WERAM Information

Tag Content
WERAM ID WERAM-Hos-0002
Ensembl Protein ID ENSP00000312244.4
Uniprot Accession Q8N5Y2; MS3L1_HUMAN; A6NCU2; A6NHW8; A8K165; B4DUV8; B7Z227; Q9UG70; Q9Y5Z8
Genbank Protein ID NP_001180199.1; NP_001269103.1; NP_006791.2; NP_523352.1; NP_523353.2; XP_005274497.1; XP_006724524.1
Protein Name Male-specific lethal 3 homolog
Genbank Nucleotide ID NM_001193270.2; NM_001282174.1; NM_006800.3; NM_078628.1; NM_078629.3; XM_005274440.2; XM_006724461.1
Gene Name MSL3;MSL3L1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005302.17 ENST00000312196.8 ENSP00000312244.4
ENSG00000005302.17 ENST00000337339.6 ENSP00000338078.2
ENSG00000005302.17 ENST00000361672.6 ENSP00000354562.2
ENSG00000005302.17 ENST00000380691.2 ENSP00000370067.2
ENSG00000005302.17 ENST00000380692.6 ENSP00000370068.2
ENSG00000005302.17 ENST00000380693.7 ENSP00000370069.3
ENSG00000005302.17 ENST00000398527.6 ENSP00000381538.2
ENSG00000005302.17 ENST00000468149.5 ENSP00000418673.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromo-Barrel Chromo H4K20me K 20657587
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromo-Barrel 4.90e-160 518.5 168 516
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.
Domain Profile
  Me_Reader Chromo-Barrel
            MRG.txt   1 eerkitlkipekLkklledDrelikrrkklvkLPakvnivtilesyvkevavelaisikedsrrekksrgarmnkeYirveknvdllkEvvd 92 
                        eer+it++ipe+Lkk+ledD+++i+rrk+lvkLP+++ni+tilesyvk++a+++a+s++e++r+++++++a+mn++Yi++eknvdl+kE+vd
  ENSP00000312244.4 168 EERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVMPHANMNVHYIPAEKNVDLCKEMVD 259
                        689***************************************************************************************** PP
            MRG.txt  93 GlriyFdvtlddvLLYklErlqydelrssklilnikeeaistsrdqeelsldgtllvessgdstesigvigegatekrkklekellqslkks 184
                        Glri+Fd+tl++vLLY++E++qy++++ssk++l+ike+a+st+r+qeels++++ll++s+++stes++++ge+at+kr+k+e+e+lqsl++s
  ENSP00000312244.4 260 GLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLPIKESATSTNRSQEELSPSPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRS 351
                        ******************************************************************************************** PP
            MRG.txt 185 tknsana.............................lekksPvtsrsksPvelrgs.................lnevlkwklvs.....adk 225
                        t++san+                             lekk+Pv+srs+sP++l++s                 +nevl+wklv+     +d+
