| Tag |
Content |
| WERAM ID |
WERAM-Hos-0222 |
| Ensembl Protein ID |
ENSP00000331310.5 |
| Uniprot Accession |
Q9UBU8; MO4L1_HUMAN; B4DKN6; B7Z6R1; D3DW88; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5
|
| Genbank Protein ID |
NP_001252532.1; NP_001252533.1; NP_001252534.1; NP_006782.1; NP_996670.1
|
| Protein Name |
Mortality factor 4-like protein 1 |
| Genbank Nucleotide ID |
NM_001265603.1; NM_001265604.1; NM_001265605.1; NM_006791.3; NM_206839.2
|
| Gene Name |
MRG15;MORF4L1MRG15;FWP006;HSPC008;HSPC061;PP368 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
Chromo-Barrel |
Chromo |
H3K36me2 |
K |
17135209
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
Chromo-Barrel |
1.40e-63 |
201.9 |
192 |
284 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
|
| Domain Profile |
Me_Reader Chromo-Barrel
MRG.txt 2 erkitlkipekLkklledDrelikrrkklvkLPakvnivtilesyvkevavelaisikedsrrekksrgarmnkeYirveknvdllkEvvdG 93
+ ++++kipe+Lk++l+dD++li+r+k+l++LPak+n+++ile+y++ +kksrg+++nkeY+ ++Evv+G
ENSP00000331310.5 192 RVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYAN----------------YKKSRGNTDNKEYA--------VNEVVAG 259
689*******************************************9................99************........******* PP
MRG.txt 94 lriyFdvtlddvLLYklErlqydel 118
+++yF+v+l+++LLYk+Er+qy+e+
ENSP00000331310.5 260 IKEYFNVMLGTQLLYKFERPQYAEI 284
***********************98 PP
MRG.txt 223 adkPpeps.rvyGAqHLlRLlvklpellsktslsekslklLlkhlddFlkyLaenhdefFdesdyvnateleyetka 298
ad+P++p+ +vyGA+HLlRL+v+++++l++t+l+eksl+lLl++l+dFlkyLa+n++++F++sdy++a++ ey++ka
ENSP00000331310.5 286 ADHPDAPMsQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPP-EYHRKA 361
89*****99*************************************************************.***997 PP
|
Protein Sequence
(Fasta) | MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN KKSAVRPRRS 60
EKSLKTHEDI VALFPVPEGA PSVHHPLLTS SWDEWVPESR VLKYVDTNLQ KQRELQKANQ 120
EQYAEGKMRG AAPGKKTSGL QQKNVEVKTK KNKQKTPGNG DGGSTSETPQ PPRKKRARVD 180
PTVENEETFM NRVEVKVKIP EELKPWLVDD WDLITRQKQL FYLPAKKNVD SILEDYANYK 240
KSRGNTDNKE YAVNEVVAGI KEYFNVMLGT QLLYKFERPQ YAEILADHPD APMSQVYGAP 300
HLLRLFVRIG AMLAYTPLDE KSLALLLNYL HDFLKYLAKN SATLFSASDY EVAPPEYHRK 360
AV 362Protein Fasta Sequence
>ENSP00000331310.5|MRG15;MORF4L1MRG15;FWP006;HSPC008;HSPC061;PP368|Homo sapiens
MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV |
Nucleotide Sequence
(Fasta) | GCGTGCGCGG CGGGCTGTCG TTGGCTGGAG CAGCGGCTGC GCGGGTCGCG GTGCTGTGAG 60
GTCTGCGGGC GCTGGCAAAT CCGGCCCAGG ATGTAGAGCT GGCAGTGCCT GACGGCGCGT 120
CTGACGCGGA GTTGGGTGGG GTAGAGAGTA GGGGGCGGTA GTCGGGGGTG GTGGGAGAAG 180
GAGGAGGCGG CGAATCACTT ATAAATGGCG CCGAAGCAGG ACCCGAAGCC TAAATTCCAG 240
GAGGGTGAGC GAGTGCTGTG CTTTCATGGG CCTCTTCTTT ATGAAGCAAA GTGTGTAAAG 300
