WERAM Information

Tag Content
WERAM ID WERAM-Hos-0128
Ensembl Protein ID ENSP00000351488.4
Uniprot Accession Q9HB58; SP110_HUMAN; B4DVI4; F5H1M1; Q14976; Q14977; Q53TG2; Q8WUZ6; Q9HCT8
Genbank Protein ID NP_001171944.1; NP_004500.3; NP_536349.2
Protein Name Sp110 nuclear body protein
Genbank Nucleotide ID NM_001185015.1; NM_004509.3; NM_080424.2
Gene Name SP110;IPR1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135899.16 ENST00000358662.8 ENSP00000351488.4
ENSG00000135899.16 ENST00000258381.10 ENSP00000258381.6
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 2.20e-24 87.6 587 658
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt   1 kehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 
                        ++h+vs++++++++pq ++i+dY ++++e+m+L+++kerl +++Y+ +++fv+D+rl+f+N+k+++++++++q
  ENSP00000351488.4 587 QCHHVSKTLERQMQPQdQLIRDYGEPFQEAMWLDLVKERLITEMYT-VAWFVRDMRLMFRNHKTFYKASDFGQ 658
                        7*********************************************.*********************99976 PP
Protein Sequence
(Fasta)		MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME SLEACRNLIP 60
VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY RSFKRVGASY EWQSRDTPIL 120
LEAPTGLAEG SSLHTPLALP PPQPPQPSCS PCAPRVSEPG TSSQQSDEIL SESPSPSDPV 180
LPLPALIQEG RSTSVTNDKL TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE 240
MPHSPLGSMP EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG 300
TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE IIDGTSEMNE 360
GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD DSTWNSEVMM RVQKARTKCA 420
RKSRLKEKKK EKDICSSSKR RFQKNIHRRG KPKSDTVDFH CSKLPVTCGE AKGILYKKKM 480
KHGSSVKCIR NEDGTWLTPN EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC 540
CQGGQLLCCG TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ 600
PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF YKASDFGQVG 660
LDLEAEFEKD LKDVLGFHEA NDGGFWTLP 689
Nucleotide Sequence
(Fasta)		TGTAACTCTC CCAATCTTGA GGAGTGATCC CTGTCCCAGC CCCTGGAAAG GGGCAGGAAC 60
GACAAACTCA AAGTCCAGGA TGTTCACCAT GACAAGAGCC ATGGAAGAGG CTCTTTTTCA 120
GCACTTCATG CACCAGAAGC TGGGGATCGC CTATGCCATA CACAAGCCAT TTCCCTTCTT 180
TGAAGGCCTC CTAGACAACT CCATCATCAC TAAGAGAATG TACATGGAAT CTCTGGAAGC 240
CTGTAGAAAT TTGATCCCTG TATCCAGAGT GGTGCACAAC ATTCTCACCC AACTGGAGAG 300
GACTTTTAAC CTGTCTCTTC TGGTGACATT GTTCAGTCAA ATTAACCTGC GTGAATATCC 360
CAATCTGGTG ACGATTTACA GAAGCTTCAA ACGTGTTGGT GCTTCCTATG AATGGCAGAG 420
CAGAGACACA CCAATCCTAC TTGAAGCCCC AACTGGCCTA GCAGAAGGAA GCTCCCTCCA 480
TACCCCACTG GCGCTGCCCC CACCACAACC CCCTCAACCA AGCTGTTCAC CCTGTGCGCC 540
AAGAGTCAGT GAGCCTGGAA CATCCTCCCA GCAAAGCGAT GAGATCCTGA GTGAGTCGCC 600
CAGCCCATCT GACCCTGTCC TGCCTCTCCC TGCACTCATC CAGGAAGGAA GAAGCACTTC 660
AGTGACCAAT GACAAGTTAA CATCCAAAAT GAATGCGGAA GAAGACTCAG AAGAGATGCC 720
CAGCCTCCTC ACTAGCACTG TGCAAGTGGC CAGTGACAAC CTGATCCCCC AAATAAGAGA 780
