Tag |
Content |
WERAM ID |
WERAM-Hos-0099 |
Ensembl Protein ID |
ENSP00000324375.5 |
Uniprot Accession |
Q9Y6K1; DNM3A_HUMAN; E9PEB8; Q86TE8; Q86XF5; Q8IZV0; Q8WXU9 |
Genbank Protein ID |
NP_072046.2; NP_715640.2; NP_783328.1; NP_783329.1; XP_005264232.1; XP_005264234.1; XP_011530969.1 |
Protein Name |
DNA (cytosine-5)-methyltransferase 3A |
Genbank Nucleotide ID |
NM_022552.4; NM_153759.3; NM_175629.2; NM_175630.1; XM_005264175.3; XM_005264177.3; XM_011532667.1 |
Gene Name |
DNMT3A |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Me_Reader |
PWWP |
PWWP |
H3K36me3 |
K |
26993463 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Me_Reader |
ADD |
9.20e-61 |
206 |
482 |
614 |
Me_Reader |
PWWP |
9.60e-17 |
63.2 |
292 |
349 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
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Domain Profile |
Me_Reader ADD
ADD.txt 1 evkrnednlediciacGkkdsilrhPlleggicknckdkfleaaisydddGyqsycticaeGrelllcgndsctrafcvecvdrlvGrgeae 92 ev+++++n+edici+cG+++++l+hPl+ gg+c+nck++fle+a++ydddGyqsyctic++Gre+l+cgn++c+r+fcvecvd lvG+g+a+ ENSP00000324375.5 482 EVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ 573 79****************************************************************************************** PP ADD.txt 93 kikkeenWvcylclpesllgllrrrkdvkerleqllqqnkd 133 +++ke++W+cy+c ++ ++gllrrr+d+ +rl++++++n+d ENSP00000324375.5 574 AAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHD 614 **************************************986 PP
Me_Reader PWWP
PWWP.txt 1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpyse 63 +g+LVw+Kl+g++wWP++++s+++++++ a e++++V++Fg + ++++v+++kl+p+s+ ENSP00000324375.5 292 IGELVWGKLRGFSWWPGRIVSWWMTGRSR----AAEGTRWVMWFG-DGKFSVVCVEKLMPLSS 349 59***************************....************.**************986 PP
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Protein Sequence (Fasta) | MPAMPSSGPG DTSSSAAERE EDRKDGEEQE EPRGKEERQE PSTTARKVGR PGRKRKHPPV 60 ESGDTPKDPA VISKSPSMAQ DSGASELLPN GDLEKRSEPQ PEEGSPAGGQ KGGAPAEGEG 120 AAETLPEASR AVENGCCTPK EGRGAPAEAG KEQKETNIES MKMEGSRGRL RGGLGWESSL 180 RQRPMPRLTF QAGDPYYISK RKRDEWLARW KREAEKKAKV IAGMNAVEEN QGPGESQKVE 240 EASPPAVQQP TDPASPTVAT TPEPVGSDAG DKNATKAGDD EPEYEDGRGF GIGELVWGKL 300 RGFSWWPGRI VSWWMTGRSR AAEGTRWVMW FGDGKFSVVC VEKLMPLSSF CSAFHQATYN 360 KQPMYRKAIY EVLQVASSRA GKLFPVCHDS DESDTAKAVE VQNKPMIEWA LGGFQPSGPK 420 GLEPPEEEKN PYKEVYTDMW VEPEAAAYAP PPPAKKPRKS TAEKPKVKEI IDERTRERLV 480 YEVRQKCRNI EDICISCGSL NVTLEHPLFV GGMCQNCKNC FLECAYQYDD DGYQSYCTIC 540 CGGREVLMCG NNNCCRCFCV ECVDLLVGPG AAQAAIKEDP WNCYMCGHKG TYGLLRRRED 600 WPSRLQMFFA NNHDQEFDPP KVYPPVPAEK RKPIRVLSLF DGIATGLLVL KDLGIQVDRY 660 IASEVCEDSI TVGMVRHQGK IMYVGDVRSV TQKHIQEWGP FDLVIGGSPC NDLSIVNPAR 720 KGLYEGTGRL FFEFYRLLHD ARPKEGDDRP FFWLFENVVA MGVSDKRDIS RFLESNPVMI 780 DAKEVSAAHR ARYFWGNLPG MNRPLASTVN DKLELQECLE HGRIAKFSKV RTITTRSNSI 840 KQGKDQHFPV FMNEKEDILW CTEMERVFGF PVHYTDVSNM SRLARQRLLG RSWSVPVIRH 900 LFAPLKEYFA CV 912Protein Fasta Sequence
