WERAM Information

Tag Content
WERAM ID WERAM-Hos-0209
Ensembl Protein ID ENSP00000316114.3
Uniprot Accession Q96ES7; SGF29_HUMAN; Q96MF5
Genbank Protein ID NP_612423.1
Protein Name SAGA-associated factor 29
Genbank Nucleotide ID NM_138414.2
Gene Name Sgf29;CCDC101
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000176476.8 ENST00000317058.7 ENSP00000316114.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader TTD SGF29C-terminal H3K4me2/3 K 21685874
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader TTD 6.20e-49 168 153 293
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.
Domain Profile
  Me_Reader TTD
            TTD.txt   2 dasievGakvaakdr....deewyqaevvkvsaettkyevd..feegkeredlskeyivpleklklrpegdpeaefqkgekVlarypdtt.f 86 
                        d+++++G+kvaa+++    de+w++aevv++s++t+kyevd  +eegker++ls+++++pl+++k++pe+dpea+fqk+++Vla+yp+tt f
  ENSP00000316114.3 153 DYVARPGDKVAARVKavdgDEQWILAEVVSYSHATNKYEVDdiDEEGKERHTLSRRRVIPLPQWKANPETDPEALFQKEQLVLALYPQTTcF 244
                        89***************************************999************************************************ PP
            TTD.txt  87 YpAkvia..skkdgtysvkFe.....Dgssevvkraqvyalskeenkkk 128
                        Y+A+++a  ++++++ysv Fe     Dg+s+++++aq+y+++++e+kkk
  ENSP00000316114.3 245 YRALIHAppQRPQDDYSVLFEdtsyaDGYSPPLNVAQRYVVACKEPKKK 293
                        **********************************************886 PP
Protein Sequence
(Fasta)		MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR 60
GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM 120
TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVARPGD KVAARVKAVD GDEQWILAEV 180
VSYSHATNKY EVDDIDEEGK ERHTLSRRRV IPLPQWKANP ETDPEALFQK EQLVLALYPQ 240
TTCFYRALIH APPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK 293
Nucleotide Sequence
(Fasta)		CGCGCGACTA CGCTCATAAA AGGAAAAAAA AGCGTGTGCG GTTCTCGACG TGCCGCCAAT 60
CTTCGAACGC AGGTCTGTGA TCATCCGCAG ACTCCGAAAA AGGGTTCGAG GAACGCGCCT 120
GCTCCCCTCG TCGCAGTTTC CAGCCCGACG AGCTTGTTTT GTCCCGGACT CGGTGCCCCT 180
GTAGACAATG GCCCTCGTGT CTGCCGATTC CCGCATTGCA GAACTTCTCA CAGAGCTCCA 240
TCAGCTGATC AAACAAACCC AGGAAGAGCG TTCGCGGAGC GAACACAACT TAGTGAACAT 300
CCAGAAGACC CATGAGCGGA TGCAGACAGA GAACAAGATT TCTCCCTATT ACCGGACAAA 360
GCTGCGTGGC CTCTACACAA CCGCCAAGGC CGATGCAGAG GCTGAGTGCA ACATCCTTCG 420
GAAAGCTCTG GACAAGATCG CGGAAATCAA GTCTCTGTTG GAAGAGAGGC GGATTGCGGC 480
CAAGATTGCC GGTCTCTACA ATGACTCGGA GCCACCCCGG AAGACCATGC GCAGAGGGGT 540
GCTGATGACC CTGCTGCAGC AGTCGGCCAT GACCCTGCCC CTGTGGATCG GGAAGCCTGG 600
TGACAAGCCC CCACCCCTCT GTGGGGCCAT CCCTGCCTCA GGAGACTACG TGGCCAGACC 660
TGGAGACAAG GTGGCTGCCC GGGTGAAGGC CGTGGATGGG GACGAGCAGT GGATCCTGGC 720
CGAGGTGGTC AGTTACAGCC ATGCCACCAA CAAGTATGAG GTAGATGACA TCGATGAAGA 780
AGGCAAAGAG AGACACACCC TGAGCCGGCG CCGTGTCATC CCGCTGCCCC AGTGGAAGGC 840
CAACCCGGAG ACGGACCCTG AGGCCTTGTT CCAGAAGGAG CAGCTCGTGC TGGCCCTGTA 900
TCCCCAGACT ACCTGCTTCT ACCGCGCCCT GATCCATGCG CCCCCACAGC GGCCCCAGGA 960
TGACTACTCG GTCCTGTTTG AAGACACCTC CTATGCAGAT GGCTATTCCC CTCCCCTCAA 1020
TGTGGCTCAG AGATACGTGG TGGCTTGTAA GGAACCCAAG AAAAAGTGAT GCCGCCTGGC 1080
AGACTCGCCA TCCCCCAACG ACACAGGGCA GGACAGCAGA GGACGTGCTG GGATTAAACA 1140
CATTCCCCCT CTA 1154
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR010750--SGF29_tudor-like_dom
PROSITE

