Tag |
Content |
WERAM ID |
WERAM-Hos-0044 |
Ensembl Protein ID |
ENSP00000328547.2 |
Uniprot Accession |
Q9UBC3; DNM3B_HUMAN; A2A2E2; B4DSM8; B4DSU1; E1P5M6; E1P5M7; E7EN63; E9PBF2; Q9UBD4; Q9UJQ5; Q9UKA6; Q9UNE5; Q9Y5R9; Q9Y5S0 |
Genbank Protein ID |
NP_001193984.1; NP_001193985.1; NP_008823.1; NP_787044.1; NP_787045.1; NP_787046.1 |
Protein Name |
DNA (cytosine-5)-methyltransferase 3B |
Genbank Nucleotide ID |
NM_001207055.1; NM_001207056.1; NM_006892.3; NM_175848.1; NM_175849.1; NM_175850.2 |
Gene Name |
DNMT3B |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Me_Reader |
PWWP |
PWWP |
H3K36me3 |
K |
26993463 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Me_Reader |
ADD |
2.30e-57 |
195 |
424 |
553 |
Me_Reader |
PWWP |
1.40e-16 |
62.6 |
225 |
281 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. |
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
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Domain Profile |
Me_Reader ADD
ADD.txt 2 vkrnednlediciacGkkdsilrhPlleggicknckdkfleaaisydddGyqsycticaeGrelllcgndsctrafcvecvdrlvGrgeaek 93 v +n+++led c++cG+k+++++hPl+egg+c++c+d+fle +++ydddGyqsyct+c+eGrelllc+n+sc+r+fcvec+++lvG+g+a + ENSP00000328547.2 424 VANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAE 515 7899**************************************************************************************** PP ADD.txt 94 ikkeenWvcylclpesllgllrrrkdvkerleqllqqn 131 +k +e+W+cy+clp++++g+lrrrkd++ rl+++++ + ENSP00000328547.2 516 AKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSD 553 ***********************************987 PP
Me_Reader PWWP
PWWP.txt 1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpys 62 +gdLVw+K+kg++wWPa+v+s++ ++k++ a++++++V++Fg + +++ v+++klv+++ ENSP00000328547.2 225 IGDLVWGKIKGFSWWPAMVVSWKATSKRQ----AMSGMRWVQWFG-DGKFSEVSADKLVALG 281 69***************************....************.*************986 PP
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Protein Sequence (Fasta) | MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV 60 SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS 120 PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT 180 PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP 240 AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK 300 AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS 360 KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM 420 ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV 480 CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK 540 DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK 600 YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA 660 RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM 720 IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS 780 IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR 840 HLFAPLKDYF ACE 853Protein Fasta Sequence