>ENSP00000324375.5|DNMT3A|Homo sapiens MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
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Nucleotide Sequence (Fasta) | GACGCGGCGC CGCGGCACCA GGGCGCGCAG CCGGGCCGGC CCGACCCCAC CGGCCATACG 60 GTGGAGCCAT CGAAGCCCCC ACCCACAGGC TGACAGAGGC ACCGTTCACC AGAGGGCTCA 120 ACACCGGGAT CTATGTTTAA GTTTTAACTC TCGCCTCCAA AGACCACGAT AATTCCTTCC 180 CCAAAGCCCA GCAGCCCCCC AGCCCCGCGC AGCCCCAGCC TGCCTCCCGG CGCCCAGATG 240 CCCGCCATGC CCTCCAGCGG CCCCGGGGAC ACCAGCAGCT CTGCTGCGGA GCGGGAGGAG 300 GACCGAAAGG ACGGAGAGGA GCAGGAGGAG CCGCGTGGCA AGGAGGAGCG CCAAGAGCCC 360 AGCACCACGG CACGGAAGGT GGGGCGGCCT GGGAGGAAGC GCAAGCACCC CCCGGTGGAA 420 AGCGGTGACA CGCCAAAGGA CCCTGCGGTG ATCTCCAAGT CCCCATCCAT GGCCCAGGAC 480 TCAGGCGCCT CAGAGCTATT ACCCAATGGG GACTTGGAGA AGCGGAGTGA GCCCCAGCCA 540 GAGGAGGGGA GCCCTGCTGG GGGGCAGAAG GGCGGGGCCC CAGCAGAGGG AGAGGGTGCA 600 GCTGAGACCC TGCCTGAAGC CTCAAGAGCA GTGGAAAATG GCTGCTGCAC CCCCAAGGAG 660 GGCCGAGGAG CCCCTGCAGA AGCGGGCAAA GAACAGAAGG AGACCAACAT CGAATCCATG 720 AAAATGGAGG GCTCCCGGGG CCGGCTGCGG GGTGGCTTGG GCTGGGAGTC CAGCCTCCGT 780 CAGCGGCCCA TGCCGAGGCT CACCTTCCAG GCGGGGGACC CCTACTACAT CAGCAAGCGC 840 AAGCGGGACG AGTGGCTGGC ACGCTGGAAA AGGGAGGCTG AGAAGAAAGC CAAGGTCATT 900 GCAGGAATGA ATGCTGTGGA AGAAAACCAG GGGCCCGGGG AGTCTCAGAA GGTGGAGGAG 960 GCCAGCCCTC CTGCTGTGCA GCAGCCCACT GACCCCGCAT CCCCCACTGT GGCTACCACG 1020 CCTGAGCCCG TGGGGTCCGA TGCTGGGGAC AAGAATGCCA CCAAAGCAGG CGATGACGAG 1080 CCAGAGTACG AGGACGGCCG GGGCTTTGGC ATTGGGGAGC TGGTGTGGGG GAAACTGCGG 1140 GGCTTCTCCT GGTGGCCAGG CCGCATTGTG TCTTGGTGGA TGACGGGCCG GAGCCGAGCA 1200 GCTGAAGGCA CCCGCTGGGT CATGTGGTTC GGAGACGGCA AATTCTCAGT GGTGTGTGTT 1260 GAGAAGCTGA TGCCGCTGAG CTCGTTTTGC AGTGCGTTCC ACCAGGCCAC GTACAACAAG 1320 CAGCCCATGT ACCGCAAAGC CATCTACGAG GTCCTGCAGG TGGCCAGCAG CCGCGCGGGG 1380 AAGCTGTTCC CGGTGTGCCA CGACAGCGAT GAGAGTGACA CTGCCAAGGC CGTGGAGGTG 1440 CAGAACAAGC CCATGATTGA ATGGGCCCTG GGGGGCTTCC AGCCTTCTGG CCCTAAGGGC 1500 CTGGAGCCAC CAGAAGAAGA GAAGAATCCC TACAAAGAAG TGTACACGGA CATGTGGGTG 1560 GAACCTGAGG CAGCTGCCTA CGCACCACCT CCACCAGCCA AAAAGCCCCG GAAGAGCACA 1620 GCGGAGAAGC CCAAGGTCAA GGAGATTATT GATGAGCGCA CAAGAGAGCG GCTGGTGTAC 1680 GAGGTGCGGC AGAAGTGCCG GAACATTGAG GACATCTGCA TCTCCTGTGG GAGCCTCAAT 1740 GTTACCCTGG AACACCCCCT CTTCGTTGGA GGAATGTGCC AAAACTGCAA GAACTGCTTT 1800 CTGGAGTGTG CGTACCAGTA CGACGACGAC GGCTACCAGT CCTACTGCAC CATCTGCTGT 1860 GGGGGCCGTG AGGTGCTCAT GTGCGGAAAC AACAACTGCT GCAGGTGCTT TTGCGTGGAG 1920 TGTGTGGACC TCTTGGTGGG GCCGGGGGCT GCCCAGGCAG CCATTAAGGA AGACCCCTGG 1980 AACTGCTACA TGTGCGGGCA CAAGGGTACC TACGGGCTGC TGCGGCGGCG AGAGGACTGG 2040 CCCTCCCGGC TCCAGATGTT CTTCGCTAAT AACCACGACC AGGAATTTGA CCCTCCAAAG 2100 GTTTACCCAC CTGTCCCAGC TGAGAAGAGG AAGCCCATCC GGGTGCTGTC TCTCTTTGAT 2160 GGAATCGCTA CAGGGCTCCT GGTGCTGAAG GACTTGGGCA TTCAGGTGGA CCGCTACATT 2220 GCCTCGGAGG TGTGTGAGGA CTCCATCACG GTGGGCATGG TGCGGCACCA GGGGAAGATC 2280 ATGTACGTCG GGGACGTCCG CAGCGTCACA CAGAAGCATA TCCAGGAGTG GGGCCCATTC 2340 GATCTGGTGA TTGGGGGCAG TCCCTGCAAT GACCTCTCCA TCGTCAACCC TGCTCGCAAG 2400 