TAAAGAAGAC CCTCAAGAGA TGCCCCACTC TCCCTTGGGC TCTATGCCAG AGATAAGAGA 840
TAATTCTCCA GAACCAAATG ACCCAGAAGA GCCCCAGGAG GTGTCCAGCA CACCTTCAGA 900
CAAGAAAGGA AAGAAAAGAA AAAGATGTAT CTGGTCAACT CCAAAAAGGA GACATAAGAA 960
AAAAAGCCTC CCAGGAGGGA CAGCCTCATC TAGACACGGA ATCCAAAAGA AGCTCAAAAG 1020
GGTGGATCAG GTTCCTCAAA AGAAAGATGA CTCAACTTGT AACTCCACGG TAGAGACAAG 1080
GGCCCAAAAG GCGAGAACTG AATGTGCCCG AAAGTCGAGA TCAGAGGAGA TCATTGATGG 1140
CACTTCAGAA ATGAATGAAG GAAAGAGGTC CCAGAAGACG CCTAGTACAC CACGAAGGGT 1200
CACACAAGGG GCAGCCTCAC CTGGGCATGG CATCCAAGAG AAGCTCCAAG TGGTGGATAA 1260
GGTGACTCAA AGGAAAGACG ACTCAACCTG GAACTCAGAG GTCATGATGA GGGTCCAAAA 1320
GGCAAGAACT AAATGTGCCC GAAAGTCCAG ATTGAAAGAA AAGAAAAAGG AGAAAGATAT 1380
CTGTTCAAGC TCAAAAAGGA GATTTCAGAA AAATATTCAC CGAAGAGGAA AACCCAAAAG 1440
TGACACTGTG GATTTTCACT GTTCTAAGCT CCCCGTGACC TGTGGTGAGG CGAAAGGGAT 1500
TTTATATAAG AAGAAAATGA AACACGGATC CTCAGTGAAG TGCATTCGGA ATGAGGATGG 1560
AACTTGGTTA ACACCAAATG AATTTGAAGT CGAAGGAAAA GGAAGGAACG CAAAGAACTG 1620
GAAACGGAAT ATACGTTGTG AAGGAATGAC CCTAGGAGAG CTGCTGAAGC GGAAAAACTC 1680
GGATGAATGC GAGGTGTGCT GTCAAGGGGG ACAACTTCTC TGCTGCGGTA CTTGTCCACG 1740
AGTCTTCCAT GAGGACTGTC ACATCCCCCC TGTGGAAGCC AAGAGGATGC TGTGGAGTTG 1800
CACCTTCTGC AGGATGAAGA GGTCTTCAGG AAGCCAACAG TGCCATCATG TATCTAAGAC 1860
CCTGGAGAGG CAGATGCAGC CTCAGGACCA GCTGATTCGA GATTACGGTG AGCCCTTTCA 1920
GGAAGCAATG TGGTTGGACC TGGTTAAGGA AAGGCTGATT ACGGAAATGT ACACGGTGGC 1980
ATGGTTTGTG CGAGACATGC GCCTGATGTT TCGCAACCAT AAAACATTTT ACAAGGCTTC 2040
TGACTTTGGC CAGGTAGGAC TTGACTTAGA GGCAGAATTT GAAAAAGATC TCAAAGACGT 2100
GCTCGGTTTT CATGAAGCCA ATGACGGCGG TTTCTGGACT CTTCCTTGAC CCTGTTCTGT 2160
AAAGACTGAA GCATCCCCAC CTCAGGATTC AGCTGATGGG ACCCTGGCTT GGACTGTTGA 2220
TTGCCAGTGA GTCTGGGATG TAATTGGCTG CCCTCAGGAC CCAAACCCAG ACACTTCATA 2280
GGATTATCAC ACCCTCCATC TTTATTCTTT CTTTTTACCT TTAAAAGTCT ATATCTA 2338
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001487--Bromodomain
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01342--SAND
PF03172--Sp100
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004871--F:signal transducer activity
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0081 ENSGGOP00000006778.2 Gorilla gorilla 95 0.0 1204
WERAM-Poa-0113 ENSPPYP00000014814.2 Pongo abelii 92 0.0 1159
WERAM-Caj-0131 ENSCJAP00000024360.2 Callithrix jacchus 80 0.0 958
WERAM-Caf-0117 ENSCAFP00000015724.3 Canis familiaris 61 0.0 708
WERAM-Mim-0140 ENSMICP00000014302.1 Microcebus murinus 57 0.0 704
WERAM-Myl-0019 ENSMLUP00000001732.2 Myotis lucifugus 59 0.0 687
WERAM-Nol-0154 ENSNLEP00000016657.2 Nomascus leucogenys 80 0.0 657
WERAM-Tut-0105 ENSTTRP00000008804.1 Tursiops truncatus 54 2e-177 620
WERAM-Aim-0190 ENSAMEP00000017460.1 Ailuropoda melanoleuca 57 2e-177 619
WERAM-Sus-0119 ENSSSCP00000017225.2 Sus scrofa 57 2e-177 619
