| Tag |
Content |
| WERAM ID |
WERAM-Mum-0126 |
| Ensembl Protein ID |
ENSMUSP00000133922.1 |
| Uniprot Accession |
Q3TKT4; SMCA4_MOUSE; Q3TUD7; Q6AXG8
|
| Genbank Protein ID |
NP_001167549.1; NP_001167550.1; NP_035547.2; XP_006510180.2; XP_006510182.2; XP_006510183.2
|
| Protein Name |
Transcription activator BRG1 |
| Genbank Nucleotide ID |
NM_001174078.1; NM_001174079.1; NM_011417.3; XM_006510117.2; XM_006510119.2; XM_006510120.2
|
| Gene Name |
SMARCA4;Baf190a;Brg1;Snf2b;Snf2l4 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Bromodomain |
Bromodomain |
|
K |
25504753
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Ac_Reader |
Bromodomain |
9.10e-18 |
65.6 |
1445 |
1512 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity). |
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity).
|
| Domain Profile |
Ac_Reader Bromodomain
BROMO.txt 3 hevsepF.repvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71
+++se+F + p+++ e+p+Yy++i++P+d+++iker+++++Y+s++++ kDv l+++Na+++n ++s +
ENSMUSP00000133922.1 1445 RQLSEVFiQLPSRK--ELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLI 1512
789****7777777..9***********************************************988766 PP
|
Protein Sequence
(Fasta) | MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPMPTQG 60
PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS GAHTGMAPPP SPMDQHSQGY 120
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL 180
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 240
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 300
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS RITPIQKPRG 360
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 420
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 480
QHAKDFREYH RSVTGKLQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 540
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 600
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES 660
GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV 720
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE 780
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA 840
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 900
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE 960
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD 1020
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG 1080
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK 1140
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 1200
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDEEE 1260
DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR KPRLMEEDEL PSWIIKDDAE 1320
VERLTCEEEE EKMFGRGSRH RKEVDYSDSL TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR 1380
KRDSEAGSST PTTSTRSRDK DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK 1440
DSSGRQLSEV FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ 1500
NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE GSESESRSVK 1560
VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSEEE QEEDRSGSGS EED 1613Protein Fasta Sequence
>ENSMUSP00000133922.1|SMARCA4;Baf190a;Brg1;Snf2b;Snf2l4|Mus musculus
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPMPTQGPGGYPQDNMHQMHKPMESMHEKGMPDDPRYNQMKGMGMRSGAHTGMAPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGSDPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPLVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFREYHRSVTGKLQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSEAGSSTPTTSTRSRDKDEESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED |
Nucleotide Sequence
(Fasta) | AGGCTTTCCC ACTCGCTTGG CAGCGGCGGA GACGGCTTCT TTGTTTCCTG AGGAGAAGCG 60
