Tag |
Content |
WERAM ID |
WERAM-Hos-0232 |
Ensembl Protein ID |
ENSP00000352185.4 |
Uniprot Accession |
O75151; PHF2_HUMAN; Q4VXG0; Q8N3K2; Q9Y6N4 |
Genbank Protein ID |
NP_005383.3 |
Protein Name |
Lysine-specific demethylase PHF2 |
Genbank Nucleotide ID |
NM_005392.3 |
Gene Name |
PHF2;CENP-35;KIAA0662 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
PHF2_PHF8 |
Jmjc |
H3K9.me2 |
K |
26674421; 25204660 |
Me_Reader |
PHD |
PHD-type |
H3K4me3 |
K |
21872465 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
PHF2_PHF8 |
1.40e-91 |
306.6 |
197 |
353 |
Me_Reader |
PHD |
1.90e-13 |
52.7 |
6 |
261 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. |
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
|
Domain Profile |
HDM PHF2_PHF8
PHF2.txt 1 fsdtklselveppdivkklslvenlwpdeavlekpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyeawesss 92 fsdt++s++veppdivkkls+ven+wpd+a+l+kpkv+kycli+vkdsytdfhid+ggas++yhvlkgek+fylirp++an++lye+w+s+s ENSP00000352185.4 197 FSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSAS 288 79****************************************************************************************** PP PHF2.txt 93 dqsevffgdkvdkaykvvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157 ++se+ff+d+vdk+yk++vkqgqtl+ip+gwi+a+ltpvdclaf+g+flhsl++emq+raye+e+ ENSP00000352185.4 289 NHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVER 353 ***************************************************************96 PP
Me_Reader PHD
PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 +C+ C+ +++ +++m++Cd C+dwfH++Cv+++++++p+ + ++Cp+C++ ENSP00000352185.4 6 VYCV-CRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEK 55 69*9.**********************************7758******86 PP PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHl 29 ++Cl+C kd++ + +++ + + w+H+ ENSP00000352185.4 235 KYCLICVKDSYTD-FHIDSGGASAWYHV 261 79****7777774.79999999999996 PP