>ENSP00000328547.2|DNMT3B|Homo sapiens MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
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Nucleotide Sequence (Fasta) | ACCCACTCCC GCTGCCCCGT CCGGCCCGCG CCGCTTCCTC GCAGCAGCTG CTCCCGGCTC 60 CGCGGCCGCA GCCCGCGTGG ACGCTCCGAG CGCCCCCCGA CGGACGGGAC CGGCTCCCTG 120 GCGGTCGGGC GAGCGGGCGG CAACGCTGCC CGGCCGGCAG CGCTGGGGTT AAGTGGCCCA 180 AGTAAACCTA GCTCGGCGAT CGGCGCCGGA GATTCGCGAG CCCAGCGCCC TGCACGGCCG 240 CCAGCCGGCC TCCCGCCAGC CAGCCCCGAC CCGCGGCTCC GCCGCCCAGC CGCGCCCCAG 300 CCAGCCCTGC GGCAGGAAAG CATGAAGGGA GACACCAGGC ATCTCAATGG AGAGGAGGAC 360 GCCGGCGGGA GGGAAGACTC GATCCTCGTC AACGGGGCCT GCAGCGACCA GTCCTCCGAC 420 TCGCCCCCAA TCCTGGAGGC TATCCGCACC CCGGAGATCA GAGGCCGAAG ATCAAGCTCG 480 CGACTCTCCA AGAGGGAGGT GTCCAGTCTG CTAAGCTACA CACAGGACTT GACAGGCGAT 540 GGCGACGGGG AAGATGGGGA TGGCTCTGAC ACCCCAGTCA TGCCAAAGCT CTTCCGGGAA 600 ACCAGGACTC GTTCAGAAAG CCCAGCTGTC CGAACTCGAA ATAACAACAG TGTCTCCAGC 660 CGGGAGAGGC ACAGGCCTTC CCCACGTTCC ACCCGAGGCC GGCAGGGCCG CAACCATGTG 720 GACGAGTCCC CCGTGGAGTT CCCGGCTACC AGGTCCCTGA GACGGCGGGC AACAGCATCG 780 GCAGGAACGC CATGGCCGTC CCCTCCCAGC TCTTACCTTA CCATCGACCT CACAGACGAC 840 ACAGAGGACA CACATGGGAC GCCCCAGAGC AGCAGTACCC CCTACGCCCG CCTAGCCCAG 900 GACAGCCAGC AGGGGGGCAT GGAGTCCCCG CAGGTGGAGG CAGACAGTGG AGATGGAGAC 960 AGTTCAGAGT ATCAGGATGG GAAGGAGTTT GGAATAGGGG ACCTCGTGTG GGGAAAGATC 1020 AAGGGCTTCT CCTGGTGGCC CGCCATGGTG GTGTCTTGGA AGGCCACCTC CAAGCGACAG 1080 GCTATGTCTG GCATGCGGTG GGTCCAGTGG TTTGGCGATG GCAAGTTCTC CGAGGTCTCT 1140 GCAGACAAAC TGGTGGCACT GGGGCTGTTC AGCCAGCACT TTAATTTGGC CACCTTCAAT 1200 AAGCTCGTCT CCTATCGAAA AGCCATGTAC CATGCTCTGG AGAAAGCTAG GGTGCGAGCT 1260 GGCAAGACCT TCCCCAGCAG CCCTGGAGAC TCATTGGAGG ACCAGCTGAA GCCCATGTTG 1320 GAGTGGGCCC ACGGGGGCTT CAAGCCCACT GGGATCGAGG GCCTCAAACC CAACAACACG 1380 CAACCAGTGG TTAATAAGTC GAAGGTGCGT CGTGCAGGCA GTAGGAAATT AGAATCAAGG 1440 AAATACGAGA ACAAGACTCG AAGACGCACA GCTGACGACT CAGCCACCTC TGACTACTGC 1500 CCCGCACCCA AGCGCCTCAA GACAAATTGC TATAACAACG GCAAAGACCG AGGGGATGAA 1560 GATCAGAGCC GAGAACAAAT GGCTTCAGAT GTTGCCAACA ACAAGAGCAG CCTGGAAGAT 1620 GGCTGTTTGT CTTGTGGCAG GAAAAACCCC GTGTCCTTCC ACCCTCTCTT TGAGGGGGGG 1680 CTCTGTCAGA CATGCCGGGA TCGCTTCCTT GAGCTGTTTT ACATGTATGA TGACGATGGC 1740 TATCAGTCTT ACTGCACTGT GTGCTGCGAG GGCCGAGAGC TGCTGCTTTG CAGCAACACG 1800 AGCTGCTGCC GGTGTTTCTG TGTGGAGTGC CTGGAGGTGC TGGTGGGCAC AGGCACAGCG 1860 GCCGAGGCCA AGCTTCAGGA GCCCTGGAGC TGTTACATGT GTCTCCCGCA GCGCTGTCAT 1920 GGCGTCCTGC GGCGCCGGAA GGACTGGAAC GTGCGCCTGC AGGCCTTCTT CACCAGTGAC 1980 ACGGGGCTTG