WERAM Information

Tag Content
WERAM ID WERAM-Hos-0115
Ensembl Protein ID ENSP00000264108.4
Uniprot Accession O14929; HAT1_HUMAN; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9;
Genbank Protein ID NP_003633.1;
Protein Name Histone acetyltransferase 1;
Genbank Nucleotide ID NM_003642.3;
Gene Name HAT1;KAT1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000128708.12 ENST00000264108.4 ENSP00000264108.4
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HAT1 H2AK5; H4K5; H4K12 K 24682716
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HAT1 1.70e-62 212.7 25 406
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
Domain Profile
  HAT HAT1
           HAT1.txt   1 rvveanevielllveakeeidtdistfkpeilyqlfgddetifGYkdlkvtvhylaksldeyidvkYsskinkekgscleaddveskleqki 92 
                        +++++n++iel+lv+++e++++di+tf+pe+++qlfgddet+fGYk+lk+ ++y+a+sl+++++v+Y+sk+ +e+++c+eaddve+k++q i
  ENSP00000264108.4  25 YKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKV-DENFDCVEADDVEGKIRQ-I 114
                        589********************************************************************.******************.* PP
           HAT1.txt  93 teetivdnkeeFlqlldkqddFkpfgelihkyrklgkd......feiykaedlsdeflellerlqtlelfFie 159
                        +++++++n+++Fl+ll+k+ dFkpfg+l+h+y++l+ +      f+iyka++++++f+e++erlqt++++Fie
  ENSP00000264108.4 115 IPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTggenftFQIYKADMTCRGFREYHERLQTFLMWFIE 187
                        ************************************************************************8 PP
           HAT1.txt  78 cleaddveskleqkiteeti..vdnkeeFlqll 108
                        cl+++ + ++++q  +e+++  ++ +e+F++l+
  ENSP00000264108.4 376 CLRPEELTNQMNQ--IEISMqhEQLEESFQELV 406
                        5666666666666..222220033345555554 PP
Protein Sequence
(Fasta)		MAGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT FFPEYTHQLF 60
GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD CVEADDVEGK IRQIIPPGFC 120
TNTNDFLSLL EKEVDFKPFG TLLHTYSVLS PTGGENFTFQ IYKADMTCRG FREYHERLQT 180
FLMWFIETAS FIDVDDERWH YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ 240
MLILTPFQGQ GHGAQLLETV HRYYTEFPTV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF 300
SREKLMQGFN EDMVIEAQQK FKINKQHARR VYEILRLLVT DMSDAEQYRS YRLDIKRRLI 360
SPYKKKQRDL AKMRKCLRPE ELTNQMNQIE ISMQHEQLEE SFQELVEDYR RVIERLAQE 419
Nucleotide Sequence
(Fasta)		CGTCCTTCCT CAGCCGCGGG TGATCGTAGC TCGGAAATGG CGGGATTTGG TGCTATGGAG 60
AAATTTTTGG TAGAATATAA GAGTGCAGTG GAGAAGAAAC TGGCAGAGTA CAAATGTAAC 120
ACCAACACAG CAATTGAACT AAAATTAGTT CGTTTTCCTG AAGATCTTGA AAATGACATT 180
AGAACTTTCT TTCCTGAGTA TACCCATCAA CTCTTTGGGG ATGATGAAAC TGCTTTTGGT 240
TACAAGGGTC TAAAGATCCT GTTATACTAT ATTGCTGGTA GCCTGTCAAC AATGTTCCGT 300
GTTGAATATG CATCTAAAGT TGATGAGAAC TTTGACTGTG TAGAGGCAGA TGATGTTGAG 360
GGCAAAATTA GACAAATCAT TCCACCTGGA TTTTGCACAA ACACGAATGA TTTCCTTTCT 420
TTACTGGAAA AGGAAGTTGA TTTCAAGCCA TTCGGAACCT TACTTCATAC CTACTCAGTT 480
CTCAGTCCAA CAGGAGGAGA AAACTTTACC TTTCAGATAT ATAAGGCTGA CATGACATGT 540
AGAGGCTTTC GAGAATATCA TGAAAGGCTT CAGACCTTTT TGATGTGGTT TATTGAAACT 600
GCTAGCTTTA TTGACGTGGA TGATGAAAGA TGGCACTACT TTCTAGTATT TGAGAAGTAT 660
AATAAGGATG GAGCTACGCT CTTTGCGACC GTAGGCTACA TGACAGTCTA TAATTACTAT 720
GTGTACCCAG ACAAAACCCG GCCACGTGTA AGTCAGATGC TGATTTTGAC TCCATTTCAA 780
GGTCAAGGCC ATGGTGCTCA ACTTCTTGAA ACAGTTCATA GATACTACAC TGAATTTCCT 840
ACAGTTCTTG ATATTACAGC GGAAGATCCA TCCAAAAGCT ATGTGAAATT ACGAGACTTT 900
GTGCTTGTGA AGCTTTGTCA AGATTTGCCC TGTTTTTCCC GGGAAAAATT AATGCAAGGA 960
TTCAATGAAG ATATGGTGAT AGAGGCACAA CAGAAGTTCA AAATAAATAA GCAACACGCT 1020
AGAAGGGTTT ATGAAATTCT TCGACTACTG GTAACTGACA TGAGTGATGC CGAACAATAC 1080
AGAAGCTACA GACTGGATAT TAAAAGAAGA CTAATTAGCC CATATAAGAA AAAGCAGAGA 1140
GATCTTGCTA AGATGAGAAA ATGTCTCAGA CCAGAAGAAC TGACAAACCA GATGAACCAA 1200
ATAGAAATAA GCATGCAACA TGAACAGCTG GAAGAGAGTT TTCAGGAACT AGTGGAAGAT 1260
TACCGGCGTG TTATTGAACG ACTTGCTCAA GAGTAAAGAT TATACTGCTC TGTACAGGAA 1320
GCTTGCAAAT TTTCTGTACA ATGTGCTGTG AAAAATCTGA TGACTTTAAT TTTAAAATCT 1380
TGTGACATTT TGCTTATACT AAAAGTTATC TATCTTTAGT TGAATATTTT CTTTTGGAGA 1440
GATTGTATAT TTTAAAATAC TGTTTAGAGT TTATGAGCAT ATATTGCATT TAAAGAAAGA 1500
TAAAGCTTCT GAAATACTAC TGCAATTGCT TCCCTTCTTA AACAGTATAA TAAATGCTTA 1560
GTTGTGATAT GTTAATGTGT GATGATATGA TTCTTAAATA CTTACAATAA ACCTCATTCT 1620
TAAATA 1627
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR019467--Hat1_N
IPR017380--Hist_AcTrfase_B-typ_cat-su
PROSITE
Pfam

PF10394--Hat1_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0042393--F:histone binding
GO:0006348--P:chromatin silencing at telomere
GO:0006323--P:DNA packaging
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0043967--P:histone H4 acetylation
GO:0006475--P:internal protein amino acid acetylation
GO:0007584--P:response to nutrient
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0112 ENSPPYP00000014436.2 Pongo abelii 100 0.0 872
WERAM-Nol-0056 ENSNLEP00000006694.2 Nomascus leucogenys 100 0.0 872
WERAM-Pat-0100 ENSPTRP00000021597.3 Pan troglodytes 100 0.0 870
WERAM-Gog-0106 ENSGGOP00000009140.2 Gorilla gorilla 100 0.0 870
WERAM-Chs-0180 ENSCSAP00000010905.1 Chlorocebus sabaeus 100 0.0 870
WERAM-Paa-0093 ENSPANP00000018512.1 Papio anubis 100 0.0 869
WERAM-Caj-0083 ENSCJAP00000013707.2 Callithrix jacchus 99 0.0 867
WERAM-Soa-0052 ENSSARP00000005106.1 Sorex araneus 99 0.0 860
WERAM-Ptv-0121 ENSPVAP00000010680.1 Pteropus vampyrus 99 0.0 860
WERAM-Otg-0107 ENSOGAP00000009328.2 Otolemur garnettii 98 0.0 860
WERAM-Vip-0017 ENSVPAP00000001693.1 Vicugna pacos 98 0.0 859
WERAM-Eqc-0073 ENSECAP00000009282.1 Equus caballus 98 0.0 857
WERAM-Fec-0026 ENSFCAP00000002278.3 Felis catus 99 0.0 856
WERAM-Sus-0118 ENSSSCP00000016904.2 Sus scrofa 98 0.0 855
WERAM-Aim-0094 ENSAMEP00000008940.1 Ailuropoda melanoleuca 98 0.0 853
WERAM-Ova-0012 ENSOARP00000001849.1 Ovis aries 98 0.0 850
WERAM-Loa-0101 ENSLAFP00000008558.3 Loxodonta africana 97 0.0 846
WERAM-Caf-0137 ENSCAFP00000018999.3 Canis familiaris 98 0.0 844
WERAM-Orc-0047 ENSOCUP00000004608.2 Oryctolagus cuniculus 96 0.0 844
WERAM-Bot-0100 ENSBTAP00000013355.2 Bos taurus 98 0.0 843
WERAM-Dan-0092 ENSDNOP00000009190.3 Dasypus novemcinctus 98 0.0 843
WERAM-Ran-0015 ENSRNOP00000002085.5 Rattus norvegicus 96 0.0 842
WERAM-Mam-0057 ENSMMUP00000009587.2 Macaca mulatta 100 0.0 838
WERAM-Myl-0187 ENSMLUP00000015650.2 Myotis lucifugus 96 0.0 836
WERAM-Mum-0084 ENSMUSP00000028408.2 Mus musculus 93 0.0 813
WERAM-Cap-0017 ENSCPOP00000001664.2 Cavia porcellus 93 0.0 798
WERAM-Ocp-0137 ENSOPRP00000014189.1 Ochotona princeps 92 0.0 785
WERAM-Mod-0069 ENSMODP00000011048.3 Monodelphis domestica 86 0.0 756
WERAM-Gaga-0098 ENSGALP00000015492.3 Gallus gallus 84 0.0 721
WERAM-Anp-0011 ENSAPLP00000002164.1 Anas platyrhynchos 81 0.0 719
WERAM-Meg-0104 ENSMGAP00000010389.2 Meleagris gallopavo 81 0.0 716
WERAM-Fia-0035 ENSFALP00000002091.1 Ficedula albicollis 83 0.0 711
WERAM-Pes-0131 ENSPSIP00000015233.1 Pelodiscus sinensis 82 0.0 706
WERAM-Tag-0111 ENSTGUP00000008605.1 Taeniopygia guttata 82 0.0 704
WERAM-Lac-0041 ENSLACP00000006166.2 Latimeria chalumnae 77 0.0 671
WERAM-Mup-0007 ENSMPUP00000000831.1 Mustela putorius furo 98 0.0 669
WERAM-Sah-0179 ENSSHAP00000018728.1 Sarcophilus harrisii 85 0.0 654
WERAM-Orn-0101 ENSONIP00000010967.1 Oreochromis niloticus 73 0.0 634
WERAM-Orla-0189 ENSORLP00000021710.1 Oryzias latipes 72 5e-179 624
WERAM-Ten-0201 ENSTNIP00000002170.1 Tetraodon nigroviridis 71 3e-177 619
WERAM-Drm-0060 FBpp0078318 Drosophila melanogaster 41 2e-84 310
WERAM-Cae-0071 M03C11.4.2 Caenorhabditis elegans 35 3e-62 236
WERAM-Scp-0004 SPAC139.06.1:pep Schizosaccharomyces pombe 28 3e-32 136
WERAM-Sac-0045 YPL001W Saccharomyces cerevisiae 25 1e-27 121
WERAM-Art-0144 AT5G56740.1 Arabidopsis thaliana 25 5e-25 112
Created Date 25-Jun-2016