WERAM-Ova-0215 ENSOARP00000022170.1 Ovis aries 49 9e-173 604
WERAM-Fec-0028 ENSFCAP00000002318.3 Felis catus 56 5e-165 578
WERAM-Ptv-0069 ENSPVAP00000006624.1 Pteropus vampyrus 52 1e-128 457
WERAM-Chs-0080 ENSCSAP00000003145.1 Chlorocebus sabaeus 47 2e-63 241
WERAM-Pat-0101 ENSPTRP00000022247.5 Pan troglodytes 45 2e-61 234
WERAM-Mam-0102 ENSMMUP00000015993.2 Macaca mulatta 47 6e-60 229
WERAM-Eqc-0184 ENSECAP00000019711.1 Equus caballus 45 5e-59 226
WERAM-Mup-0048 ENSMPUP00000004304.1 Mustela putorius furo 52 9e-59 226
WERAM-Loa-0030 ENSLAFP00000001920.4 Loxodonta africana 45 1e-58 225
WERAM-Tas-0089 ENSTSYP00000009104.1 Tarsius syrichta 40 8e-51 199
WERAM-Cap-0119 ENSCPOP00000009466.2 Cavia porcellus 42 5e-50 196
WERAM-Bot-0209 ENSBTAP00000012736.5 Bos taurus 42 8e-50 196
WERAM-Prc-0057 ENSPCAP00000005387.1 Procavia capensis 40 6e-49 193
WERAM-Mum-0221 ENSMUSP00000079095.4 Mus musculus 40 6e-48 189
WERAM-Paa-0007 ENSPANP00000010902.1 Papio anubis 40 9e-48 189
WERAM-Ict-0054 ENSSTOP00000004707.2 Ictidomys tridecemlineatus 40 9e-48 189
WERAM-Ran-0148 ENSRNOP00000031057.6 Rattus norvegicus 41 2e-47 188
WERAM-Dan-0044 ENSDNOP00000004457.3 Dasypus novemcinctus 38 2e-43 174
WERAM-Tub-0081 ENSTBEP00000009522.1 Tupaia belangeri 45 2e-42 171
WERAM-Otg-0069 ENSOGAP00000004949.2 Otolemur garnettii 43 9e-41 166
WERAM-Vip-0071 ENSVPAP00000006559.1 Vicugna pacos 37 3e-38 157
WERAM-Sah-0029 ENSSHAP00000003206.1 Sarcophilus harrisii 41 3e-35 147
WERAM-Ere-0052 ENSEEUP00000004410.1 Erinaceus europaeus 36 3e-35 147
WERAM-Lac-0066 ENSLACP00000008975.1 Latimeria chalumnae 36 8e-32 136
WERAM-Ocp-0089 ENSOPRP00000007990.1 Ochotona princeps 35 8e-31 132
WERAM-Dar-0111 ENSDARP00000072168.5 Danio rerio 33 5e-27 120
WERAM-Ect-0021 ENSETEP00000001537.1 Echinops telfairi 52 3e-26 117
WERAM-Mod-0208 ENSMODP00000038934.1 Monodelphis domestica 32 1e-25 115
WERAM-Ora-0139 ENSOANP00000030270.1 Ornithorhynchus anatinus 36 3e-21 101
WERAM-Gaa-0083 ENSGACP00000011071.1 Gasterosteus aculeatus 29 2e-18 92.4
WERAM-Leo-0114 ENSLOCP00000014415.1 Lepisosteus oculatus 29 1e-17 89.0
WERAM-Pof-0069 ENSPFOP00000006195.2 Poecilia formosa 26 1e-16 86.3
WERAM-Orn-0097 ENSONIP00000010786.1 Oreochromis niloticus 30 6e-15 80.1
WERAM-Soa-0030 ENSSARP00000003044.1 Sorex araneus 33 3e-13 74.7
WERAM-Xim-0010 ENSXMAP00000001247.1 Xiphophorus maculatus 25 1e-10 66.2
WERAM-Orla-0067 ENSORLP00000008644.1 Oryzias latipes 28 8e-09 60.1
WERAM-Ten-0003 ENSTNIP00000003156.1 Tetraodon nigroviridis 30 5e-08 57.4
WERAM-Pes-0100 ENSPSIP00000012511.1 Pelodiscus sinensis 31 6e-08 57.0
WERAM-Drm-0020 FBpp0083320 Drosophila melanogaster 29 2e-07 55.1
WERAM-Gam-0014 ENSGMOP00000001531.1 Gadus morhua 31 6e-07 53.5
WERAM-Xet-0078 ENSXETP00000025313.3 Xenopus tropicalis 31 1e-06 52.8
WERAM-Tar-0093 ENSTRUP00000018722.1 Takifugu rubripes 31 8e-06 50.1
Created Date 25-Jun-2016