AATATGAAGC CCCCAAGCTG TACCCTGCCA TTCCCGCAGC CCGAAGGCGG 2040 CCCATTCGAG TCCTGTCATT GTTTGATGGC ATCGCGACAG GCTACCTAGT CCTCAAAGAG 2100 TTGGGCATAA AGGTAGGAAA GTACGTCGCT TCTGAAGTGT GTGAGGAGTC CATTGCTGTT 2160 GGAACCGTGA AGCACGAGGG GAATATCAAA TACGTGAACG ACGTGAGGAA CATCACAAAG 2220 AAAAATATTG AAGAATGGGG CCCATTTGAC TTGGTGATTG GCGGAAGCCC ATGCAACGAT 2280 CTCTCAAATG TGAATCCAGC CAGGAAAGGC CTGTATGAGG GTACAGGCCG GCTCTTCTTC 2340 GAATTTTACC ACCTGCTGAA TTACTCACGC CCCAAGGAGG GTGATGACCG GCCGTTCTTC 2400 TGGATGTTTG AGAATGTTGT AGCCATGAAG GTTGGCGACA AGAGGGACAT CTCACGGTTC 2460 CTGGAGTGTA ATCCAGTGAT GATTGATGCC ATCAAAGTTT CTGCTGCTCA CAGGGCCCGA 2520 TACTTCTGGG GCAACCTACC CGGGATGAAC AGGCCCGTGA TAGCATCAAA GAATGATAAA 2580 CTCGAGCTGC AGGACTGCTT GGAATACAAT AGGATAGCCA AGTTAAAGAA AGTACAGACA 2640 ATAACCACCA AGTCGAACTC GATCAAACAG GGGAAAAACC AACTTTTCCC TGTTGTCATG 2700 AATGGCAAAG AAGATGTTTT GTGGTGCACT GAGCTCGAAA GGATCTTTGG CTTTCCTGTG 2760 CACTACACAG ACGTGTCCAA CATGGGCCGT GGTGCCCGCC AGAAGCTGCT GGGAAGGTCC 2820 TGGAGCGTGC CTGTCATCCG ACACCTCTTC GCCCCTCTGA AGGACTACTT TGCATGTGAA 2880 TAGTTCCAGC CAGGCCCCAA GCCCACTGGG GTGTGTGGCA GAGCCAGGAC CCAGGAGGTG 2940 TGATTCCTGA AGGCATCCCC AGGCCCTGCT CTTCCTCAGC TGTGTGGGTC ATACCGTGTA 3000 CCTCAGTTCC CTCTTGCTCA GTGGGGGCAG AGCCACCTGA CTCTTGCAGG GGTAGCCTGA 3060 GGTGCCGCCT CCTTGTGCAC AAATCAGACC TGGCTGCTTG GAGCAGCCTA ACACGGTGCT 3120 CATTTTTTCT TCTCCTAAAA CTTTAAAACT TGAAGTAGGT AGCAACGTGG CTTTTTTTTT 3180 TTCCCTTCCT GGGTCTACCA CTCAGAGAAA CAATGGCTAA GATACCAAAA CCACAGTGCC 3240 GACAGCTCTC CAATACTCAG GTTAATGCTG AAAAATCATC CAAGACAGTT ATTGCAAGAG 3300 TTTAATTTTT GAAAACTGGC TACTGCTCTG TGTTTACAGA CGTGTGCAGT TGTAGGCATG 3360 TAGCTACAGG ACATTTTTAA GGGCCCAGGA TCGTTTTTTC CCAGGGCAAG CAGAAGAGAA 3420 AATGTTGTAT ATGTCTTTTA CCCGGCACAT TCCCCTTGCC TAAATACAAG GGCTGGAGTC 3480 TGCACGGGAC CTATTAGAGT ATTTTCCACA ATGATGATGA TTTCAGCAGG GATGACGTCA 3540 TCATCACATT CAGGGCTATT TTTTCCCCCA CAAACCCAAG GGCAGGGGCC ACTCTTAGCT 3600 AAATCCCTCC CCGTGACTGC AATAGAACCC TCTGGGGAGC TCAGGAAGGG GTGTGCTGAG 3660 TTCTATAATA TAAGCTGCCA TATATTTTGT AGACAAGTAT GGCTCCTCCA TATCTCCCTC 3720 TTCCCTAGGA GAGGAGTGTG AAGCAAGGAG CTTAGATAAG ACACCCCCTC AAACCCATTC 3780 CCTCTCCAGG AGACCTACCC TCCACAGGCA CAGGTCCCCA GATGAGAAGT CTGCTACCCT 3840 CATTTCTCAT CTTTTTACTA AACTCAGAGG CAGTGACAGC AGTCAGGGAC AGACATACAT 3900 TTCTCATACC TTCCCCACAT CTGAGAGATG ACAGGGAAAA CTGCAAAGCT CGGTGCTCCC 3960 TTTGGAGATT TTTTAATCCT TTTTTATTCC ATAAGAAGTC GTTTTTAGGG AGAACGGGAA 4020 TTCAGACAAG CTGCATTTCA GAAATGCTGT CATAATGGTT TTTAACACCT TTTACTCTTC 4080 TTACTGGTGC TATTTTGTAG AATAAGGAAC AACGTTGACA AGTTTTGTGG GGCTTTTTAT 4140 ACACTTTTTA AAATCTCAAA CTTCTATTTT TATGTTTAAC GTTTTCATTA AAATTTTTTT 4200 TGTAACTGGA GCCACGACGT AACAAATATG GGGAAAAAAC TGTGCCTTGT TTCAACAGTT 4260 TTTGCTAATT TTTAGGCTGA AAGATGACGG ATGCCTAGAG TTTACCTTAT GTTTAATTAA 4320 AATCAGTATT TGTCTA
