| Tag |
Content |
| WERAM ID |
WERAM-Mum-0035 |
| Ensembl Protein ID |
ENSMUSP00000136280.1 |
| Uniprot Accession |
P58269; DPF3_MOUSE; Q80W78; Q8CAD8
|
| Genbank Protein ID |
NP_001254554.1; NP_478119.1
|
| Protein Name |
Zinc finger protein DPF3 |
| Genbank Nucleotide ID |
NM_001267625.1; NM_058212.2
|
| Gene Name |
DPF3;Baf45c;Cerd4 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Tandem-PHD |
PHD1;PHD2 |
H3K9; H3K14; H4K5; H4K8; H4K12; H4K16 |
K |
18765789
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
9.60e-15 |
56 |
198 |
364 |
| Ac_Reader |
Tandem-PHD |
1.10e-44 |
137.8 |
259 |
319 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 2 tiClvCgkdde 12
+C +Cgk+++
ENSMUSP00000136280.1 198 YVCDICGKRYK 208
45666666655 PP
PHD.txt 2 tiClvC.gkddegeke.....mvqCdeCddwfHlkCvklp..lsslpegkswyCpsCk 51
++C +C g ++ ++k +v C C + H +C++++ ++++ + +w C +Ck
ENSMUSP00000136280.1 260 NYCDFClGGSNMNKKSgrpeeLVSCADCGRSGHPTCLQFTlnMTEAVKTYKWQCIECK 317
79****666666655567777*******************44444445589******8 PP
PHD.txt 3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51
+C++Cg++++++ +++ Cd Cd+ +H++C+++p + peg sw C C
ENSMUSP00000136280.1 318 SCILCGTSENDD-QLLFCDDCDRGYHMYCLNPPVAEPPEG-SWSCHLCW 364
7****6555555.5**************************.*******5 PP
Ac_Reader Tandem-PHD
PHD1.txt 1 inicdfclGtkesnkkk.kPeelvscadcGrsGhPsclkftlelteavkalkWqciecksc 60
+n+cdfclG++++nkk+ +PeelvscadcGrsGhP+cl+ftl++teavk++kWqciecksc
ENSMUSP00000136280.1 259 NNYCDFCLGGSNMNKKSgRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSC 319
79*********************************************************** PP
PHD1.txt 20 eelvscadcGrsGhPsclk 38
++l+ c dc r h cl+
ENSMUSP00000136280.1 329 DQLLFCDDCDRGYHMYCLN 347
6899*************96 PP
|
Protein Sequence
(Fasta) | MATVIHNPLK ALGDQFYKEA IEHCRSYNSR LCAERSVRLP FLDSQTGVAQ NNCYIWMEKR 60
HRGPGLAPGQ LYTYPARCWR KKRRLHPPED PKLRLLEIKP EVELPLKKDG FTSESTTLEA 120
LLRGEGVEKK VDAREEESIQ EIQRVLENDE NVEEGNEEED LEEDVPKRKN RTRGRARGSA 180
GGRRRHDAAS QEDHDKPYVC DICGKRYKNR PGLSYHYAHT HLASEEGDEA QDQETRSPPN 240
HRNENHRPQK GPDGTVIPNN YCDFCLGGSN MNKKSGRPEE LVSCADCGRS GHPTCLQFTL 300
NMTEAVKTYK WQCIECKSCI LCGTSENDDQ LLFCDDCDRG YHMYCLNPPV AEPPEGSWSC 360
HLCWELLKEK ASAFGCQA 378Protein Fasta Sequence
>ENSMUSP00000136280.1|DPF3;Baf45c;Cerd4|Mus musculus
MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDVPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA |
Nucleotide Sequence
(Fasta) | GTAGCAAAAT GGCGACTGTC ATTCACAACC CCCTGAAAGC GCTTGGGGAC CAGTTCTACA 60
