| Tag |
Content |
| WERAM ID |
WERAM-Hos-0120 |
| Ensembl Protein ID |
ENSP00000253024.4 |
| Uniprot Accession |
Q13263; TIF1B_HUMAN; O00677; Q7Z632; Q93040; Q96IM1
|
| Genbank Protein ID |
NP_005753.1
|
| Protein Name |
Transcription intermediary factor 1-beta |
| Genbank Nucleotide ID |
NM_005762.2
|
| Gene Name |
TRIM28;KAP1;RNF96;TIF1B |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Bromodomain |
Bromodomain |
|
K |
22464331
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Ac_Reader |
Bromodomain |
3.00e-18 |
67.9 |
704 |
783 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). |
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306).
|
| Domain Profile |
Ac_Reader Bromodomain
BROMO.txt 2 ehevsepF..repvdpq.leipdYydiikeP...mdLstikerleegn...YsspeefvkDvrlifnNakaynenkssvq 72
+++v+ ++ +ep++p ++++d+++++++P +dL++i++rl+e+ Yssp+ef++Dv ++f+++++++e+k++vq
ENSP00000253024.4 704 CERVLLALfcHEPCRPLhQLATDSTFSLDQPggtLDLTLIRARLQEKLsppYSSPQEFAQDVGRMFKQFNKLTEDKADVQ 783
6666666669*******************************************************************997 PP
|
Protein Sequence
(Fasta) | MAASAAAASA AAASAASGSP GPGEGSAGGE KRSTAPSAAA SASASAAASS PAGGGAEALE 60
LLEHCGVCRE RLRPEREPRL LPCLHSACSA CLGPAAPAAA NSSGDGGAAG DGTVVDCPVC 120
KQQCFSKDIV ENYFMRDSGS KAATDAQDAN QCCTSCEDNA PATSYCVECS EPLCETCVEA 180
HQRVKYTKDH TVRSTGPAKS RDGERTVYCN VHKHEPLVLF CESCDTLTCR DCQLNAHKDH 240
QYQFLEDAVR NQRKLLASLV KRLGDKHATL QKSTKEVRSS IRQVSDVQKR VQVDVKMAIL 300
QIMKELNKRG RVLVNDAQKV TEGQQERLER QHWTMTKIQK HQEHILRFAS WALESDNNTA 360
LLLSKKLIYF QLHRALKMIV DPVEPHGEMK FQWDLNAWTK SAEAFGKIVA ERPGTNSTGP 420
APMAPPRAPG PLSKQGSGSS QPMEVQEGYG FGSGDDPYSS AEPHVSGVKR SRSGEGEVSG 480
LMRKVPRVSL ERLDLDLTAD SQPPVFKVFP GSTTEDYNLI VIERGAAAAA TGQPGTAPAG 540
TPGAPPLAGM AIVKEEETEA AIGAPPTATE GPETKPVLMA LAEGPGAEGP RLASPSGSTS 600
SGLEVVAPEG TSAPGGGPGT LDDSATICRV CQKPGDLVMC NQCEFCFHLD CHLPALQDVP 660
GEEWSCSLCH VLPDLKEEDG SLSLDGADST GVVAKLSPAN QRKCERVLLA LFCHEPCRPL 720
HQLATDSTFS LDQPGGTLDL TLIRARLQEK LSPPYSSPQE FAQDVGRMFK QFNKLTEDKA 780
DVQSIIGLQR FFETRMNEAF GDTKFSAVLV EPPPMSLPGA GLSSQELSGG PGDGP 835Protein Fasta Sequence
>ENSP00000253024.4|TRIM28;KAP1;RNF96;TIF1B|Homo sapiens
MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP |
Nucleotide Sequence
(Fasta) | GGCGCGCGGG CGAGCGGTTG TGCTTGTGCT TGTGGCGCGT GGTGCGGGTT TCGGCGGCGG 60
CTGAGGAAGA AGCGCGGGCG GCGCCTTCGG GAGGCGAGCA GGCAGCAGTT GGCCGTGCCG 120
TAGCAGCGTC CCGCGCGCGG CGGGCAGCGG CCCAGGAGGC GCGTGGCGGC GCTCGGCCTC 180