  ENSP00000312244.4 352 TRHSANCdrlsessaspqpkrrqqdtsasmpklflhLEKKTPVHSRSSSPIPLTPSkegsavfagfegrrtneINEVLSWKLVPdnyppGDQ 443
                        ************************************************************************************99*9**** PP
            MRG.txt 226 PpepsrvyGAqHLlRLlvklpellsktslsekslklLlkhlddFlkyLaenhdefFdesdyvnateleyetka 298
                        Pp+ps++yGAqHLlRL+vklpe+l+k+s+sek+lk+Llkh+d+Fl++Lae+hd+fF+es+yv+a+e++y+tk+
  ENSP00000312244.4 444 PPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKN 516
                        ***********************************************************************98 PP
Protein Sequence
(Fasta)		MSASEGMKFK FHSGEKVLCF EPDPTKARVL YDAKIVDVIV GKDEKGRKIP EYLIHFNGWN 60
RSWDRWAAED HVLRDTDENR RLQRKLARKA VARLRSTGRK KKRCRLPGVD SVLKGLPTEE 120
KDENDENSLS SSSDCSENKD EEISEESDIE EKTEVKEEPE LQTRREMEER TITIEIPEVL 180
KKQLEDDCYY INRRKRLVKL PCQTNIITIL ESYVKHFAIN AAFSANERPR HHHVMPHANM 240
NVHYIPAEKN VDLCKEMVDG LRITFDYTLP LVLLYPYEQA QYKKVTSSKF FLPIKESATS 300
TNRSQEELSP SPPLLNPSTP QSTESQPTTG EPATPKRRKA EPEALQSLRR STRHSANCDR 360
LSESSASPQP KRRQQDTSAS MPKLFLHLEK KTPVHSRSSS PIPLTPSKEG SAVFAGFEGR 420
RTNEINEVLS WKLVPDNYPP GDQPPPPSYI YGAQHLLRLF VKLPEILGKM SFSEKNLKAL 480
LKHFDLFLRF LAEYHDDFFP ESAYVAACEA HYSTKNPRAI Y 521
Nucleotide Sequence
(Fasta)		CGGCCCCCCC CGGCCACGGC GCACCGCCTC CCCGCCCCCG CCCGCCCTCC CCCACCGCGC 60
GCGCTCCGCC CGCCCCGGAG CCTCGCCCTC CGCCACGATG AGCAAATGAG CGCGAGCGAG 120
GGCATGAAAT TTAAATTCCA CTCAGGGGAG AAAGTGCTGT GCTTCGAGCC TGACCCCACC 180
AAGGCGCGAG TGCTGTACGA TGCCAAGATT GTTGATGTTA TTGTTGGGAA AGACGAAAAA 240
GGCAGAAAGA TCCCAGAATA TCTGATCCAT TTTAATGGTT GGAACAGAAG CTGGGATAGA 300
TGGGCAGCAG AAGATCATGT GCTTCGTGAT ACCGATGAAA ATCGTAGATT ACAGCGTAAA 360
TTGGCAAGAA AAGCTGTAGC TCGCCTGAGG AGCACAGGAA GAAAGAAGAA GCGCTGCAGG 420
TTGCCTGGTG TGGACTCTGT CTTAAAAGGC CTCCCCACTG AAGAAAAAGA TGAAAATGAT 480
GAAAACTCAT TAAGCAGTTC CTCTGACTGT AGTGAAAACA AGGATGAAGA AATAAGTGAA 540
GAAAGTGATA TTGAAGAAAA GACTGAAGTG AAAGAAGAAC CAGAGCTTCA AACAAGAAGG 600
GAAATGGAAG AAAGAACAAT AACTATAGAA ATCCCTGAAG TTCTGAAGAA GCAGCTGGAG 660
GATGATTGTT ACTACATTAA CAGGAGGAAA CGGTTAGTGA AACTTCCATG CCAGACCAAC 720
ATCATAACGA TTTTGGAATC CTATGTGAAG CATTTTGCTA TCAATGCAGC CTTTTCAGCC 780
AATGAGAGGC CTCGTCACCA TCACGTTATG CCACATGCCA ACATGAACGT GCATTATATC 840
CCAGCAGAAA AGAATGTTGA CCTTTGTAAG GAGATGGTGG ATGGATTAAG AATAACCTTT 900
GATTACACTC TCCCGTTGGT TTTACTCTAT CCATATGAAC AAGCTCAGTA TAAAAAGGTG 960
