| Tag |
Content |
| WERAM ID |
WERAM-Hos-0227 |
| Ensembl Protein ID |
ENSP00000351446.3 |
| Uniprot Accession |
P61964; WDR5_HUMAN; Q91VA5; Q9NWX7; Q9UGP9
|
| Genbank Protein ID |
NP_060058.1; NP_438172.1; XP_005272220.1
|
| Protein Name |
WD repeat-containing protein 5 |
| Genbank Nucleotide ID |
NM_017588.2; NM_052821.3; XM_005272163.1
|
| Gene Name |
WDR5;BIG3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
WD40 |
WD1-7 |
H3K4me2/3; H3R2 |
K,R |
15960974
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
WD40 |
6.30e-113 |
379.7 |
44 |
332 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. |
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
|
| Domain Profile |
Me_Reader WD40
WD40.txt 2 hekelsavkfepaseegaslvaatvgseavtvydcqtqgeikllqkykghdeefysvawtadsnkrhslLasAgdrglirlldveagqcikv 93
h+k++s+vkf s++g+ ++a++++++ +++++++++ k++++++gh+ ++++vaw++dsn lL+sA+d+++++++dv++g+c+k+
ENSP00000351446.3 44 HTKAVSSVKF---SPNGE-WLASSSADKLIKIWGAYDG---KFEKTISGHKLGISDVAWSSDSN----LLVSASDDKTLKIWDVSSGKCLKT 124
99********...*****.*******************...***********************....9*********************** PP
WD40.txt 94 lvgHknaiaelkFsPkdenlllsaSfdkrvrlWdiktdklkkifeahsdevldvdydlrgslivScgmdgslkiWdvrskrrvcevklvdde 185
l+gH+n++++++F+P+ +nl++s+Sfd++vr+Wd+kt+k++k+++ahsd+v++v+++++gslivS+++dg+++iWd +++++c ++l+dd+
ENSP00000351446.3 125 LKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDD 213
****************.***********************************************************..99************ PP
WD40.txt 186 npeksnrrVdcvrfs.ngdlilsgsldntivlWdirkikqsevavvvLkrfeyskteiyyislsfsvdnkkilvsgdedgkvyvwdlsveaa 276
np+ V++v+fs ng++il+++ldnt++lWd++k+k +Lk+++++k+e+y+i+++fsv+++k++vsg+ed+ vy+w+l+
ENSP00000351446.3 214 NPP-----VSFVKFSpNGKYILAATLDNTLKLWDYSKGK-------CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ---- 289
***.....*******************************.......******************************************.... PP
WD40.txt 277 lkakelllklgkvtakimqtsvspnesiiiltaltddnivkiWdr 321
+ke+++kl+++t+++++t+++p+e+ii+++al++d+++k+W++
ENSP00000351446.3 290 --TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
..*****************************************96 PP
|
Protein Sequence
(Fasta) | MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 60
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 120
CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN 180
RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL 240
WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 300
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC 334Protein Fasta Sequence