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Protein Sequence (Fasta) | MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 60 TLKKKRTWHK HGPGQAPDVK PVQNGSQLFI KELRSRTFPS AEDVVARVPG SQLTLGYMEE 120 HGFTEPILVP KKDGLGLAVP APTFYVSDVE NYVGPERSVD VTDVTKQKDC KMKLKEFVDY 180 YYSTNRKRVL NVTNLEFSDT RMSSFVEPPD IVKKLSWVEN YWPDDALLAK PKVTKYCLIC 240 VKDSYTDFHI DSGGASAWYH VLKGEKTFYL IRPASANISL YERWRSASNH SEMFFADQVD 300 KCYKCIVKQG QTLFIPSGWI YATLTPVDCL AFAGHFLHSL SVEMQMRAYE VERRLKLGSL 360 TQFPNFETAC WYMGKHLLEA FKGSHKSGKQ LPPHLVQGAK ILNGAFRSWT KKQALAEHED 420 ELPEHFKPSQ LIKDLAKEIR LSENASKAVR PEVNTVASSD EVCDGDREKE EPPSPIEATP 480 PQSLLEKVSK KKTPKTVKMP KPSKIPKPPK PPKPPRPPKT LKLKDGGKKK GKKSRESASP 540 TIPNLDLLEA HTKEALTKME PPKKGKATKS VLSVPNKDVV HMQNDVERLE IREQTKSKSE 600 AKWKYKNSKP DSLLKMEEEQ KLEKSPLAGN KDNKFSFSFS NKKLLGSKAL RPPTSPGVFG 660 ALQNFKEDKP KPVRDEYEYV SDDGELKIDE FPIRRKKNAP KRDLSFLLDK KAVLPTPVTK 720 PKLDSAAYKS DDSSDEGSLH IDTDTKPGRN ARVKKESGSS AAGILDLLQA SEEVGALEYN 780 PSSQPPASPS TQEAIQGMLS MANLQASDSC LQTTWGAGQA KGSSLAAHGA RKNGGGSGKS 840 AGKRLLKRAA KNSVDLDDYE EEQDHLDACF KDSDYVYPSL ESDEDNPIFK SRSKKRKGSD 900 DAPYSPTARV GPSVPRQDRP VREGTRVASI ETGLAAAAAK LSQQEEQKSK KKKSAKRKLT 960 PNTTSPSTST SISAGTTSTS TTPASTTPAS TTPASTSTAS SQASQEGSSP EPPPESHSSS 1020 LADHEYTAAG TFTGAQAGRT SQPMAPGVFL TQRRPSASSP NNNTAAKGKR TKKGMATAKQ 1080 RLGKILKIHR NGKLLL 1096Protein Fasta Sequence
>ENSP00000352185.4|PHF2;CENP-35;KIAA0662|Homo sapiens MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
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Nucleotide Sequence (Fasta) | GGCCGCTCGG CGGCCGGGGG TCCCTTCGGT GGGGCCGCGG CTCCCCGCCC GCCGCCCCCG 60 CGCGTCCATT CCCTTTTGTG TCCCGCGCGC GGCCCGTCCC CCGCGCACAC TAGCGCCCTG 120 AGCCCCGCGG GCCGGCGGGC GGCTCCCGGC GCGGCCCCTC CAGCCAGCGC GCCCGGCATT 180 GTGTGGACGC GCCTGGCCGG GAGCGCGCGC GGGGGCTGTC GTGCGCCCCC GTCCCCGTCC 240 CCTCCCGGCC GCGGCGCCGC CTGCGCCCCG CCGCCCCCGC CGCCCCCGCG CGGCCCGGCC 300 CCCGGCCCGG CCCGGACCGA CCCGGGCAGC GCAGCGGCGG GGCCGAGCGG CGGCGCGGCG 360 CGGCAACATG GCGACGGTGC CCGTGTACTG CGTCTGCCGG CTCCCCTACG ACGTTACCCG 420 CTTCATGATC GAGTGCGACG CCTGCAAGGA CTGGTTCCAC GGCAGCTGTG TTGGGGTGGA 480 AGAGGAGGAG GCGCCCGACA TCGACATATA CCACTGCCCA AACTGTGAGA AAACCCATGG 540 GAAGTCCACC TTAAAGAAGA AGCGGACCTG GCACAAACAC GGCCCGGGGC AAGCGCCTGA 600 CGTCAAGCCC GTGCAGAATG GCAGCCAGCT CTTCATCAAG