WERAM Information

Tag Content
WERAM ID WERAM-Hos-0054
Ensembl Protein ID ENSP00000216133.5
Uniprot Accession O95931; CBX7_HUMAN; Q86T17
Genbank Protein ID NP_783640.1
Protein Name Chromobox protein homolog 7
Genbank Nucleotide ID NM_175709.3
Gene Name CBX7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100307.12 ENST00000216133.9 ENSP00000216133.5
ENSG00000100307.12 ENST00000401405.7 ENSP00000384035.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K27me3 K 26985288
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 1.20e-22 82 11 68
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Domain Profile
  Me_Reader Chromodomain
   Chromodomain.txt  1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59
                       F+ve+i  kk++rkg+veYlV+WkG++++++tWepee++l+++l++++e+k+e+++++g
  ENSP00000216133.5 11 FAVESIR-KKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASG 68
                       99*****.***********************************************9987 PP
Protein Sequence
(Fasta)		MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK 60
EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK LCFSLTCPLG SGSPEGVVKA 120
GAPELVDKGP LVPTLPFPLR KPRKAHKYLR LSRKKFPPRG PNLESHSHRR ELFLQEPPAP 180
DVLQAAGEWE PAAQPPEEEA DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA 240
EGFFRDRSGK F 251
Nucleotide Sequence
(Fasta)		CCGAGGAAAA CGTTGCGCAG GTTCAAAAAT GGAACGTCGG CGGCGTGAGG GAGCGCGAGG 60
GGGTGTGCGC GCGTGCGCGT GCGCGTGCGC GCCCGGACGA GGGTGACGGG GACCCCGCCA 120
GCCCCAGCAT CGCGCGCCGC AGCCGCGGCC CCGCAGCTCC GCCCCCGGCC CGGCCCGGCC 180
CCGGGCCCGC TCGCCCGCCG CCCCGCATGG AGCTGTCAGC CATCGGCGAG CAGGTGTTCG 240
CCGTGGAGAG CATCCGGAAG AAGCGCGTGC GGAAGGGTAA AGTCGAGTAT CTGGTGAAGT 300
GGAAAGGATG GCCCCCAAAG TACAGCACGT GGGAGCCAGA AGAGCACATC TTGGACCCCC 360
GCCTCGTCAT GGCCTACGAG GAGAAGGAGG AGAGAGACCG AGCATCGGGG TATAGGAAGA 420
GAGGTCCGAA ACCCAAGCGG CTTCTGCTGC AGCGGCTGTA CAGCATGGAC CTGCGGAGCT 480
CCCACAAGGC CAAGGGCAAG GAGAAGCTCT GCTTCTCCCT GACGTGCCCA CTCGGCAGCG 540
GGAGCCCTGA GGGGGTGGTC AAGGCGGGGG CACCTGAGCT GGTGGACAAG GGCCCCTTGG 600
TGCCCACCCT GCCCTTCCCG CTCCGCAAGC CCCGAAAGGC CCACAAGTAC CTGCGGCTCT 660
CGCGCAAGAA GTTCCCGCCC CGCGGGCCCA ACCTGGAGAG CCACAGCCAT CGACGGGAGC 720
TCTTCCTGCA GGAGCCACCG GCCCCAGACG TCCTGCAGGC GGCTGGCGAG TGGGAGCCTG 780
CTGCGCAGCC CCCTGAAGAG GAGGCAGATG CCGACCTGGC CGAGGGGCCC CCTCCCTGGA 840
CACCTGCGCT CCCCTCAAGT GAGGTGACCG TGACCGACAT CACCGCCAAC TCCATCACCG 900
TCACCTTCCG CGAGGCCCAG GCAGCTGAGG GCTTCTTCCG AGACCGCAGT GGGAAGTTCT 960
GAATCACCGT TTTTACTCTT CTTAAACTGT TTTCTTTTGG GCTTGGGGTG GGACTTCCAG 1020
AGATAGGGAT GGGTTGGGGG CGGGGTAATT ATTTTATTTA AAAAAATACC GAGCAGCAAA 1080