>ENSP00000351446.3|WDR5;BIG3|Homo sapiens
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC |
Nucleotide Sequence
(Fasta) | GCCGCCTGGC GCCCGCCCGA GCTGCCGCCT TGTCGAGCTG AGTCCGCGCT CCCGCCCAGG 60
CGGCGGCCGA CGCGACGCCC CGAGCGCCCG GCCCCGCCGC CGCGGCCCGG CAGACTGCCT 120
CTGTCACCGG GTCCCTCCAC CCTTGTCTCC TGTGCGGCCA GCGTCAGAGC CATGGCGACG 180
GAGGAGAAGA AGCCCGAGAC CGAGGCCGCC AGAGCACAGC CAACCCCTTC GTCATCCGCC 240
ACTCAGAGCA AGCCTACACC TGTGAAGCCA AACTATGCTC TAAAGTTCAC CCTTGCTGGC 300
CACACCAAAG CAGTGTCCTC CGTGAAATTC AGCCCGAATG GAGAGTGGCT GGCAAGTTCA 360
TCTGCTGATA AACTTATTAA AATTTGGGGC GCGTATGATG GGAAATTTGA GAAAACCATA 420
TCTGGTCACA AGCTGGGAAT ATCCGATGTA GCCTGGTCGT CAGATTCTAA CCTTCTTGTT 480
TCTGCCTCAG ATGACAAAAC CTTGAAGATA TGGGACGTGA GCTCGGGCAA GTGTCTGAAA 540
ACCCTGAAGG GACACAGTAA TTATGTCTTT TGCTGCAACT TCAATCCCCA GTCCAACCTT 600
ATTGTCTCAG GATCCTTTGA CGAAAGCGTG AGGATATGGG ATGTGAAAAC AGGGAAGTGC 660
CTCAAGACTT TGCCAGCTCA CTCGGATCCA GTCTCGGCCG TTCATTTTAA TCGTGATGGA 720
TCCTTGATAG TTTCAAGTAG CTATGATGGT CTCTGTCGCA TCTGGGACAC CGCCTCAGGC 780
CAGTGCCTGA AGACGCTCAT CGATGACGAC AACCCCCCCG TGTCTTTTGT GAAGTTCTCC 840
CCGAACGGCA AATACATCCT GGCCGCCACG CTGGACAACA CTCTGAAGCT CTGGGACTAC 900
AGCAAGGGGA AGTGCCTGAA GACGTACACT GGCCACAAGA ATGAGAAATA CTGCATATTT 960
GCCAATTTCT CTGTTACTGG TGGGAAGTGG ATTGTGTCTG GCTCAGAGGA TAACCTTGTT 1020
TACATCTGGA ACCTTCAGAC GAAAGAGATT GTACAGAAAC TACAAGGCCA CACAGATGTC 1080
GTGATCTCAA CAGCTTGTCA CCCAACAGAA AACATCATCG CCTCTGCTGC GCTAGAAAAT 1140
GACAAAACAA TTAAACTGTG GAAGAGTGAC TGCTAAGTCC CTTTGCTCCT GCCCGCGAGA 1200
GACTGTCGGG AAGTTGACCC GGATTGGCAA GAAACAGGGT GTCTTGGAGG TGGTCCCCCA 1260
GATCTGCGCC TGGGGGTCAG GACAGGGCCT GATTTGAGCC TCCTCTCTGA AGATGATTTG 1320
GCCGAGCGGA AGGTGTGGAC CACCGGAAAG TTCTTAAAAG TTGCTGGTGA CATTTCTTGC 1380
CAATTCTAAC ACTGTCTAGG GAAGAGTTCC TAGTCTATTG TGTTCAAACA GAGTCAACAA 1440
AAGTTTTTAA TTTTTTATTA CAGAAGGGTG AAGTTCAATT TAACATGCGT TGTGTTTTTT 1500
CAGTAAACGT TCTGTATCTT TTTGATATTC CATGACCCAG TGCACGCTGT GGCCTGTCAC 1560
CGCCACCGTG GCCCCGCCAG CTGGCCTCCC CTTTGGCCCA CGCCGGCCGC CCCCATTCTC 1620
TGCTGCGTAG ATGCCCTGGC CCAGGGCCCT GACTCCTCCA TTCCCGCCAG TAGCTGTTCC 1680
TAGTGTATTT TCGTCTTTCT GGAAAACAGC ATTGAGTGGT TGTTTTCTGT GTAAAGAGCC 1740
GTTTGTGTCT TGGGAGTTTG TGGCCCACAT GCCGATAGCA CGGTCATCGC ACATGACTCT 1800
CCCGTTTGTC TCAGTGTCCC TGCAACAAGC AGCACCGCAG ACTGTAATAA AAGGTGGGGT 1860
TTTGTGAATG GTTGTGGCAA GTGCGTCCTT GTGAAGCTCG TCTCCATGTG GCTTTCTTGG 1920
AGAAAGGCTC CCCTGGGGCA AGAGGGTGGA AGGTTTCTTT GGACAGGAGG TGCTGAGGCT 1980
GGCTGCACCT GCTCTCTGAA GACGCCTTCC TCTCTAGGTT CATTGTTCAG TGTTGCTGGG 2040
GGCGGGGAAC GGGGGTGGGG AGGTTCTTAG TTGCGAAGGA GCCAAGCTCC TGATGGACTT 2100