ACTTCGTCTA AATTTTTTCT TCCAATTAAG GAAAGTGCCA CAAGCACTAA CAGGAGCCAG 1020
GAGGAACTCT CTCCCAGTCC GCCTTTGTTG AATCCATCCA CGCCACAGTC CACAGAGAGT 1080
CAGCCGACCA CCGGTGAACC AGCCACCCCC AAAAGGCGCA AAGCTGAGCC AGAAGCATTG 1140
CAGTCTCTGA GGCGGTCCAC GCGCCACAGT GCCAACTGTG ACAGGCTTTC TGAGAGCAGC 1200
GCTTCACCTC AGCCCAAGCG CCGGCAGCAG GACACATCCG CCAGCATGCC CAAGCTCTTC 1260
CTGCACCTGG AAAAGAAGAC ACCTGTGCAT AGCAGATCAT CTTCACCTAT TCCTCTGACT 1320
CCTAGCAAGG AAGGGAGTGC TGTGTTTGCT GGCTTTGAAG GGAGAAGAAC TAATGAAATA 1380
AACGAGGTCC TCTCCTGGAA GCTTGTGCCT GACAATTACC CCCCAGGTGA CCAGCCGCCT 1440
CCACCCTCTT ACATTTATGG GGCACAACAT TTGCTGCGAT TGTTTGTGAA ACTTCCAGAA 1500
ATCCTTGGAA AGATGTCCTT TTCTGAGAAG AATCTGAAGG CTTTATTGAA GCACTTTGAT 1560
CTCTTTTTGA GGTTTTTAGC AGAATACCAC GATGACTTCT TCCCAGAGTC GGCTTATGTC 1620
GCTGCCTGTG AGGCACATTA CAGCACCAAG AACCCCCGGG CAATTTATTA AAATGTTGTT 1680
GGTTCTGTAA GAGCAACTGC TCTGTCTAGT TTGGCGCTCT GGGTTCCAGG TGAATAACTA 1740
ACAAGGTGGT GGGTCTTTAC CCACAGCGCA AACACAATGC CCACCTTGGG GCTCTGTTGT 1800
TTGAGTTGCC CACATACTGC AGTTATTCTG TTAGGAATGA TTCCCTGGGT GCCTGAAAGT 1860
GCTCTGACAC GACACTTGTT ACTTTGCAGG CCATCTGTGA TGGCAAGGAA AAAGCAACTA 1920
TGTTCACAGT GAAATATTCG TGGAATAGGT TAGGCCATTT CAGTAGACAT TGCAGTTAGT 1980
TAGCAAGAAC CACATTGTCT CTTTATTTGT TAGCATTAAA CAAATTTTTT TTTGCAAATT 2040
GGTTTTATTT TTTTGATGAA GCCGAGCAAC TCTGTCCAAA AAGGTTTAGT TTGTACTCGG 2100
AAACCACAAA GTAGTCTCAA AGTATTTTAG AGGGAATCGA TATTGATGGC AAAAGAAAAT 2160
TTGCAGCTAT GCATTTGCTT CTAACGGTTC CCTCTCTGTG AAACATTATT TTTGGTGATC 2220
TAAAGAAAGC ATTGCCTTTC TTATTTGAGA TTTTACAGCT ATACTTTGTT GTGTAATGTT 2280
ATGGTTCCCT TTCTGTAAAA TGTTATTTTT GGTGATCTAA ATAAAGCCTG TCTTGTTTGA 2340
AAGAA 2346
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot
PROSITE

PS51640--MRG
Pfam

PF05712--MRG
PF11717--Tudor-knot
Gene Ontology

GO:0072487--C:MSL complex
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0006338--P:chromatin remodeling
GO:0006342--P:chromatin silencing
GO:0016575--P:histone deacetylation
GO:0043968--P:histone H2A acetylation
GO:0043984--P:histone H4-K16 acetylation
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0192 ENSPPYP00000022509.2 Pongo abelii 100 0.0 811
WERAM-Nol-0096 ENSNLEP00000011055.1 Nomascus leucogenys 100 0.0 810
WERAM-Gog-0075 ENSGGOP00000006441.2 Gorilla gorilla 99 0.0 806
WERAM-Chs-0183 ENSCSAP00000011299.1 Chlorocebus sabaeus 98 0.0 801
WERAM-Pat-0182 ENSPTRP00000038929.3 Pan troglodytes 100 0.0 797
WERAM-Caf-0129 ENSCAFP00000017070.3 Canis familiaris 95 0.0 793