GAGCTGCGGA GCCGGACCTT 660 TCCCAGTGCT GAAGACGTGG TGGCCCGTGT GCCAGGAAGT CAGCTCACGC TGGGCTACAT 720 GGAGGAGCAC GGCTTCACCG AGCCCATCCT CGTCCCTAAG AAAGACGGGC TGGGTCTGGC 780 TGTCCCGGCC CCCACGTTCT ATGTCAGTGA CGTCGAGAAC TACGTGGGGC CGGAACGGAG 840 TGTGGATGTG ACAGATGTCA CCAAGCAGAA GGACTGCAAG ATGAAGCTGA AGGAGTTTGT 900 GGACTATTAC TACAGCACCA ACCGCAAGCG GGTCCTCAAC GTCACCAACC TCGAGTTCTC 960 TGACACCCGA ATGTCCAGCT TCGTGGAGCC ACCTGACATT GTAAAGAAAC TGTCATGGGT 1020 AGAAAACTAC TGGCCAGATG ATGCATTGCT GGCCAAGCCC AAAGTGACCA AGTACTGCCT 1080 AATCTGCGTG AAGGACAGTT ACACCGACTT CCACATCGAC TCTGGGGGCG CCTCTGCCTG 1140 GTACCACGTG CTCAAGGGGG AGAAGACCTT CTATCTCATC AGGCCGGCCT CGGCCAACAT 1200 CTCCCTGTAT GAGCGCTGGC GGTCTGCCTC TAACCACAGC GAGATGTTCT TTGCTGACCA 1260 GGTCGACAAA TGCTACAAGT GCATCGTCAA GCAGGGCCAG ACCCTCTTCA TCCCCTCAGG 1320 CTGGATCTAC GCCACACTCA CCCCTGTGGA CTGCCTGGCC TTCGCGGGAC ATTTCCTCCA 1380 CAGCCTGAGT GTGGAGATGC AGATGAGAGC ATATGAAGTG GAAAGGAGGT TGAAACTGGG 1440 CAGCCTGACT CAGTTTCCCA ACTTTGAAAC TGCGTGCTGG TACATGGGGA AGCACCTGCT 1500 GGAGGCATTC AAAGGCTCTC ACAAATCTGG GAAGCAGCTG CCCCCTCATC TAGTCCAAGG 1560 AGCTAAAATT CTCAATGGTG CTTTCCGATC GTGGACGAAG AAGCAGGCTT TGGCAGAGCA 1620 TGAGGACGAG CTCCCGGAGC ACTTCAAACC TTCACAGCTA ATCAAAGACC TGGCCAAAGA 1680 GATCCGGCTC AGTGAGAATG CCTCCAAAGC CGTCCGACCG GAAGTGAATA CTGTCGCCTC 1740 GTCAGATGAG GTGTGTGACG GGGACCGGGA GAAGGAGGAG CCCCCGTCTC CCATTGAGGC 1800 CACCCCGCCT CAATCCCTCC TGGAGAAAGT GTCCAAAAAA AAGACTCCCA AAACTGTGAA 1860 GATGCCCAAG CCATCCAAAA TCCCCAAGCC CCCGAAGCCC CCTAAGCCCC CAAGGCCCCC 1920 CAAAACGCTG AAGCTCAAAG ATGGAGGCAA GAAGAAAGGG AAGAAGTCCC GGGAGTCAGC 1980 CTCACCCACC ATCCCCAACC TGGACCTGCT CGAAGCCCAC ACCAAGGAGG CACTGACCAA 2040 GATGGAGCCG CCCAAGAAGG GCAAGGCCAC AAAGAGTGTC CTGAGTGTGC CCAACAAAGA 2100 TGTGGTTCAC ATGCAGAATG ATGTGGAGAG GCTGGAAATT CGAGAGCAAA CCAAGAGCAA 2160 GTCAGAGGCC AAGTGGAAGT ACAAGAACAG CAAACCTGAC TCCTTACTGA AGATGGAAGA 2220 GGAGCAGAAG CTAGAGAAGT CGCCTCTAGC TGGAAACAAA GACAATAAGT TCTCTTTTTC 2280 TTTCTCCAAC AAGAAACTCC TCGGCTCCAA GGCTCTCAGG CCCCCGACGA GCCCTGGTGT 2340 GTTCGGGGCC TTGCAGAACT TCAAGGAGGA CAAGCCCAAG CCCGTGCGGG ATGAGTATGA 2400 GTACGTGTCG GATGACGGTG