GCGGCGGCGG CGGCGGCAGC GGCCCAGCAG TTGGCGGCGA GCGCGTCTGC GCCTGCGCGG 240
CGGGCCCCGC GCCCCTCCTC CCCCCCTGGG CGCCCCCGGC GGCGTGTGAA TGGCGGCCTC 300
CGCGGCGGCA GCCTCGGCAG CAGCGGCCTC GGCCGCCTCT GGCAGCCCGG GCCCGGGCGA 360
GGGCTCCGCT GGCGGCGAAA AGCGCTCCAC CGCCCCTTCG GCCGCAGCCT CGGCCTCTGC 420
CTCAGCCGCG GCGTCGTCGC CCGCGGGGGG CGGCGCCGAG GCGCTGGAGC TGCTGGAGCA 480
CTGCGGCGTG TGCAGAGAGC GCCTGCGACC CGAGAGGGAG CCCCGCCTGC TGCCCTGTTT 540
GCACTCGGCC TGTAGTGCCT GCTTAGGGCC CGCGGCCCCC GCCGCCGCCA ACAGCTCGGG 600
GGACGGCGGG GCGGCGGGCG ACGGCACCGT GGTGGACTGT CCCGTGTGCA AGCAACAGTG 660
CTTCTCCAAA GACATCGTGG AGAATTATTT CATGCGTGAT AGTGGCAGCA AGGCTGCCAC 720
CGACGCCCAG GATGCGAACC AGTGCTGCAC TAGCTGTGAG GATAATGCCC CAGCCACCAG 780
CTACTGTGTG GAGTGCTCGG AGCCTCTGTG TGAGACCTGT GTAGAGGCGC ACCAGCGGGT 840
GAAGTACACC AAGGACCATA CTGTGCGCTC TACTGGGCCA GCCAAGTCTC GGGATGGTGA 900
ACGTACTGTC TATTGCAACG TACACAAGCA TGAACCCCTT GTGCTGTTTT GTGAGAGCTG 960
TGATACTCTC ACCTGCCGAG ACTGCCAGCT CAATGCCCAC AAGGACCACC AGTACCAGTT 1020
CTTAGAGGAT GCAGTGAGGA ACCAGCGCAA GCTCCTGGCC TCACTGGTGA AGCGCCTTGG 1080
GGACAAACAT GCAACATTGC AGAAGAGCAC CAAGGAGGTT CGCAGCTCAA TCCGCCAGGT 1140
GTCTGACGTA CAGAAGCGTG TGCAAGTGGA TGTCAAGATG GCCATCCTGC AGATCATGAA 1200
GGAGCTGAAT AAGCGGGGCC GTGTGCTGGT CAATGATGCC CAGAAGGTGA CTGAGGGGCA 1260
GCAGGAGCGC CTGGAGCGGC AGCACTGGAC CATGACCAAG ATCCAGAAGC ACCAGGAGCA 1320
CATTCTGCGC TTTGCCTCTT GGGCTCTGGA GAGTGACAAC AACACAGCCC TTTTGCTTTC 1380
TAAGAAGTTG ATCTACTTCC AGCTGCACCG GGCCCTCAAG ATGATTGTGG ATCCCGTGGA 1440
GCCACATGGC GAGATGAAGT TTCAGTGGGA CCTCAATGCC TGGACCAAGA GTGCCGAGGC 1500
CTTTGGCAAG ATTGTGGCAG AGCGTCCTGG CACTAACTCA ACAGGCCCTG CACCCATGGC 1560
CCCTCCAAGA GCCCCAGGGC CCCTGAGCAA GCAGGGCTCT GGCAGCAGCC AGCCCATGGA 1620
GGTGCAGGAA GGCTATGGCT TTGGGTCAGG AGATGATCCC TACTCAAGTG CAGAGCCCCA 1680
TGTGTCAGGT GTGAAACGGT CCCGCTCAGG TGAGGGCGAG GTGAGCGGCC TTATGCGCAA 1740
GGTGCCACGA GTGAGCCTTG AACGCCTGGA CCTGGACCTC ACAGCTGACA GCCAGCCACC 1800
CGTCTTCAAG GTCTTCCCAG GCAGTACCAC TGAGGACTAC AACCTTATTG TTATTGAACG 1860
TGGCGCTGCC GCTGCAGCTA CCGGCCAGCC AGGGACTGCG CCTGCAGGAA CCCCTGGTGC 1920
CCCACCCCTG GCTGGCATGG CCATTGTCAA GGAGGAGGAG ACGGAGGCTG CCATTGGAGC 1980
CCCTCCTACT GCCACTGAGG GCCCTGAGAC CAAACCTGTG CTTATGGCTC TTGCGGAGGG 2040
TCCTGGTGCT GAGGGTCCCC GCCTGGCCTC ACCTAGTGGC AGCACCAGCT CAGGGCTGGA 2100
GGTGGTGGCT CCTGAGGGTA CCTCAGCCCC AGGTGGTGGC CCGGGAACCC TGGATGACAG 2160
TGCCACCATT TGCCGTGTCT GCCAGAAGCC AGGCGATCTG GTTATGTGCA ACCAGTGTGA 2220