4337Nucleotide Fasta Sequence
>ENSP00000328547.2|PWWP|Homo sapiens ACCCACTCCCGCTGCCCCGTCCGGCCCGCGCCGCTTCCTCGCAGCAGCTGCTCCCGGCTCCGCGGCCGCAGCCCGCGTGGACGCTCCGAGCGCCCCCCGACGGACGGGACCGGCTCCCTGGCGGTCGGGCGAGCGGGCGGCAACGCTGCCCGGCCGGCAGCGCTGGGGTTAAGTGGCCCAAGTAAACCTAGCTCGGCGATCGGCGCCGGAGATTCGCGAGCCCAGCGCCCTGCACGGCCGCCAGCCGGCCTCCCGCCAGCCAGCCCCGACCCGCGGCTCCGCCGCCCAGCCGCGCCCCAGCCAGCCCTGCGGCAGGAAAGCATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCGATCCTCGTCAACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCTATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGTGTCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGATGGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGCCCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAGGCCTTCCCCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTCCCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCCCCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACGCCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATGGAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGGAAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCCGCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGGGTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTCTCTGCAGACAAACTGGTGGCACTGGGGCTGTTCAGCCAGCACTTTAATTTGGCCACCTTCAATAAGCTCGTCTCCTATCGAAAAGCCATGTACCATGCTCTGGAGAAAGCTAGGGTGCGAGCTGGCAAGACCTTCCCCAGCAGCCCTGGAGACTCATTGGAGGACCAGCTGAAGCCCATGTTGGAGTGGGCCCACGGGGGCTTCAAGCCCACTGGGATCGAGGGCCTCAAACCCAACAACACGCAACCAGTGGTTAATAAGTCGAAGGTGCGTCGTGCAGGCAGTAGGAAATTAGAATCAAGGAAATACGAGAACAAGACTCGAAGACGCACAGCTGACGACTCAGCCACCTCTGACTACTGCCCCGCACCCAAGCGCCTCAAGACAAATTGCTATAACAACGGCAAAGACCGAGGGGATGAAGATCAGAGCCGAGAACAAATGGCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGATGGCTGTTTGTCTTGTGGCAGGAAAAACCCCGTGTCCTTCCACCCTCTCTTTGAGGGGGGGCTCTGTCAGACATGCCGGGATCGCTTCCTTGAGCTGTTTTACATGTATGATGACGATGGCTATCAGTCTTACTGCACTGTGTGCTGCGAGGGCCGAGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTGTTTCTGTGTGGAGTGCCTGGAGGTGCTGGTGGGCACAGGCACAGCGGCCGAGGCCAAGCTTCAGGAGCCCTGGAGCTGTTACATGTGTCTCCCGCAGCGCTGTCATGGCGTCCTGCGGCGCCGGAAGGACTGGAACGTGCGCCTGCAGGCCTTCTTCACCAGTGACACGGGGCTTGAATATGAAGCCCCCAAGCTGTACCCTGCCATTCCCGCAGCCCGAAGGCGGCCCATTCGAGTCCTGTCATTGTTTGATGGCATCGCGACAGGCTACCTAGTCCTCAAAGAGTTGGGCATAAAGGTAGGAAAGTACGTCGCTTCTGAAGTGTGTGAGGAGTCCATTGCTGTTGGAACCGTGAAGCACGAGGGGAATATCAAATACGTGAACGACGTGAGGAACATCACAAAGAAAAATATTGAAGAATGGGGCCCATTTGACTTGGTGATTGGCGGAAGCCCATGCAACGATCTCTCAAATGTGAATCCAGCCAGGAAAGGCCTGTATGAGGGTACAGGCCGGCTCTTCTTCGAATTTTACCACCTGCTGAATTACTCACGCCCCAAGGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAATGTTGTAGCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGTGTAATCCAGTGATGATTGATGCCATCAAAGTTTCTGCTGCTCACAGGGCCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGGACTGCTTGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAACTTTTCCCTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGTTTAATTAAAATCAGTATTTGTCTA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0010--Activator