WERAM Information

Tag Content
WERAM ID WERAM-Hos-0172
Ensembl Protein ID ENSP00000292616.5
Uniprot Accession Q9UFC0; LRWD1_HUMAN; A8K4K2; B2R9G2; Q8N0T9; Q8WV43; Q96GJ2
Genbank Protein ID NP_001304650.1; NP_690852.1
Protein Name Leucine-rich repeat and WD repeat-containing protein 1
Genbank Nucleotide ID NM_001317721.1; NM_152892.2
Gene Name LRWD1;CENP33;ORCA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000161036.10 ENST00000292616.9 ENSP00000292616.5
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader WD40 WD1-7 H3K9me3 K 20850016
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader WD40 2.60e-132 443.4 290 646
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Domain Profile
  Me_Reader WD40
           WD40.txt   1 dhekelsavkfepaseega.slvaatvgseavtvydcqtqgeikllqkykghdeefysvawt.......adsnkrhslLasAgdrglirlld 84 
                        d+e++l+a++fepa+eega s+++at+g+eav+v+dcqt+   ++l+kyk+++eef+svawt       a+++kr+s+La+Ag+rgl+rll+
  ENSP00000292616.5 290 DLETQLWACAFEPAWEEGAtSQTVATCGGEAVCVIDCQTG---IVLHKYKAPGEEFFSVAWTalmvvtqAGHKKRWSVLAAAGLRGLVRLLH 378
                        789*************************************...************************************************* PP
           WD40.txt  85 veagqcikvlvgHknaiaelkFsPkdenlllsaSfdkrvrlWdiktdklkkifeahsdevldvdyd.lrgslivSc.......gmdgslkiW 168
                        v+ag+c++v+++Hk+aia+l+FsP++e++l++aS+dkr++lWdi++++++++f+a+++++ld++++ lr+++++Sc       g++g++++W
  ENSP00000292616.5 379 VRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQDYEFQASQLLTLDTTSIpLRLCPVASCpdarllaGCEGGCCCW 470
                        ******************************************************************************************** PP
           WD40.txt 169 dvr....skrrvcevklvddenpeksnrrVdcvrfsngdlils.gsldntivlWdir.....kikqsevavvvLkrfeyskteiyyislsfs 250
                        dvr    +krrvcev++v++e++e+s+rrVd+++f+n+d+++s gs+++ti+lW++r     +++qs+vavvvL+r+++s+te++y+sls++
  ENSP00000292616.5 471 DVRldqpQKRRVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASkGSGLGTICLWSWRqtwggRGSQSTVAVVVLARLQWSSTELAYFSLSAC 562
                        ******************************************************************************************** PP
           WD40.txt 251 vdnkkilvsgdedgkvyvwdls........veaalkakelllk......lgkvtakimqtsvspnesiiiltaltddnivkiWdr 321
                        +d k+i+++gde+g+v+++d+s        ++aal+a++++lk      lg+v++k+m+++v++n+s+++ltaltd+niv+iW+r
  ENSP00000292616.5 563 PD-KGIVLCGDEEGNVWLYDVSnilkqpplLPAALQAPTQILKwpqpwaLGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGR 646
                        **.********************************************************************************98 PP
Protein Sequence
(Fasta)		MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ ELDLSNNHLE 60
TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG NPFLTVNDNL KVSFLLPTLR 120
KVNGKDASST YSQVENLNRE LTSRVTAHWE KFMATLGPEE EAEKAQADFV KSAVRDVRYG 180
PESLSEFTQW RVRMISEELV AASRTQVQKA NSPEKPPEAG AAHKPRARLA ALKRPDDVPL 240
SLSPSKRACA SPSAQVEGSP VAGSDGSQPA VKLEPLHFLQ CHSKNNSPQD LETQLWACAF 300