AGGGGAGAAG ATCCCACTAC TCTCCCACCA CCTGCCCTTT CTCTGAGGGA CGTTTACCAC 1140
GAGGCCTCAG GCTGGGGATG GAGAGAGTTG CTCTGGGAGT TGGGGTACCA CCCCCAGGGC 1200
AGGATGGGGA CAGGATCACC TGCCCGGGAC ACCACCATTA TCATTCTCCT CTAGTGACGC 1260
AGCAGCTGGT TCTGGGAGTT AAAGGAGCAT TGGAAGGCCC AAACCCTCTC CCTTGAGTGG 1320
CCACCCCAGC CTGGTTGGCT GGTTTTCCCC TTTTCTCTTG TTTCAATTGG GTCTTTACCT 1380
TGAACTCTCC TCTCTGGCTT TGCGGTGGGC TGTGGAGGCT GGTTTTGACC AAAAGTGAGT 1440
GGGGCGGGAG GAAGGGGCAG GAGGAAGGGT TGAGGTTACT TGGGGCGAGT CCCTTCCCCT 1500
TCAGAGAGGC TTCTATCCTT CCCAGGGAGG AGGCGCCGCT GAGACCCTTC TGCTGAGAGC 1560
TCTGCCCTCC CCTCATCACC TGGCCTGTGC AGAAACGCTC ATGCACACCT GGCTGCACAG 1620
GTGTGCACGC ATTACCCTTC GCGTGTACGT TCCCATGTGC CCCGTGAAAG CATGTGTGGC 1680
TGCAGACGTG TCCACATGGG CCTTGCGAAC CTGGGTTAGA AACCCTGGCC AGGCGAACGT 1740
GGGGTGATTC ACAGCACAAA AGACCTCACC ACCACACCTG CACTCACCCC ACCTTGCATG 1800
CACCTTGCTA CCTGCTTGCG GCTTTCAGTG GAGGGCAGGG GTCTGGCACA GGTGCGATGG 1860
CACCCCATGC TCCAGGCATA CAGATGTGGT TTCTCGGCTG CACCGGGCCA GGCTGCGGGT 1920
GTGCAGGCGT CTGCTAAGTT GTGTGATGTA TCAGCACAGG CTTTGAGACG TCTGGACCCT 1980
GTCCTTCCTC CCGTGAGGGG TTCTTGTTCT TTCTGACTCA GGTGACTTTT CAGCCCTTCC 2040
AATTCCCCTC TTTTTCTGCC CTCCCCTCCA ACTCAGCCAA CCCAGGTGTG GGCAGTCAGG 2100
GAGGGAGGGA GTGTCCCACC ACGTTCTCAG GGCAGCCCTT GACTCCTAAG CCCCTTCCTC 2160
CTTCCATTCT GCATCCCCTC CCCATCCAAC CTAAATGCCA CAGCTGGGGC TGAGCTGTAT 2220
TCCTGTGGAG GGACCTCTGC CGTGCCTCTC TGAGGTCAGG CTGTGCTGTG TGATGGGCAG 2280
GCTTTGCCCC AGCCCACCCC TGGCAAGGTG CACTTGTTTT CTGGTTTGTA CAAGGTGTCC 2340
TGGGGGCCCG TGGCTTCCCT GCCAGTGAGG AGTGACTTCT CCCTCTCTTC CAGTCCTGTA 2400
GGGGAGACAA AACCAGATTG GGGGGCCCAA GGGGAGCATG GAAAAGGCCG GCTCCCCTGT 2460
CTTTCCTTGG CTGTCAGAGT CAGGGTAACA CACACCAAGA GTGGAGTGCG GCCAGCAAGT 2520
TTGAGACCTG CCCGCCCTCC TCGCAGCTCT GCTCTGTGTC CTCAGGAAGT CACAGAGTCT 2580
ACTGAGGCAA GGAGAGGGTG ATTCTTTCCC CAAATCCCTT CTTCCCTGGT TCCCAAACCA 2640
AAGACAGCCT GCAGCCCTTT CTGCATGGGG TGCTCTGTTG ACAGGCTTCC CAGATCCCTG 2700
AGTCTCTCTT TCCTTCCTCC TCGATCTTTA GTTGTCCACG GTCAATTCAG TGCTTCCATT 2760
GGGGGACAGT CCCCTCCGGG ATGACCTGAT TCACCTCCAG CCCAGGGAAT GGAATCTAGA 2820
GGAATACGTG GGGTGGGTCT GGACAAGGAG CGGCAGGAAT CACCACCCAT CTCCAGCTGT 2880
GGAGCCCTGT GGAGGGGAAG GGGAAGCTTG GGGTTCAGAG GGGACTCTTC CAGGAGAGGG 2940
GTGCCCAGCG GAGGTAAAGA TGATAGAGGG TTGTGGGGGG TCTCTAGTTG AATGTTTTGG 3000
CCCATGACTT TGGAACATGG CTGGCAGCTT CCAGCAGAAG TCACGCTCCC CATCCCCCAG 3060
GGGACATAGG ACCTTTTTCC TGCTTCCTGG TCACTTTCAA AGAACTATTT GCGCAATCTG 3120
TGGGTCTGTG GATTCACGGG GCTTTCTGTG TGGGTGCTGC AGTTGCTTTT GTCTGCAGCA 3180
GCAGGACACA TCTTTCCTCT TACTCAGCCC TTTATGGCCC ATGGGGAACT CCGTGGCTCA 3240
GGGAGAGCTG AACTCCAGGG GTGTGACCTG GGACGGGTGG GCCTGAGGTG CCCAGCTCAG 3300