KW-0025--Alternative splicing KW-0164--Citrullination KW-0181--Complete proteome KW-0225--Disease mutation KW-0238--DNA-binding KW-0479--Metal-binding KW-0489--Methyltransferase KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0678--Repressor KW-0949--S-adenosyl-L-methionine KW-0808--Transferase KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR025766--ADD IPR018117--C5_DNA_meth_AS IPR001525--C5_MeTfrase IPR030488--DNMT3B IPR000313--PWWP_dom IPR029063--SAM-dependent_MTases IPR011011--Znf_FYVE_PHD
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PROSITE |
PS51533--ADD PS00094--C5_MTASE_1 PS50812--PWWP PS51679--SAM_MT_C5
|
Pfam |
PF00145--DNA_methylase PF00855--PWWP
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0043231--C:intracellular membrane-bounded organelle GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0003682--F:chromatin binding GO:0003886--F:DNA (cytosine-5-)-methyltransferase activity GO:0051718--F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates GO:0009008--F:DNA-methyltransferase activity GO:0046872--F:metal ion binding GO:0003714--F:transcription corepressor activity GO:0045322--F:unmethylated CpG binding GO:0071549--P:cellular response to dexamethasone stimulus GO:0071455--P:cellular response to hyperoxia GO:0006306--P:DNA methylation GO:0010424--P:DNA methylation on cytosine within a CG sequence GO:0045814--P:negative regulation of gene expression, epigenetic GO:0051573--P:negative regulation of histone H3-K9 methylation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0010628--P:positive regulation of gene expression GO:0051571--P:positive regulation of histone H3-K4 methylation GO:0045666--P:positive regulation of neuron differentiation GO:0014823--P:response to activity GO:0031000--P:response to caffeine GO:0042220--P:response to cocaine GO:0042493--P:response to drug GO:0032355--P:response to estradiol GO:0001666--P:response to hypoxia GO:0010212--P:response to ionizing radiation GO:0009636--P:response to toxic substance GO:0033189--P:response to vitamin A GO:0046498--P:S-adenosylhomocysteine metabolic process GO:0046499--P:S-adenosylmethioninamine metabolic process
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Orthology |
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Created Date |
25-Jun-2016 |