AGCTCAAGAT CGACGAGTTT CCCATCAGGA GGAAGAAAAA 2460 CGCCCCGAAA AGGGACTTGT CCTTCTTGTT GGATAAGAAG GCTGTGCTGC CCACGCCTGT 2520 CACGAAGCCA AAGCTGGACT CGGCAGCGTA CAAGAGTGAT GACTCCTCGG ACGAGGGTTC 2580 GCTGCACATC GACACAGACA CCAAGCCCGG CCGCAATGCC AGAGTCAAGA AGGAGAGTGG 2640 GAGCTCGGCA GCTGGCATCT TGGACCTGCT GCAGGCCAGT GAGGAGGTTG GCGCGCTGGA 2700 GTACAACCCC AGCAGCCAGC CCCCGGCCTC CCCCAGCACA CAGGAAGCCA TTCAGGGAAT 2760 GCTGTCCATG GCCAACCTGC AGGCCTCCGA CTCCTGCCTG CAGACCACGT GGGGAGCTGG 2820 CCAGGCCAAG GGGAGCTCGC TGGCTGCCCA TGGTGCCCGG AAGAATGGGG GTGGCAGTGG 2880 CAAGAGTGCA GGCAAACGAC TGCTGAAGAG GGCTGCCAAG AACAGTGTCG ACCTGGACGA 2940 CTACGAGGAA GAGCAGGACC ACCTGGATGC CTGCTTCAAG GACTCAGACT ACGTTTACCC 3000 CTCACTGGAG TCAGATGAAG ACAACCCCAT CTTTAAGTCC CGGTCGAAGA AAAGGAAAGG 3060 CTCAGACGAC GCTCCCTACA GCCCAACAGC AAGGGTCGGC CCATCGGTGC CAAGACAGGA 3120 CAGGCCTGTG CGTGAGGGTA CACGGGTGGC TTCCATCGAG ACCGGGCTGG CGGCTGCTGC 3180 AGCTAAGTTG TCCCAGCAGG AGGAGCAGAA AAGCAAGAAA AAAAAGAGTG CCAAGAGGAA 3240 GCTGACTCCT AACACCACCT CCCCTTCCAC CTCCACCTCC ATCTCTGCCG GCACCACCTC 3300 CACCTCCACC ACGCCAGCCT CTACCACCCC GGCCTCCACC ACCCCGGCCT CCACCAGCAC 3360 GGCCAGCAGC CAGGCCTCGC AGGAGGGCAG CTCGCCAGAG CCCCCGCCTG AGTCGCATAG 3420 CAGCAGCCTG GCGGACCATG AGTACACAGC CGCTGGCACC TTCACCGGGG CCCAGGCTGG 3480 CCGCACCTCC CAGCCCATGG CCCCTGGGGT CTTTCTCACA CAGAGGCGGC CCTCCGCATC 3540 GTCTCCAAAC AACAACACCG CTGCCAAAGG AAAACGTACG AAAAAGGGCA TGGCGACCGC 3600 CAAGCAGAGG CTTGGGAAAA TTTTGAAAAT TCATCGGAAC GGGAAACTAC TCCTTTAAGA 3660 TTTGGAAAGC CAGGATCCTT CTGCTCCGCT CAGGACCCCC GGAGCCCCGC GAAAACATCT 3720 GCCTCCCAGG AGGGTGCCGA GCTGCCTCAC CAGGGAGGGC CTTGCCTCTT CCCGGCTGCC 3780 ATCTCCCCAA CAAGCGTCTG TCCCTTCAGC CGGCAGAGCG AGCCCAGCGT GGCCCCTCAA 3840 TTTGAAAATG GACGTCTTTT CTCAAGTTGC TAAGAGTGAT CTGTCCCAGA AAAGCGGCCC 3900 TGCAAGTTTG AGGACCGCTT ATTCCACTTT AAGGACAGCC TTCAGGCCCC CTGAGCGTGG 3960 GTGTGATTGC AGGGCCTCTG CAGCTCTGCT GAGAGCATGA GTCCTTCAAG GAAGACAGAG 4020 TGAGCCAATG CTCACCAGCC CCAGAGTCAG AGCTGGCCAC AGGCTGGCAG CCTCCAGGGG 4080 CTTAAAAAAA AAGGCAAAGA ACACAGAAAG AGGAGGAGCA AGTGGGATGT TTATGTCCCC 4140 CCTTCTCTTC CTGAGTGATT CTCAGCCAAG TCCAGACAGT GCTCGGCGGG