GGCCTCTACG AGGGCACTGG CCGGCTCTTC TTTGAGTTCT ACCGCCTCCT GCATGATGCG 2460 CGGCCCAAGG AGGGAGATGA TCGCCCCTTC TTCTGGCTCT TTGAGAATGT GGTGGCCATG 2520 GGCGTTAGTG ACAAGAGGGA CATCTCGCGA TTTCTCGAGT CCAACCCTGT GATGATTGAT 2580 GCCAAAGAAG TGTCAGCTGC ACACAGGGCC CGCTACTTCT GGGGTAACCT TCCCGGTATG 2640 AACAGGCCGT TGGCATCCAC TGTGAATGAT AAGCTGGAGC TGCAGGAGTG TCTGGAGCAT 2700 GGCAGGATAG CCAAGTTCAG CAAAGTGAGG ACCATTACTA CGAGGTCAAA CTCCATAAAG 2760 CAGGGCAAAG ACCAGCATTT TCCTGTCTTC ATGAATGAGA AAGAGGACAT CTTATGGTGC 2820 ACTGAAATGG AAAGGGTATT TGGTTTCCCA GTCCACTATA CTGACGTCTC CAACATGAGC 2880 CGCTTGGCGA GGCAGAGACT GCTGGGCCGG TCATGGAGCG TGCCAGTCAT CCGCCACCTC 2940 TTCGCTCCGC TGAAGGAGTA TTTTGCGTGT GTGTAAGGGA CATGGGGGCA AACTGAGGTA 3000 GCGACACAAA GTTAAACAAA CAAACAAAAA ACACAAAACA TAATAAAACA CCAAGAACAT 3060 GAGGATGGAG AGAAGTATCA GCACCCAGAA GAGAAAAAGG AATTTAAAAC AAAAACCACA 3120 GAGGCGGAAA TACCGGAGGG CTTTGCCTTG CGAAAAGGGT TGGACATCAT CTCCTGATTT 3180 TTCAATGTTA TTCTTCAGTC CTATTTAAAA ACAAAACCAA GCTCCCTTCC CTTCCTCCCC 3240 CTTCCCTTTT TTTTCGGTCA GACCTTTTAT TTTCTACTCT TTTCAGAGGG GTTTTCTGTT 3300 TGTTTGGGTT TTGTTTCTTG CTGTGACTGA AACAAGAAGG TTATTGCAGC AAAAATCAGT 3360 AACAAAAAAT AGTAACAATA CCTTGCAGAG GAAAGGTGGG AGAGAGGAAA AAAGGAAATT 3420 CTATAGAAAT CTATATATTG GGTTGTTTTT TTTTTTGTTT TTTGTTTTTT TTTTTTGGGT 3480 TTTTTTTTTT ACTATATATC TTTTTTTTGT TGTCTCTAGC CTGATCAGAT AGGAGCACAA 3540 GCAGGGGACG GAAAGAGAGA GACACTCAGG CGGCAGCATT CCCTCCCAGC CACTGAGCTG 3600 TCGTGCCAGC ACCATTCCTG GTCACGCAAA ACAGAACCCA GTTAGCAGCA GGGAGACGAG 3660 AACACCACAC AAGACATTTT TCTACAGTAT TTCAGGTGCC TACCACACAG GAAACCTTGA 3720 AGAAAATCAG TTTCTAGAAG CCGCTGTTAC CTCTTGTTTA CAGTTTATAT ATATATGATA 3780 GATATGAGAT ATATATATAA AAGGTACTGT TAACTACTGT ACAACCCGAC TTCATAATGG 3840 TGCTTTCAAA CAGCGAGATG AGTAAAAACA TCAGCTTCCA CGTTGCCTTC TGCGCAAAGG 3900 GTTTCACCAA GGATGGAGAA AGGGAGACAG CTTGCAGATG GCGCGTTCTC ACGGTGGGCT 3960 CTTCCCCTTG GTTTGTAACG AAGTGAAGGA GGAGAACTTG GGAGCCAGGT TCTCCCTGCC 4020 AAAAAGGGGG CTAGATGAGG TGGTCGGGCC CGTGGACAGC TGAGAGTGGG ATTCATCCAG 4080 ACTCATGCAA TAACCCTTTG ATTGTTTTCT AAAAGGAGAC TCCCTCGGCA AGATGGCAGA 4140 GGGTACGGAG TCTTCAGGCC CAGTTTCTCA CTTTAGCCAA TTCGAGGGCT CCTTGTGGTG 4200 GGATCAGAAC TAATCCAGAG TGTGGGAAAG TGACAGTCAA AACCCCACCT GGAGCAAATA 4260 AAAAAACATA CAAAACGTA
Nucleotide Fasta Sequence
>ENSP00000324375.5|PWWP|Homo sapiens GACGCGGCGCCGCGGCACCAGGGCGCGCAGCCGGGCCGGCCCGACCCCACCGGCCATACGGTGGAGCCATCGAAGCCCCCACCCACAGGCTGACAGAGGCACCGTTCACCAGAGGGCTCAACACCGGGATCTATGTTTAAGTTTTAACTCTCGCCTCCAAAGACCACGATAATTCCTTCCCCAAAGCCCAGCAGCCCCCCAGCCCCGCGCAGCCCCAGCCTGCCTCCCGGCGCCCAGATGCCCGCCATGCCCTCCAGCGGCCCCGGGGACACCAGCAGCTCTGCTGCGGAGCGGGAGGAGGACCGAAAGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGCAAAGAACAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGTGGCTTGGGCTGGGAGTCCAGCCTCCGTCAGCGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAGCGGGACGAGTGGCTGGCACGCTGGAAAAGGGAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGGCCCGGGGAGTCTCAGAAGGTGGAGGAGGCCAGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCTGAGCCCGTGGGGTCCGATGCTGGGGACAAGAATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATTGGGGAGCTGGTGTGGGGGAAACTGCGGGGCTTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCTGAAGGCACCCGCTGGGTCATGTGGTTCGGAGACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGTGCGTTCCACCAGGCCACGTACAACAAGCAGCCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAGCTGTTCCCGGTGTGCCACGACAGCGATGAGAGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGGGGCTTCCAGCCTTCTGGCCCTAAGGGCCTGGAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAACCTGAGGCAGCTGCCTACGCACCACCTCCACCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGATGAGCGCACAAGAGAGCGGCTGGTGTACGAGGTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTTACCCTGGAACACCCCCTCTTCGTTGGAGGAATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGCTACCAGTCCTACTGCACCATCTGCTGTGGGGGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTGTGGACCTCTTGGTGGGGCCGGGGGCTGCCCAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTACGGGCTGCTGCGGCGGCGAGAGGACTGGCCCTCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTTTACCCACCTGTCCCAGCTGAGAAGAGGAAGCCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGACTTGGGCATTCAGGTGGACCGCTACATTGCCTCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATGTACGTCGGGGACGTCCGCAGCGTCACACAGAAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGACCTCTCCATCGTCAACCCTGCTCGCAAGGGCCTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGGCCCAAGGAGGGAGATGATCGCCCCTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTTCTCGAGTCCAACCCTGTGATGATTGATGCCAAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAACAGGCCGTTGGCATCCACTGTGAATGATAAGCTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACCATTACTACGAGGTCAAACTCCATAAAGCAGGGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACTGAAATGGAAAGGGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCATGGAGCGTGCCAGTCATCCGCCACCTCTTCGCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCGACACAAAGTTAAACAAACAAACAAAAAACACAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAGAAAAAGGAATTTAAAACAAAAACCACAGAGGCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTCAATGTTATTCTTCAGTCCTATTTAAAAACAAAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTTCTACTCTTTTCAGAGGGGTTTTCTGTTTGTTTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAACAAAAAATAGTAACAATACCTTGCAGAGGAAAGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTTTTTGTTTTTTGTTTTTTTTTTTTGGGTTTTTTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCAGGGGACGGAAAGAGAGAGACACTCAGGCGGCAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACAGAACCCAGTTAGCAGCAGGGAGACGAGAACACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGAAAATCAGTTTCTAGAAGCCGCTGTTACCTCTTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAACTACTGTACAACCCGACTTCATAATGGTGCTTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTTTCACCAAGGATGGAGAAAGGGAGACAGCTTGCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGAGAACTTGGGAGCCAGGTTCTCCCTGCCAAAAAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACTCATGCAATAACCCTTTGATTGTTTTCTAAAAGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTTTAGCCAATTCGAGGGCTCCTTGTGGTGGGATCAGAACTAATCCAGAGTGTGGGAAAGTGACAGTCAAAACCCCACCTGGAGCAAATAAAAAAACATACAAAACGTA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0877--Alternative