| Tag |
Content |
| WERAM ID |
WERAM-Hos-0159 |
| Ensembl Protein ID |
ENSP00000346997.6 |
| Uniprot Accession |
Q9H5I1; SUV92_HUMAN; D3DRT4; Q5JSS4; Q5JSS5; Q6I9Y3; Q8ND06
|
| Genbank Protein ID |
NP_001180353.1; NP_001180354.1; NP_001180355.1; NP_001180356.1; NP_078946.1; XP_006717566.1; XP_011517964.1
|
| Protein Name |
Histone-lysine N-methyltransferase SUV39H2 |
| Genbank Nucleotide ID |
NM_001193424.1; NM_001193425.1; NM_001193426.1; NM_001193427.1; NM_024670.3; XM_006717503.2; XM_011519662.1
|
| Gene Name |
SUV39h2;KMT1B |
| Ensembl Information |
|
| Details |
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SUV39 |
1.80e-39 |
137.4 |
251 |
373 |
| HMT |
SET1 |
3.90e-28 |
100.2 |
255 |
373 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
|
| Domain Profile |
HMT SUV39
SUV39.txt 2 rLqvfktenk.GwGvrclddiakgsFvciyaGeiltddeaekegl...eegdeyladldske 59
+L +f+t+n GwGv++l +i++ sFv++y+Ge++t++eae++g+ ++g +yl+dld+ +
ENSP00000346997.6 251 SLCIFRTSNGrGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQfydNKGITYLFDLDYES 312
799******99********************************888999999******9865 PP
SUV39.txt 88 eeseyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdYg 150
e++e+++da+++gnv++f+nHsc+pNl v nvf+d+ d+r+pr+a+F++++i+ag+ELt+dY+
ENSP00000346997.6 311 ESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQ 373
6789**********************************************************7 PP
HMT SET1
SET1.txt 5 vakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeigvylfrldedae.vvvdatkkgniarfinhscepNceakvvavd 95
+++s+ +g+g+++ +i+ +v+EYvGevi se+a++r + y++k+i+ ylf ld +++ + vda + gn+++f+nhsc+pN+++ v +d
ENSP00000346997.6 255 FRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGIT-YLFDLDYESDeFTVDAARYGNVSHFVNHSCDPNLQVFNVFID 345
5678889***************************************766.*****988777************************9999888 PP
SET1.txt 96 ge....kkiviyakraIekgeeltydYk 119
+ +i ++++r+I++geelt+dY+
ENSP00000346997.6 346 NLdtrlPRIALFSTRTINAGEELTFDYQ 373
64222369*******************6 PP
|
Protein Sequence
(Fasta) | MAAVGAEARG AWCVPCLVSL DTLQELCRKE KLTCKSIGIT KRNLNNYEVE YLCDYKVVKD 60
MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFSNDKHNY LSQVKKGKAI TPKDNNKTLK 120
PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV DLEGPPSDFY YINEYKPAPG 180
ISLVNEATFG CSCTDCFFQK CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP 240
NRIVQKGTQY SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK 300
GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR 360
TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC GAVTCRGYLN Protein Fasta Sequence
>ENSP00000346997.6|SUV39h2;KMT1B|Homo sapiens
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN |
Nucleotide Sequence
(Fasta) | ATGGCGGCGG TCGGGGCCGA GGCGCGAGGA GCTTGGTGTG TGCCTTGCCT AGTTTCACTT 60
GATACTCTTC AGGAATTATG TAGAAAAGAA AAGCTCACAT GTAAATCGAT TGGAATCACC 120
AAAAGGAATC TAAACAATTA TGAGGTGGAA TACTTGTGTG ACTACAAGGT AGTAAAGGAT 180
ATGGAATATT ATCTTGTAAA ATGGAAAGGA TGGCCAGATT CTACAAATAC TTGGGAACCT 240
TTGCAAAATC TGAAGTGCCC GTTACTGCTT CAGCAATTCT CTAATGACAA GCATAATTAT 300
TTATCTCAGG TAAAGAAAGG CAAAGCAATA ACTCCAAAAG ACAATAACAA AACTTTGAAA 360
CCTGCCATTG CTGAGTACAT TGTGAAGAAG GCTAAACAAA GGATAGCTCT GCAGAGATGG 420