GTTGCCATAA AGGACAAACA AGTGAAATAC TTCATACATT ACAGTGGTTG GAATAAAAAA 360
AGTGCTGTGA GGCCCAGGCG CTCTGAAAAA TCTTTGAAGA CACATGAGGA TATTGTAGCC 420
CTTTTTCCTG TTCCTGAAGG AGCTCCCTCA GTACACCACC CCCTCCTGAC CTCTAGTTGG 480
GATGAATGGG TTCCGGAGAG CAGAGTACTC AAATACGTGG ACACCAATTT GCAGAAACAG 540
CGAGAACTTC AAAAAGCCAA TCAGGAGCAG TATGCAGAGG GGAAGATGAG AGGGGCTGCC 600
CCAGGAAAGA AGACATCTGG TCTGCAACAG AAAAATGTTG AAGTGAAAAC GAAAAAGAAC 660
AAACAGAAAA CACCTGGAAA TGGAGATGGT GGCAGTACCA GTGAGACCCC TCAGCCTCCT 720
CGGAAGAAAA GGGCCCGGGT AGATCCTACT GTTGAAAATG AGGAAACATT CATGAACAGA 780
GTTGAAGTTA AAGTAAAGAT TCCTGAAGAG CTAAAACCGT GGCTTGTTGA TGACTGGGAC 840
TTAATTACCA GGCAAAAACA GCTCTTTTAT CTTCCTGCCA AGAAGAATGT GGATTCCATT 900
CTTGAGGATT ATGCAAATTA CAAGAAATCT CGTGGAAACA CAGATAATAA GGAGTATGCG 960
GTTAATGAAG TTGTGGCAGG GATAAAAGAA TACTTCAACG TAATGTTGGG TACCCAGCTA 1020
CTCTATAAAT TTGAGAGACC ACAGTATGCT GAAATTCTTG CAGATCATCC CGATGCACCC 1080
ATGTCCCAGG TGTATGGAGC GCCACATCTC CTGAGATTAT TTGTACGAAT TGGAGCAATG 1140
TTGGCTTATA CACCTCTGGA TGAGAAGAGC CTTGCTTTAT TACTCAATTA TCTTCACGAT 1200
TTCCTAAAGT ACCTGGCAAA GAATTCTGCA ACTTTGTTCA GTGCCAGCGA TTATGAAGTG 1260
GCTCCTCCTG AGTACCATCG GAAAGCTGTG TGAGAGGCAC TCTCACTCAC TTATGTTTGG 1320
ATCTCCGTAA ACACATTTTT GTTCTTAGTC TATCTCTTGT ACAAACGATG TGCTTTGAAG 1380
ATGTTAGTGT ATAACAATTG ATGTTTGTTT TCTGTTTGAT TTTAAACAGA GAAAAAATAA 1440
AAGGGGGTAA TAGCTCCTTT TTTCTTCTTT CTTTTTTTTT TTCATTTCAA AATTGCTGCC 1500
AGTGTTTTCA ATGATGGACA ACAGAGGGAT ATGCTGTAGA GTGTTTTATT GCCTAGTTGA 1560
CAAAGCTGCT TTTGAATGCT GGTGGTTCTA TTCCTTTGAC ACTACGCACT TTTATAATAC 1620
ATGTTAATGC TATATGACAA AATGCTCTGA TTCCTAGTGC CAAAGGTTCA ATTCAGTGTA 1680
TATAACTGAA CACACTCATC CATTTGTGCT TTTGTTTTTT TTTATGGTGC TTAAAGTAAA 1740
GAGCCCATCC TTTGCAAGTC ATCCATGTTG TTACTTAGGC ATTTTATCTT GGCTCAAATT 1800
GTTGAAGAAT GGTGGCTTGT TTCATGGTTT TTGTATTTGT GTCTAATGCA CGTTTTAACA 1860
TGATAGACGC AATGCATTGT GTAGCTAGTT TTCTGGAAAA GTCAATCTTT TAGGAATTGT 1920
TTTTCAGATC TTCAATAAAT TTTTTCTTTA AATTTCAAAG AACAATGTGC TTGTGTTGAT 1980
GCCTTACAAA AACCATTGTA TATTTGTGTA TTCCTTCTTG TATTTAGACA GTGGTTTTTC 2040
AGGTGCGTGC TTTGTTTTCT GGTATGGCCT TTATGGAATG AGACGCTTTA GCTTTGGTAC 2100
GTAGCGCTAA TCCATAGCAG CTTTGGCAGT TTGCTGTCTT GAGTCTTAGC TAAAAAGTTA 2160
GAAGTTTACA TGACTGTTTT TTTTATTTTC CCTAAATTAT TACTTACTCT GAGCATTAAT 2220
TAAGGGCATT TTCACCTGTG TAAAATTATG GTCAGCTTTT TTCTGTCTAT AATTGTTTAC 2280
TTTTGTGGGT TTACTCTAGA AACATGAGCC AAAAATGTCA ATAGACAACA CAGTATTAAA 2340
ATAACCCAAA AGTTGTAAA
Nucleotide Fasta Sequence
>ENSP00000331310.5|Chromo-Barrel|Homo sapiens
GCGTGCGCGGCGGGCTGTCGTTGGCTGGAGCAGCGGCTGCGCGGGTCGCGGTGCTGTGAGGTCTGCGGGCGCTGGCAAATCCGGCCCAGGATGTAGAGCTGGCAGTGCCTGACGGCGCGTCTGACGCGGAGTTGGGTGGGGTAGAGAGTAGGGGGCGGTAGTCGGGGGTGGTGGGAGAAGGAGGAGGCGGCGAATCACTTATAAATGGCGCCGAAGCAGGACCCGAAGCCTAAATTCCAGGAGGGTGAGCGAGTGCTGTGCTTTCATGGGCCTCTTCTTTATGAAGCAAAGTGTGTAAAGGTTGCCATAAAGGACAAACAAGTGAAATACTTCATACATTACAGTGGTTGGAATAAAAAAAGTGCTGTGAGGCCCAGGCGCTCTGAAAAATCTTTGAAGACACATGAGGATATTGTAGCCCTTTTTCCTGTTCCTGAAGGAGCTCCCTCAGTACACCACCCCCTCCTGACCTCTAGTTGGGATGAATGGGTTCCGGAGAGCAGAGTACTCAAATACGTGGACACCAATTTGCAGAAACAGCGAGAACTTCAAAAAGCCAATCAGGAGCAGTATGCAGAGGGGAAGATGAGAGGGGCTGCCCCAGGAAAGAAGACATCTGGTCTGCAACAGAAAAATGTTGAAGTGAAAACGAAAAAGAACAAACAGAAAACACCTGGAAATGGAGATGGTGGCAGTACCAGTGAGACCCCTCAGCCTCCTCGGAAGAAAAGGGCCCGGGTAGATCCTACTGTTGAAAATGAGGAAACATTCATGAACAGAGTTGAAGTTAAAGTAAAGATTCCTGAAGAGCTAAAACCGTGGCTTGTTGATGACTGGGACTTAATTACCAGGCAAAAACAGCTCTTTTATCTTCCTGCCAAGAAGAATGTGGATTCCATTCTTGAGGATTATGCAAATTACAAGAAATCTCGTGGAAACACAGATAATAAGGAGTATGCGGTTAATGAAGTTGTGGCAGGGATAAAAGAATACTTCAACGTAATGTTGGGTACCCAGCTACTCTATAAATTTGAGAGACCACAGTATGCTGAAATTCTTGCAGATCATCCCGATGCACCCATGTCCCAGGTGTATGGAGCGCCACATCTCCTGAGATTATTTGTACGAATTGGAGCAATGTTGGCTTATACACCTCTGGATGAGAAGAGCCTTGCTTTATTACTCAATTATCTTCACGATTTCCTAAAGTACCTGGCAAAGAATTCTGCAACTTTGTTCAGTGCCAGCGATTATGAAGTGGCTCCTCCTGAGTACCATCGGAAAGCTGTGTGAGAGGCACTCTCACTCACTTATGTTTGGATCTCCGTAAACACATTTTTGTTCTTAGTCTATCTCTTGTACAAACGATGTGCTTTGAAGATGTTAGTGTATAACAATTGATGTTTGTTTTCTGTTTGATTTTAAACAGAGAAAAAATAAAAGGGGGTAATAGCTCCTTTTTTCTTCTTTCTTTTTTTTTTTCATTTCAAAATTGCTGCCAGTGTTTTCAATGATGGACAACAGAGGGATATGCTGTAGAGTGTTTTATTGCCTAGTTGACAAAGCTGCTTTTGAATGCTGGTGGTTCTATTCCTTTGACACTACGCACTTTTATAATACATGTTAATGCTATATGACAAAATGCTCTGATTCCTAGTGCCAAAGGTTCAATTCAGTGTATATAACTGAACACACTCATCCATTTGTGCTTTTGTTTTTTTTTATGGTGCTTAAAGTAAAGAGCCCATCCTTTGCAAGTCATCCATGTTGTTACTTAGGCATTTTATCTTGGCTCAAATTGTTGAAGAATGGTGGCTTGTTTCATGGTTTTTGTATTTGTGTCTAATGCACGTTTTAACATGATAGACGCAATGCATTGTGTAGCTAGTTTTCTGGAAAAGTCAATCTTTTAGGAATTGTTTTTCAGATCTTCAATAAATTTTTTCTTTAAATTTCAAAGAACAATGTGCTTGTGTTGATGCCTTACAAAAACCATTGTATATTTGTGTATTCCTTCTTGTATTTAGACAGTGGTTTTTCAGGTGCGTGCTTTGTTTTCTGGTATGGCCTTTATGGAATGAGACGCTTTAGCTTTGGTACGTAGCGCTAATCCATAGCAGCTTTGGCAGTTTGCTGTCTTGAGTCTTAGCTAAAAAGTTAGAAGTTTACATGACTGTTTTTTTTATTTTCCCTAAATTATTACTTACTCTGAGCATTAATTAAGGGCATTTTCACCTGTGTAAAATTATGGTCAGCTTTTTTCTGTCTATAATTGTTTACTTTTGTGGGTTTACTCTAGAAACATGAGCCAAAAATGTCAATAGACAACACAGTATTAAAATAACCCAAAAGTTGTAAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0341--Growth regulation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot
|
| PROSITE |
PS51640--MRG
|
| Pfam |
PF05712--MRG
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0047485--F:protein N-terminus binding
GO:0008283--P:cell proliferation
GO:0006338--P:chromatin remodeling
GO:0006342--P:chromatin silencing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0016575--P:histone deacetylation
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0040008--P:regulation of growth
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
