WERAM Information

Tag Content
WERAM ID WERAM-Hos-0190
Ensembl Protein ID ENSP00000307183.3
Uniprot Accession Q9H160; ING2_HUMAN; B6ZDS1; O95698
Genbank Protein ID NP_001278888.1; NP_001555.1
Protein Name Inhibitor of growth protein 2
Genbank Nucleotide ID NM_001291959.1; NM_001564.3
Gene Name ING2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168556.6 ENST00000302327.3 ENSP00000307183.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 17884155
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 2.50e-12 49 213 259
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Domain Profile
  Me_Reader PHD
            PHD.txt   2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCk 51 
                        t+Cl C+++++ge  m+ Cd+  C+ +wfH +Cv+l+    p+g +wyCp+C+
  ENSP00000307183.3 213 TYCL-CNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT--YKPKG-KWYCPKCR 259
                        89*9.*******6..**********************..*****.*******8 PP
Protein Sequence
(Fasta)		MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 60
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 120
HSQCFQDPAE SERASDKAKM DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE 180
KKSKSAKKKK RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF 240
SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR
Nucleotide Sequence
(Fasta)		CGCCCCTGGG CTGGTGCTGC GGGGGCGGGG AGTGAGGGCT GCTCTGGGGG GAGTGGAGAT 60
CGGGGAGCGC GGCCGTGCCC TCTCGAGCGG CTGCGGGGTC CCCGCGGCGC CGGGCTGCTG 120
AGCTGAGGGC CCGCGGCGGC CGCGGCCGGT GCATGTGCGG CTGCTGGATG CGGAGGCGGC 180
GGCGACGGCG CGGATCGGCA GGATGTTAGG GCAGCAGCAG CAGCAACTGT ACTCGTCGGC 240
CGCGCTCCTG ACCGGGGAGC GGAGCCGGCT GCTCACCTGC TACGTGCAGG ACTACCTTGA 300
GTGCGTGGAG TCGCTGCCCC ACGACATGCA GAGGAACGTG TCTGTGCTGC GAGAGCTGGA 360
CAACAAATAT CAAGAAACGT TAAAGGAAAT TGATGATGTC TACGAAAAAT ATAAGAAAGA 420
AGATGATTTA AACCAGAAGA AACGTCTACA GCAGCTTCTC CAGAGAGCAC TAATTAATAG 480
TCAAGAATTG GGAGATGAAA AAATACAGAT TGTTACACAA ATGCTCGAAT TGGTGGAAAA 540
TCGGGCAAGA CAAATGGAGT TACACTCACA GTGTTTCCAA GATCCTGCTG AAAGTGAACG 600
AGCCTCAGAT AAAGCAAAGA TGGATTCCAG CCAACCAGAA AGATCTTCAA GAAGACCCCG 660
CAGGCAGCGG ACCAGTGAAA GCCGTGATTT ATGTCACATG GCAAATGGGA TTGAAGACTG 720
TGATGATCAG CCACCTAAAG AAAAGAAATC CAAGTCAGCA AAGAAAAAGA AACGCTCCAA 780
GGCCAAGCAG GAAAGGGAAG CTTCACCTGT TGAGTTTGCA ATAGATCCTA ATGAACCTAC 840
ATACTGCTTA TGCAACCAAG TGTCTTATGG GGAGATGATA GGATGTGACA ATGAACAGTG 900
TCCAATTGAA TGGTTTCACT TTTCATGTGT TTCACTTACC TATAAACCAA AGGGGAAATG 960
GTATTGCCCA AAGTGCAGGG GAGATAATGA GAAAACAATG GACAAAAGTA CTGAAAAGAC 1020
AAAAAAGGAT AGAAGATCGA GGTAGTAAAG GCCATCCACA TTTTAAAGGG TTATTTGTCT 1080