CAAGATGAAC TCAACAGAAG AAAGAATCAT AAAGGAATGA TATTTGTTGA AAATACTGTT 480
GATTTAGAGG GCCCACCTTC AGACTTCTAT TACATTAACG AATACAAACC AGCTCCTGGA 540
ATCAGCTTAG TCAATGAAGC TACCTTTGGT TGTTCATGCA CAGATTGCTT CTTTCAAAAA 600
TGTTGTCCTG CTGAAGCTGG AGTTCTTTTG GCTTATAATA AAAACCAACA AATTAAAATC 660
CCACCTGGTA CTCCCATCTA TGAATGCAAC TCAAGGTGTC AGTGTGGTCC TGATTGTCCC 720
AATAGGATTG TACAAAAAGG CACACAGTAT TCGCTTTGCA TCTTTCGAAC TAGCAATGGA 780
CGTGGCTGGG GTGTAAAGAC CCTTGTGAAG ATTAAAAGAA TGAGTTTTGT CATGGAATAT 840
GTTGGAGAGG TAATCACAAG TGAAGAAGCT GAAAGACGAG GACAGTTCTA TGACAACAAG 900
GGAATCACGT ATCTCTTTGA TCTGGACTAT GAGTCTGATG AATTCACAGT GGATGCGGCT 960
CGATACGGCA ATGTGTCTCA TTTTGTGAAT CACAGCTGTG ACCCAAATCT TCAGGTGTTC 1020
AATGTTTTCA TTGATAACCT CGATACTCGT CTTCCCCGAA TAGCATTGTT TTCCACAAGA 1080
ACCATAAATG CTGGAGAAGA GCTGACTTTT GATTATCAAA TGAAAGGTTC TGGAGATATA 1140
TCTTCAGATT CTATTGACCA CAGCCCAGCC AAAAAGAGGG TCAGAACAGT ATGTAAATGT 1200
GGAGCTGTGA CTTGCAGAGG TTACCTCAAC TGA
1234Nucleotide Fasta Sequence
>ENSP00000346997.6|SET1|Homo sapiens
ATGGCGGCGGTCGGGGCCGAGGCGCGAGGAGCTTGGTGTGTGCCTTGCCTAGTTTCACTTGATACTCTTCAGGAATTATGTAGAAAAGAAAAGCTCACATGTAAATCGATTGGAATCACCAAAAGGAATCTAAACAATTATGAGGTGGAATACTTGTGTGACTACAAGGTAGTAAAGGATATGGAATATTATCTTGTAAAATGGAAAGGATGGCCAGATTCTACAAATACTTGGGAACCTTTGCAAAATCTGAAGTGCCCGTTACTGCTTCAGCAATTCTCTAATGACAAGCATAATTATTTATCTCAGGTAAAGAAAGGCAAAGCAATAACTCCAAAAGACAATAACAAAACTTTGAAACCTGCCATTGCTGAGTACATTGTGAAGAAGGCTAAACAAAGGATAGCTCTGCAGAGATGGCAAGATGAACTCAACAGAAGAAAGAATCATAAAGGAATGATATTTGTTGAAAATACTGTTGATTTAGAGGGCCCACCTTCAGACTTCTATTACATTAACGAATACAAACCAGCTCCTGGAATCAGCTTAGTCAATGAAGCTACCTTTGGTTGTTCATGCACAGATTGCTTCTTTCAAAAATGTTGTCCTGCTGAAGCTGGAGTTCTTTTGGCTTATAATAAAAACCAACAAATTAAAATCCCACCTGGTACTCCCATCTATGAATGCAACTCAAGGTGTCAGTGTGGTCCTGATTGTCCCAATAGGATTGTACAAAAAGGCACACAGTATTCGCTTTGCATCTTTCGAACTAGCAATGGACGTGGCTGGGGTGTAAAGACCCTTGTGAAGATTAAAAGAATGAGTTTTGTCATGGAATATGTTGGAGAGGTAATCACAAGTGAAGAAGCTGAAAGACGAGGACAGTTCTATGACAACAAGGGAATCACGTATCTCTTTGATCTGGACTATGAGTCTGATGAATTCACAGTGGATGCGGCTCGATACGGCAATGTGTCTCATTTTGTGAATCACAGCTGTGACCCAAATCTTCAGGTGTTCAATGTTTTCATTGATAACCTCGATACTCGTCTTCCCCGAATAGCATTGTTTTCCACAAGAACCATAAATGCTGGAGAAGAGCTGACTTTTGATTATCAAATGAAAGGTTCTGGAGATATATCTTCAGATTCTATTGACCACAGCCCAGCCAAAAAGAGGGTCAGAACAGTATGTAAATGTGGAGCTGTGACTTGCAGAGGTTACCTCAACTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR011381--Histone_H3-K9_MeTrfase
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR001214--SET_dom
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
PS50868--POST_SET
PS50867--PRE_SET
PS51579--SAM_MT43_SUVAR39_3
PS50280--SET
|
| Pfam |
PF00385--Chromo
PF05033--Pre-SET
PF00856--SET
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0000775--C:chromosome, centromeric region
GO:0005654--C:nucleoplasm
GO:0046974--F:histone methyltransferase activity (H3-K9 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030154--P:cell differentiation
GO:0071456--P:cellular response to hypoxia
GO:0006333--P:chromatin assembly or disassembly
GO:0006338--P:chromatin remodeling
GO:0036123--P:histone H3-K9 dimethylation
GO:0036124--P:histone H3-K9 trimethylation
GO:0042754--P:negative regulation of circadian rhythm
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