EPAWEEGATS QTVATCGGEA VCVIDCQTGI VLHKYKAPGE EFFSVAWTAL MVVTQAGHKK 360
RWSVLAAAGL RGLVRLLHVR AGFCCGVIRA HKKAIATLCF SPAHETHLFT ASYDKRIILW 420
DIGVPNQDYE FQASQLLTLD TTSIPLRLCP VASCPDARLL AGCEGGCCCW DVRLDQPQKR 480
RVCEVEFVFS EGSEASGRRV DGLAFVNEDI VASKGSGLGT ICLWSWRQTW GGRGSQSTVA 540
VVVLARLQWS STELAYFSLS ACPDKGIVLC GDEEGNVWLY DVSNILKQPP LLPAALQAPT 600
QILKWPQPWA LGQVVTKTMV NTVVANASFT YLTALTDSNI VAIWGRM 647
Nucleotide Sequence
(Fasta)		GCTTCCTTCC GGTCGTTAAC GCCCACGGGC TCGCGCGGCG CCGCCTCCTG GGCTCAGTTA 60
CCGCGGACGC CAGTGCCGGG CTCCAGGAGA CGCAGGGCGA CGCCACACGC CGGGGTGGCC 120
GACTGGGTCA GCGCGGGCTG CGCCTCCTCG CCATGGGCCC CCTCTCGGCG CGGCTGCTAA 180
TGCAGCGCGG GCGCCCCAAG AGCGACCGGC TGGGGAAGAT CCGGAGTCTG GACCTGTCAG 240
GATTGGAGCT GCTTTCCGAG CACCTGGACC CCAAACTCCT GTGCCGCCTG ACGCAGCTGC 300
AGGAGCTTGA CCTGTCTAAC AACCACCTGG AGACGCTGCC GGACAACCTG GGCCTGTCCC 360
ACCTGCGTGT CCTCCGCTGC GCCAACAACC AGCTGGGGGA TGTTACTGCC TTGTGCCAGT 420
TCCCCAAGCT CGAGGAACTC AGCCTGGAGG GCAACCCCTT CCTGACGGTC AATGACAACC 480
TGAAAGTCTC CTTTCTCCTG CCCACGCTCC GTAAGGTCAA TGGCAAGGAT GCGTCCTCAA 540
CTTACTCTCA GGTGGAGAAC CTGAATCGGG AGCTGACCAG CAGGGTCACA GCTCACTGGG 600
AGAAGTTCAT GGCCACACTG GGTCCTGAAG AGGAGGCTGA GAAGGCCCAG GCGGACTTTG 660
TGAAGTCGGC TGTCAGGGAT GTCCGCTACG GGCCCGAGTC CCTCAGCGAG TTCACCCAGT 720
GGCGGGTGCG GATGATCTCT GAGGAGCTGG TGGCCGCCAG TAGGACCCAG GTGCAAAAGG 780
CTAACAGCCC AGAGAAGCCC CCAGAAGCTG GAGCTGCCCA CAAGCCCAGG GCCAGACTGG 840
CGGCCTTGAA ACGGCCAGAC GACGTCCCAC TCAGCCTCTC TCCCAGCAAG CGGGCGTGTG 900
CCTCCCCGTC GGCCCAGGTG GAGGGCAGCC CTGTGGCAGG CTCCGATGGC AGCCAGCCTG 960
CTGTGAAGCT GGAGCCCCTG CACTTCCTGC AGTGCCACAG CAAGAACAAC AGCCCCCAGG 1020
ACCTCGAGAC CCAGCTGTGG GCCTGTGCCT TCGAGCCGGC CTGGGAGGAG GGGGCCACAT 1080
CCCAGACCGT GGCCACGTGC GGCGGGGAGG CTGTGTGCGT AATTGATTGC CAGACGGGCA 1140
TCGTGCTCCA CAAGTACAAG GCACCCGGCG AGGAGTTCTT TTCTGTGGCC TGGACCGCTC 1200
TGATGGTGGT CACACAGGCT GGCCACAAGA AGCGCTGGAG TGTGCTGGCG GCTGCAGGCC 1260
TACGGGGCCT GGTCCGGCTG CTGCACGTGC GTGCCGGCTT CTGCTGCGGG GTCATCCGAG 1320
CCCACAAGAA GGCCATCGCC ACCCTGTGCT TCAGCCCCGC CCACGAGACC CATCTCTTCA 1380
CGGCCTCCTA TGACAAGCGG ATCATCCTCT GGGACATCGG GGTGCCCAAC CAGGACTACG 1440
AATTCCAGGC CAGCCAGCTG CTCACACTGG ACACCACCTC TATCCCCCTG CGCCTCTGCC 1500
CTGTCGCCTC CTGCCCGGAC GCCCGCCTGC TGGCCGGCTG CGAGGGCGGC TGCTGCTGCT 1560
GGGACGTGCG GCTGGACCAG CCCCAAAAGA GGAGGGTGTG TGAAGTGGAA TTCGTCTTCT 1620
CTGAGGGCTC CGAGGCATCT GGACGGAGAG TGGATGGGCT GGCATTTGTG AATGAGGACA 1680
TCGTGGCCTC CAAGGGGAGC GGCCTGGGCA CCATCTGCCT GTGGAGCTGG AGGCAGACGT 1740
GGGGGGGCCG GGGCAGCCAG TCCACGGTGG CAGTGGTGGT CCTGGCGCGG CTGCAATGGT 1800
CGTCCACCGA GTTGGCCTAC TTCTCGCTCA GCGCCTGCCC TGATAAGGGG ATTGTGCTCT 1860
GTGGGGATGA GGAGGGCAAC GTGTGGCTCT ACGACGTCAG CAACATCCTG AAGCAGCCAC 1920
CCCTGCTGCC GGCAGCCCTG CAGGCCCCCA CACAGATCCT GAAGTGGCCC CAGCCCTGGG 1980
CCCTTGGCCA GGTGGTGACC AAGACCATGG TGAACACAGT GGTGGCCAAT GCCTCCTTCA 2040
CCTACCTCAC CGCCCTGACG GACTCCAACA TCGTAGCCAT CTGGGGGAGG ATGTAGCCTC 2100
ACACCATCGC AAAGGACCAG GGACACAGCT AACTAACTTA TTCAGCTTTG GGCCGATGGG 2160