TTTATATAAT TCGTTTGCTT TCAGAAAATG TTTTAGGGTA AATGCATAAG ACTATGCAAT 1140
AATTTTTAAT CATTAGTATT AATGGTGTAT TAAAAGTTGT TGTACTTTG
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0035091--F:phosphatidylinositol binding
GO:0032403--F:protein complex binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:0008285--P:negative regulation of cell proliferation
GO:1902166--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065--P:positive regulation of apoptotic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0040008--P:regulation of growth
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0072520--P:seminiferous tubule development
GO:0007165--P:signal transduction
GO:0030317--P:sperm motility
GO:0007286--P:spermatid development
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Paa-0070 ENSPANP00000001839.1 Papio anubis 100 8e-114 407
WERAM-Mam-0072 ENSMMUP00000011648.2 Macaca mulatta 100 8e-114 407
WERAM-Chs-0033 ENSCSAP00000015014.1 Chlorocebus sabaeus 100 8e-114 407
WERAM-Sus-0166 ENSSSCP00000028185.1 Sus scrofa 99 1e-113 406
WERAM-Poa-0135 ENSPPYP00000017012.2 Pongo abelii 100 2e-113 405
WERAM-Mim-0014 ENSMICP00000001205.1 Microcebus murinus 100 2e-113 405
WERAM-Fec-0192 ENSFCAP00000019449.1 Felis catus 98 1e-112 403
WERAM-Vip-0056 ENSVPAP00000005332.1 Vicugna pacos 98 3e-112 401
WERAM-Ptv-0141 ENSPVAP00000011934.1 Pteropus vampyrus 99 4e-112 401
WERAM-Aim-0091 ENSAMEP00000008687.1 Ailuropoda melanoleuca 98 6e-112 400
WERAM-Ict-0126 ENSSTOP00000012796.2 Ictidomys tridecemlineatus 98 7e-112 400
WERAM-Caf-0090 ENSCAFP00000011661.2 Canis familiaris 98 2e-111 399
WERAM-Orc-0119 ENSOCUP00000010152.3 Oryctolagus cuniculus 99 5e-111 397
WERAM-Otg-0175 ENSOGAP00000014951.2 Otolemur garnettii 99 6e-111 397
WERAM-Bot-0224 ENSBTAP00000054457.1 Bos taurus 98 1e-110 396
WERAM-Dio-0155 ENSDORP00000014378.1 Dipodomys ordii 96 2e-110 395
WERAM-Eqc-0120 ENSECAP00000013009.1 Equus caballus 99 2e-110 395
WERAM-Dan-0032 ENSDNOP00000003012.2 Dasypus novemcinctus 98 3e-110 395
WERAM-Cap-0134 ENSCPOP00000010891.2 Cavia porcellus 96 5e-110 394
WERAM-Mum-0214 ENSMUSP00000079226.2 Mus musculus 96 9e-110 393
WERAM-Ran-0086 ENSRNOP00000018689.4 Rattus norvegicus 96 2e-109 392
WERAM-Ect-0001 ENSETEP00000000063.1 Echinops telfairi 97 3e-109 391
WERAM-Ova-0072 ENSOARP00000007677.1 Ovis aries 98 4e-109 391
WERAM-Gog-0204 ENSGGOP00000017999.1 Gorilla gorilla 99 2e-108 389
WERAM-Sah-0143 ENSSHAP00000014993.1 Sarcophilus harrisii 92 3e-104 375
WERAM-Mod-0032 ENSMODP00000005181.3 Monodelphis domestica 93 5e-104 374
WERAM-Mae-0079 ENSMEUP00000007772.1 Macropus eugenii 92 3e-101 365
WERAM-Prc-0101 ENSPCAP00000009149.1 Procavia capensis 96 2e-97 352