WERAM-Ict-0063 ENSSTOP00000005572.2 Ictidomys tridecemlineatus 91 0.0 791
WERAM-Cap-0048 ENSCPOP00000004224.2 Cavia porcellus 93 0.0 790
WERAM-Sus-0084 ENSSSCP00000012895.2 Sus scrofa 93 0.0 790
WERAM-Bot-0087 ENSBTAP00000030520.4 Bos taurus 92 0.0 788
WERAM-Otg-0062 ENSOGAP00000004494.2 Otolemur garnettii 96 0.0 787
WERAM-Mup-0027 ENSMPUP00000002516.1 Mustela putorius furo 93 0.0 767
WERAM-Dio-0030 ENSDORP00000003216.1 Dipodomys ordii 92 0.0 762
WERAM-Mum-0118 ENSMUSP00000033725.9 Mus musculus 87 0.0 746
WERAM-Paa-0011 ENSPANP00000006015.1 Papio anubis 95 0.0 744
WERAM-Tub-0102 ENSTBEP00000011858.1 Tupaia belangeri 87 0.0 743
WERAM-Caj-0007 ENSCJAP00000001822.2 Callithrix jacchus 97 0.0 734
WERAM-Aim-0110 ENSAMEP00000010677.1 Ailuropoda melanoleuca 92 0.0 717
WERAM-Ova-0120 ENSOARP00000011804.1 Ovis aries 91 0.0 715
WERAM-Eqc-0128 ENSECAP00000014407.1 Equus caballus 95 0.0 712
WERAM-Tut-0098 ENSTTRP00000008231.1 Tursiops truncatus 84 0.0 705
WERAM-Ptv-0044 ENSPVAP00000004729.1 Pteropus vampyrus 91 0.0 701
WERAM-Tas-0115 ENSTSYP00000011734.1 Tarsius syrichta 85 0.0 688
WERAM-Mam-0020 ENSMMUP00000003621.2 Macaca mulatta 95 0.0 687
WERAM-Myl-0037 ENSMLUP00000003509.2 Myotis lucifugus 79 0.0 639
WERAM-Tag-0109 ENSTGUP00000008550.1 Taeniopygia guttata 80 0.0 638
WERAM-Mim-0132 ENSMICP00000013129.1 Microcebus murinus 84 0.0 634
WERAM-Ran-0026 ENSRNOP00000061187.1 Rattus norvegicus 85 1e-178 623
WERAM-Fec-0036 ENSFCAP00000002569.3 Felis catus 97 1e-172 603
WERAM-Vip-0085 ENSVPAP00000007970.1 Vicugna pacos 97 4e-172 602
WERAM-Ere-0122 ENSEEUP00000012841.1 Erinaceus europaeus 97 2e-170 595
WERAM-Dan-0167 ENSDNOP00000019977.1 Dasypus novemcinctus 94 2e-167 586
WERAM-Mod-0158 ENSMODP00000021652.2 Monodelphis domestica 89 3e-159 559
WERAM-Sah-0150 ENSSHAP00000015540.1 Sarcophilus harrisii 89 3e-159 558
WERAM-Ora-0027 ENSOANP00000004172.2 Ornithorhynchus anatinus 89 1e-158 556
WERAM-Anp-0072 ENSAPLP00000008755.1 Anas platyrhynchos 87 2e-156 550
WERAM-Fia-0064 ENSFALP00000004670.1 Ficedula albicollis 87 2e-156 549
WERAM-Gaga-0153 ENSGALP00000026739.4 Gallus gallus 87 2e-156 549
WERAM-Pes-0062 ENSPSIP00000008402.1 Pelodiscus sinensis 87 8e-156 547
WERAM-Meg-0150 ENSMGAP00000015584.1 Meleagris gallopavo 87 9e-156 547
WERAM-Anc-0008 ENSACAP00000001400.2 Anolis carolinensis 86 5e-152 535
WERAM-Lac-0005 ENSLACP00000000561.1 Latimeria chalumnae 72 7e-150 528
WERAM-Leo-0090 ENSLOCP00000012145.1 Lepisosteus oculatus 75 9e-134 474