GGTGGGGGGG GGTCTTTCAG TGAATATTTT TATTAAACTC TACTGTGGAC AAGAA 2216
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0235--DNA replication
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0853--WD repeat
--
Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR025875--Leu-rich_rpt_4
IPR003591--Leu-rich_rpt_typical-subtyp
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS51450--LRR
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12799--LRR_4
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0031933--C:telomeric heterochromatin
GO:0003682--F:chromatin binding
GO:0008327--F:methyl-CpG binding
GO:0035064--F:methylated histone binding
GO:0016568--P:chromatin modification
GO:0006325--P:chromatin organization
GO:0006270--P:DNA replication initiation
GO:0071169--P:establishment of protein localization to chromatin
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0202 ENSGGOP00000025398.1 Gorilla gorilla 100 0.0 1214
WERAM-Pat-0162 ENSPTRP00000033454.4 Pan troglodytes 100 0.0 1214
WERAM-Poa-0159 ENSPPYP00000019572.2 Pongo abelii 98 0.0 1199
WERAM-Mam-0100 ENSMMUP00000015768.2 Macaca mulatta 98 0.0 1196
WERAM-Chs-0214 ENSCSAP00000014105.1 Chlorocebus sabaeus 97 0.0 1186
WERAM-Caj-0168 ENSCJAP00000029831.2 Callithrix jacchus 95 0.0 1168
WERAM-Paa-0219 ENSPANP00000008728.1 Papio anubis 96 0.0 1159
WERAM-Nol-0084 ENSNLEP00000010177.1 Nomascus leucogenys 95 0.0 1142
WERAM-Eqc-0135 ENSECAP00000015157.1 Equus caballus 89 0.0 1068
WERAM-Dan-0064 ENSDNOP00000006444.3 Dasypus novemcinctus 87 0.0 1063
WERAM-Mup-0181 ENSMPUP00000015856.1 Mustela putorius furo 87 0.0 1056
WERAM-Sus-0052 ENSSSCP00000008209.2 Sus scrofa 87 0.0 1053
WERAM-Caf-0147 ENSCAFP00000020197.3 Canis familiaris 87 0.0 1046
WERAM-Loa-0076 ENSLAFP00000005701.3 Loxodonta africana 86 0.0 1045
WERAM-Myl-0116 ENSMLUP00000009526.2 Myotis lucifugus 86 0.0 1043
WERAM-Ict-0065 ENSSTOP00000005680.2 Ictidomys tridecemlineatus 85 0.0 1042
WERAM-Tut-0164 ENSTTRP00000014076.1 Tursiops truncatus 86 0.0 1040
WERAM-Otg-0089 ENSOGAP00000007382.2 Otolemur garnettii 81 0.0 1031
WERAM-Ptv-0187 ENSPVAP00000016762.1 Pteropus vampyrus 84 0.0 1014
WERAM-Cap-0010 ENSCPOP00000001265.2 Cavia porcellus 83 0.0 1006
WERAM-Orc-0122 ENSOCUP00000010328.2 Oryctolagus cuniculus 83 0.0 1003
WERAM-Ova-0155 ENSOARP00000015317.1 Ovis aries 81 0.0 966
WERAM-Mim-0101 ENSMICP00000009393.1 Microcebus murinus 81 0.0 962
WERAM-Bot-0135 ENSBTAP00000019617.5 Bos taurus 79 0.0 961
WERAM-Fec-0004 ENSFCAP00000000347.2 Felis catus 84 0.0 960
WERAM-Mum-0102 ENSMUSP00000006301.4 Mus musculus 78 0.0 944
WERAM-Ran-0013 ENSRNOP00000001940.7 Rattus norvegicus 78 0.0 939
WERAM-Ocp-0111 ENSOPRP00000010943.1 Ochotona princeps 78 0.0 917
WERAM-Prc-0034 ENSPCAP00000003012.1 Procavia capensis 75 0.0 883
WERAM-Dio-0060 ENSDORP00000005556.1 Dipodomys ordii 81 0.0 814
WERAM-Aim-0173 ENSAMEP00000016321.1 Ailuropoda melanoleuca 85 0.0 679
WERAM-Ere-0107 ENSEEUP00000011616.1 Erinaceus europaeus 76 1e-169 593
WERAM-Tub-0035 ENSTBEP00000004172.1 Tupaia belangeri 89 3e-138 489
Created Date 25-Jun-2016