WERAM-Mup-0125 ENSMPUP00000010954.1 Mustela putorius furo 97 9e-90 327
WERAM-Lac-0118 ENSLACP00000014384.1 Latimeria chalumnae 81 3e-85 312
WERAM-Pat-0135 ENSPTRP00000028526.3 Pan troglodytes 100 1e-83 306
WERAM-Tas-0017 ENSTSYP00000002061.1 Tarsius syrichta 99 5e-83 305
WERAM-Loa-0132 ENSLAFP00000012180.2 Loxodonta africana 99 5e-83 304
WERAM-Nol-0114 ENSNLEP00000013029.1 Nomascus leucogenys 99 7e-83 304
WERAM-Caj-0059 ENSCJAP00000010218.2 Callithrix jacchus 99 8e-83 303
WERAM-Tut-0111 ENSTTRP00000009087.1 Tursiops truncatus 99 1e-82 303
WERAM-Ere-0043 ENSEEUP00000003677.1 Erinaceus europaeus 98 3e-82 302
WERAM-Anc-0071 ENSACAP00000006812.3 Anolis carolinensis 81 5e-81 298
WERAM-Soa-0115 ENSSARP00000010879.1 Sorex araneus 96 2e-80 296
WERAM-Asm-0005 ENSAMXP00000000685.1 Astyanax mexicanus 72 1e-77 286
WERAM-Xet-0119 ENSXETP00000041302.3 Xenopus tropicalis 70 9e-75 277
WERAM-Anp-0003 ENSAPLP00000000292.1 Anas platyrhynchos 90 1e-74 276
WERAM-Tag-0099 ENSTGUP00000006752.1 Taeniopygia guttata 90 2e-74 276
WERAM-Gaga-0105 ENSGALP00000017323.5 Gallus gallus 90 4e-74 275
WERAM-Meg-0069 ENSMGAP00000006505.2 Meleagris gallopavo 90 4e-74 275
WERAM-Fia-0171 ENSFALP00000015237.1 Ficedula albicollis 90 5e-74 275
WERAM-Dar-0238 ENSDARP00000134787.1 Danio rerio 72 8e-73 270
WERAM-Gam-0075 ENSGMOP00000008031.1 Gadus morhua 62 2e-72 269
WERAM-Pof-0169 ENSPFOP00000014200.1 Poecilia formosa 66 7e-71 264
WERAM-Orn-0189 ENSONIP00000019769.1 Oreochromis niloticus 66 1e-70 263
WERAM-Xim-0083 ENSXMAP00000007731.1 Xiphophorus maculatus 66 2e-70 263
WERAM-Gaa-0007 ENSGACP00000001097.1 Gasterosteus aculeatus 62 2e-70 263
WERAM-Myl-0204 ENSMLUP00000021136.1 Myotis lucifugus 79 2e-68 256
WERAM-Ten-0001 ENSTNIP00000000290.1 Tetraodon nigroviridis 62 6e-65 244
WERAM-Tar-0165 ENSTRUP00000035350.1 Takifugu rubripes 61 2e-64 243
WERAM-Pes-0156 ENSPSIP00000018616.1 Pelodiscus sinensis 59 1e-60 230
WERAM-Ora-0131 ENSOANP00000024605.3 Ornithorhynchus anatinus 58 2e-59 226
WERAM-Leo-0081 ENSLOCP00000011043.1 Lepisosteus oculatus 60 8e-54 207
WERAM-Orla-0129 ENSORLP00000015380.1 Oryzias latipes 59 3e-50 196
WERAM-Chh-0082 ENSCHOP00000008858.1 Choloepus hoffmanni 58 2e-47 186
WERAM-Ocp-0050 ENSOPRP00000004396.1 Ochotona princeps 78 5e-36 148
WERAM-Pem-0082 ENSPMAP00000008755.1 Petromyzon marinus 67 2e-29 126
WERAM-Tub-0041 ENSTBEP00000005072.1 Tupaia belangeri 33 5e-29 125
WERAM-Cii-0033 ENSCINP00000012930.3 Ciona intestinalis 31 4e-27 119
WERAM-Drm-0046 FBpp0080103 Drosophila melanogaster 74 7e-27 118
WERAM-Cis-0005 ENSCSAVP00000000824.1 Ciona savignyi 72 8e-25 111
Created Date 25-Jun-2016