WERAM Information

Tag Content
WERAM ID WERAM-Hos-0063
Ensembl Protein ID ENSP00000251900.4
Uniprot Accession Q9UQR0; SCML2_HUMAN; Q5JXE6; Q86U98; Q8IWD0; Q8NDP2; Q9UGC5
Genbank Protein ID NP_006080.1
Protein Name Sex comb on midleg-like protein 2
Genbank Nucleotide ID NM_006089.2
Gene Name SCML2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000102098.17 ENST00000251900.8 ENSP00000251900.4
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader MBT MBT1 H3K27 K 12952983
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader MBT 3.60e-65 205.1 34 131
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
Domain Profile
  Me_Reader MBT
          MBT-2.txt   2 dwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGwa 93 
                         w+eyl++t  g+++ap + +++  + ++ ++fkvgm+lE+ d +n +++++atv  + g rl+++ ++s d+  d+W   +sp+i pvG +
  ENSP00000251900.4  34 HWEEYLKET--GSISAPSECFRQS-QIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGS-DNRNDFWRLVDSPDIQPVGTC 121
                        7********..*********9865.5677788**************************************.********************* PP
          MBT-2.txt  94 akqgkelqpp 103
                        +k+g+ lqpp
  ENSP00000251900.4 122 EKEGDLLQPP 131
                        *******998 PP
          MBT-2.txt   1 sdwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGw 92 
                        s+w+++l ktl+g+++a+++l++k++++++l++fkvgm+lE++dkkn+++i+ at+ +v+g++++++f+++ + ++dyW++++s++ifp+Gw
  ENSP00000251900.4 139 SSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGW-SGAFDYWCKYDSRDIFPAGW 229
                        68*********************************************************************.******************** PP
          MBT-2.txt  93 aakqgkelqpp 103
                        ++ +g+ lqpp
  ENSP00000251900.4 230 CRLTGDVLQPP 240
                        *********98 PP
Protein Sequence
(Fasta)		MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV 60
NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT 120
CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA 180
IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP 240
GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS 300
VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY 360
VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG 420
EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH 480
DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL 540
SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF 600
QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI 660
DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS
Nucleotide Sequence
(Fasta)		GGCGGCAGTG GCGGTTGCGG GGCATGCGCG GCTCCGCGCG CGGCTTCTCA AACATGGCGG 60
CGGCGGTGTG AAGCTCGGTG CCGGCTCGCG CGATCGGTGG GACAGAATTT CGTTGTTTTC 120
ACCGACGAGA CTGGAGGAAA CAACACCAAA TAGGGATACC ATGGGACAAA CAGTGAATGA 180
AGATTCCATG GATGTCAAGA AGGAGAATCA AGAGAAAACT CCTCAGTCAA GTACATCTTC 240
TGTACAAAGG GATGATTTCC ACTGGGAGGA GTATTTGAAA GAGACTGGGT CTATAAGTGC 300
TCCTTCAGAG TGCTTCCGTC AGTCTCAGAT TCCACCTGTG AATGATTTCA AAGTTGGTAT 360
GAAATTGGAA GCCCGTGACC CTCGCAATGC CACTTCAGTA TGTATTGCTA CGGTTATTGG 420
AATTACTGGG GCCAGGTTAC GGTTACGACT GGATGGTAGT GACAACAGAA ATGATTTTTG 480
GAGGCTTGTC GATTCCCCAG ACATACAACC TGTTGGGACA TGTGAAAAGG AAGGAGACTT 540
ACTTCAACCT CCACTAGGGT ACCAGATGAA TACATCCTCC TGGCCGATGT TCCTCTTAAA 600
GACACTAAAT GGGTCTGAAA TGGCATCTGC CACATTATTT AAGAAGGAAC CACCAAAGCC 660
CCCACTAAAT AATTTTAAAG TGGGGATGAA ACTGGAAGCT ATTGACAAAA AGAACCCGTA 720
TCTCATCTGT CCTGCGACCA TTGGAGATGT TAAAGGGGAT GAAGTTCATA TCACATTTGA 780
TGGCTGGAGT GGAGCTTTTG ATTACTGGTG CAAGTATGAT TCTCGAGATA TTTTCCCAGC 840
TGGGTGGTGT CGCCTGACAG GAGATGTATT ACAACCCCCA GGAACTAGTG TTCCTATTGT 900
AAAGAATATA GCAAAAACAG AGTCTTCTCC TTCCGAAGCA AGCCAGCATT CAATGCAGTC 960
TCCACAGAAA ACTACTCTAA TATTACCAAC ACAGCAGGTC AGGAGATCAA GTCGAATTAA 1020
ACCACCTGGA CCTACTGCAG TCCCCAAAAG GAGCAGTTCT GTTAAAAATA TCACACCAAG 1080
GAAAAAAGGT CCAAACTCAG GAAAAAAGGA AAAACCTTTG CCCGTGATAT GTTCTACATC 1140
TGCAGCTTCT CTAAAATCGC TGACCAGAGA CCGTGGCATG TTATATAAAG ATGTCGCTTC 1200
TGGGCCATGT AAAATAGTGA TGTCTACAGT CTGTGTCTAT GTAAACAAAC ATGGAAACTT 1260
TGGCCCTCAT CTGGATCCCA AGAGAATCCA GCAGCTGCCT GACCACTTCG GCCCGGGCCC 1320
GGTGAATGTG GTGCTTCGCC GGATTGTGCA GGCCTGTGTG GATTGTGCCC TTGAAACTAA 1380
AACTGTTTTT GGATACCTGA AGCCAGATAA TCGTGGAGGA GAAGTGATAA CTGCCTCCTT 1440
TGATGGGGAA ACTCATTCCA TCCAGCTCCC TCCAGTGAAC AGTGCATCAT TTGCTCTTCG 1500
CTTTCTTGAG AACTTCTGCC ACAGTCTGCA GTGTGATAAC CTTTTGAGTA GCCAGCCTTT 1560
TAGTTCTTCC AGGGGTCATA CTCACAGCTC TGCAGAGCAT GATAAAAATC AGTCAGCAAA 1620
AGAAGATGTA ACAGAAAGGC AAAGCACCAA ACGATCTCCT CAGCAAACTG TACCATATGT 1680
TGTTCCTCTC TCTCCTAAGC TCCCCAAAAC AAAGGAGTAT GCGTCTGAAG GAGAACCATT 1740
GTTTGCTGGG GGAAGTGCCA TTCCCAAAGA GGAGAATCTT TCAGAAGATT CTAAGAGCTC 1800
ATCACTAAAT TCAGGAAATT ATTTGAATCC TGCCTGTAGA AATCCTATGT ATATTCATAC 1860
TTCAGTCTCC CAGGATTTTT CTCGAAGTGT GCCAGGCACC ACAAGTTCAC CACTAGTTGG 1920
GGACATATCC CCCAAGAGCA GTCCCCATGA AGTTAAATTC CAAATGCAGA GGAAAAGTGA 1980
AGCTCCAAGT TATATAGCTG TACCTGATCC CAGTGTCCTG AAACAAGGCT TCTCTAAGGA 2040
CCCTTCAACC TGGTCTGTGG ATGAAGTGAT ACAGTTTATG AAACATACAG ATCCTCAGAT 2100
ATCAGGCCCC CTCGCCGACC TCTTCAGGCA ACATGAAATT GATGGGAAGG CTCTGTTCCT 2160
ACTCAAGAGT GATGTGATGA TGAAGTATAT GGGGCTGAAG CTGGGGCCAG CATTAAAGCT 2220
GTGTTACTAC ATTGAAAAGC TTAAAGAAGG AAAATACAGT TAAAAAAATG TGTAAGTTTA 2280
GATTGGACAT AATTCTCAGG TGTACTGTTA ACATTTTAAT TTAAAAGTAT TTCTCTTAGC 2340
AGTTTTTGTT TTGTAGACAG TTCCCATAAA AATATTTTAT CAGAATTGCA GAACTGTAGT 2400
AACAGTTCAG TCAACTTTGT TTTTTTCCTG GAGTCACCAA CCAGCTTTGG GAGACACAGC 2460
CGCCACTCCC CCAGTCTACT TCTTTAAAAA GCATTTAACA GGTTAGTATT GGCATATTCA 2520
AATTGGCAGT TCTTTATGTC TTTTTAAATT TTCATTGTAC AGTTTACAAA TATACTTAAT 2580
GTAGTTAACA GAGAAAAACC TTTGATTTTG GTTAACCTTT ATATCTAGAA CCAAAACAGC 2640
TAAATCCCAA AGGGGAAAAT ATCAGGGATT GACAACTTCT ATAATTAAAT CCATGAGAAT 2700
TTTTCCTCAC TAGAGAATTT AAAGGTGCAC CTGTAGATAT CATCTTTTCT CAGATATTTT 2760
GTGTGATACT CTGTGGTGTT CTGTTCATGT TCTATCAGTA TATCTAGAAA GGGAATAGCC 2820
ATATAAATTA TTTTCCTTTT ATTATTTCTC TGTATGTTGT ATTTGATCAT ATTTAAAGGA 2880
AAAAAGCAAG CTTATAAGCT TTCATGAAGT GTTCTTACCA GTTTTTGATA AATTTTTTAA 2940
ATTATAGGAT AGAATTGTCA TTTTATGCAG GAGATATTTA TACTACGAGG GTTGTTTGGA 3000
TGGAGTCAGA TTAAATTTTT TCAGTGAAAT TCCTATTATT TTAAAACTTT CCATATTTTC 3060
ACTACGCTTG GACATTTAAC TAGGCATTCT TTTCTTACAT CTCTATATGA AGATACCTGT 3120
GTCCAAAATT TTTGAAGATA TATATTGTAT GTGTTTATTC TTCATATGGT ACTTTACCAT 3180
ATTTATATAT TGTTTTATAC CTGTAGGTTT ACACACAAGT AAATCTTTTT TTTCTTGAAT 3240
TTAATCTGGC ACTTTGCACT GCCACAGAGG TGACGATGAA CTATGTATAT AGTTAGATGT 3300
TTTGATTTCG TAAAAAATAT ATGTCCATCG TTTGCTATCA CCAGTACCTC TCAGCTTACT 3360
CTTCAGGGGA TATGAAACAA TCTGTAGATT GGTTTCCATA CAGGGAAGTT CTCTGTCCTA 3420
TGCAATGTTT CTAATTAATT TGCTTAGTTC TGAGCCATTT ATTCTGCTAC ACTTTGAAAG 3480
ATATATTAGT TCTGACTTAT TGTTTGGGGC TTTATTTTAT TTTTATTTTT TTGAGATGGA 3540
GTTTCACTCT TGTTGCCCAG GCTGGAGTGC AATAGCTCGA TCTCGGCTCA CTGCAACCTC 3600
GCCTCCCTGG TTCAAGCAAT TCTCCTGCCT CAGCGATTAC AGGAATGCAC CACCACGCCC 3660
AGCTAATTTT GTAGAGATGG GGTTTCTCCA TGTTGGTCAG GCTGGTCTCA AACTCCTGAC 3720
CTCAGGTGAT CCGCCCACCT CGGCCTTGCA AAATGCTGGG ATTACAGGCA TGAGCCACCA 3780
TGCCCAGCCA TGTTTGGGGC TTTATTTTAT AAGTTAGAAC TTTGAAGAGG AAATGGTGCT 3840
ATATGTTTAT TGTTATTACT TTGTGTAACT TTGATGTAAT GTTTATAAGC TATGAGAATC 3900
AGTTATAAAA GTATTAGCCA TTTGTTGTAA ATGCCAATAA AATATTCACC AGGGGCAAGA 3960
ATGTACATTT TCTTTTTAGA AAACCAAATG TACTTTAGAC ATGAATGCAA CTATTTAAAG 4020
AATAGCTTCA TTTATGTTAT TCCTTACATG TCATAAGATT CTTACTTAAA CTTGGTCTTC 4080
TTTCAAGTTG TTTGTATGAA GATGCTGTAC CCACTTGAAC AGTCCTCAGG TGTTTACATA 4140
AATACTATGT TTTACAGTTT TCATATTTTA AAATATTAAT AAAGTTAATC GCAACGATTC 4200
4201
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
Interpro

IPR021987--DUF3588
IPR004092--Mbt
IPR001660--SAM
IPR013761--SAM/pointed
PROSITE

PS51079--MBT
Pfam

PF12140--DUF3588
PF02820--MBT
PF00536--SAM_1
Gene Ontology

GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0009653--P:anatomical structure morphogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0101 ENSNLEP00000011764.1 Nomascus leucogenys 97 0.0 1354
WERAM-Mam-0036 ENSMMUP00000006741.2 Macaca mulatta 98 0.0 1352
WERAM-Gog-0173 ENSGGOP00000015571.2 Gorilla gorilla 99 0.0 1334
WERAM-Chs-0177 ENSCSAP00000010853.1 Chlorocebus sabaeus 97 0.0 1231
WERAM-Eqc-0183 ENSECAP00000019523.1 Equus caballus 81 0.0 1160
WERAM-Poa-0193 ENSPPYP00000022558.1 Pongo abelii 86 0.0 1147
WERAM-Aim-0191 ENSAMEP00000017807.1 Ailuropoda melanoleuca 81 0.0 1139
WERAM-Sus-0085 ENSSSCP00000012940.2 Sus scrofa 80 0.0 1137
WERAM-Vip-0031 ENSVPAP00000002967.1 Vicugna pacos 80 0.0 1119
WERAM-Caf-0136 ENSCAFP00000018840.3 Canis familiaris 81 0.0 1119
WERAM-Paa-0130 ENSPANP00000006797.1 Papio anubis 97 0.0 1117
WERAM-Mup-0029 ENSMPUP00000002833.1 Mustela putorius furo 82 0.0 1097
WERAM-Fec-0071 ENSFCAP00000005984.3 Felis catus 78 0.0 1097
WERAM-Dan-0018 ENSDNOP00000001856.3 Dasypus novemcinctus 78 0.0 1092
WERAM-Ict-0025 ENSSTOP00000001729.2 Ictidomys tridecemlineatus 81 0.0 1078
WERAM-Caj-0063 ENSCJAP00000010784.2 Callithrix jacchus 88 0.0 1053
WERAM-Ova-0144 ENSOARP00000014644.1 Ovis aries 74 0.0 1046
WERAM-Bot-0090 ENSBTAP00000012397.4 Bos taurus 74 0.0 1043
WERAM-Ptv-0015 ENSPVAP00000002293.1 Pteropus vampyrus 72 0.0 986
WERAM-Myl-0173 ENSMLUP00000014088.2 Myotis lucifugus 71 0.0 978
WERAM-Mod-0153 ENSMODP00000021393.3 Monodelphis domestica 61 0.0 867
WERAM-Pes-0115 ENSPSIP00000013723.1 Pelodiscus sinensis 61 0.0 816
WERAM-Gaga-0152 ENSGALP00000026636.4 Gallus gallus 59 0.0 814
WERAM-Anc-0122 ENSACAP00000011431.3 Anolis carolinensis 59 0.0 811
WERAM-Fia-0061 ENSFALP00000004491.1 Ficedula albicollis 58 0.0 808
WERAM-Otg-0128 ENSOGAP00000011150.2 Otolemur garnettii 63 0.0 800
WERAM-Meg-0149 ENSMGAP00000015548.2 Meleagris gallopavo 61 0.0 797
WERAM-Anp-0090 ENSAPLP00000010486.1 Anas platyrhynchos 58 0.0 795
WERAM-Tub-0086 ENSTBEP00000009916.1 Tupaia belangeri 73 0.0 786
WERAM-Lac-0026 ENSLACP00000004182.2 Latimeria chalumnae 58 0.0 773
WERAM-Xet-0005 ENSXETP00000002450.3 Xenopus tropicalis 55 0.0 720
WERAM-Leo-0072 ENSLOCP00000009205.1 Lepisosteus oculatus 52 0.0 708
WERAM-Tut-0002 ENSTTRP00000000050.1 Tursiops truncatus 77 0.0 686
WERAM-Ora-0093 ENSOANP00000016657.2 Ornithorhynchus anatinus 64 0.0 672
WERAM-Orn-0033 ENSONIP00000003960.1 Oreochromis niloticus 52 0.0 667
WERAM-Tar-0149 ENSTRUP00000032053.1 Takifugu rubripes 51 0.0 661
WERAM-Pof-0230 ENSPFOP00000018943.2 Poecilia formosa 51 0.0 651
WERAM-Xim-0125 ENSXMAP00000010575.1 Xiphophorus maculatus 49 0.0 642
WERAM-Dar-0031 ENSDARP00000016700.7 Danio rerio 49 0.0 636
WERAM-Asm-0082 ENSAMXP00000008649.1 Astyanax mexicanus 49 3e-178 622
WERAM-Orla-0176 ENSORLP00000020478.1 Oryzias latipes 48 1e-175 613
WERAM-Ten-0073 ENSTNIP00000009135.1 Tetraodon nigroviridis 50 1e-175 613
WERAM-Loa-0121 ENSLAFP00000011138.3 Loxodonta africana 49 2e-172 603
WERAM-Ran-0177 ENSRNOP00000051099.3 Rattus norvegicus 48 2e-170 597
WERAM-Tag-0107 ENSTGUP00000008015.1 Taeniopygia guttata 61 4e-170 595
WERAM-Mum-0002 ENSMUSP00000000087.6 Mus musculus 49 7e-170 595
WERAM-Sah-0113 ENSSHAP00000012035.1 Sarcophilus harrisii 61 2e-168 590
WERAM-Prc-0071 ENSPCAP00000006551.1 Procavia capensis 47 3e-166 582
WERAM-Cap-0038 ENSCPOP00000003071.2 Cavia porcellus 46 1e-158 557
WERAM-Dio-0044 ENSDORP00000004639.1 Dipodomys ordii 44 1e-146 517
WERAM-Orc-0042 ENSOCUP00000004062.3 Oryctolagus cuniculus 54 4e-145 512
WERAM-Pat-0004 ENSPTRP00000056840.2 Pan troglodytes 56 2e-143 507
WERAM-Ere-0038 ENSEEUP00000002917.1 Erinaceus europaeus 54 3e-143 506
WERAM-Mim-0115 ENSMICP00000011266.1 Microcebus murinus 54 2e-139 494
WERAM-Gaa-0144 ENSGACP00000018461.1 Gasterosteus aculeatus 50 4e-132 469
WERAM-Tas-0009 ENSTSYP00000001233.1 Tarsius syrichta 51 4e-129 459
WERAM-Gam-0085 ENSGMOP00000008797.1 Gadus morhua 47 1e-126 451
WERAM-Mae-0026 ENSMEUP00000001773.1 Macropus eugenii 69 4e-88 323
WERAM-Soa-0090 ENSSARP00000008503.1 Sorex araneus 54 1e-85 315
WERAM-Drm-0008 FBpp0297150 Drosophila melanogaster 63 5e-82 303
WERAM-Cis-0067 ENSCSAVP00000015010.1 Ciona savignyi 54 4e-71 266
WERAM-Cii-0016 ENSCINP00000025543.2 Ciona intestinalis 56 1e-70 265
WERAM-Pem-0053 ENSPMAP00000006206.1 Petromyzon marinus 43 1e-47 189
WERAM-Ocp-0026 ENSOPRP00000002220.1 Ochotona princeps 39 2e-45 181
WERAM-Ect-0004 ENSETEP00000000278.1 Echinops telfairi 41 5e-43 173
Created Date 25-Jun-2016