GCGTTGGGAT GTGGGGGACA CCTGTGGCAT GGTAAGGCTC CCTGAGTCCC TTACTCCAGG 2160
TCAGATGCCA GTGGGACTCA TGCGCCCTAT GAGGGCTGCA GGGCCAGTGC TGCCCCTCGG 2220
ACTCCTCGAG GGGTTGGGTG CTAAGCGCGA GCCTCGCCGT CCCTGCTGGA GCCCTCGCCT 2280
GCCTGCCCCT CTGCCTGTGC TCCTGGCAGT GTGGCTTCCC GGTGCTCACC TGCACAGCAG 2340
TTAACAGCAG AGGCCGAGCG GGAGCCTCTG GGGAGCGAGG CTGAAACCTG AACCTGCCCA 2400
TGGAGACAGT TGTGGTGAGG GTTGCCACAC ACAGTGAGGG CGGAGCAGGG TGGCTGAGGG 2460
CACAGGTGCC TGGGTCTGTC CCACGGGGCA GGGCTTTGGG GCTGTGATGC TCTGGGAAGC 2520
CAGCTTGGGT CCTGGGTCTA CAGAGGGCCC TGGCCCCGGA GCCCAGCCAG CTCTGCCTCT 2580
CTCAGGGCCT GGAGTCCTGG GGGAGCTCAG CCAGCTCTGC CTTTCTCAGG GCCTGGAGTC 2640
CTGGATGAAT CCTGCAGGTT TTTGGTTGCA CCGGCCCAGG GAGGAAGCGG GGGGTTTGTC 2700
AGGTGGGCTC TCCTGGAGGT CCTCGAGTGG CAGGGGTGAG GAGGGGATTA TCTGAGGCAT 2760
CTGGAGATGT ATATCCTGTG GTTTCCCCTG CCCCTCTGTT TCCGATGAGG TGTACGGATG 2820
AGTGACCTGC ACTAAGAAGT GAGTTGCCAC AGTGAAAATG GGTTGGTTTT TGTCTTCGAC 2880
GCTCAGGGTC TGGGCGCCTC GCATTTGCAG TCTGTTGTGA CAGACACGGG GAGCTCCGCG 2940
TGCCAGCCTG TGGCTGCCCT GCTGTGGGGG TCCTGGGGCC GGCGAGGCCC CTTCAGTCTT 3000
GTTCTGGGGG GACGGCCCAC TCCGGGGAGG GGGTGTGCTG TGCTGAGCGC TGTATCCCTG 3060
AATATAGTTT ATTTTTTCTA CATTTGAATT CTGTTGTAGA TTTATGTAAA AATACATTCT 3120
TTTTGAAAAT AAAAATTTTC ATGTCTTCTA A
3152Nucleotide Fasta Sequence
>ENSP00000351446.3|WD40|Homo sapiens
GCCGCCTGGCGCCCGCCCGAGCTGCCGCCTTGTCGAGCTGAGTCCGCGCTCCCGCCCAGGCGGCGGCCGACGCGACGCCCCGAGCGCCCGGCCCCGCCGCCGCGGCCCGGCAGACTGCCTCTGTCACCGGGTCCCTCCACCCTTGTCTCCTGTGCGGCCAGCGTCAGAGCCATGGCGACGGAGGAGAAGAAGCCCGAGACCGAGGCCGCCAGAGCACAGCCAACCCCTTCGTCATCCGCCACTCAGAGCAAGCCTACACCTGTGAAGCCAAACTATGCTCTAAAGTTCACCCTTGCTGGCCACACCAAAGCAGTGTCCTCCGTGAAATTCAGCCCGAATGGAGAGTGGCTGGCAAGTTCATCTGCTGATAAACTTATTAAAATTTGGGGCGCGTATGATGGGAAATTTGAGAAAACCATATCTGGTCACAAGCTGGGAATATCCGATGTAGCCTGGTCGTCAGATTCTAACCTTCTTGTTTCTGCCTCAGATGACAAAACCTTGAAGATATGGGACGTGAGCTCGGGCAAGTGTCTGAAAACCCTGAAGGGACACAGTAATTATGTCTTTTGCTGCAACTTCAATCCCCAGTCCAACCTTATTGTCTCAGGATCCTTTGACGAAAGCGTGAGGATATGGGATGTGAAAACAGGGAAGTGCCTCAAGACTTTGCCAGCTCACTCGGATCCAGTCTCGGCCGTTCATTTTAATCGTGATGGATCCTTGATAGTTTCAAGTAGCTATGATGGTCTCTGTCGCATCTGGGACACCGCCTCAGGCCAGTGCCTGAAGACGCTCATCGATGACGACAACCCCCCCGTGTCTTTTGTGAAGTTCTCCCCGAACGGCAAATACATCCTGGCCGCCACGCTGGACAACACTCTGAAGCTCTGGGACTACAGCAAGGGGAAGTGCCTGAAGACGTACACTGGCCACAAGAATGAGAAATACTGCATATTTGCCAATTTCTCTGTTACTGGTGGGAAGTGGATTGTGTCTGGCTCAGAGGATAACCTTGTTTACATCTGGAACCTTCAGACGAAAGAGATTGTACAGAAACTACAAGGCCACACAGATGTCGTGATCTCAACAGCTTGTCACCCAACAGAAAACATCATCGCCTCTGCTGCGCTAGAAAATGACAAAACAATTAAACTGTGGAAGAGTGACTGCTAAGTCCCTTTGCTCCTGCCCGCGAGAGACTGTCGGGAAGTTGACCCGGATTGGCAAGAAACAGGGTGTCTTGGAGGTGGTCCCCCAGATCTGCGCCTGGGGGTCAGGACAGGGCCTGATTTGAGCCTCCTCTCTGAAGATGATTTGGCCGAGCGGAAGGTGTGGACCACCGGAAAGTTCTTAAAAGTTGCTGGTGACATTTCTTGCCAATTCTAACACTGTCTAGGGAAGAGTTCCTAGTCTATTGTGTTCAAACAGAGTCAACAAAAGTTTTTAATTTTTTATTACAGAAGGGTGAAGTTCAATTTAACATGCGTTGTGTTTTTTCAGTAAACGTTCTGTATCTTTTTGATATTCCATGACCCAGTGCACGCTGTGGCCTGTCACCGCCACCGTGGCCCCGCCAGCTGGCCTCCCCTTTGGCCCACGCCGGCCGCCCCCATTCTCTGCTGCGTAGATGCCCTGGCCCAGGGCCCTGACTCCTCCATTCCCGCCAGTAGCTGTTCCTAGTGTATTTTCGTCTTTCTGGAAAACAGCATTGAGTGGTTGTTTTCTGTGTAAAGAGCCGTTTGTGTCTTGGGAGTTTGTGGCCCACATGCCGATAGCACGGTCATCGCACATGACTCTCCCGTTTGTCTCAGTGTCCCTGCAACAAGCAGCACCGCAGACTGTAATAAAAGGTGGGGTTTTGTGAATGGTTGTGGCAAGTGCGTCCTTGTGAAGCTCGTCTCCATGTGGCTTTCTTGGAGAAAGGCTCCCCTGGGGCAAGAGGGTGGAAGGTTTCTTTGGACAGGAGGTGCTGAGGCTGGCTGCACCTGCTCTCTGAAGACGCCTTCCTCTCTAGGTTCATTGTTCAGTGTTGCTGGGGGCGGGGAACGGGGGTGGGGAGGTTCTTAGTTGCGAAGGAGCCAAGCTCCTGATGGACTTGCGTTGGGATGTGGGGGACACCTGTGGCATGGTAAGGCTCCCTGAGTCCCTTACTCCAGGTCAGATGCCAGTGGGACTCATGCGCCCTATGAGGGCTGCAGGGCCAGTGCTGCCCCTCGGACTCCTCGAGGGGTTGGGTGCTAAGCGCGAGCCTCGCCGTCCCTGCTGGAGCCCTCGCCTGCCTGCCCCTCTGCCTGTGCTCCTGGCAGTGTGGCTTCCCGGTGCTCACCTGCACAGCAGTTAACAGCAGAGGCCGAGCGGGAGCCTCTGGGGAGCGAGGCTGAAACCTGAACCTGCCCATGGAGACAGTTGTGGTGAGGGTTGCCACACACAGTGAGGGCGGAGCAGGGTGGCTGAGGGCACAGGTGCCTGGGTCTGTCCCACGGGGCAGGGCTTTGGGGCTGTGATGCTCTGGGAAGCCAGCTTGGGTCCTGGGTCTACAGAGGGCCCTGGCCCCGGAGCCCAGCCAGCTCTGCCTCTCTCAGGGCCTGGAGTCCTGGGGGAGCTCAGCCAGCTCTGCCTTTCTCAGGGCCTGGAGTCCTGGATGAATCCTGCAGGTTTTTGGTTGCACCGGCCCAGGGAGGAAGCGGGGGGTTTGTCAGGTGGGCTCTCCTGGAGGTCCTCGAGTGGCAGGGGTGAGGAGGGGATTATCTGAGGCATCTGGAGATGTATATCCTGTGGTTTCCCCTGCCCCTCTGTTTCCGATGAGGTGTACGGATGAGTGACCTGCACTAAGAAGTGAGTTGCCACAGTGAAAATGGGTTGGTTTTTGTCTTCGACGCTCAGGGTCTGGGCGCCTCGCATTTGCAGTCTGTTGTGACAGACACGGGGAGCTCCGCGTGCCAGCCTGTGGCTGCCCTGCTGTGGGGGTCCTGGGGCCGGCGAGGCCCCTTCAGTCTTGTTCTGGGGGGACGGCCCACTCCGGGGAGGGGGTGTGCTGTGCTGAGCGCTGTATCCCTGAATATAGTTTATTTTTTCTACATTTGAATTCTGTTGTAGATTTATGTAAAAATACATTCTTTTTGAAAATAAAAATTTTCATGTCTTCTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
--
|
| Interpro |
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF00400--WD40
|
| Gene Ontology |
GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0000123--C:histone acetyltransferase complex
GO:0035097--C:histone methyltransferase complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0035064--F:methylated histone binding
GO:0043966--P:histone H3 acetylation
GO:0051568--P:histone H3-K4 methylation
GO:0043984--P:histone H4-K16 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0031175--P:neuron projection development
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