AGGAAGCCAT TGAGCACTGC CGGAGCTACA ACTCGAGGCT GTGCGCAGAG CGGAGCGTGC 120
GTCTCCCCTT CCTGGACTCG CAGACTGGGG TGGCTCAGAA CAACTGCTAC ATCTGGATGG 180
AGAAGAGGCA CCGCGGCCCA GGCCTCGCTC CGGGCCAGTT GTACACATAC CCTGCCCGCT 240
GCTGGCGCAA GAAGCGACGA TTGCACCCAC CAGAGGACCC AAAACTACGA CTCCTGGAAA 300
TCAAACCCGA AGTAGAACTG CCCCTGAAGA AAGATGGATT TACCTCTGAG AGTACCACAC 360
TGGAAGCCTT GCTTCGCGGC GAGGGAGTAG AGAAGAAGGT GGATGCCAGA GAAGAGGAAA 420
GCATCCAGGA GATACAGAGG GTTTTGGAAA ATGATGAAAA CGTAGAAGAA GGGAATGAAG 480
AGGAGGATTT GGAAGAAGAT GTTCCCAAGC GCAAGAACAG GACCAGAGGA CGGGCTCGCG 540
GCTCTGCAGG CGGAAGGAGG AGGCATGATG CCGCCTCTCA GGAAGACCAC GACAAACCCT 600
ACGTCTGCGA CATCTGTGGC AAGCGCTACA AGAACCGGCC AGGACTCAGC TACCACTACG 660
CTCATACTCA CCTGGCCAGC GAGGAGGGAG ACGAAGCCCA AGACCAGGAG ACCCGATCCC 720
CACCCAACCA CAGAAATGAG AACCACAGAC CCCAGAAAGG ACCAGACGGG ACAGTCATTC 780
CTAATAACTA CTGTGACTTC TGCTTGGGGG GCTCCAACAT GAACAAGAAG AGTGGGAGGC 840
CTGAAGAGCT GGTGTCCTGT GCAGACTGTG GACGCTCTGG TCATCCAACT TGCCTGCAGT 900
TCACTCTGAA CATGACTGAG GCAGTTAAGA CCTACAAGTG GCAGTGCATA GAGTGTAAAT 960
CCTGTATCCT GTGTGGGACC TCGGAGAACG ACGACCAGCT ACTCTTCTGT GATGACTGCG 1020
ATCGTGGCTA TCACATGTAC TGTTTAAATC CCCCAGTGGC TGAGCCCCCA GAAGGAAGCT 1080
GGAGCTGCCA TTTATGCTGG GAGCTGCTCA AAGAGAAAGC ATCAGCCTTT GGCTGCCAGG 1140
CCTAGGGCTC CACCCAGGTC ACAGAGTGCA GCCCACCACT AGAGAGGCTG AACTGAAGCC 1200
CTGTTCAACC CAGATGGAGG TCTCCTCCTG TATATGCACA CAGACCAACT ACAAGGAAAA 1260
CGAATAGTTA CAGAAGGGAA CGGAGGGAGC AAGGTCTCCA CTCACTTCTC GCCCTACCCA 1320
TGACCTCCCA CCCCACACAT CCTTCAGCCA GCTCTTCCTC ATTTCTACCA GCGGGAACTT 1380
GGCACTTTTG AAGAATAATC CAGCCCCGGC TCTGTGGAAA CTTCCTCATG TTCACTGTCA 1440
CAGGCATCTC TCTTTGTTGC TTCTTGTTTT GGAGGAAGCC ATTTTGTGAC TGCTCATCAA 1500
CCACTCGTGT GTTGCTTGGT GGGGTTCTTG TTTTGTTGTC TATTGTGTTT CAAGAACTTG 1560
TCACAGAGTG TCCTCACCCT TAGCTTAGGC TCTTCATCCT GAAACTCACA GAGGAACAAA 1620
ATGCCGTGGT GGGGAAGCTC CTGCCTATTA CGAGTCTCAC TGGAAGCATC CATGTTTGGA 1680
GGCCATCTTG AAGACAGAAC TTGGAAAATG TCTTGGTTTT CTTAGTCTCT GCTGAGAAGA 1740
GAAGTTGTAG CATTTGAGCC TTGGCAGTAG CATCCCCAGC TGCGATGACC TTGATCCACT 1800
GCACTGCCAT TTGATCAGGG GTTCAGAGGG CCTGGGAGAT GGGAGGAACA CTTGGGGCCC 1860
TGCTATAGCC AGCCAGTATT TGCTGTTCCT CAGGAGGGAC TAGGTGGTTC CTTGACCTTC 1920
AGAACTGTGG TGTCCTTGAG GTGAGACAAC ACAGTCTCTA AACACAGAAA AGTGCTGAAG 1980
ATCCTGCCCC CAACCGAATT GACCGTGAAG GTCTGGCTCA GTCTCTGGGG GGTGGGACTC 2040
AAGCTCTGGA GAGGTGGGCA AAGGATGCCC ATTCAACAGT CCAGGGTTGG TTAGAAGAGA 2100