promoter usage KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0225--Disease mutation KW-0238--DNA-binding KW-0991--Mental retardation KW-0479--Metal-binding KW-0489--Methyltransferase KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0678--Repressor KW-0949--S-adenosyl-L-methionine KW-0808--Transferase KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR025766--ADD IPR018117--C5_DNA_meth_AS IPR001525--C5_MeTfrase IPR030487--DNMT3A IPR000313--PWWP_dom IPR029063--SAM-dependent_MTases
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PROSITE |
PS51533--ADD PS00094--C5_MTASE_1 PS50812--PWWP PS51679--SAM_MT_C5
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Pfam |
PF00145--DNA_methylase PF00855--PWWP
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Gene Ontology |
GO:0000775--C:chromosome, centromeric region GO:0005737--C:cytoplasm GO:0000791--C:euchromatin GO:0005720--C:nuclear heterochromatin GO:0016363--C:nuclear matrix GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0001741--C:XY body GO:0003682--F:chromatin binding GO:0003886--F:DNA (cytosine-5-)-methyltransferase activity GO:0051718--F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates GO:0003677--F:DNA binding GO:0009008--F:DNA-methyltransferase activity GO:0042802--F:identical protein binding GO:0046872--F:metal ion binding GO:0045322--F:unmethylated CpG binding GO:0007568--P:aging GO:0071230--P:cellular response to amino acid stimulus GO:0071361--P:cellular response to ethanol GO:0071456--P:cellular response to hypoxia GO:0006306--P:DNA methylation GO:0043045--P:DNA methylation involved in embryo development GO:0043046--P:DNA methylation involved in gamete generation GO:0010424--P:DNA methylation on cytosine within a CG sequence GO:0097284--P:hepatocyte apoptotic process GO:0044027--P:hypermethylation of CpG island GO:0006346--P:methylation-dependent chromatin silencing GO:0000278--P:mitotic cell cycle GO:0045814--P:negative regulation of gene expression, epigenetic GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0030182--P:neuron differentiation GO:0010942--P:positive regulation of cell death GO:0006349--P:regulation of gene expression by genetic imprinting GO:0036276--P:response to antidepressant GO:0042220--P:response to cocaine GO:0032355--P:response to estradiol GO:0010212--P:response to ionizing radiation GO:0010288--P:response to lead ion GO:0009636--P:response to toxic substance GO:0033189--P:response to vitamin A GO:0046498--P:S-adenosylhomocysteine metabolic process GO:0046499--P:S-adenosylmethioninamine metabolic process GO:0007283--P:spermatogenesis
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Orthology |
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Created Date |
25-Jun-2016 |