WERAM Information

Tag Content
WERAM ID WERAM-Hos-0161
Ensembl Protein ID ENSP00000330512.5
Uniprot Accession Q9Y232; CDYL1_HUMAN; A8K6D6; B4DLG4; Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y424
Genbank Protein ID NP_001137442.1; NP_001137443.1; NP_004815.3
Protein Name Chromodomain Y-like protein
Genbank Nucleotide ID NM_001143970.1; NM_001143971.1; NM_004824.3
Gene Name CDYL;CDYL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153046.17 ENST00000328908.9 ENSP00000330512.5
ENSG00000153046.17 ENST00000397588.7 ENSP00000380718.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K9me3; H3K27me3 K 20850016
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 3.50e-24 86.9 62 119
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.
Domain Profile
  Me_Reader Chromodomain
   Chromodomain.txt   2 everivdkkelrkgeveYlVrWkGynksddtWepeenLl.ckelleefekkkekkkkq 58 
                        +verivdk++++kg++eYlVrWkGy+++ddtWepe++L+ c+e++++f++++++k+k+
  ENSP00000330512.5  62 QVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVnCEEYIHDFNRRHTEKQKE 119
                        79*****************************************************997 PP
Protein Sequence
(Fasta)		MTFQASHRSA WGKSRKKNWQ YEGPTQKLFL KRNNVSAPDG PSDPSISVSS EQSGAQQPPA 60
LQVERIVDKR KNKKGKTEYL VRWKGYDSED DTWEPEQHLV NCEEYIHDFN RRHTEKQKES 120
TLTRTNRTSP NNARKQISRS TNSNFSKTSP KALVIGKDHE SKNSQLFAAS QKFRKNTAPS 180
LSSRKNMDLA KSGIKILVPK SPVKSRTAVD GFQSESPEKL DPVEQGQEDT VAPEVAAEKP 240
VGALLGPGAE RARMGSRPRI HPLVPQVPGP VTAAMATGLA VNGKGTSPFM DALTANGTTN 300
IQTSVTGVTA SKRKFIDDRR DQPFDKRLRF SVRQTESAYR YRDIVVRKQD GFTHILLSTK 360
SSENNSLNPE VMREVQSALS TAAADDSKLV LLSAVGSVFC CGLDFIYFIR RLTDDRKRES 420
TKMAEAIRNF VNTFIQFKKP IIVAVNGPAI GLGASILPLC DVVWANEKAW FQTPYTTFGQ 480
SPDGCSTVMF PKIMGGASAN EMLLSGRKLT AQEACGKGLV SQVFWPGTFT QEVMVRIKEL 540
ASCNPVVLEE SKALVRCNMK MELEQANERE CEVLKKIWGS AQGMDSMLKY LQRKIDEF 598
Nucleotide Sequence
(Fasta)		GGAGAGAGGA CCTATTTCTA CCTAAGGACA TTCCCGGAAG GCAATGGGTT TCAAACAATA 60
TCCTGAAGAG ACTCATCTCG GGGAACTAAG CAGGTGGTCA TCAGAGAACA CAGAGCCCCC 120
GGAAGAATTT TATGACATTT CAGGCAAGCC ACAGGTCAGC CTGGGGAAAA AGCAGGAAGA 180
AAAACTGGCA ATACGAGGGC CCAACCCAAA AGTTATTCCT GAAGAGAAAC AACGTGTCAG 240
CACCAGATGG GCCTTCAGAC CCCAGCATCT CCGTGAGCAG TGAGCAAAGC GGGGCACAGC 300
AGCCTCCCGC TTTACAGGTT GAAAGGATTG TTGACAAAAG GAAAAATAAA AAAGGGAAGA 360
CAGAGTATTT GGTTCGGTGG AAAGGCTATG ACAGCGAGGA CGACACTTGG GAGCCGGAAC 420
AGCACCTCGT GAACTGTGAG GAATACATCC ACGACTTCAA CAGACGCCAC ACGGAGAAGC 480
AGAAGGAGAG CACATTGACC AGAACAAACA GGACCTCTCC CAACAATGCT AGGAAACAAA 540
TCTCCAGATC CACCAACAGC AACTTTTCTA AGACCTCTCC TAAGGCACTC GTGATTGGGA 600
AAGACCACGA ATCCAAAAAC AGCCAGCTGT TTGCTGCCAG CCAGAAGTTC AGGAAGAACA 660
CAGCTCCATC TCTCTCCAGC CGGAAGAACA TGGACCTAGC GAAGTCAGGT ATCAAGATCC 720
TCGTGCCTAA AAGCCCCGTT AAGAGCAGGA CCGCAGTGGA CGGCTTTCAG AGCGAGAGCC 780
CTGAGAAACT GGACCCCGTC GAGCAGGGTC AGGAGGACAC AGTGGCACCC GAAGTGGCAG 840
CGGAAAAGCC GGTCGGAGCT TTATTGGGCC CCGGTGCCGA GAGGGCCAGG ATGGGGAGCA 900
GGCCCAGGAT ACACCCACTA GTGCCTCAGG TGCCCGGCCC TGTGACTGCA GCCATGGCCA 960
CAGGCTTAGC TGTTAACGGG AAAGGTACAT CTCCGTTCAT GGATGCATTA ACAGCCAATG 1020
GGACAACCAA CATACAGACA TCTGTTACAG GAGTGACTGC CAGCAAAAGG AAATTTATTG 1080
ACGACAGAAG AGACCAGCCT TTTGACAAGC GATTGCGTTT CAGCGTGAGG CAAACAGAAA 1140
GTGCCTACAG ATACAGAGAT ATTGTGGTCA GGAAGCAGGA TGGCTTCACC CACATCTTGT 1200
TATCCACAAA GTCCTCAGAG AATAACTCAC TAAATCCAGA GGTAATGAGA GAAGTCCAGA 1260
GTGCTCTGAG CACGGCCGCT GCCGATGACA GCAAGCTGGT ACTGCTCAGC GCCGTTGGCA 1320
GCGTCTTCTG TTGTGGACTT GACTTTATTT ATTTTATACG ACGTCTGACA GATGACAGGA 1380
AAAGAGAAAG CACTAAAATG GCAGAAGCTA TCAGAAACTT CGTGAATACT TTCATTCAAT 1440
TTAAGAAGCC CATTATTGTA GCAGTCAATG GCCCAGCCAT TGGTCTAGGA GCATCTATAT 1500
TGCCTCTTTG CGATGTGGTT TGGGCTAATG AAAAGGCTTG GTTTCAAACA CCCTATACCA 1560
CCTTCGGACA GAGTCCAGAT GGCTGTTCTA CCGTTATGTT TCCCAAGATA ATGGGAGGAG 1620
CATCTGCAAA CGAGATGCTG CTCAGTGGAC GGAAGCTGAC AGCGCAGGAG GCGTGTGGCA 1680
AGGGCCTGGT CTCCCAGGTG TTTTGGCCCG GGACGTTCAC TCAGGAAGTG ATGGTTCGCA 1740
TTAAGGAGCT TGCCTCGTGC AATCCAGTTG TGCTTGAGGA ATCCAAAGCC CTCGTGCGCT 1800
GCAACATGAA GATGGAGCTG GAGCAGGCCA ACGAGAGGGA GTGTGAGGTG CTGAAGAAAA 1860
TCTGGGGCTC GGCCCAGGGG ATGGACTCCA TGTTAAAGTA CTTGCAGAGG AAGATCGATG 1920
AGTTCTGAGT GTCGGGCTGC CCACTGGTGA CACCGGGATC GGGCTGAGCA GGAGAACATC 1980
ACCGGCTCCA GTTCCCCTGA TCCATTCTCA CAGCCTGAAA CAAGCTCACC CGTAGCTTAC 2040
GCTTGGAAGC AGGACTGGGA ACATCCACGC TATTTATTAT CGAGGAGTTT TAAAGTACTG 2100
TAACTTTAAA ATAAATAACT ACAAAGCTTC TTTGTCCAAA CGTCATTATT TTATACTTAT 2160
ATACACGCAG GTGTAAAAGT ATAAAGGTGA GCACTAGACT GCTCTTAGAA GCTCTAATTT 2220
TTGTTTTCTT TGGCTAGTAC TGTATAAAAA ACAGAATTGT GTTTTATTGG TTTTGGATGA 2280
CAGAAAAGTC TGGAATAATG TTTGTTTTCC TCATTTCTTC CTTCTAGAAC ACAGAATCTA 2340
AAGGGGTATT AGCCAGCCTC GCCTCCCTGC CCCACGTAGA GACACAGAGT GATGTGAGGC 2400
GTTGGCTTTT TCTCCAAGAA GGTACAGATA CCTCAGATTC GGGAAACTCA AAATCAAAAG 2460
ACTTAGCTTC TAGGATAAAT ACTTCTGATG AAAAATCCGC TGAGGAGCAT ACCCCAAACC 2520
AGACATATGC TTAGGATTCA TGCTGAGATA TCAATTGGTT TCCCCTTCTT TTTAAAATAC 2580
GTCCAGTTCT TACCCAGTTA ACATGAAGAA ACCACTGTCT CTAGAAGAAA GCTTGTTTTG 2640
CAGTATTAGT GAATCACTGA ATAGCTTAAG TATGACTATC TAAGTTATAA GTTAGTCTTT 2700
AGTGGGTTTT AAATAGTTTT TCTGACCCTT CTGAAAAATA ACTACATAAG TGCTTCTTGT 2760
TGCTGGGTGA GAAATACTAC TTTATAGACA GTTTTGGTTT TCTGTTTGCA GATATGATTG 2820
ATGTATTTCA CCAAAATAAA ATATTTTTAT GTTTATAAAG TGTAATTTTT AGGTTCACTT 2880
AGAATATATT TTATTTAATA AGTTAAAATT CTTTTGGCAC ACTATTAAAT GCAAAAACTC 2940
CTTTCAAAAC AAAAAAGAAC TACCTTATAT TCAACATTTA ATGTTCTTGG CCTCTGCTTT 3000
TATGTCTATA CAATATACTG AGTTCAGTAT GGTGTCCAAG AGTGCCCTGT GTGGATAGAC 3060
ATGTGCACTC CTTCCAGGAG TGGGTACTGA TTCCAGACTC CAGATGCCTA TTATTAGTTA 3120
GGCTTCTGAG CTTGCAATCA TATTGAATGT ATGAAGAGCG AAATCAAATT CTTATTTTTG 3180
TACAGTTTTG AAGTTTATAC TTAGAACTGA CCACCTCCCC GGCCACGCGG AGAGCTGTAC 3240
AGTGTGTAAA TCTGCCTTTA TCTTGGATTG ATTGGTACAG TATTTTTGCA TCTGTGGGAC 3300
CTACCTTTTC GTTCAGTAGT TTGAACTATA TATAAACTGT ACAATCTGTA AAGTTTTTAT 3360
AGAATAAATA TTCAGCTGTG AAAACTGGTT AAATAAAACT AATATTTCTT AACACATTT 3420
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR029045--ClpP/crotonase-like_dom
IPR001753--Crotonase_core_superfam
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
PF00378--ECH_1
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004402--F:histone acetyltransferase activity
GO:0035064--F:methylated histone binding
GO:0003714--F:transcription corepressor activity
GO:1903507--P:negative regulation of nucleic acid-templated transcription
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0144 ENSPTRP00000030202.3 Pan troglodytes 99 0.0 1235
WERAM-Gog-0199 ENSGGOP00000022358.1 Gorilla gorilla 99 0.0 1229
WERAM-Nol-0120 ENSNLEP00000013918.1 Nomascus leucogenys 98 0.0 1225
WERAM-Poa-0144 ENSPPYP00000018112.2 Pongo abelii 99 0.0 1113
WERAM-Mam-0034 ENSMMUP00000006579.2 Macaca mulatta 99 0.0 1111
WERAM-Chs-0087 ENSCSAP00000003568.1 Chlorocebus sabaeus 99 0.0 1108
WERAM-Caj-0223 ENSCJAP00000039775.2 Callithrix jacchus 99 0.0 1108
WERAM-Caf-0104 ENSCAFP00000013867.3 Canis familiaris 98 0.0 1102
WERAM-Ptv-0179 ENSPVAP00000015848.1 Pteropus vampyrus 98 0.0 1101
WERAM-Otg-0168 ENSOGAP00000014264.2 Otolemur garnettii 98 0.0 1101
WERAM-Mup-0005 ENSMPUP00000000515.1 Mustela putorius furo 98 0.0 1095
WERAM-Aim-0145 ENSAMEP00000013615.1 Ailuropoda melanoleuca 98 0.0 1095
WERAM-Loa-0167 ENSLAFP00000015437.3 Loxodonta africana 97 0.0 1093
WERAM-Tas-0043 ENSTSYP00000004340.1 Tarsius syrichta 97 0.0 1092
WERAM-Myl-0005 ENSMLUP00000000450.2 Myotis lucifugus 97 0.0 1090
WERAM-Eqc-0104 ENSECAP00000011853.1 Equus caballus 97 0.0 1090
WERAM-Fec-0185 ENSFCAP00000017712.1 Felis catus 98 0.0 1082
WERAM-Ict-0097 ENSSTOP00000010036.2 Ictidomys tridecemlineatus 96 0.0 1074
WERAM-Cap-0071 ENSCPOP00000005275.2 Cavia porcellus 96 0.0 1066
WERAM-Mum-0206 ENSMUSP00000074707.6 Mus musculus 89 0.0 1056
WERAM-Dan-0073 ENSDNOP00000007459.3 Dasypus novemcinctus 94 0.0 1049
WERAM-Ran-0178 ENSRNOP00000048651.3 Rattus norvegicus 89 0.0 1042
WERAM-Prc-0113 ENSPCAP00000009984.1 Procavia capensis 95 0.0 1041
WERAM-Bot-0151 ENSBTAP00000021803.5 Bos taurus 94 0.0 1039
WERAM-Sah-0088 ENSSHAP00000010186.1 Sarcophilus harrisii 91 0.0 1036
WERAM-Mod-0080 ENSMODP00000012255.3 Monodelphis domestica 91 0.0 1036
WERAM-Ocp-0100 ENSOPRP00000009200.2 Ochotona princeps 92 0.0 1030
WERAM-Ova-0001 ENSOARP00000000051.1 Ovis aries 92 0.0 1013
WERAM-Ora-0013 ENSOANP00000001917.2 Ornithorhynchus anatinus 89 0.0 1008
WERAM-Anp-0051 ENSAPLP00000005516.1 Anas platyrhynchos 90 0.0 1006
WERAM-Gaga-0119 ENSGALP00000020866.4 Gallus gallus 90 0.0 1006
WERAM-Pes-0070 ENSPSIP00000008652.1 Pelodiscus sinensis 89 0.0 1006
WERAM-Orc-0035 ENSOCUP00000003807.3 Oryctolagus cuniculus 90 0.0 1002
WERAM-Ere-0138 ENSEEUP00000014340.1 Erinaceus europaeus 88 0.0 993
WERAM-Fia-0161 ENSFALP00000013732.1 Ficedula albicollis 89 0.0 991
WERAM-Tag-0032 ENSTGUP00000002323.1 Taeniopygia guttata 89 0.0 988
WERAM-Anc-0139 ENSACAP00000013040.3 Anolis carolinensis 88 0.0 973
WERAM-Dio-0023 ENSDORP00000002640.1 Dipodomys ordii 87 0.0 953
WERAM-Tut-0047 ENSTTRP00000003953.1 Tursiops truncatus 85 0.0 942
WERAM-Ect-0115 ENSETEP00000012627.1 Echinops telfairi 80 0.0 919
WERAM-Xet-0170 ENSXETP00000058332.1 Xenopus tropicalis 81 0.0 913
WERAM-Leo-0112 ENSLOCP00000014301.1 Lepisosteus oculatus 75 0.0 839
WERAM-Mim-0107 ENSMICP00000010255.1 Microcebus murinus 77 0.0 820
WERAM-Mae-0082 ENSMEUP00000008225.1 Macropus eugenii 83 0.0 815
WERAM-Meg-0040 ENSMGAP00000003834.2 Meleagris gallopavo 75 0.0 796
WERAM-Tub-0103 ENSTBEP00000011867.1 Tupaia belangeri 87 0.0 763
WERAM-Dar-0088 ENSDARP00000073586.2 Danio rerio 65 0.0 715
WERAM-Chh-0092 ENSCHOP00000010408.1 Choloepus hoffmanni 92 0.0 684
WERAM-Asm-0012 ENSAMXP00000001823.1 Astyanax mexicanus 64 0.0 674
WERAM-Orn-0171 ENSONIP00000017623.1 Oreochromis niloticus 58 0.0 643
WERAM-Gaa-0021 ENSGACP00000003221.1 Gasterosteus aculeatus 60 0.0 639
WERAM-Orla-0077 ENSORLP00000009659.1 Oryzias latipes 58 1e-177 620
WERAM-Gam-0207 ENSGMOP00000020036.1 Gadus morhua 60 2e-174 609
WERAM-Pof-0152 ENSPFOP00000012380.2 Poecilia formosa 57 7e-161 565
WERAM-Lac-0092 ENSLACP00000011748.1 Latimeria chalumnae 49 4e-145 512
WERAM-Paa-0107 ENSPANP00000003836.1 Papio anubis 51 7e-139 491
WERAM-Xim-0223 ENSXMAP00000018601.1 Xiphophorus maculatus 65 3e-131 466
WERAM-Ten-0110 ENSTNIP00000000668.1 Tetraodon nigroviridis 46 4e-128 456
WERAM-Tar-0221 ENSTRUP00000046743.1 Takifugu rubripes 47 7e-128 455
WERAM-Pem-0021 ENSPMAP00000002854.1 Petromyzon marinus 59 3e-101 367
WERAM-Vip-0001 ENSVPAP00000000085.1 Vicugna pacos 70 7e-52 202
WERAM-Sus-0066 ENSSSCP00000010219.2 Sus scrofa 41 2e-10 65.1
WERAM-Cii-0059 ENSCINP00000026937.2 Ciona intestinalis 45 5e-10 63.9
WERAM-Drm-0069 FBpp0083702 Drosophila melanogaster 43 1e-08 59.3
WERAM-Soa-0076 ENSSARP00000007237.1 Sorex araneus 41 6e-07 53.5
WERAM-Cae-0010 K01G5.2a Caenorhabditis elegans 36 6e-07 53.5
Created Date 25-Jun-2016