PS51518--SGF29_C
Pfam

PF07039--DUF1325
Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0070461--C:SAGA-type complex
GO:0035064--F:methylated histone binding
GO:0071169--P:establishment of protein localization to chromatin
GO:0043966--P:histone H3 acetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0064 ENSPPYP00000008178.2 Pongo abelii 100 2e-173 605
WERAM-Paa-0137 ENSPANP00000012534.1 Papio anubis 100 2e-173 605
WERAM-Pat-0061 ENSPTRP00000013546.3 Pan troglodytes 100 2e-173 605
WERAM-Mam-0096 ENSMMUP00000014921.2 Macaca mulatta 100 2e-173 605
WERAM-Caj-0075 ENSCJAP00000012147.2 Callithrix jacchus 100 2e-173 605
WERAM-Gog-0011 ENSGGOP00000000797.2 Gorilla gorilla 100 7e-173 603
WERAM-Dan-0201 ENSDNOP00000030563.1 Dasypus novemcinctus 99 2e-172 601
WERAM-Ova-0024 ENSOARP00000003438.1 Ovis aries 99 2e-172 601
WERAM-Myl-0192 ENSMLUP00000017362.1 Myotis lucifugus 99 2e-172 601
WERAM-Mup-0144 ENSMPUP00000012575.1 Mustela putorius furo 99 2e-172 601
WERAM-Loa-0206 ENSLAFP00000020801.1 Loxodonta africana 99 2e-172 601
WERAM-Ict-0117 ENSSTOP00000011884.2 Ictidomys tridecemlineatus 99 2e-172 601
WERAM-Fec-0124 ENSFCAP00000011410.3 Felis catus 99 2e-172 601
WERAM-Eqc-0075 ENSECAP00000009386.1 Equus caballus 99 2e-172 601
WERAM-Ran-0126 ENSRNOP00000026146.4 Rattus norvegicus 99 7e-172 600
WERAM-Ocp-0094 ENSOPRP00000008519.1 Ochotona princeps 99 1e-171 599
WERAM-Mum-0111 ENSMUSP00000032956.8 Mus musculus 98 2e-171 598
WERAM-Cap-0219 ENSCPOP00000018704.1 Cavia porcellus 98 3e-171 598
WERAM-Sah-0126 ENSSHAP00000013194.1 Sarcophilus harrisii 97 1e-170 595
WERAM-Mod-0138 ENSMODP00000019525.2 Monodelphis domestica 97 4e-170 594
WERAM-Xet-0181 ENSXETP00000063382.1 Xenopus tropicalis 96 6e-168 587
WERAM-Anc-0068 ENSACAP00000006479.1 Anolis carolinensis 96 2e-167 585
WERAM-Nol-0017 ENSNLEP00000001893.1 Nomascus leucogenys 96 4e-166 580
WERAM-Meg-0120 ENSMGAP00000012819.2 Meleagris gallopavo 95 2e-165 578
WERAM-Gaga-0162 ENSGALP00000037055.2 Gallus gallus 95 2e-165 578
WERAM-Caf-0182 ENSCAFP00000025225.3 Canis familiaris 99 9e-165 576
WERAM-Chs-0071 ENSCSAP00000002544.1 Chlorocebus sabaeus 94 3e-161 564
WERAM-Dar-0002 ENSDARP00000002714.7 Danio rerio 91 5e-161 563
WERAM-Pof-0115 ENSPFOP00000010049.1 Poecilia formosa 92 4e-160 560
WERAM-Xim-0132 ENSXMAP00000010959.1 Xiphophorus maculatus 92 5e-160 560
WERAM-Ten-0017 ENSTNIP00000004385.1 Tetraodon nigroviridis 91 2e-159 558
WERAM-Otg-0167 ENSOGAP00000014142.2 Otolemur garnettii 92 5e-159 557
WERAM-Orc-0193 ENSOCUP00000017486.1 Oryctolagus cuniculus 99 9e-159 556
WERAM-Ere-0082 ENSEEUP00000007748.1 Erinaceus europaeus 99 9e-158 553
WERAM-Orn-0114 ENSONIP00000011784.1 Oreochromis niloticus 90 2e-157 552
WERAM-Mim-0098 ENSMICP00000009094.1 Microcebus murinus 92 8e-155 543
WERAM-Dio-0065 ENSDORP00000006564.1 Dipodomys ordii 90 4e-154 541
WERAM-Gam-0004 ENSGMOP00000000324.1 Gadus morhua 89 4e-154 541
WERAM-Asm-0027 ENSAMXP00000003470.1 Astyanax mexicanus 91 2e-135 478
WERAM-Tas-0029 ENSTSYP00000003034.1 Tarsius syrichta 97 5e-123 437
WERAM-Mae-0060 ENSMEUP00000005683.1 Macropus eugenii 97 1e-85 313
WERAM-Amt-0061 ERN13844 Amborella trichopoda 28 2e-13 73.9
WERAM-Osl-0023 ABO96036 Ostreococcus lucimarinus 39 5e-12 68.9
WERAM-Orni-0121 ONIVA12G08890.1 Oryza nivara 27 6e-10 62.0
WERAM-Orr-0122 ORUFI12G10040.1 Oryza rufipogon 26 7e-10 62.0
WERAM-Orgl-0118 OGLUM12G10350.1 Oryza glumaepatula 26 7e-10 62.0
WERAM-Php-0040 PP1S19_93V6.3 Physcomitrella patens 34 7e-09 58.5
WERAM-Pot-0012 POPTR_0001s35610.1 Populus trichocarpa 30 7e-08 55.1
Created Date 25-Jun-2016