCCCA AGAAAAGAAA 60
GCTTGAGTCG GGGGGCGGCG GCGAAGGAGG GGAGGGAACT GAAGAGGAAG ATGGCGCGGA 120
GCGGGAGGCG GCCCTGGAGC GACCCCGGAG GACTAAGCGG GAACGGGACC AGCTGTACTA 180
CGAGTGCTAC TCGGACGTTT CGGTCCACGA GGAGATGATC GCGGACCGCG TCCGCACCGA 240
TGCCTACCGC CTGGGTATCC TTCGGAACTG GGCAGCACTG CGAGGCAAGA CGGTACTGGA 300
CGTGGGCGCG GGCACCGGCA TTCTGAGCAT CTTCTGTGCC CAGGCCGGGG CCCGGCGCGT 360
GTACGCGGTA GAGGCCAGCG CCATCTGGCA ACAGGCCCGG GAGGTGGTGC GGTTCAACGG 420
GCTGGAGGAC CGGGTGCACG TCCTGCCGGG ACCAGTGGAG ACTGTAGAGT TGCCGGAACA 480
GGTGGATGCC ATCGTGAGCG AGTGGATGGG CTACGGACTC CTGCACGAGT CCATGCTGAG 540
CTCCGTCCTC CACGCGCGAA CCAAGTGGCT GAAGGAGGGC GGTCTTCTCC TGCCGGCCTC 600
CGCCGAGCTC TTCATAGCCC CCATCAGCGA CCAGATGCTG GAATGGCGCC TGGGCTTCTG 660
GAGCCAGGTG AAGCAGCACT ATGGTGTGGA CATGAGCTGC CTGGAGGGCT TCGCCACGCG 720
CTGTCTCATG GGCCACTCGG AGATCGTTGT GCAGGGATTG TCCGGCGAGG ACGTGCTGGC 780
CCGGCCGCAG CGCTTTGCTC AGCTAGAGCT CTCCCGCGCC GGCTTGGAGC AGGAGCTGGA 840
GGCCGGAGTG GGCGGGCGCT TCCGCTGCAG CTGCTATGGC TCGGCGCCCA TGCATGGCTT 900
TGCCATCTGG TTCCAGGTGA CCTTCCCTGG AGGGGAGTCG GAGAAACCCC TGGTGCTGTC 960
CACCTCGCCT TTTCACCCGG CCACTCACTG GAAACAGGCG CTCCTCTACC TGAACGAGCC 1020
GGTGCAAGTG GAGCAAGACA CGGACGTTTC AGGAGAGATC ACGCTGCTGC CCTCCCGGGA 1080
CAACCCCCGT CGCCTGCGCG TGCTGCTGCG CTACAAAGTG GGAGACCAGG AGGAGAAGAC 1140
CAAAGACTTT GCCATGGAGG ACTGAGCGTT GCCTTTTCTC CCAGCTACCT CCCAAAGCAG 1200
CCTGACCTGC GTGGGAGAGG CGTAGCGAGG TCGGAGGGGA AAGGGAGATC CCACGTGCAA 1260
GTAGGGGGAA TATCTCCCCC TTTTCCCTCA TAGCCTCTAG GGAGGGAGAG TGACTTCATT 1320
CTCCATTTGA AGAGATTCTT CTGGTGATGT TTACTTAAAA AGTGATCCCC CTCAACAACG 1380
GATACAGCGT GCTTATTATT GGGCATTTAG CCTCAAAAGC ATGTAGTACC AAGCACTTGT 1440
ATTTCCGTAT ATTTTGTTTC GCGGGGGAGT GAGGGGGAAG AACACGGATG AAAATGTCAG 1500
TTTTTGAAGG GTCCATGCAC ATCCCTGACA CCTCACACCT TATCTAAGTC TGAAGCTGGG 1560
GAGAAAGGGG TTCATTTAGA CTTCATACAT TTCCAGTACG ACTTTAGTAT CTCTCCAGAG 1620
CCATATTTTC TCAGTCCGAA TTAATTCCCC CTCCCTAGGT GCCTGTAGGC TATGGTACTT 1680
CTTCCTCATT GTTTTCTAGG TAAACTTCAC TACTGGTAAT TAAGGGGAAG GATATGAGGA 1740
AGCAGTTTAA ATAGCCCTGT TCTCATTACT CTGACCACAT ACATCATAGG GTGCTAAAGT 1800
TGATGAACAC ATTAATCCGT TAAGTAAAAT GGACTTTGTA ATTGTACAGC ATACCTAAGA 1860
AACTCAGAAG GTGCATTTAA GAGAGAGACC TGAAAGAAAT AGTATGGATT TTTAAAAATT 1920
CTTGTCTCTA CTATTATAAC CAAAAAATAT TTCTTGTATG TCCCATAAAA ATATTTGTGT 1980
AATTCTTATG AAACAGGCTG GTAGAGGAGG TTTCTGAGCC TAGCCCAAGG GCTTATTCAT 2040
CACCATGGGT AAATTATTTA AACTCACTTA ATTAAGGAAA ATATTTTCCC AGCTAGAAAA 2100
GTATACTCAT TCTCATTTAA ACTCTCTCAT TTGGAGGGAT CATGTGAGTT GGCCTACTTA 2160
CAAGTAGTGA AAGTTCCCTT TTCAGTTTTG TTTTGTTTTG TTTTGTTTTT CTCTTTCACT 2220
CAGCCAAATG TGAAAGTTGT GAATTTAGGA AAATCACTTG TAATGAAGTG TGAATCTTGT 2280
TATCAAATTT ATTTCTCTGA TGTTTCCTTC CTTATCCTTG TAGCCAATAA AACATTGACA 2340
TTCTCACGTT TTATAGATGA GGTAAAAAGT CTTGTGTGCT GTGAGTTATA ATGCTTTTGC 2400
CTTTTTAATA TTATTAGTTC TTAAGTGTTA CAGCCCCTTC AGAATATAAC TTCAGGACAA 2460
TTCAAACTAT GCTTAATGTA TGATTTTCGA GCTTCTGTAT GCTAAGAAAA TAGGTGTGAA 2520
AAACTGGTGT TCTGAAATAG CCTAACATTT ATTGTAATTC TGAATTTTCT GCCCTTTTAT 2580
TCATTGCATA TTAAAGTATT AGAGTATAAA AACTAA
2617Nucleotide Fasta Sequence
>ENSP00000359095.1|PRMT|Homo sapiens
GCGCTACGCCCGCCGGGAGCCGGGCAGAGCGGCCAAGATGTCGCAGCCCAAGAAAAGAAAGCTTGAGTCGGGGGGCGGCGGCGAAGGAGGGGAGGGAACTGAAGAGGAAGATGGCGCGGAGCGGGAGGCGGCCCTGGAGCGACCCCGGAGGACTAAGCGGGAACGGGACCAGCTGTACTACGAGTGCTACTCGGACGTTTCGGTCCACGAGGAGATGATCGCGGACCGCGTCCGCACCGATGCCTACCGCCTGGGTATCCTTCGGAACTGGGCAGCACTGCGAGGCAAGACGGTACTGGACGTGGGCGCGGGCACCGGCATTCTGAGCATCTTCTGTGCCCAGGCCGGGGCCCGGCGCGTGTACGCGGTAGAGGCCAGCGCCATCTGGCAACAGGCCCGGGAGGTGGTGCGGTTCAACGGGCTGGAGGACCGGGTGCACGTCCTGCCGGGACCAGTGGAGACTGTAGAGTTGCCGGAACAGGTGGATGCCATCGTGAGCGAGTGGATGGGCTACGGACTCCTGCACGAGTCCATGCTGAGCTCCGTCCTCCACGCGCGAACCAAGTGGCTGAAGGAGGGCGGTCTTCTCCTGCCGGCCTCCGCCGAGCTCTTCATAGCCCCCATCAGCGACCAGATGCTGGAATGGCGCCTGGGCTTCTGGAGCCAGGTGAAGCAGCACTATGGTGTGGACATGAGCTGCCTGGAGGGCTTCGCCACGCGCTGTCTCATGGGCCACTCGGAGATCGTTGTGCAGGGATTGTCCGGCGAGGACGTGCTGGCCCGGCCGCAGCGCTTTGCTCAGCTAGAGCTCTCCCGCGCCGGCTTGGAGCAGGAGCTGGAGGCCGGAGTGGGCGGGCGCTTCCGCTGCAGCTGCTATGGCTCGGCGCCCATGCATGGCTTTGCCATCTGGTTCCAGGTGACCTTCCCTGGAGGGGAGTCGGAGAAACCCCTGGTGCTGTCCACCTCGCCTTTTCACCCGGCCACTCACTGGAAACAGGCGCTCCTCTACCTGAACGAGCCGGTGCAAGTGGAGCAAGACACGGACGTTTCAGGAGAGATCACGCTGCTGCCCTCCCGGGACAACCCCCGTCGCCTGCGCGTGCTGCTGCGCTACAAAGTGGGAGACCAGGAGGAGAAGACCAAAGACTTTGCCATGGAGGACTGAGCGTTGCCTTTTCTCCCAGCTACCTCCCAAAGCAGCCTGACCTGCGTGGGAGAGGCGTAGCGAGGTCGGAGGGGAAAGGGAGATCCCACGTGCAAGTAGGGGGAATATCTCCCCCTTTTCCCTCATAGCCTCTAGGGAGGGAGAGTGACTTCATTCTCCATTTGAAGAGATTCTTCTGGTGATGTTTACTTAAAAAGTGATCCCCCTCAACAACGGATACAGCGTGCTTATTATTGGGCATTTAGCCTCAAAAGCATGTAGTACCAAGCACTTGTATTTCCGTATATTTTGTTTCGCGGGGGAGTGAGGGGGAAGAACACGGATGAAAATGTCAGTTTTTGAAGGGTCCATGCACATCCCTGACACCTCACACCTTATCTAAGTCTGAAGCTGGGGAGAAAGGGGTTCATTTAGACTTCATACATTTCCAGTACGACTTTAGTATCTCTCCAGAGCCATATTTTCTCAGTCCGAATTAATTCCCCCTCCCTAGGTGCCTGTAGGCTATGGTACTTCTTCCTCATTGTTTTCTAGGTAAACTTCACTACTGGTAATTAAGGGGAAGGATATGAGGAAGCAGTTTAAATAGCCCTGTTCTCATTACTCTGACCACATACATCATAGGGTGCTAAAGTTGATGAACACATTAATCCGTTAAGTAAAATGGACTTTGTAATTGTACAGCATACCTAAGAAACTCAGAAGGTGCATTTAAGAGAGAGACCTGAAAGAAATAGTATGGATTTTTAAAAATTCTTGTCTCTACTATTATAACCAAAAAATATTTCTTGTATGTCCCATAAAAATATTTGTGTAATTCTTATGAAACAGGCTGGTAGAGGAGGTTTCTGAGCCTAGCCCAAGGGCTTATTCATCACCATGGGTAAATTATTTAAACTCACTTAATTAAGGAAAATATTTTCCCAGCTAGAAAAGTATACTCATTCTCATTTAAACTCTCTCATTTGGAGGGATCATGTGAGTTGGCCTACTTACAAGTAGTGAAAGTTCCCTTTTCAGTTTTGTTTTGTTTTGTTTTGTTTTTCTCTTTCACTCAGCCAAATGTGAAAGTTGTGAATTTAGGAAAATCACTTGTAATGAAGTGTGAATCTTGTTATCAAATTTATTTCTCTGATGTTTCCTTCCTTATCCTTGTAGCCAATAAAACATTGACATTCTCACGTTTTATAGATGAGGTAAAAAGTCTTGTGTGCTGTGAGTTATAATGCTTTTGCCTTTTTAATATTATTAGTTCTTAAGTGTTACAGCCCCTTCAGAATATAACTTCAGGACAATTCAAACTATGCTTAATGTATGATTTTCGAGCTTCTGTATGCTAAGAAAATAGGTGTGAAAAACTGGTGTTCTGAAATAGCCTAACATTTATTGTAATTCTGAATTTTCTGCCCTTTTATTCATTGCATATTAAAGTATTAGAGTATAAAAACTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-0488--Methylation
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR025799--Arg_MeTrfase
IPR029063--SAM-dependent_MTases
|
| PROSITE |
PS51678--SAM_MT_PRMT
|
| Pfam |
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0042054--F:histone methyltransferase activity
GO:0070612--F:histone methyltransferase activity (H2A-R3 specific)
GO:0070611--F:histone methyltransferase activity (H3-R2 specific)
GO:0044020--F:histone methyltransferase activity (H4-R3 specific)
GO:0008469--F:histone-arginine N-methyltransferase activity
GO:0016274--F:protein-arginine N-methyltransferase activity
GO:0035242--F:protein-arginine omega-N asymmetric methyltransferase activity
GO:0035241--F:protein-arginine omega-N monomethyltransferase activity
GO:0006284--P:base-excision repair
GO:0016049--P:cell growth
GO:0090398--P:cellular senescence
GO:0034970--P:histone H3-R2 methylation
GO:0043985--P:histone H4-R3 methylation
GO:0016571--P:histone methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0019919--P:peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