GGCAGCCAGG TGGCTCATGG GCTGTAGTGA GCCAGCTCCC TGGGGGAAAA GGCTGTGGGC 3360
CGTTAGGACC ATCCTCCAGG ACAGGTGACC TCTATGAGGT CACCTACGGC TGTGGCCGTG 3420
CAGGCCTCCT TCCAGCCCAG AGTGGCCCAG TAGAGCAAGG CAGACAGTGA CCTCCACCCC 3480
CGCAGCCCTC TTAAAAGGCC AGTACTCTTG GGGGTGGGGG GAGGGTTTAG AAAGCATTTG 3540
CCCATCTGCC TTTCTTTCCC CCAGCCCCCA CCCGCTTTGA ATGTAGAGAC CCGTGGGCAC 3600
TTTTCCTTTT GTGGTGGGGG GTGCGGAGGA GGTACCCCCA CCCCTGGCAC AGCCGCCTGG 3660
AATGCAGGAC TGTCACTGCT GTTCGGGTGA TGACCTCGTT GCCAAGCTCC TCCTGTCCCC 3720
TTGTTCTGGG GGCAGGCGCT GTGCTTCTGT GAGGTGGTTT AGCTTTTGCT TTCGAAGTGG 3780
CCAGCTGCGG CCACCAGGTC TCAGCACAAG AGCGCTTCCT TTGCACAGAA TGAGCTTCGA 3840
GCTTTGTTCA GACTAAATGA ATGTATCTGG GAGGGGTCGG GGGCACGAGT TGATTCCAAG 3900
CACATGCCTT TGCTGAGTGT GTGTGTGCTG GGAGAGTCAG AGTGGATGTA GAGCGCGGTT 3960
TTATTTTTGT ACTGACATTG GTAAGAGACT GTATAGCATC TATTTATTTA GATGATTTAT 4020
CTGGTAAATG AGGCAAAAAA ATTATTAAAA ATACATTAAA GATGATTTAA AAAAAAGAAA 4080
A 4082
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003682--F:chromatin binding
GO:0003727--F:single-stranded RNA binding
GO:0016568--P:chromatin modification
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042493--P:response to drug
GO:0048733--P:sebaceous gland development
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Paa-0057 ENSPANP00000013357.1 Papio anubis 100 3e-124 441
WERAM-Pat-0117 ENSPTRP00000024790.2 Pan troglodytes 100 3e-124 441
WERAM-Mam-0061 ENSMMUP00000010301.2 Macaca mulatta 100 3e-124 441
WERAM-Gog-0055 ENSGGOP00000004773.2 Gorilla gorilla 100 3e-124 441
WERAM-Chs-0072 ENSCSAP00000002655.1 Chlorocebus sabaeus 95 2e-122 435
WERAM-Sus-0004 ENSSSCP00000000094.2 Sus scrofa 96 1e-120 429
WERAM-Bot-0076 ENSBTAP00000009507.5 Bos taurus 96 3e-120 427
WERAM-Mup-0151 ENSMPUP00000013148.1 Mustela putorius furo 96 6e-116 414
WERAM-Aim-0120 ENSAMEP00000011388.1 Ailuropoda melanoleuca 92 2e-115 412
WERAM-Loa-0182 ENSLAFP00000017563.2 Loxodonta africana 95 3e-115 411
WERAM-Otg-0001 ENSOGAP00000000028.2 Otolemur garnettii 94 3e-115 411
WERAM-Caf-0017 ENSCAFP00000001948.3 Canis familiaris 90 3e-115 411
WERAM-Tut-0014 ENSTTRP00000001188.1 Tursiops truncatus 95 7e-115 410
WERAM-Fec-0174 ENSFCAP00000024437.1 Felis catus 92 4e-114 407
WERAM-Dan-0191 ENSDNOP00000026605.1 Dasypus novemcinctus 94 4e-114 407
WERAM-Ict-0120 ENSSTOP00000011974.2 Ictidomys tridecemlineatus 92 6e-113 404
WERAM-Dio-0093 ENSDORP00000009462.1 Dipodomys ordii 89 3e-111 398
WERAM-Ova-0175 ENSOARP00000017609.1 Ovis aries 88 2e-88 322
WERAM-Anc-0080 ENSACAP00000007637.2 Anolis carolinensis 69 3e-84 308
WERAM-Pes-0116 ENSPSIP00000013945.1 Pelodiscus sinensis 71 1e-83 306
WERAM-Tub-0125 ENSTBEP00000013781.1 Tupaia belangeri 76 3e-81 298
WERAM-Gaga-0164 ENSGALP00000037077.2 Gallus gallus 68 7e-80 293
WERAM-Poa-0100 ENSPPYP00000013205.1 Pongo abelii 77 8e-76 280
WERAM-Tag-0129 ENSTGUP00000010594.1 Taeniopygia guttata 68 1e-72 270
WERAM-Lac-0025 ENSLACP00000004172.1 Latimeria chalumnae 59 3e-67 252
WERAM-Xet-0046 ENSXETP00000015104.1 Xenopus tropicalis 60 1e-66 249
WERAM-Mod-0073 ENSMODP00000036781.1 Monodelphis domestica 53 4e-50 194
WERAM-Tar-0211 ENSTRUP00000043720.1 Takifugu rubripes 48 6e-48 187
WERAM-Ten-0072 ENSTNIP00000009023.1 Tetraodon nigroviridis 46 1e-46 183
WERAM-Xim-0109 ENSXMAP00000009743.1 Xiphophorus maculatus 47 1e-45 180
WERAM-Asm-0071 ENSAMXP00000007701.1 Astyanax mexicanus 79 5e-44 174
WERAM-Ran-0110 ENSRNOP00000022631.5 Rattus norvegicus 92 6e-42 167
WERAM-Mum-0191 ENSMUSP00000105244.1 Mus musculus 92 6e-42 167
WERAM-Gaa-0046 ENSGACP00000006413.1 Gasterosteus aculeatus 42 9e-40 160
WERAM-Prc-0153 ENSPCAP00000014543.1 Procavia capensis 98 1e-39 160
WERAM-Dar-0188 ENSDARP00000108294.1 Danio rerio 80 6e-39 157
WERAM-Gam-0144 ENSGMOP00000014429.1 Gadus morhua 66 7e-39 157
WERAM-Pof-0214 ENSPFOP00000017223.2 Poecilia formosa 73 2e-38 156
WERAM-Orn-0230 ENSONIP00000024802.1 Oreochromis niloticus 80 1e-37 153
WERAM-Cap-0184 ENSCPOP00000020807.1 Cavia porcellus 77 3e-31 132
WERAM-Myl-0018 ENSMLUP00000014628.2 Myotis lucifugus 75 4e-30 128
WERAM-Leo-0140 ENSLOCP00000017081.1 Lepisosteus oculatus 71 5e-30 128
WERAM-Orla-0091 ENSORLP00000011275.1 Oryzias latipes 68 6e-30 128
WERAM-Eqc-0147 ENSECAP00000016028.1 Equus caballus 64 3e-27 119
WERAM-Ect-0139 ENSETEP00000015740.1 Echinops telfairi 67 7e-27 117
WERAM-Ptv-0108 ENSPVAP00000009576.2 Pteropus vampyrus 68 9e-27 117
WERAM-Nol-0165 ENSNLEP00000018459.1 Nomascus leucogenys 66 9e-26 114
WERAM-Caj-0191 ENSCJAP00000032804.1 Callithrix jacchus 65 1e-25 113
WERAM-Sah-0110 ENSSHAP00000011795.1 Sarcophilus harrisii 65 4e-25 112
WERAM-Ere-0051 ENSEEUP00000004327.1 Erinaceus europaeus 71 8e-21 97.8
WERAM-Ora-0048 ENSOANP00000007669.2 Ornithorhynchus anatinus 64 5e-16 82.0
WERAM-Zem-0068 GRMZM2G117100_P01 Zea mays 43 6e-11 65.1
WERAM-Drm-0009 FBpp0079252 Drosophila melanogaster 50 2e-09 59.7
WERAM-Sei-0132 Si036395m Setaria italica 51 2e-09 59.7
WERAM-Pem-0038 ENSPMAP00000004890.1 Petromyzon marinus 38 3e-08 55.8
WERAM-Orc-0176 ENSOCUP00000020504.2 Oryctolagus cuniculus 49 9e-08 54.7
WERAM-Vip-0106 ENSVPAP00000009695.1 Vicugna pacos 49 1e-07 54.3
WERAM-Soa-0076 ENSSARP00000007237.1 Sorex araneus 49 1e-07 54.3
WERAM-Mim-0066 ENSMICP00000006372.1 Microcebus murinus 49 1e-07 54.3
WERAM-Chh-0115 ENSCHOP00000012258.1 Choloepus hoffmanni 49 1e-07 54.3
Created Date 25-Jun-2016