WERAM-Soa-0080 ENSSARP00000007667.1 Sorex araneus 93 2e-125 446
WERAM-Orc-0211 ENSOCUP00000025036.1 Oryctolagus cuniculus 75 4e-120 429
WERAM-Prc-0054 ENSPCAP00000005002.1 Procavia capensis 86 7e-108 388
WERAM-Xet-0174 ENSXETP00000062098.1 Xenopus tropicalis 62 4e-107 386
WERAM-Orn-0144 ENSONIP00000015236.1 Oreochromis niloticus 62 1e-101 367
WERAM-Tar-0147 ENSTRUP00000031948.1 Takifugu rubripes 60 5e-101 365
WERAM-Xim-0103 ENSXMAP00000009086.1 Xiphophorus maculatus 61 4e-100 362
WERAM-Loa-0174 ENSLAFP00000016634.2 Loxodonta africana 96 6e-100 362
WERAM-Gaa-0153 ENSGACP00000019849.1 Gasterosteus aculeatus 62 9e-100 361
WERAM-Pof-0198 ENSPFOP00000016396.2 Poecilia formosa 60 9e-100 361
WERAM-Ten-0177 ENSTNIP00000017573.1 Tetraodon nigroviridis 62 2e-96 350
WERAM-Asm-0079 ENSAMXP00000008117.1 Astyanax mexicanus 56 3e-92 336
WERAM-Orla-0047 ENSORLP00000005915.1 Oryzias latipes 51 1e-75 281
WERAM-Ect-0117 ENSETEP00000013513.1 Echinops telfairi 92 3e-72 270
WERAM-Gam-0172 ENSGMOP00000017086.1 Gadus morhua 67 4e-49 193
WERAM-Mae-0005 ENSMEUP00000000374.1 Macropus eugenii 65 2e-40 164
WERAM-Pem-0043 ENSPMAP00000005296.1 Petromyzon marinus 66 1e-37 155
WERAM-Cis-0071 ENSCSAVP00000015365.1 Ciona savignyi 60 2e-22 104
WERAM-Drm-0006 FBpp0076635 Drosophila melanogaster 51 1e-14 78.6
WERAM-Dar-0092 ENSDARP00000112985.1 Danio rerio 39 2e-09 61.2
WERAM-Glm-0056 GLYMA06G04620.1 Glycine max 54 7e-09 59.7
WERAM-Asfu-0038 CADAFUAP00008363 Aspergillus fumigatus 39 9e-09 59.3
WERAM-Asc-0018 CADACLAP00004414 Aspergillus clavatus 39 1e-08 58.9
WERAM-Coi-0009 EAS36116 Coccidioides immitis 38 3e-08 57.8
WERAM-Asni-0012 CADANGAP00004222 Aspergillus niger 38 3e-08 57.4
WERAM-Aso-0013 CADAORAP00001673 Aspergillus oryzae 41 5e-08 56.6
WERAM-Asn-0032 CADANIAP00008637 Aspergillus nidulans 40 8e-08 56.2
WERAM-Yal-0008 CAG80821 Yarrowia lipolytica 38 2e-07 55.1
WERAM-Prp-0089 EMJ27088 Prunus persica 44 3e-07 53.9
WERAM-Sot-0010 PGSC0003DMT400008563 Solanum tuberosum 52 4e-07 53.5
WERAM-Sol-0036 Solyc02g092910.2.1 Solanum lycopersicum 49 5e-07 53.5
WERAM-Aet-0017 EMT06876 Aegilops tauschii 35 5e-07 53.5
WERAM-Arl-0141 scaffold_700360.1 Arabidopsis lyrata 42 8e-07 52.8
WERAM-Art-0002 AT1G02740.1 Arabidopsis thaliana 48 8e-07 52.8
WERAM-Thc-0003 EOX91556 Theobroma cacao 49 8e-07 52.8
WERAM-Tum-0023 CAZ84135 Tuber melanosporum 33 2e-06 51.6
WERAM-Mua-0073 GSMUA_Achr4P12960_001 Musa acuminata 36 3e-06 51.2
Created Date 25-Jun-2016