GTTTTGTTTC CACCTGGACT GTCACCTGCC GGCCCTGCAG GATGTACCAG GGGAGGAGTG 2280
GAGCTGCTCA CTCTGCCATG TGCTCCCTGA CCTGAAGGAG GAGGATGGCA GCCTCAGCCT 2340
GGATGGTGCA GACAGCACTG GCGTGGTGGC CAAGCTCTCA CCAGCCAACC AGCGGAAATG 2400
TGAGCGTGTA CTGCTGGCCC TATTCTGTCA CGAACCCTGC CGCCCCCTGC ATCAGCTGGC 2460
TACCGACTCC ACCTTCTCCC TGGACCAGCC CGGTGGCACC CTGGATCTGA CCCTGATCCG 2520
TGCCCGCCTC CAGGAGAAGT TGTCACCTCC CTACAGCTCC CCACAGGAGT TTGCCCAGGA 2580
TGTGGGCCGC ATGTTCAAGC AATTCAACAA GTTAACTGAG GACAAGGCAG ACGTGCAGTC 2640
CATCATCGGC CTGCAGCGCT TCTTCGAGAC GCGCATGAAC GAGGCCTTCG GTGACACCAA 2700
GTTCTCTGCT GTGCTGGTGG AGCCCCCGCC GATGAGCCTG CCTGGTGCTG GCCTGAGTTC 2760
CCAGGAGCTG TCTGGTGGCC CTGGTGATGG CCCCTGAGGC TGGAGCCCCC ATGGCCAGCC 2820
CAGCCTGGCT CTGTTCTCTG TCCTGTCACC CCATCCCCAC TCCCCTGGTG GCCTGACTCC 2880
CACTCCCTGG TGGCCCCATC CCCCAGTTCC TCACGATATG GTTTTTACTT CTGTGGATTT 2940
AATAAAAACT TCACCAGTTC
2961Nucleotide Fasta Sequence
>ENSP00000253024.4|Bromodomain|Homo sapiens
GGCGCGCGGGCGAGCGGTTGTGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAGAGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCGACGGCACCGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGACATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGACGCCCAGGATGCGAACCAGTGCTGCACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCTCGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTACACCAAGGACCATACTGTGCGCTCTACTGGGCCAGCCAAGTCTCGGGATGGTGAACGTACTGTCTATTGCAACGTACACAAGCATGAACCCCTTGTGCTGTTTTGTGAGAGCTGTGATACTCTCACCTGCCGAGACTGCCAGCTCAATGCCCACAAGGACCACCAGTACCAGTTCTTAGAGGATGCAGTGAGGAACCAGCGCAAGCTCCTGGCCTCACTGGTGAAGCGCCTTGGGGACAAACATGCAACATTGCAGAAGAGCACCAAGGAGGTTCGCAGCTCAATCCGCCAGGTGTCTGACGTACAGAAGCGTGTGCAAGTGGATGTCAAGATGGCCATCCTGCAGATCATGAAGGAGCTGAATAAGCGGGGCCGTGTGCTGGTCAATGATGCCCAGAAGGTGACTGAGGGGCAGCAGGAGCGCCTGGAGCGGCAGCACTGGACCATGACCAAGATCCAGAAGCACCAGGAGCACATTCTGCGCTTTGCCTCTTGGGCTCTGGAGAGTGACAACAACACAGCCCTTTTGCTTTCTAAGAAGTTGATCTACTTCCAGCTGCACCGGGCCCTCAAGATGATTGTGGATCCCGTGGAGCCACATGGCGAGATGAAGTTTCAGTGGGACCTCAATGCCTGGACCAAGAGTGCCGAGGCCTTTGGCAAGATTGTGGCAGAGCGTCCTGGCACTAACTCAACAGGCCCTGCACCCATGGCCCCTCCAAGAGCCCCAGGGCCCCTGAGCAAGCAGGGCTCTGGCAGCAGCCAGCCCATGGAGGTGCAGGAAGGCTATGGCTTTGGGTCAGGAGATGATCCCTACTCAAGTGCAGAGCCCCATGTGTCAGGTGTGAAACGGTCCCGCTCAGGTGAGGGCGAGGTGAGCGGCCTTATGCGCAAGGTGCCACGAGTGAGCCTTGAACGCCTGGACCTGGACCTCACAGCTGACAGCCAGCCACCCGTCTTCAAGGTCTTCCCAGGCAGTACCACTGAGGACTACAACCTTATTGTTATTGAACGTGGCGCTGCCGCTGCAGCTACCGGCCAGCCAGGGACTGCGCCTGCAGGAACCCCTGGTGCCCCACCCCTGGCTGGCATGGCCATTGTCAAGGAGGAGGAGACGGAGGCTGCCATTGGAGCCCCTCCTACTGCCACTGAGGGCCCTGAGACCAAACCTGTGCTTATGGCTCTTGCGGAGGGTCCTGGTGCTGAGGGTCCCCGCCTGGCCTCACCTAGTGGCAGCACCAGCTCAGGGCTGGAGGTGGTGGCTCCTGAGGGTACCTCAGCCCCAGGTGGTGGCCCGGGAACCCTGGATGACAGTGCCACCATTTGCCGTGTCTGCCAGAAGCCAGGCGATCTGGTTATGTGCAACCAGTGTGAGTTTTGTTTCCACCTGGACTGTCACCTGCCGGCCCTGCAGGATGTACCAGGGGAGGAGTGGAGCTGCTCACTCTGCCATGTGCTCCCTGACCTGAAGGAGGAGGATGGCAGCCTCAGCCTGGATGGTGCAGACAGCACTGGCGTGGTGGCCAAGCTCTCACCAGCCAACCAGCGGAAATGTGAGCGTGTACTGCTGGCCCTATTCTGTCACGAACCCTGCCGCCCCCTGCATCAGCTGGCTACCGACTCCACCTTCTCCCTGGACCAGCCCGGTGGCACCCTGGATCTGACCCTGATCCGTGCCCGCCTCCAGGAGAAGTTGTCACCTCCCTACAGCTCCCCACAGGAGTTTGCCCAGGATGTGGGCCGCATGTTCAAGCAATTCAACAAGTTAACTGAGGACAAGGCAGACGTGCAGTCCATCATCGGCCTGCAGCGCTTCTTCGAGACGCGCATGAACGAGGCCTTCGGTGACACCAAGTTCTCTGCTGTGCTGGTGGAGCCCCCGCCGATGAGCCTGCCTGGTGCTGGCCTGAGTTCCCAGGAGCTGTCTGGTGGCCCTGGTGATGGCCCCTGAGGCTGGAGCCCCCATGGCCAGCCCAGCCTGGCTCTGTTCTCTGTCCTGTCACCCCATCCCCACTCCCCTGGTGGCCTGACTCCCACTCCCTGGTGGCCCCATCCCCCAGTTCCTCACGATATGGTTTTTACTTCTGTGGATTTAATAAAAACTTCACCAGTTC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
|
| Pfam |
PF00628--PHD
PF00643--zf-B_box
PF14634--zf-RING_5
|
| Gene Ontology |
GO:0005719--C:nuclear euchromatin
GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0070087--F:chromo shadow domain binding
GO:0003677--F:DNA binding
GO:0035851--F:Krueppel-associated box domain binding
GO:0016874--F:ligase activity
GO:0044822--F:poly(A) RNA binding
GO:1990841--F:promoter-specific chromatin binding
GO:0004672--F:protein kinase activity
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0060028--P:convergent extension involved in axis elongation
GO:0043045--P:DNA methylation involved in embryo development
GO:0006281--P:DNA repair
GO:0007566--P:embryo implantation
GO:0060669--P:embryonic placenta morphogenesis
GO:0001837--P:epithelial to mesenchymal transition
GO:0045087--P:innate immune response
GO:1901536--P:negative regulation of DNA demethylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1902187--P:negative regulation of viral release from host cell
GO:0045739--P:positive regulation of DNA repair
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0051259--P:protein oligomerization
GO:0016925--P:protein sumoylation
GO:0016567--P:protein ubiquitination
GO:0007265--P:Ras protein signal transduction
GO:2000653--P:regulation of genetic imprinting
GO:0006367--P:transcription initiation from RNA polymerase II promoter
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