CTGTATGTAG CTTTGAGAAA CTCTCCCAGT ATTGATGCTA CACTATGGAT TTCTTTTCTG 2160
GGCAATTTCT TCCTTCCATG TAGTATATGT TTGCCAATGA CCACTGAGAT GTGACTGGAA 2220
ATTTTAGAAT GGTGAAGAGA TGAACATTAC TTAACCAGAT CATTGGGCAC AGTGATTACT 2280
TGTGACTGGG TGGCAATGAT TCAGAGCCCT TGTCCGTTCT TGCACCCTAA GCTCCCCCAT 2340
ATGGAATGGG CTCTCGTTTG AAGCAAGGTT TCTAGAAGAT GTAGGAAGGT CTAGATTCTG 2400
AGAACTCTTG TGTGTCAGAA GAGAAGCCTT GAGGGCTGGA GTGGGCTGGG CTGCCTTTGA 2460
CGCACGGCAC CAGCATGATA ACTGACACAT TTCTGGAAAA ATCGTTTGCC CAAAGGGCAG 2520
GTCTCCGTGA GCAGGACCCT CGCGCATGCT CGGCTTCCCT GGATTCAGCT CCATCGCTGT 2580
GGTCCAGCAG CTTGCAACAA AGGCCTGGGT TATTTTTAGT CGTCAGCTCC TGAAGAAGCC 2640
CCTGGAGACC TGGGCTGGCT GGGCCCCTCT GCCCAGCGGC AGCATGGCCT CTGCCACTCC 2700
ACAGGAGTCA TCCTCCCCCT GGCTAATTGC TCTTGGCACG TGGACCCAGG GCAGCCTGGC 2760
ATGGAACCAA GCAGTGTGAC CCCCCCTGCA ACTTCTTTGC AGAGTGACCT GTGGCAAGAG 2820
AGTGGGGGTC ACTTTCCTGC AGGCCCTGTG GCCTCAGAGC TAGTTCCATG CATACGAAAT 2880
GATCTCATTT AAAGGGCCCC TGTCCAGAGA GCATCTGTCT CCTCCTCTCA AGCTCTCTTC 2940
TTCCTCCTGC TGGTTGCTGT GCCTGTGTGG ATTCAAAAGA CCCAAGGGAG GGCTGGAGGA 3000
ATGGCCCGTC TCCACGGAGG GGTACATTCC CTCTCCAGAC TCTGCGGGCT CTCTCGTTCC 3060
ACAAAACCCA AAGCAGAGTA TCTTCAGAGA CTAACTACTT GTTTGGGGGA TCATATTAAA 3120
TTAATTTCAG AAGGG
3136Nucleotide Fasta Sequence
>ENSMUSP00000136280.1|Tandem-PHD|Mus musculus
GTAGCAAAATGGCGACTGTCATTCACAACCCCCTGAAAGCGCTTGGGGACCAGTTCTACAAGGAAGCCATTGAGCACTGCCGGAGCTACAACTCGAGGCTGTGCGCAGAGCGGAGCGTGCGTCTCCCCTTCCTGGACTCGCAGACTGGGGTGGCTCAGAACAACTGCTACATCTGGATGGAGAAGAGGCACCGCGGCCCAGGCCTCGCTCCGGGCCAGTTGTACACATACCCTGCCCGCTGCTGGCGCAAGAAGCGACGATTGCACCCACCAGAGGACCCAAAACTACGACTCCTGGAAATCAAACCCGAAGTAGAACTGCCCCTGAAGAAAGATGGATTTACCTCTGAGAGTACCACACTGGAAGCCTTGCTTCGCGGCGAGGGAGTAGAGAAGAAGGTGGATGCCAGAGAAGAGGAAAGCATCCAGGAGATACAGAGGGTTTTGGAAAATGATGAAAACGTAGAAGAAGGGAATGAAGAGGAGGATTTGGAAGAAGATGTTCCCAAGCGCAAGAACAGGACCAGAGGACGGGCTCGCGGCTCTGCAGGCGGAAGGAGGAGGCATGATGCCGCCTCTCAGGAAGACCACGACAAACCCTACGTCTGCGACATCTGTGGCAAGCGCTACAAGAACCGGCCAGGACTCAGCTACCACTACGCTCATACTCACCTGGCCAGCGAGGAGGGAGACGAAGCCCAAGACCAGGAGACCCGATCCCCACCCAACCACAGAAATGAGAACCACAGACCCCAGAAAGGACCAGACGGGACAGTCATTCCTAATAACTACTGTGACTTCTGCTTGGGGGGCTCCAACATGAACAAGAAGAGTGGGAGGCCTGAAGAGCTGGTGTCCTGTGCAGACTGTGGACGCTCTGGTCATCCAACTTGCCTGCAGTTCACTCTGAACATGACTGAGGCAGTTAAGACCTACAAGTGGCAGTGCATAGAGTGTAAATCCTGTATCCTGTGTGGGACCTCGGAGAACGACGACCAGCTACTCTTCTGTGATGACTGCGATCGTGGCTATCACATGTACTGTTTAAATCCCCCAGTGGCTGAGCCCCCAGAAGGAAGCTGGAGCTGCCATTTATGCTGGGAGCTGCTCAAAGAGAAAGCATCAGCCTTTGGCTGCCAGGCCTAGGGCTCCACCCAGGTCACAGAGTGCAGCCCACCACTAGAGAGGCTGAACTGAAGCCCTGTTCAACCCAGATGGAGGTCTCCTCCTGTATATGCACACAGACCAACTACAAGGAAAACGAATAGTTACAGAAGGGAACGGAGGGAGCAAGGTCTCCACTCACTTCTCGCCCTACCCATGACCTCCCACCCCACACATCCTTCAGCCAGCTCTTCCTCATTTCTACCAGCGGGAACTTGGCACTTTTGAAGAATAATCCAGCCCCGGCTCTGTGGAAACTTCCTCATGTTCACTGTCACAGGCATCTCTCTTTGTTGCTTCTTGTTTTGGAGGAAGCCATTTTGTGACTGCTCATCAACCACTCGTGTGTTGCTTGGTGGGGTTCTTGTTTTGTTGTCTATTGTGTTTCAAGAACTTGTCACAGAGTGTCCTCACCCTTAGCTTAGGCTCTTCATCCTGAAACTCACAGAGGAACAAAATGCCGTGGTGGGGAAGCTCCTGCCTATTACGAGTCTCACTGGAAGCATCCATGTTTGGAGGCCATCTTGAAGACAGAACTTGGAAAATGTCTTGGTTTTCTTAGTCTCTGCTGAGAAGAGAAGTTGTAGCATTTGAGCCTTGGCAGTAGCATCCCCAGCTGCGATGACCTTGATCCACTGCACTGCCATTTGATCAGGGGTTCAGAGGGCCTGGGAGATGGGAGGAACACTTGGGGCCCTGCTATAGCCAGCCAGTATTTGCTGTTCCTCAGGAGGGACTAGGTGGTTCCTTGACCTTCAGAACTGTGGTGTCCTTGAGGTGAGACAACACAGTCTCTAAACACAGAAAAGTGCTGAAGATCCTGCCCCCAACCGAATTGACCGTGAAGGTCTGGCTCAGTCTCTGGGGGGTGGGACTCAAGCTCTGGAGAGGTGGGCAAAGGATGCCCATTCAACAGTCCAGGGTTGGTTAGAAGAGACTGTATGTAGCTTTGAGAAACTCTCCCAGTATTGATGCTACACTATGGATTTCTTTTCTGGGCAATTTCTTCCTTCCATGTAGTATATGTTTGCCAATGACCACTGAGATGTGACTGGAAATTTTAGAATGGTGAAGAGATGAACATTACTTAACCAGATCATTGGGCACAGTGATTACTTGTGACTGGGTGGCAATGATTCAGAGCCCTTGTCCGTTCTTGCACCCTAAGCTCCCCCATATGGAATGGGCTCTCGTTTGAAGCAAGGTTTCTAGAAGATGTAGGAAGGTCTAGATTCTGAGAACTCTTGTGTGTCAGAAGAGAAGCCTTGAGGGCTGGAGTGGGCTGGGCTGCCTTTGACGCACGGCACCAGCATGATAACTGACACATTTCTGGAAAAATCGTTTGCCCAAAGGGCAGGTCTCCGTGAGCAGGACCCTCGCGCATGCTCGGCTTCCCTGGATTCAGCTCCATCGCTGTGGTCCAGCAGCTTGCAACAAAGGCCTGGGTTATTTTTAGTCGTCAGCTCCTGAAGAAGCCCCTGGAGACCTGGGCTGGCTGGGCCCCTCTGCCCAGCGGCAGCATGGCCTCTGCCACTCCACAGGAGTCATCCTCCCCCTGGCTAATTGCTCTTGGCACGTGGACCCAGGGCAGCCTGGCATGGAACCAAGCAGTGTGACCCCCCCTGCAACTTCTTTGCAGAGTGACCTGTGGCAAGAGAGTGGGGGTCACTTTCCTGCAGGCCCTGTGGCCTCAGAGCTAGTTCCATGCATACGAAATGATCTCATTTAAAGGGCCCCTGTCCAGAGAGCATCTGTCTCCTCCTCTCAAGCTCTCTTCTTCCTCCTGCTGGTTGCTGTGCCTGTGTGGATTCAAAAGACCCAAGGGAGGGCTGGAGGAATGGCCCGTCTCCACGGAGGGGTACATTCCCTCTCCAGACTCTGCGGGCTCTCTCGTTCCACAAAACCCAAAGCAGAGTATCTTCAGAGACTAACTACTTGTTTGGGGGATCATATTAAATTAATTTCAGAAGGG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR025750--Requiem/DPF_N_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
PF00628--PHD
PF14051--Requiem_N
|
| Gene Ontology |
GO:0071565--C:nBAF complex
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0007399--P:nervous system development
GO:0002230--P:positive regulation of defense response to virus by host
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0098792--P:xenophagy
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