TGAGGAAGGG 4200 TCTGCCCCGA GCTTTCTGGT TGGCAGGTGG CAGCAGGATG GTGGGTGTTC AGCCTGAATG 4260 CCCAGGAGCA TTTCTGGGGG GCAGCTAAGA CTGGCAGCTG GGTTGGTGTG TTAGCGGGCA 4320 GGGGAGCCAT TGTGGGGTCC CCAGGAAAGG GCAAGGGCTC AGCCACATCT TGGGGTCTGG 4380 GAGGCCCAGG CTAAGCCATG TGGCAGGGAC CGTCTTGCCC TGCTGGCCAC ACTCTGGAGA 4440 AGCACTTCTC AGCCAAGGCA CCCCTGCCCT GGGACTGGCA GGGCAGGGGC AGGGGCAGGG 4500 ACAGTGGCCA GGCGGCCCGA GGACTTACGG TCGGCACTTC TCTGTTCTCC CGTGTCAGCG 4560 TGTGGTGTCG CCTGCATGGG TCGTACCTGG ATGGTGTGTC CACCATCGAC ACGGAGGGGC 4620 TGGATTTGTT TCTCAGGCAA TCCTGTATTT TAATTTTAGA TGTATTTCCT GAAGCATATT 4680 TTTCATAGAA TGTAGCGTGT AAATAGCTTT TTAAATAACT TCTTTTTTAT AAGAGTAAAA 4740 GTATCTTTAG GAATTTCTTT CTATAGAGTT CTTCATTAAC ATTTATACGA GTTTTTTGCT 4800 GAGTCAGATG GACAGTTGGG TTCTGATGCT TTTTCCTTCT CCTTTCCTTT TATTATTATT 4860 ATTTTTTTCT TTTAAGAACT AAGGTATTGC CTGAAAAACA AGTGATGTCT GTGCAGCCTT 4920 ACACTCTGTC TTTACAGAAG CAAATAGTAC ACAAAAGATC TATTTCAGAC ACATTTTGAA 4980 GATGAATCTT CAACTTTAAT ACCAGCTCTT TGTTTTCCTT GTATGATGAG GGGATTGGGG 5040 GATACAGTTA TTTTACTAGC ACCTTGTGAA GTGTTTCCGT GTTTTGTGAT GCTGTAATTT 5100 ATTAATGTTT GTAGCTTTTT ATATTTGTAC ATTTCTTATG AGCTTTGTTT ATATACCCAT 5160 TACCTGGATG TTTTTGTCCA CTGGGAGAGG CAGCTTGGTG GAGGCCTTAT CCACTCCCAC 5220 TTGTCCTGTT TGGAGGGACG CAGTCCCTAG GGCCCGAGAC TGGGTGGGAG AGGGGGAGTC 5280 TCACGGGGCC CCAGGCTTAT TCAGAACTGG TGTTTTTAAA GTTTCCTTTA CCCTGCCCTT 5340 GTTGAACATT TATATAATCT AACCTGGACA TCAAGCTGTT CTCTCTCTCT CTTTTTTTTA 5400 ATTTTATTAT TATTATTTTG GCAACATGTA CATTTCTAAC AAAGTTTATC GTGGCTATTA 5460 AAGTGTTTTA TTTCCCAATT CATATTACTC TTGTATCGAG TCCATGAGGT CTAAGGCAAC 5520 TTAGATCAAA GTTTTAAAAA AGTAAAAATA TTTCAGGTTT TGTACAGAA
Nucleotide Fasta Sequence
>ENSP00000352185.4|PHD|Homo sapiens GGCCGCTCGGCGGCCGGGGGTCCCTTCGGTGGGGCCGCGGCTCCCCGCCCGCCGCCCCCGCGCGTCCATTCCCTTTTGTGTCCCGCGCGCGGCCCGTCCCCCGCGCACACTAGCGCCCTGAGCCCCGCGGGCCGGCGGGCGGCTCCCGGCGCGGCCCCTCCAGCCAGCGCGCCCGGCATTGTGTGGACGCGCCTGGCCGGGAGCGCGCGCGGGGGCTGTCGTGCGCCCCCGTCCCCGTCCCCTCCCGGCCGCGGCGCCGCCTGCGCCCCGCCGCCCCCGCCGCCCCCGCGCGGCCCGGCCCCCGGCCCGGCCCGGACCGACCCGGGCAGCGCAGCGGCGGGGCCGAGCGGCGGCGCGGCGCGGCAACATGGCGACGGTGCCCGTGTACTGCGTCTGCCGGCTCCCCTACGACGTTACCCGCTTCATGATCGAGTGCGACGCCTGCAAGGACTGGTTCCACGGCAGCTGTGTTGGGGTGGAAGAGGAGGAGGCGCCCGACATCGACATATACCACTGCCCAAACTGTGAGAAAACCCATGGGAAGTCCACCTTAAAGAAGAAGCGGACCTGGCACAAACACGGCCCGGGGCAAGCGCCTGACGTCAAGCCCGTGCAGAATGGCAGCCAGCTCTTCATCAAGGAGCTGCGGAGCCGGACCTTTCCCAGTGCTGAAGACGTGGTGGCCCGTGTGCCAGGAAGTCAGCTCACGCTGGGCTACATGGAGGAGCACGGCTTCACCGAGCCCATCCTCGTCCCTAAGAAAGACGGGCTGGGTCTGGCTGTCCCGGCCCCCACGTTCTATGTCAGTGACGTCGAGAACTACGTGGGGCCGGAACGGAGTGTGGATGTGACAGATGTCACCAAGCAGAAGGACTGCAAGATGAAGCTGAAGGAGTTTGTGGACTATTACTACAGCACCAACCGCAAGCGGGTCCTCAACGTCACCAACCTCGAGTTCTCTGACACCCGAATGTCCAGCTTCGTGGAGCCACCTGACATTGTAAAGAAACTGTCATGGGTAGAAAACTACTGGCCAGATGATGCATTGCTGGCCAAGCCCAAAGTGACCAAGTACTGCCTAATCTGCGTGAAGGACAGTTACACCGACTTCCACATCGACTCTGGGGGCGCCTCTGCCTGGTACCACGTGCTCAAGGGGGAGAAGACCTTCTATCTCATCAGGCCGGCCTCGGCCAACATCTCCCTGTATGAGCGCTGGCGGTCTGCCTCTAACCACAGCGAGATGTTCTTTGCTGACCAGGTCGACAAATGCTACAAGTGCATCGTCAAGCAGGGCCAGACCCTCTTCATCCCCTCAGGCTGGATCTACGCCACACTCACCCCTGTGGACTGCCTGGCCTTCGCGGGACATTTCCTCCACAGCCTGAGTGTGGAGATGCAGATGAGAGCATATGAAGTGGAAAGGAGGTTGAAACTGGGCAGCCTGACTCAGTTTCCCAACTTTGAAACTGCGTGCTGGTACATGGGGAAGCACCTGCTGGAGGCATTCAAAGGCTCTCACAAATCTGGGAAGCAGCTGCCCCCTCATCTAGTCCAAGGAGCTAAAATTCTCAATGGTGCTTTCCGATCGTGGACGAAGAAGCAGGCTTTGGCAGAGCATGAGGACGAGCTCCCGGAGCACTTCAAACCTTCACAGCTAATCAAAGACCTGGCCAAAGAGATCCGGCTCAGTGAGAATGCCTCCAAAGCCGTCCGACCGGAAGTGAATACTGTCGCCTCGTCAGATGAGGTGTGTGACGGGGACCGGGAGAAGGAGGAGCCCCCGTCTCCCATTGAGGCCACCCCGCCTCAATCCCTCCTGGAGAAAGTGTCCAAAAAAAAGACTCCCAAAACTGTGAAGATGCCCAAGCCATCCAAAATCCCCAAGCCCCCGAAGCCCCCTAAGCCCCCAAGGCCCCCCAAAACGCTGAAGCTCAAAGATGGAGGCAAGAAGAAAGGGAAGAAGTCCCGGGAGTCAGCCTCACCCACCATCCCCAACCTGGACCTGCTCGAAGCCCACACCAAGGAGGCACTGACCAAGATGGAGCCGCCCAAGAAGGGCAAGGCCACAAAGAGTGTCCTGAGTGTGCCCAACAAAGATGTGGTTCACATGCAGAATGATGTGGAGAGGCTGGAAATTCGAGAGCAAACCAAGAGCAAGTCAGAGGCCAAGTGGAAGTACAAGAACAGCAAACCTGACTCCTTACTGAAGATGGAAGAGGAGCAGAAGCTAGAGAAGTCGCCTCTAGCTGGAAACAAAGACAATAAGTTCTCTTTTTCTTTCTCCAACAAGAAACTCCTCGGCTCCAAGGCTCTCAGGCCCCCGACGAGCCCTGGTGTGTTCGGGGCCTTGCAGAACTTCAAGGAGGACAAGCCCAAGCCCGTGCGGGATGAGTATGAGTACGTGTCGGATGACGGTGAGCTCAAGATCGACGAGTTTCCCATCAGGAGGAAGAAAAACGCCCCGAAAAGGGACTTGTCCTTCTTGTTGGATAAGAAGGCTGTGCTGCCCACGCCTGTCACGAAGCCAAAGCTGGACTCGGCAGCGTACAAGAGTGATGACTCCTCGGACGAGGGTTCGCTGCACATCGACACAGACACCAAGCCCGGCCGCAATGCCAGAGTCAAGAAGGAGAGTGGGAGCTCGGCAGCTGGCATCTTGGACCTGCTGCAGGCCAGTGAGGAGGTTGGCGCGCTGGAGTACAACCCCAGCAGCCAGCCCCCGGCCTCCCCCAGCACACAGGAAGCCATTCAGGGAATGCTGTCCATGGCCAACCTGCAGGCCTCCGACTCCTGCCTGCAGACCACGTGGGGAGCTGGCCAGGCCAAGGGGAGCTCGCTGGCTGCCCATGGTGCCCGGAAGAATGGGGGTGGCAGTGGCAAGAGTGCAGGCAAACGACTGCTGAAGAGGGCTGCCAAGAACAGTGTCGACCTGGACGACTACGAGGAAGAGCAGGACCACCTGGATGCCTGCTTCAAGGACTCAGACTACGTTTACCCCTCACTGGAGTCAGATGAAGACAACCCCATCTTTAAGTCCCGGTCGAAGAAAAGGAAAGGCTCAGACGACGCTCCCTACAGCCCAACAGCAAGGGTCGGCCCATCGGTGCCAAGACAGGACAGGCCTGTGCGTGAGGGTACACGGGTGGCTTCCATCGAGACCGGGCTGGCGGCTGCTGCAGCTAAGTTGTCCCAGCAGGAGGAGCAGAAAAGCAAGAAAAAAAAGAGTGCCAAGAGGAAGCTGACTCCTAACACCACCTCCCCTTCCACCTCCACCTCCATCTCTGCCGGCACCACCTCCACCTCCACCACGCCAGCCTCTACCACCCCGGCCTCCACCACCCCGGCCTCCACCAGCACGGCCAGCAGCCAGGCCTCGCAGGAGGGCAGCTCGCCAGAGCCCCCGCCTGAGTCGCATAGCAGCAGCCTGGCGGACCATGAGTACACAGCCGCTGGCACCTTCACCGGGGCCCAGGCTGGCCGCACCTCCCAGCCCATGGCCCCTGGGGTCTTTCTCACACAGAGGCGGCCCTCCGCATCGTCTCCAAACAACAACACCGCTGCCAAAGGAAAACGTACGAAAAAGGGCATGGCGACCGCCAAGCAGAGGCTTGGGAAAATTTTGAAAATTCATCGGAACGGGAAACTACTCCTTTAAGATTTGGAAAGCCAGGATCCTTCTGCTCCGCTCAGGACCCCCGGAGCCCCGCGAAAACATCTGCCTCCCAGGAGGGTGCCGAGCTGCCTCACCAGGGAGGGCCTTGCCTCTTCCCGGCTGCCATCTCCCCAACAAGCGTCTGTCCCTTCAGCCGGCAGAGCGAGCCCAGCGTGGCCCCTCAATTTGAAAATGGACGTCTTTTCTCAAGTTGCTAAGAGTGATCTGTCCCAGAAAAGCGGCCCTGCAAGTTTGAGGACCGCTTATTCCACTTTAAGGACAGCCTTCAGGCCCCCTGAGCGTGGGTGTGATTGCAGGGCCTCTGCAGCTCTGCTGAGAGCATGAGTCCTTCAAGGAAGACAGAGTGAGCCAATGCTCACCAGCCCCAGAGTCAGAGCTGGCCACAGGCTGGCAGCCTCCAGGGGCTTAAAAAAAAAGGCAAAGAACACAGAAAGAGGAGGAGCAAGTGGGATGTTTATGTCCCCCCTTCTCTTCCTGAGTGATTCTCAGCCAAGTCCAGACAGTGCTCGGCGGGTGAGGAAGGGTCTGCCCCGAGCTTTCTGGTTGGCAGGTGGCAGCAGGATGGTGGGTGTTCAGCCTGAATGCCCAGGAGCATTTCTGGGGGGCAGCTAAGACTGGCAGCTGGGTTGGTGTGTTAGCGGGCAGGGGAGCCATTGTGGGGTCCCCAGGAAAGGGCAAGGGCTCAGCCACATCTTGGGGTCTGGGAGGCCCAGGCTAAGCCATGTGGCAGGGACCGTCTTGCCCTGCTGGCCACACTCTGGAGAAGCACTTCTCAGCCAAGGCACCCCTGCCCTGGGACTGGCAGGGCAGGGGCAGGGGCAGGGACAGTGGCCAGGCGGCCCGAGGACTTACGGTCGGCACTTCTCTGTTCTCCCGTGTCAGCGTGTGGTGTCGCCTGCATGGGTCGTACCTGGATGGTGTGTCCACCATCGACACGGAGGGGCTGGATTTGTTTCTCAGGCAATCCTGTATTTTAATTTTAGATGTATTTCCTGAAGCATATTTTTCATAGAATGTAGCGTGTAAATAGCTTTTTAAATAACTTCTTTTTTATAAGAGTAAAAGTATCTTTAGGAATTTCTTTCTATAGAGTTCTTCATTAACATTTATACGAGTTTTTTGCTGAGTCAGATGGACAGTTGGGTTCTGATGCTTTTTCCTTCTCCTTTCCTTTTATTATTATTATTTTTTTCTTTTAAGAACTAAGGTATTGCCTGAAAAACAAGTGATGTCTGTGCAGCCTTACACTCTGTCTTTACAGAAGCAAATAGTACACAAAAGATCTATTTCAGACACATTTTGAAGATGAATCTTCAACTTTAATACCAGCTCTTTGTTTTCCTTGTATGATGAGGGGATTGGGGGATACAGTTATTTTACTAGCACCTTGTGAAGTGTTTCCGTGTTTTGTGATGCTGTAATTTATTAATGTTTGTAGCTTTTTATATTTGTACATTTCTTATGAGCTTTGTTTATATACCCATTACCTGGATGTTTTTGTCCACTGGGAGAGGCAGCTTGGTGGAGGCCTTATCCACTCCCACTTGTCCTGTTTGGAGGGACGCAGTCCCTAGGGCCCGAGACTGGGTGGGAGAGGGGGAGTCTCACGGGGCCCCAGGCTTATTCAGAACTGGTGTTTTTAAAGTTTCCTTTACCCTGCCCTTGTTGAACATTTATATAATCTAACCTGGACATCAAGCTGTTCTCTCTCTCTCTTTTTTTTAATTTTATTATTATTATTTTGGCAACATGTACATTTCTAACAAAGTTTATCGTGGCTATTAAAGTGTTTTATTTCCCAATTCATATTACTCTTGTATCGAGTCCATGAGGTCTAAGGCAACTTAGATCAAAGTTTTAAAAAAGTAAAAATATTTCAGGTTTTGTACAGAA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0010--Activator KW-0137--Centromere KW-0156--Chromatin regulator KW-0158--Chromosome KW-0181--Complete proteome KW-0223--Dioxygenase KW-0408--Iron KW-0995--Kinetochore KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR003347--JmjC_dom IPR019786--Zinc_finger_PHD-type_CS IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR019787--Znf_PHD-finger IPR013083--Znf_RING/FYVE/PHD
|
PROSITE |
PS51184--JMJC PS01359--ZF_PHD_1 PS50016--ZF_PHD_2
|
Pfam |
PF02373--JmjC PF00628--PHD
|
Gene Ontology |
GO:0000777--C:condensed chromosome kinetochore GO:0005737--C:cytoplasm GO:0005730--C:nucleolus GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0051213--F:dioxygenase activity GO:0032452--F:histone demethylase activity GO:0032454--F:histone demethylase activity (H3-K9 specific) GO:0005506--F:iron ion binding GO:0035064--F:methylated histone binding GO:0008270--F:zinc ion binding GO:0001889--P:liver development GO:0061188--P:negative regulation of chromatin silencing at rDNA GO:0006482--P:protein demethylation GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |