Tag |
Content |
WERAM ID |
WERAM-Hos-0055 |
Ensembl Protein ID |
ENSP00000263253.7 |
Uniprot Accession |
Q09472; EP300_HUMAN; B1AKC2 |
Genbank Protein ID |
NP_001420.2 |
Protein Name |
Histone acetyltransferase p300 |
Genbank Nucleotide ID |
NM_001429.3 |
Gene Name |
EP300;p300;KAT3B;P300 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Ac_Reader |
Bromodomain |
Bromodomain |
H1.4K74; H2AK5; H2AK15; H2AK36; H2BK43; H2BK46; H3K36; H3K56; H3K79; H3K115; H3K122; H4K5; H4K12; H4K20; H4K44 |
K |
22464331; 24704920 |
HAT |
p300_CBP |
CBP/p300-type HAT |
H1.4K74; H2AK5; H2AK15; H2AK36; H2BK43; H2BK46; H3K56; H3K79; H3K115; H3K122; H4K5; H4K20; H4K44 |
K |
19698979; 22464331; 26625199; 24704920 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HAT |
p300_CBP |
7.10e-177 |
591.2 |
336 |
1704 |
Ac_Reader |
Bromodomain |
2.10e-25 |
90.9 |
1068 |
1139 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:10733570, PubMed:11430825, PubMed:11701890, PubMed:12402037, PubMed:12586840, PubMed:12929931, PubMed:14645221, PubMed:15186775, PubMed:15890677, PubMed:16617102, PubMed:16762839, PubMed:18722353, PubMed:18995842, PubMed:23415232, PubMed:23911289, PubMed:23934153, PubMed:8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D. |
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:10733570, PubMed:11430825, PubMed:11701890, PubMed:12402037, PubMed:12586840, PubMed:12929931, PubMed:14645221, PubMed:15186775, PubMed:15890677, PubMed:16617102, PubMed:16762839, PubMed:18722353, PubMed:18995842, PubMed:23415232, PubMed:23911289, PubMed:23934153, PubMed:8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D.
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Domain Profile |
HAT p300_CBP
CBP.txt 298 lllmeklgetilpkk...kdkilvelqksn.kkksklvvsgnrwvcekcknlqlcdkcyeaeq 356 l+ ++l ++ +k +++ e++++n ++ +++++ n+ +c++ + c+ ++ a ENSP00000263253.7 336 KLIQQQLVLLLHAHKcqrREQANGEVRQCNlPHCRTMKNVLNH--MTHCQSGKSCQVAHCASS 396 3555555544444331112233334444442578888888887..667777666666555544 PP CBP.txt 1 klgakkLpetkLskfleqrlfkklkkerqerarlqgksyeevpeaeelvvrvvassdktlevkkrlkerfveen.fpeefpyrskalllf 89 k++ak+Lp+t+L++fle+r++++l+++++ pe++e++vrvv++sdkt+evk+++k+rfv+++ ++e+fpyr+kal++f ENSP00000263253.7 1287 KFSAKRLPSTRLGTFLENRVNDFLRRQNH-------------PESGEVTVRVVHASDKTVEVKPGMKARFVDSGeMAESFPYRTKALFAF 1363 689*************************9.............************************************************ PP CBP.txt 90 ekidgvdvClfglyvqefGsecsaPnqrrvyisyLdsvkyfrPevrtvagealrtavyheiLiGyleyvkklGfttayiWaCPPseGddy 179 e+idgvd+C+fg++vqe+Gs+c++PnqrrvyisyLdsv++frP ++lrtavyheiLiGyleyvkklG+tt++iWaCPPseGddy ENSP00000263253.7 1364 EEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRP-------KCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDY 1446 *******************************************.......**************************************** PP CBP.txt 180 ilychPedqkiPktkkLreWykkmLekavkerivvevtnlykdifkqaeedrlvtaarLPyfeGdfWpnvleelikeleqeeeerkkkek 269 i++chP+dqkiPk+k+L+eWykkmL+kav+eriv++ ykdifkqa+edrl++a++LPyfeGdfWpnvlee+ikeleqeeeerk++e+ ENSP00000263253.7 1447 IFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHD----YKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREEN 1532 ************************************....************************************************** PP CBP.txt 270 kaaskkkvkkralkaegqldlsknakkklllmeklgetilpkkkdkilvelqksnkkksklvvsgnrwvcekcknlqlcdkcyeaeqerl 359 +++++++v+k ++sknakkk ++kk++k++++l++ nkkk+ +++++n+ l ENSP00000263253.7 1533 TSNESTDVTK---------GDSKNAKKK-----------NNKKTSKNKSSLSRGNKKKPGMPNVSND----------------------L 1580 *******988.........89*******...........9***************************......................9 PP CBP.txt 360 seklyatmekekevlfvvrlkdvpa....aeiedkdellesdlldgrdafLtlardkhyefssLrrakhsslmllyeLhnqtk 438 s+klyatmek+kev+fv+rl + pa ++i+d+d+l+ +dl+dgrdafLtlardkh+efssLrra++s++++l+eLh+q++ ENSP00000263253.7 1581 SQKLYATMEKHKEVFFVIRLIAGPAanslPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQ 1663 9**********************9999999**************************************************985 PP CBP.txt 324 nkkksklvvsgnrwvcekcknlqlcdkcyeaeqerls 360 ++++ + + rw c c++++lc +cy+++++ + ENSP00000263253.7 1670 CNECK--HHVETRWHCTVCEDYDLCITCYNTKNHDHK 1704 44444..467889****************99876554 PP
Ac_Reader Bromodomain
BROMO.txt 2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 + ++s pFr+pvdpq l ipdY+di+k PmdLstik++l++g+Y++p + v+D++l+fnNa yn++ s v+ ENSP00000263253.7 1068 QDPESLPFRQPVDPQlLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVY 1139 56899**************************************************************99887 PP
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Protein Sequence (Fasta) | MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD 60 INQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQVMASQAQQ SSPGLGLINS 120 MVKSPMTQAG LTSPNMGMGT SGPNQGPTQS TGMMNSPVNQ PAMGMNTGMN AGMNPGMLAA 180 GNGQGIMPNQ VMNGSIGAGR GRQNMQYPNP GMGSAGNLLT EPLQQGSPQM GGQTGLRGPQ 240 PLKMGMMNNP NPYGSPYTQN PGQQIGASGL GLQIQTKTVL SNNLSPFAMD KKAVPGGGMP 300 NMGQQPAPQV QQPGLVTPVA QGMGSGAHTA DPEKRKLIQQ QLVLLLHAHK CQRREQANGE 360 VRQCNLPHCR TMKNVLNHMT HCQSGKSCQV AHCASSRQII SHWKNCTRHD CPVCLPLKNA 420 GDKRNQQPIL TGAPVGLGNP SSLGVGQQSA PNLSTVSQID PSSIERAYAA LGLPYQVNQM 480 PTQPQVQAKN QQNQQPGQSP QGMRPMSNMS ASPMGVNGGV GVQTPSLLSD SMLHSAINSQ 540 NPMMSENASV PSLGPMPTAA QPSTTGIRKQ WHEDITQDLR NHLVHKLVQA IFPTPDPAAL 600 KDRRMENLVA YARKVEGDMY ESANNRAEYY HLLAEKIYKI QKELEEKRRT RLQKQNMLPN 660 AAGMVPVSMN PGPNMGQPQP GMTSNGPLPD PSMIRGSVPN QMMPRITPQS GLNQFGQMSM 720 AQPPIVPRQT PPLQHHGQLA QPGALNPPMG YGPRMQQPSN QGQFLPQTQF PSQGMNVTNI 780 PLAPSSGQAP VSQAQMSSSS CPVNSPIMPP GSQGSHIHCP QLPQPALHQN SPSPVPSRTP 840 TPHHTPPSIG AQQPPATTIP APVPTPPAMP PGPQSQALHP PPRQTPTPPT TQLPQQVQPS 900 LPAAPSADQP QQQPRSQQST AASVPTPTAP LLPPQPATPL SQPAVSIEGQ VSNPPSTSST 960 EVNSQAIAEK QPSQEVKMEA KMEVDQPEPA DTQPEDISES KVEDCKMEST ETEERSTELK 1020 TEIKEEEDQP STSATQSSPA PGQSKKKIFK PEELRQALMP TLEALYRQDP ESLPFRQPVD 1080 PQLLGIPDYF DIVKSPMDLS TIKRKLDTGQ YQEPWQYVDD IWLMFNNAWL YNRKTSRVYK 1140 YCSKLSEVFE QEIDPVMQSL GYCCGRKLEF SPQTLCCYGK QLCTIPRDAT YYSYQNRYHF 1200 CEKCFNEIQG ESVSLGDDPS QPQTTINKEQ FSKRKNDTLD PELFVECTEC GRKMHQICVL 1260 HHEIIWPAGF VCDGCLKKSA RTRKENKFSA KRLPSTRLGT FLENRVNDFL RRQNHPESGE 1320 VTVRVVHASD KTVEVKPGMK ARFVDSGEMA ESFPYRTKAL FAFEEIDGVD LCFFGMHVQE 1380 YGSDCPPPNQ RRVYISYLDS VHFFRPKCLR TAVYHEILIG YLEYVKKLGY TTGHIWACPP 1440 SEGDDYIFHC HPPDQKIPKP KRLQEWYKKM LDKAVSERIV HDYKDIFKQA TEDRLTSAKE 1500 LPYFEGDFWP NVLEESIKEL EQEEEERKRE ENTSNESTDV TKGDSKNAKK KNNKKTSKNK 1560 SSLSRGNKKK PGMPNVSNDL SQKLYATMEK HKEVFFVIRL IAGPAANSLP PIVDPDPLIP 1620 CDLMDGRDAF LTLARDKHLE FSSLRRAQWS TMCMLVELHT QSQDRFVYTC NECKHHVETR 1680 WHCTVCEDYD LCITCYNTKN HDHKMEKLGL GLDDESNNQQ AAATQSPGDS RRLSIQRCIQ 1740 SLVHACQCRN ANCSLPSCQK MKRVVQHTKG CKRKTNGGCP ICKQLIALCC YHAKHCQENK 1800 CPVPFCLNIK QKLRQQQLQH RLQQAQMLRR RMASMQRTGV VGQQQGLPSP TPATPTTPTG 1860 QQPTTPQTPQ PTSQPQPTPP NSMPPYLPRT QAAGPVSQGK AAGQVTPPTP PQTAQPPLPG 1920 PPPAAVEMAM QIQRAAETQR QMAHVQIFQR PIQHQMPPMT PMAPMGMNPP PMTRGPSGHL 1980 EPGMGPTGMQ QQPPWSQGGL PQPQQLQSGM PRPAMMSVAQ HGQPLNMAPQ PGLGQVGISP 2040 LKPGTVSQQA LQNLLRTLRS PSSPLQQQQV LSILHANPQL LAAFIKQRAA KYANSNPQPI 2100 PGQPGMPQGQ PGLQPPTMPG QQGVHSNPAM QNMNPMQAGV QRAGLPQQQP QQQLQPPMGG 2160 MSPQAQQMNM NHNTMPSQFR DILRRQQMMQ QQQQQGAGPG IGPGMANHNQ FQQPQGVGYP 2220 PQQQQRMQHH MQQMQQGNMG QIGQLPQALG AEAGASLQAY QQRLLQQQMG SPVQPNPMSP 2280 QQHMLPNQAQ SPHLQGQQIP NSLSNQVRSP QPVPSPRPQS QPPHSSPSPR MQPQPSPHHV 2340 SPQTSSPHPG LVAAQANPME QGHFASPDQN SMLSQLASNP GMANLHGASA TDLGLSTDNS 2400 DLNSNLSQST LDIH 2414Protein Fasta Sequence
>ENSP00000263253.7|EP300;p300;KAT3B;P300|Homo sapiens MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH
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Nucleotide Sequence (Fasta) | CTTGTTTGTG TGCTAGGCTG GGGGGGAGAG AGGGCGAGAG AGAGCGGGCG AGAGTGGGCA 60 AGCAGGACGC CGGGCTGAGT GCTAACTGCG GGAGCCAGAG AGTGCGGAGG GGAGTCGGGT 120 CGGAGAGAGG CGGCAGGGGC CGAGACAGTG GCAGGGGGCC CGGGGCGCAC GGGCTGAGGC 180 GACCCCCAGC CCCCTCCCGT CCGCACACAC CCCCACCGCG GTCCAGCAGC CGGGCCGGCG 240 TCGACGCCTA GGGGGGACCA TTACATAACC CCGCGCCCCG CGGCGTCTTC TCCCGCCGCC 300 GCGGGCGGCC CCGAACGGAG CCCCGGGGGG CGGGCGCTCC CAGCACCTGG CCGCCGGCGG 360 TGGGGGCCGT AGCAGCGGCC GTATTTATTT ATTTTCCGCG GGAAAGGAAG GCGAAGGAGG 420 GGAGCGCGGC GCGAGGAGGG GCCGCCTGCG CCGCCGCCGG AGCGGGGCCT CCTCGGTGGG 480 CTCCGCGTCG GCGCGGGCGT GCGGGCGGCG CTGCTCGGCC CGGCCCCCTC GGCCCTCTGG 540 TCCGGCCAGC TCCGCTCCCG GCGTCCTTGC CGCGCCTCCG CCGGCCGCCG CGCGATGTGA 600 GGCGGCGGCG CCAGCCTGGC TCTCGGCTCG GGCGAGTTCT CTGCGGCCAT TAGGGGCCGG 660 TGCGGCGGCG GCGGCGCGGA GCGCGGCGGC AGGAGGAGGG TTCGGAGGGT GGGGGCGCAG 720 GCCCGGGAGG GGGCACCGGG AGGAGGTGAG TGTCTCTTGT CGCCTCCTCC TCTCCCCCCT 780 TTTCGCCCCC GCCTCCTTGT GGCGATGAGA AGGAGGAGGA CAGCGCCGAG GAGGAAGAGG 840 TTGATGGCGG CGGCGGAGCT CCGAGAGACC TCGGCTGGGC AGGGGCCGGC CGTGGCGGGC 900 CGGGGACTGC GCCTCTAGAG CCGCGAGTTC TCGGGAATTC GCCGCAGCGG ACGCGCTCGG 960 CGAATTTGTG CTCTTGTGCC CTCCTCCGGG CTTGGGCCCA GGCCCGGCCC CTCGCACTTG 1020 CCCTTACCTT TTCTATCGAG TCCGCATCCC TCTCCAGCCA CTGCGACCCG GCGAAGAGAA 1080 AAAGGAACTT CCCCCACCCC CTCGGGTGCC GTCGGAGCCC CCCAGCCCAC CCCTGGGTGC 1140 GGCGCGGGGA CCCCGGGCCG AAGAAGAGAT TTCCTGAGGA TTCTGGTTTT CCTCGCTTGT 1200 ATCTCCGAAA GAATTAAAAA TGGCCGAGAA TGTGGTGGAA CCGGGGCCGC CTTCAGCCAA 1260 GCGGCCTAAA CTCTCATCTC CGGCCCTCTC GGCGTCCGCC AGCGATGGCA CAGATTTTGG 1320 CTCTCTATTT GACTTGGAGC ACGACTTACC AGATGAATTA ATCAACTCTA CAGAATTGGG 1380 ACTAACCAAT GGTGGTGATA TTAATCAGCT TCAGACAAGT CTTGGCATGG TACAAGATGC 1440 AGCTTCTAAA CATAAACAGC TGTCAGAATT GCTGCGATCT GGTAGTTCCC CTAACCTCAA 1500 TATGGGAGTT GGTGGCCCAG GTCAAGTCAT GGCCAGCCAG GCCCAACAGA GCAGTCCTGG 1560 ATTAGGTTTG ATAAATAGCA TGGTCAAAAG CCCAATGACA CAGGCAGGCT TGACTTCTCC 1620 CAACATGGGG ATGGGCACTA GTGGACCAAA TCAGGGTCCT ACGCAGTCAA CAGGTATGAT 1680 GAACAGTCCA GTAAATCAGC CTGCCATGGG AATGAACACA GGGATGAATG CGGGCATGAA 1740 TCCTGGAATG TTGGCTGCAG GCAATGGACA AGGGATAATG CCTAATCAAG TCATGAACGG 1800 TTCAATTGGA GCAGGCCGAG GGCGACAGAA TATGCAGTAC CCAAACCCAG GCATGGGAAG 1860 TGCTGGCAAC TTACTGACTG AGCCTCTTCA GCAGGGCTCT CCCCAGATGG GAGGACAAAC 1920 AGGATTGAGA GGCCCCCAGC CTCTTAAGAT GGGAATGATG AACAACCCCA ATCCTTATGG 1980 TTCACCATAT ACTCAGAATC CTGGACAGCA GATTGGAGCC AGTGGCCTTG GTCTCCAGAT 2040 TCAGACAAAA ACTGTACTAT CAAATAACTT ATCTCCATTT GCTATGGACA AAAAGGCAGT 2100 TCCTGGTGGA GGAATGCCCA ACATGGGTCA ACAGCCAGCC CCGCAGGTCC AGCAGCCAGG 2160 CCTGGTGACT CCAGTTGCCC AAGGGATGGG TTCTGGAGCA CATACAGCTG ATCCAGAGAA 2220 GCGCAAGCTC ATCCAGCAGC AGCTTGTTCT CCTTTTGCAT GCTCACAAGT GCCAGCGCCG 2280 GGAACAGGCC AATGGGGAAG TGAGGCAGTG CAACCTTCCC CACTGTCGCA CAATGAAGAA 2340 TGTCCTAAAC CACATGACAC ACTGCCAGTC AGGCAAGTCT TGCCAAGTGG CACACTGTGC 2400 ATCTTCTCGA CAAATCATTT CACACTGGAA GAATTGTACA AGACATGATT GTCCTGTGTG 2460 TCTCCCCCTC AAAAATGCTG GTGATAAGAG AAATCAACAG CCAATTTTGA CTGGAGCACC 2520 CGTTGGACTT GGAAATCCTA GCTCTCTAGG GGTGGGTCAA CAGTCTGCCC CCAACCTAAG 2580 CACTGTTAGT CAGATTGATC CCAGCTCCAT AGAAAGAGCC TATGCAGCTC TTGGACTACC 2640 CTATCAAGTA AATCAGATGC CGACACAACC CCAGGTGCAA GCAAAGAACC AGCAGAATCA 2700 GCAGCCTGGG CAGTCTCCCC AAGGCATGCG GCCCATGAGC AACATGAGTG CTAGTCCTAT 2760 GGGAGTAAAT GGAGGTGTAG GAGTTCAAAC GCCGAGTCTT CTTTCTGACT CAATGTTGCA 2820 TTCAGCCATA AATTCTCAAA ACCCAATGAT GAGTGAAAAT GCCAGTGTGC CCTCCCTGGG 2880 TCCTATGCCA ACAGCAGCTC AACCATCCAC TACTGGAATT CGGAAACAGT GGCACGAAGA 2940 TATTACTCAG GATCTTCGAA ATCATCTTGT TCACAAACTC GTCCAAGCCA TATTTCCTAC 3000 GCCGGATCCT GCTGCTTTAA AAGACAGACG GATGGAAAAC CTAGTTGCAT ATGCTCGGAA 3060 AGTTGAAGGG GACATGTATG AATCTGCAAA CAATCGAGCG GAATACTACC ACCTTCTAGC 3120 TGAGAAAATC TATAAGATCC AGAAAGAACT AGAAGAAAAA CGAAGGACCA GACTACAGAA 3180 GCAGAACATG CTACCAAATG CTGCAGGCAT GGTTCCAGTT TCCATGAATC CAGGGCCTAA 3240 CATGGGACAG CCGCAACCAG GAATGACTTC TAATGGCCCT CTACCTGACC CAAGTATGAT 3300 CCGTGGCAGT GTGCCAAACC AGATGATGCC TCGAATAACT CCACAATCTG GTTTGAATCA 3360 ATTTGGCCAG ATGAGCATGG CCCAGCCCCC TATTGTACCC CGGCAAACCC CTCCTCTTCA 3420 GCACCATGGA CAGTTGGCTC AACCTGGAGC TCTCAACCCG CCTATGGGCT ATGGGCCTCG 3480 TATGCAACAG CCTTCCAACC AGGGCCAGTT CCTTCCTCAG ACTCAGTTCC CATCACAGGG 3540 AATGAATGTA ACAAATATCC CTTTGGCTCC GTCCAGCGGT CAAGCTCCAG TGTCTCAAGC 3600 ACAAATGTCT AGTTCTTCCT GCCCGGTGAA CTCTCCTATA ATGCCTCCAG GGTCTCAGGG 3660 GAGCCACATT CACTGTCCCC AGCTTCCTCA ACCAGCTCTT CATCAGAATT CACCCTCGCC 3720 TGTACCTAGT CGTACCCCCA CCCCTCACCA TACTCCCCCA AGCATAGGGG CTCAGCAGCC 3780 ACCAGCAACA ACAATTCCAG CCCCTGTTCC TACACCTCCT GCCATGCCAC CTGGGCCACA 3840 GTCCCAGGCT CTACATCCCC CTCCAAGGCA GACACCTACA CCACCAACAA CACAACTTCC 3900 CCAACAAGTG CAGCCTTCAC TTCCTGCTGC ACCTTCTGCT GACCAGCCCC AGCAGCAGCC 3960 TCGCTCACAG CAGAGCACAG CAGCGTCTGT TCCTACCCCA ACAGCACCGC TGCTTCCTCC 4020 GCAGCCTGCA ACTCCACTTT CCCAGCCAGC TGTAAGCATT GAAGGACAGG TATCAAATCC 4080 TCCATCTACT AGTAGCACAG AAGTGAATTC TCAGGCCATT GCTGAGAAGC AGCCTTCCCA 4140 GGAAGTGAAG ATGGAGGCCA AAATGGAAGT GGATCAACCA GAACCAGCAG ATACTCAGCC 4200 GGAGGATATT TCAGAGTCTA AAGTGGAAGA CTGTAAAATG GAATCTACCG AAACAGAAGA 4260 GAGAAGCACT GAGTTAAAAA CTGAAATAAA AGAGGAGGAA GACCAGCCAA GTACTTCAGC 4320 TACCCAGTCA TCTCCGGCTC CAGGACAGTC AAAGAAAAAG ATTTTCAAAC CAGAAGAACT 4380 ACGACAGGCA CTGATGCCAA CTTTGGAGGC ACTTTACCGT CAGGATCCAG AATCCCTTCC 4440 CTTTCGTCAA CCTGTGGACC CTCAGCTTTT AGGAATCCCT GATTACTTTG ATATTGTGAA 4500 GAGCCCCATG GATCTTTCTA CCATTAAGAG GAAGTTAGAC ACTGGACAGT ATCAGGAGCC 4560 CTGGCAGTAT GTCGATGATA TTTGGCTTAT GTTCAATAAT GCCTGGTTAT ATAACCGGAA 4620 AACATCACGG GTATACAAAT ACTGCTCCAA GCTCTCTGAG GTCTTTGAAC AAGAAATTGA 4680 CCCAGTGATG CAAAGCCTTG GATACTGTTG TGGCAGAAAG TTGGAGTTCT CTCCACAGAC 4740 ACTGTGTTGC TACGGCAAAC AGTTGTGCAC AATACCTCGT GATGCCACTT ATTACAGTTA 4800 CCAGAACAGG TATCATTTCT GTGAGAAGTG TTTCAATGAG ATCCAAGGGG AGAGCGTTTC 4860 TTTGGGGGAT GACCCTTCCC AGCCTCAAAC TACAATAAAT AAAGAACAAT TTTCCAAGAG 4920 AAAAAATGAC ACACTGGATC CTGAACTGTT TGTTGAATGT ACAGAGTGCG GAAGAAAGAT 4980 GCATCAGATC TGTGTCCTTC ACCATGAGAT CATCTGGCCT GCTGGATTCG TCTGTGATGG 5040 CTGTTTAAAG AAAAGTGCAC GAACTAGGAA AGAAAATAAG TTTTCTGCTA AAAGGTTGCC 5100 ATCTACCAGA CTTGGCACCT TTCTAGAGAA TCGTGTGAAT GACTTTCTGA GGCGACAGAA 5160 TCACCCTGAG TCAGGAGAGG TCACTGTTAG AGTAGTTCAT GCTTCTGACA AAACCGTGGA 5220 AGTAAAACCA GGCATGAAAG CAAGGTTTGT GGACAGTGGA GAGATGGCAG AATCCTTTCC 5280 ATACCGAACC AAAGCCCTCT TTGCCTTTGA AGAAATTGAT GGTGTTGACC TGTGCTTCTT 5340 TGGCATGCAT GTTCAAGAGT ATGGCTCTGA CTGCCCTCCA CCCAACCAGA GGAGAGTATA 5400 CATATCTTAC CTCGATAGTG TTCATTTCTT CCGTCCTAAA TGCTTGAGGA CTGCAGTCTA 5460 TCATGAAATC CTAATTGGAT ATTTAGAATA TGTCAAGAAA TTAGGTTACA CAACAGGGCA 5520 TATTTGGGCA TGTCCACCAA GTGAGGGAGA TGATTATATC TTCCATTGCC ATCCTCCTGA 5580 CCAGAAGATA CCCAAGCCCA AGCGACTGCA GGAATGGTAC AAAAAAATGC TTGACAAGGC 5640 TGTATCAGAG CGTATTGTCC ATGACTACAA GGATATTTTT AAACAAGCTA CTGAAGATAG 5700 ATTAACAAGT GCAAAGGAAT TGCCTTATTT CGAGGGTGAT TTCTGGCCCA ATGTTCTGGA 5760 AGAAAGCATT AAGGAACTGG AACAGGAGGA AGAAGAGAGA AAACGAGAGG AAAACACCAG 5820 CAATGAAAGC ACAGATGTGA CCAAGGGAGA CAGCAAAAAT GCTAAAAAGA AGAATAATAA 5880 GAAAACCAGC AAAAATAAGA GCAGCCTGAG TAGGGGCAAC AAGAAGAAAC CCGGGATGCC 5940 CAATGTATCT AACGACCTCT CACAGAAACT ATATGCCACC ATGGAGAAGC ATAAAGAGGT 6000 CTTCTTTGTG ATCCGCCTCA TTGCTGGCCC TGCTGCCAAC TCCCTGCCTC CCATTGTTGA 6060 TCCTGATCCT CTCATCCCCT GCGATCTGAT GGATGGTCGG GATGCGTTTC TCACGCTGGC 6120 AAGGGACAAG CACCTGGAGT TCTCTTCACT CCGAAGAGCC CAGTGGTCCA CCATGTGCAT 6180 GCTGGTGGAG CTGCACACGC AGAGCCAGGA CCGCTTTGTC TACACCTGCA ATGAATGCAA 6240 GCACCATGTG GAGACACGCT GGCACTGTAC TGTCTGTGAG GATTATGACT TGTGTATCAC 6300 CTGCTATAAC ACTAAAAACC ATGACCACAA AATGGAGAAA CTAGGCCTTG GCTTAGATGA 6360 TGAGAGCAAC AACCAGCAGG CTGCAGCCAC CCAGAGCCCA GGCGATTCTC GCCGCCTGAG 6420 TATCCAGCGC TGCATCCAGT CTCTGGTCCA TGCTTGCCAG TGTCGGAATG CCAATTGCTC 6480 ACTGCCATCC TGCCAGAAGA TGAAGCGGGT TGTGCAGCAT ACCAAGGGTT GCAAACGGAA 6540 AACCAATGGC GGGTGCCCCA TCTGCAAGCA GCTCATTGCC CTCTGCTGCT ACCATGCCAA 6600 GCACTGCCAG GAGAACAAAT GCCCGGTGCC GTTCTGCCTA AACATCAAGC AGAAGCTCCG 6660 GCAGCAACAG CTGCAGCACC GACTACAGCA GGCCCAAATG CTTCGCAGGA GGATGGCCAG 6720 CATGCAGCGG ACTGGTGTGG TTGGGCAGCA ACAGGGCCTC CCTTCCCCCA CTCCTGCCAC 6780 TCCAACGACA CCAACTGGCC AACAGCCAAC CACCCCGCAG ACGCCCCAGC CCACTTCTCA 6840 GCCTCAGCCT ACCCCTCCCA ATAGCATGCC ACCCTACTTG CCCAGGACTC AAGCTGCTGG 6900 CCCTGTGTCC CAGGGTAAGG CAGCAGGCCA GGTGACCCCT CCAACCCCTC CTCAGACTGC 6960 TCAGCCACCC CTTCCAGGGC CCCCACCTGC AGCAGTGGAA ATGGCAATGC AGATTCAGAG 7020 AGCAGCGGAG ACGCAGCGCC AGATGGCCCA CGTGCAAATT TTTCAAAGGC CAATCCAACA 7080 CCAGATGCCC CCGATGACTC CCATGGCCCC CATGGGTATG AACCCACCTC CCATGACCAG 7140 AGGTCCCAGT GGGCATTTGG AGCCAGGGAT GGGACCGACA GGGATGCAGC AACAGCCACC 7200 CTGGAGCCAA GGAGGATTGC CTCAGCCCCA GCAACTACAG TCTGGGATGC CAAGGCCAGC 7260 CATGATGTCA GTGGCCCAGC ATGGTCAACC TTTGAACATG GCTCCACAAC CAGGATTGGG 7320 CCAGGTAGGT ATCAGCCCAC TCAAACCAGG CACTGTGTCT CAACAAGCCT TACAAAACCT 7380 TTTGCGGACT CTCAGGTCTC CCAGCTCTCC CCTGCAGCAG CAACAGGTGC TTAGTATCCT 7440 TCACGCCAAC CCCCAGCTGT TGGCTGCATT CATCAAGCAG CGGGCTGCCA AGTATGCCAA 7500 CTCTAATCCA CAACCCATCC CTGGGCAGCC TGGCATGCCC CAGGGGCAGC CAGGGCTACA 7560 GCCACCTACC ATGCCAGGTC AGCAGGGGGT CCACTCCAAT CCAGCCATGC AGAACATGAA 7620 TCCAATGCAG GCGGGCGTTC AGAGGGCTGG CCTGCCCCAG CAGCAACCAC AGCAGCAACT 7680 CCAGCCACCC ATGGGAGGGA TGAGCCCCCA GGCTCAGCAG ATGAACATGA ACCACAACAC 7740 CATGCCTTCA CAATTCCGAG ACATCTTGAG ACGACAGCAA ATGATGCAAC AGCAGCAGCA 7800 ACAGGGAGCA GGGCCAGGAA TAGGCCCTGG AATGGCCAAC CATAACCAGT TCCAGCAACC 7860 CCAAGGAGTT GGCTACCCAC CACAGCAGCA GCAGCGGATG CAGCATCACA TGCAACAGAT 7920 GCAACAAGGA AATATGGGAC AGATAGGCCA GCTTCCCCAG GCCTTGGGAG CAGAGGCAGG 7980 TGCCAGTCTA CAGGCCTATC AGCAGCGACT CCTTCAGCAA CAGATGGGGT CCCCTGTTCA 8040 GCCCAACCCC ATGAGCCCCC AGCAGCATAT GCTCCCAAAT CAGGCCCAGT CCCCACACCT 8100 ACAAGGCCAG CAGATCCCTA ATTCTCTCTC CAATCAAGTG CGCTCTCCCC AGCCTGTCCC 8160 TTCTCCACGG CCACAGTCCC AGCCCCCCCA CTCCAGTCCT TCCCCAAGGA TGCAGCCTCA 8220 GCCTTCTCCA CACCACGTTT CCCCACAGAC AAGTTCCCCA CATCCTGGAC TGGTAGCTGC 8280 CCAGGCCAAC CCCATGGAAC AAGGGCATTT TGCCAGCCCG GACCAGAATT CAATGCTTTC 8340 TCAGCTTGCT AGCAATCCAG GCATGGCAAA CCTCCATGGT GCAAGCGCCA CGGACCTGGG 8400 ACTCAGCACC GATAACTCAG ACTTGAATTC AAACCTCTCA CAGAGTACAC TAGACATACA 8460 CTAGAGACAC CTTGTAGTAT TTTGGGAGCA AAAAAATTAT TTTCTCTTAA CAAGACTTTT 8520 TGTACTGAAA ACAATTTTTT TGAATCTTTC GTAGCCTAAA AGACAATTTT CCTTGGAACA 8580 CATAAGAACT GTGCAGTAGC CGTTTGTGGT TTAAAGCAAA CATGCAAGAT GAACCTGAGG 8640 GATGATAGAA TACAAAGAAT ATATTTTTGT TATGGCTGGT TACCACCAGC CTTTCTTCCC 8700 CTTTGTGTGT GTGGTTCAAG TGTGCACTGG GAGGAGGCTG AGGCCTGTGA AGCCAAACAA 8760 TATGCTCCTG CCTTGCACCT CCAATAGGTT TTATTATTTT TTTTAAATTA ATGAACATAT 8820 GTAATATTAA TAGTTATTAT TTACTGGTGC AGATGGTTGA CATTTTTCCC TATTTTCCTC 8880 ACTTTATGGA AGAGTTAAAA CATTTCTAAA CCAGAGGACA AAAGGGGTTA ATGTTACTTT 8940 AAAATTACAT TCTATATATA TATAAATATA TATAAATATA TATTAAAATA CCAGTTTTTT 9000 TTCTCTGGGT GCAAAGATGT TCATTCTTTT AAAAAATGTT TAAAAAAAAA AAAAAACTGC 9060 CTTTCTTCCC CTCAAGTCAA CTTTTGTGCT CCAGAAAATT TTCTATTCTG TAAGTCTGAG 9120 CGTAAAACTT CAAGTATTAA AATAATTTGT ACATGTAGAG AGAAAAATGA CTTTTTCAAA 9180 AATATACAGG GGCAGCTGCC AAATTGATGT ATTATATATT GTGGTTTCTG TTTCTTGAAA 9240 GAATTTTTTT CGTTATTTTT ACATCTAACA AAGTAAAAAA ATTAAAAAGA GGGTAAGAAA 9300 CGATTCCGGT GGGATGATTT TAACATGCAA AATGTCCCTG GGGGTTTCTT CTTTGCTTGC 9360 TTTCTTCCTC CTTACCCTAC CCCCCACTCA CACACACACA CACACACACA CACACACACA 9420 CACACACACA CTTTCTATAA AACTTGAAAA TAGCAAAAAC CCTCAACTGT TGTAAATCAT 9480 GCAATTAAAG TTGATTACTT ATAAATATGA ACTTTGGATC ACTGTATAGA CTGTTAAATT 9540 TGATTTCTTA TTACCTATTG TTAAATAAAC TGTGTGAGAC AGACACC
9588Nucleotide Fasta Sequence
>ENSP00000263253.7|Bromodomain|Homo sapiens CTTGTTTGTGTGCTAGGCTGGGGGGGAGAGAGGGCGAGAGAGAGCGGGCGAGAGTGGGCAAGCAGGACGCCGGGCTGAGTGCTAACTGCGGGAGCCAGAGAGTGCGGAGGGGAGTCGGGTCGGAGAGAGGCGGCAGGGGCCGAGACAGTGGCAGGGGGCCCGGGGCGCACGGGCTGAGGCGACCCCCAGCCCCCTCCCGTCCGCACACACCCCCACCGCGGTCCAGCAGCCGGGCCGGCGTCGACGCCTAGGGGGGACCATTACATAACCCCGCGCCCCGCGGCGTCTTCTCCCGCCGCCGCGGGCGGCCCCGAACGGAGCCCCGGGGGGCGGGCGCTCCCAGCACCTGGCCGCCGGCGGTGGGGGCCGTAGCAGCGGCCGTATTTATTTATTTTCCGCGGGAAAGGAAGGCGAAGGAGGGGAGCGCGGCGCGAGGAGGGGCCGCCTGCGCCGCCGCCGGAGCGGGGCCTCCTCGGTGGGCTCCGCGTCGGCGCGGGCGTGCGGGCGGCGCTGCTCGGCCCGGCCCCCTCGGCCCTCTGGTCCGGCCAGCTCCGCTCCCGGCGTCCTTGCCGCGCCTCCGCCGGCCGCCGCGCGATGTGAGGCGGCGGCGCCAGCCTGGCTCTCGGCTCGGGCGAGTTCTCTGCGGCCATTAGGGGCCGGTGCGGCGGCGGCGGCGCGGAGCGCGGCGGCAGGAGGAGGGTTCGGAGGGTGGGGGCGCAGGCCCGGGAGGGGGCACCGGGAGGAGGTGAGTGTCTCTTGTCGCCTCCTCCTCTCCCCCCTTTTCGCCCCCGCCTCCTTGTGGCGATGAGAAGGAGGAGGACAGCGCCGAGGAGGAAGAGGTTGATGGCGGCGGCGGAGCTCCGAGAGACCTCGGCTGGGCAGGGGCCGGCCGTGGCGGGCCGGGGACTGCGCCTCTAGAGCCGCGAGTTCTCGGGAATTCGCCGCAGCGGACGCGCTCGGCGAATTTGTGCTCTTGTGCCCTCCTCCGGGCTTGGGCCCAGGCCCGGCCCCTCGCACTTGCCCTTACCTTTTCTATCGAGTCCGCATCCCTCTCCAGCCACTGCGACCCGGCGAAGAGAAAAAGGAACTTCCCCCACCCCCTCGGGTGCCGTCGGAGCCCCCCAGCCCACCCCTGGGTGCGGCGCGGGGACCCCGGGCCGAAGAAGAGATTTCCTGAGGATTCTGGTTTTCCTCGCTTGTATCTCCGAAAGAATTAAAAATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAAGCGGCCTAAACTCTCATCTCCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAGCACGACTTACCAGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGATATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGCAGCTTCTAAACATAAACAGCTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCAGGTCAAGTCATGGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGCATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCCCAACATGGGGATGGGCACTAGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAGCCTGCCATGGGAATGAACACAGGGATGAATGCGGGCATGAATCCTGGAATGTTGGCTGCAGGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGGTTCAATTGGAGCAGGCCGAGGGCGACAGAATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACTGAGCCTCTTCAGCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAGCCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGGTTCACCATATACTCAGAATCCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTATCAAATAACTTATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCCAACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGGCCTGGTGACTCCAGTTGCCCAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAGCAGCTTGTTCTCCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAAGTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAATGTCCTAAACCACATGACACACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATTTCACACTGGAAGAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCTGGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACCCGTTGGACTTGGAAATCCTAGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGATCCCAGCTCCATAGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATGCCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCAGCAGCCTGGGCAGTCTCCCCAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTAGGAGTTCAAACGCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAAAACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGGTCCTATGCCAACAGCAGCTCAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGAAATCATCTTGTTCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTAAAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAAAGTTGAAGGGGACATGTATGAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATCCAGAAAGAACTAGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAATGCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAACATGGGACAGCCGCAACCAGGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAACCAGATGATGCCTCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATGGCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCAGCACCATGGACAGTTGGCTCAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTTCCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGCACAAATGTCTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCAACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCCACCAGCAACAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCAGACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCCTCGCTCACAGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTTTCCCAGCCAGCTGTAAGCATTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACAGAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCCCAGGAAGTGAAGATGGAGGCCAAAATGGAAGTGGATCAACCAGAACCAGCAGATACTCAGCCGGAGGATATTTCAGAGTCTAAAGTGGAAGACTGTAAAATGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAAACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCAGCTACCCAGTCATCTCCGGCTCCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCAACTTTGGAGGCACTTTACCGTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGACCCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCATGGATCTTTCTACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGATATTTGGCTTATGTTCAATAATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAATACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATTGACCCAGTGATGCAAAGCCTTGGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAACAGTTGTGCACAATACCTCGTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTCTGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTTTCTTTGGGGGATGACCCTTCCCAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGATCCTGAACTGTTTGTTGAATGTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTTCACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGATGGCTGTTTAAAGAAAAGTGCACGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACCTTTCTAGAGAATCGTGTGAATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAGGTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTGGAAGTAAAACCAGGCATGAAAGCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTCTTTGCCTTTGAAGAAATTGATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAGTATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTATACATATCTTACCTCGATAGTGTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGATATTTAGAATATGTCAAGAAATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCAAGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCTGACCAGAAGATACCCAAGCCCAAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTCCATGACTACAAGGATATTTTTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAATTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTGGAAGAAAGCATTAAGGAACTGGAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTGACCAAGGGAGACAGCAAAAATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAGAGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATGCCCAATGTATCTAACGACCTCTCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTCATTGCTGGCCCTGCTGCCAACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCCTGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTGGCAAGGGACAAGCACCTGGAGTTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACGCAGAGCCAGGACCGCTTTGTCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGCTGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATCACCTGCTATAACACTAAAAACCATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAGGCTGCAGCCACCCAGAGCCCAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAGTCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGCTCACTGCCATCCTGCCAGAAGATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCCATCTGCAAGCAGCTCATTGCCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAATGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTCCGGCAGCAACAGCTGCAGCACCGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTGGTTGGGCAGCAACAGGGCCTCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGCCAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCTCAGCCTCAGCCTACCCCTCCCAATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAGGCAGCAGGCCAGGTGACCCCTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGGCCCCCACCTGCAGCAGTGGAAATGGCAATGCAGATTCAGAGAGCAGCGGAGACGCAGCGCCAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACTCCCATGGCCCCCATGGGTATGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTGGAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCACCCTGGAGCCAAGGAGGATTGCCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAGCATGGTCAACCTTTGAACATGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCACTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGACTCTCAGGTCTCCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTGTTGGCTGCATTCATCAAGCAGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATCCCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTACAGCCACCTACCATGCCAGGTCAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTTCAGAGGGCTGGCCTGCCCCAGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGGATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAACACCATGCCTTCACAATTCCGAGACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGAATAGGCCCTGGAATGGCCAACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCACCACAGCAGCAGCAGCGGATGCAGCATCACATGCAACAGATGCAACAAGGAAATATGGGACAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTATCAGCAGCGACTCCTTCAGCAACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCCCAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACACCTACAAGGCCAGCAGATCCCTAATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCCCAGCCCCCCCACTCCAGTCCTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTTTCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCCAACCCCATGGAACAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCAGGCATGGCAAACCTCCATGGTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCAGACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAGAGACACCTTGTAGTATTTTGGGAGCAAAAAAATTATTTTCTCTTAACAAGACTTTTTGTACTGAAAACAATTTTTTTGAATCTTTCGTAGCCTAAAAGACAATTTTCCTTGGAACACATAAGAACTGTGCAGTAGCCGTTTGTGGTTTAAAGCAAACATGCAAGATGAACCTGAGGGATGATAGAATACAAAGAATATATTTTTGTTATGGCTGGTTACCACCAGCCTTTCTTCCCCTTTGTGTGTGTGGTTCAAGTGTGCACTGGGAGGAGGCTGAGGCCTGTGAAGCCAAACAATATGCTCCTGCCTTGCACCTCCAATAGGTTTTATTATTTTTTTTAAATTAATGAACATATGTAATATTAATAGTTATTATTTACTGGTGCAGATGGTTGACATTTTTCCCTATTTTCCTCACTTTATGGAAGAGTTAAAACATTTCTAAACCAGAGGACAAAAGGGGTTAATGTTACTTTAAAATTACATTCTATATATATATAAATATATATAAATATATATTAAAATACCAGTTTTTTTTCTCTGGGTGCAAAGATGTTCATTCTTTTAAAAAATGTTTAAAAAAAAAAAAAAACTGCCTTTCTTCCCCTCAAGTCAACTTTTGTGCTCCAGAAAATTTTCTATTCTGTAAGTCTGAGCGTAAAACTTCAAGTATTAAAATAATTTGTACATGTAGAGAGAAAAATGACTTTTTCAAAAATATACAGGGGCAGCTGCCAAATTGATGTATTATATATTGTGGTTTCTGTTTCTTGAAAGAATTTTTTTCGTTATTTTTACATCTAACAAAGTAAAAAAATTAAAAAGAGGGTAAGAAACGATTCCGGTGGGATGATTTTAACATGCAAAATGTCCCTGGGGGTTTCTTCTTTGCTTGCTTTCTTCCTCCTTACCCTACCCCCCACTCACACACACACACACACACACACACACACACACACACACACACTTTCTATAAAACTTGAAAATAGCAAAAACCCTCAACTGTTGTAAATCATGCAATTAAAGTTGATTACTTATAAATATGAACTTTGGATCACTGTATAGACTGTTAAATTTGATTTCTTATTACCTATTGTTAAATAAACTGTGTGAGACAGACACC
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0012--Acyltransferase KW-0090--Biological rhythms KW-0103--Bromodomain KW-0131--Cell cycle KW-0160--Chromosomal rearrangement KW-0164--Citrullination KW-0181--Complete proteome KW-0963--Cytoplasm KW-0903--Direct protein sequencing KW-0225--Disease mutation KW-0945--Host-virus interaction KW-1017--Isopeptide bond KW-0479--Metal-binding KW-0488--Methylation KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0677--Repeat KW-0804--Transcription KW-0805--Transcription regulation KW-0808--Transferase KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR001487--Bromodomain IPR018359--Bromodomain_CS IPR031162--CBP_P300_HAT IPR010303--DUF902_CREBbp IPR013178--Histone_AcTrfase_Rtt109/CBP IPR003101--KIX_dom IPR009110--Nuc_rcpt_coact IPR014744--Nuc_rcpt_coact_CREBbp IPR000197--Znf_TAZ IPR000433--Znf_ZZ
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PROSITE |
PS00633--BROMODOMAIN_1 PS50014--BROMODOMAIN_2 PS51727--CBP_P300_HAT PS50952--KIX PS50134--ZF_TAZ PS01357--ZF_ZZ_1 PS50135--ZF_ZZ_2
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Pfam |
PF00439--Bromodomain PF09030--Creb_binding PF06001--DUF902 PF08214--HAT_KAT11 PF02172--KIX PF02135--zf-TAZ PF00569--ZZ
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Gene Ontology |
GO:0000785--C:chromatin GO:0005737--C:cytoplasm GO:0000123--C:histone acetyltransferase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0032993--C:protein-DNA complex GO:0005667--C:transcription factor complex GO:0016407--F:acetyltransferase activity GO:0033613--F:activating transcription factor binding GO:0050681--F:androgen receptor binding GO:0003823--F:antigen binding GO:0008013--F:beta-catenin binding GO:0003682--F:chromatin binding GO:0031490--F:chromatin DNA binding GO:0001047--F:core promoter binding GO:0003684--F:damaged DNA binding GO:0003677--F:DNA binding GO:0004402--F:histone acetyltransferase activity GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0035257--F:nuclear hormone receptor binding GO:0034212--F:peptide N-acetyltransferase activity GO:0097157--F:pre-mRNA intronic binding GO:0008022--F:protein C-terminus binding GO:0001102--F:RNA polymerase II activating transcription factor binding GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding GO:0003713--F:transcription coactivator activity GO:0008134--F:transcription factor binding GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0016746--F:transferase activity, transferring acyl groups GO:0008270--F:zinc ion binding GO:0006915--P:apoptotic process GO:0030183--P:B cell differentiation GO:1904837--P:beta-catenin-TCF complex assembly GO:0071320--P:cellular response to cAMP GO:0071549--P:cellular response to dexamethasone stimulus GO:0035690--P:cellular response to drug GO:0071333--P:cellular response to glucose stimulus GO:0070301--P:cellular response to hydrogen peroxide GO:0071389--P:cellular response to mineralocorticoid stimulus GO:1990090--P:cellular response to nerve growth factor stimulus GO:0071300--P:cellular response to retinoic acid GO:0035984--P:cellular response to trichostatin A GO:0034644--P:cellular response to UV GO:0007623--P:circadian rhythm GO:0048565--P:digestive tract development GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0045444--P:fat cell differentiation GO:0007507--P:heart development GO:0043969--P:histone H2B acetylation GO:0043966--P:histone H3 acetylation GO:0043967--P:histone H4 acetylation GO:0018393--P:internal peptidyl-lysine acetylation GO:0006475--P:internal protein amino acid acetylation GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0001889--P:liver development GO:0030324--P:lung development GO:0035855--P:megakaryocyte development GO:0007613--P:memory GO:0018076--P:N-terminal peptidyl-lysine acetylation GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:2000629--P:negative regulation of miRNA metabolic process GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0007399--P:nervous system development GO:0007219--P:Notch signaling pathway GO:0009887--P:organ morphogenesis GO:0030220--P:platelet formation GO:0043923--P:positive regulation by host of viral transcription GO:0045773--P:positive regulation of axon extension GO:0010942--P:positive regulation of cell death GO:0045793--P:positive regulation of cell size GO:0032967--P:positive regulation of collagen biosynthetic process GO:0043388--P:positive regulation of DNA binding GO:0045815--P:positive regulation of gene expression, epigenetic GO:0010560--P:positive regulation of glycoprotein biosynthetic process GO:0035066--P:positive regulation of histone acetylation GO:0014737--P:positive regulation of muscle atrophy GO:0032092--P:positive regulation of protein binding GO:0033160--P:positive regulation of protein import into nucleus, translocation GO:0001934--P:positive regulation of protein phosphorylation GO:0050714--P:positive regulation of protein secretion GO:0045862--P:positive regulation of proteolysis GO:0060298--P:positive regulation of sarcomere organization GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0045727--P:positive regulation of translation GO:0032481--P:positive regulation of type I interferon production GO:0006473--P:protein acetylation GO:0043491--P:protein kinase B signaling GO:0050821--P:protein stabilization GO:0065004--P:protein-DNA complex assembly GO:0060765--P:regulation of androgen receptor signaling pathway GO:0060177--P:regulation of angiotensin metabolic process GO:0010506--P:regulation of autophagy GO:0051726--P:regulation of cell cycle GO:1900034--P:regulation of cellular response to heat GO:1901796--P:regulation of signal transduction by p53 class mediator GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0006355--P:regulation of transcription, DNA-templated GO:0090043--P:regulation of tubulin deacetylation GO:0051592--P:response to calcium ion GO:0032025--P:response to cobalt ion GO:0043627--P:response to estrogen GO:0045471--P:response to ethanol GO:0070542--P:response to fatty acid GO:0001666--P:response to hypoxia GO:0034612--P:response to tumor necrosis factor GO:0007519--P:skeletal muscle tissue development GO:0001756--P:somitogenesis GO:0002223--P:stimulatory C-type lectin receptor signaling pathway GO:0006283--P:transcription-coupled nucleotide-excision repair GO:0016032--P:viral process
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Orthology |
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Created Date |
25-Jun-2016 |