AGACGCCCAC TCTGTCCCCG ACCCCTCGTG GAGGGTTGGG GGCGGCGCCA GGAAGGTTAC 120
GGCGCCGTTA CCTCCAGGAG ACCAGTGCCT GTAGCTCCAG TAAAGATGTC TACTCCAGAC 180
CCACCCTTGG GTGGGACTCC TCGGCCTGGT CCTTCCCCAG GCCCTGGTCC TTCACCTGGT 240
GCAATGCTGG GTCCTAGCCC TGGCCCCTCA CCAGGTTCTG CCCACAGCAT GATGGGGCCA 300
AGCCCAGGAC CTCCTTCAGC AGGACATCCC ATGCCCACCC AGGGGCCTGG AGGGTACCCC 360
CAGGACAACA TGCATCAGAT GCACAAGCCT ATGGAGTCCA TGCACGAGAA GGGCATGCCT 420
GATGACCCAC GATACAACCA GATGAAAGGG ATGGGCATGC GGTCAGGGGC CCACACAGGC 480
ATGGCACCTC CACCTAGTCC CATGGACCAG CATTCTCAAG GTTACCCCTC ACCCCTCGGC 540
GGCTCTGAAC ATGCCTCCAG TCCTGTCCCA GCCAGTGGCC CATCTTCAGG CCCCCAGATG 600
TCCTCTGGGC CAGGAGGGGC CCCACTAGAT GGTTCTGATC CCCAGGCCTT GGGACAGCAA 660
AACAGAGGCC CAACCCCATT TAACCAGAAC CAGCTGCATC AACTCAGAGC TCAGATAATG 720
GCCTACAAGA TGTTGGCCAG GGGCCAGCCA TTGCCCGACC ACCTGCAGAT GGCCGTGCAA 780
GGCAAGCGGC CGATGCCTGG AATGCAGCAA CAGATGCCAA CACTACCTCC ACCCTCAGTG 840
TCCGCCACAG GACCCGGACC TGGACCCGGC CCTGGCCCTG GCCCTGGCCC AGGACCAGCC 900
CCTCCAAATT ACAGTAGACC CCATGGTATG GGAGGGCCCA ACATGCCTCC CCCAGGACCC 960
TCAGGTGTGC CCCCCGGGAT GCCTGGTCAG CCGCCTGGAG GGCCTCCCAA GCCATGGCCT 1020
GAAGGACCCA TGGCCAATGC TGCTGCCCCC ACAAGCACCC CACAGAAGCT GATTCCTCCG 1080
CAACCAACAG GCCGTCCTTC ACCTGCACCT CCTGCTGTCC CGCCTGCTGC CTCACCTGTA 1140
ATGCCACCAC AAACACAGTC CCCAGGGCAG CCAGCCCAGC CTGCTCCATT GGTGCCACTG 1200
CACCAGAAGC AGAGCCGAAT CACCCCCATC CAGAAGCCCC GAGGCCTTGA CCCTGTGGAG 1260
ATCCTACAAG AGCGGGAGTA CAGGCTTCAG GCTCGAATCG CACACAGAAT TCAGGAACTT 1320
GAAAACCTCC CTGGGTCCCT GGCTGGGGAC CTTCGAACCA AAGCAACCAT CGAACTCAAG 1380
GCCCTTAGGT TGCTGAACTT CCAGAGGCAG CTGCGCCAGG AGGTGGTGGT GTGCATGCGA 1440
AGAGACACAG CCCTGGAGAC AGCCCTCAAT GCCAAGGCCT ACAAGCGCAG CAAACGTCAG 1500
TCACTACGGG AGGCCCGCAT CACTGAGAAG TTGGAGAAGC AGCAGAAGAT TGAACAGGAG 1560
CGCAAGCGCC GCCAGAAGCA CCAGGAGTAC CTCAACAGCA TTCTGCAGCA TGCCAAGGAC 1620
TTCAGGGAGT ATCACAGATC AGTCACAGGC AAACTCCAGA AACTCACCAA GGCTGTGGCC 1680
ACCTACCATG CCAACACTGA GCGGGAGCAG AAGAAAGAAA ATGAGCGCAT TGAGAAGGAG 1740
CGAATGCGGA GGCTTATGGC TGAAGATGAG GAGGGCTACC GCAAACTCAT TGACCAGAAG 1800
AAGGACAAGC GCCTGGCCTA CCTTCTGCAG CAGACAGATG AGTATGTGGC CAACCTCACA 1860
GAGCTGGTGC GGCAGCACAA AGCTGCCCAG GTTGCCAAGG AGAAGAAGAA GAAAAAGAAA 1920
AAGAAGAAGG CAGAAAATGC TGAAGGACAG ACACCTGCTA TTGGACCAGA TGGTGAGCCT 1980
CTGGATGAGA CCAGCCAGAT GAGTGACCTC CCTGTGAAGG TGATCCACGT GGAGAGTGGC 2040
AAGATCCTCA CTGGCACAGA TGCCCCAAAA GCCGGGCAGC TGGAAGCCTG GCTTGAAATG 2100
AACCCAGGGT ATGAAGTAGC CCCCAGGTCA GACAGTGAAG AAAGTGGCTC TGAAGAGGAG 2160
GAGGAGGAGG AGGAAGAGGA GCAGCCTCAG CCCGCACAGC CCCCTACACT GCCTGTGGAA 2220
GAAAAGAAGA AGATTCCAGA CCCAGACAGC GATGATGTCT CTGAGGTGGA CGCCCGACAC 2280
ATTATTGAGA ACGCCAAGCA AGATGTGGAC GATGAGTACG GTGTGTCCCA GGCCCTTGCT 2340
CGTGGCCTGC AGTCTTACTA TGCTGTGGCC CATGCAGTCA CAGAGAGAGT AGATAAGCAG 2400
TCCGCCCTCA TGGTCAACGG TGTCCTCAAA CAGTACCAGA TCAAGGGTTT GGAGTGGCTG 2460
GTGTCCCTGT ACAACAACAA CCTGAATGGC ATCCTGGCTG ATGAGATGGG GCTGGGGAAG 2520
ACCATCCAGA CCATCGCGCT CATCACATAC CTCATGGAGC ACAAGCGCAT CAACGGGCCT 2580
TTCCTCATCA TCGTGCCTCT CTCGACACTG TCAAACTGGG CGTATGAATT TGACAAGTGG 2640
GCCCCCTCTG TGGTGAAGGT TTCTTACAAG GGCTCTCCAG CTGCAAGGCG AGCTTTTGTC 2700
CCACAGCTTC GCAGTGGGAA GTTCAACGTC TTACTGACCA CCTATGAATA TATCATCAAA 2760
GACAAGCATA TCCTAGCCAA GATCCGCTGG AAGTACATGA TTGTGGATGA AGGCCACCGC 2820
ATGAAAAACC ACCACTGCAA GTTGACGCAG GTCCTTAACA CACACTACGT GGCCCCTCGG 2880
CGCCTGCTTC TTACAGGCAC ACCACTGCAG AACAAGCTAC CGGAGCTCTG GGCCCTGCTT 2940
AACTTCCTGC TCCCCACTAT CTTCAAGAGC TGCAGCACCT TCGAACAGTG GTTCAATGCA 3000
CCCTTTGCCA TGACTGGAGA AAAGGTGGAC CTGAATGAAG AGGAGACTAT CCTCATTATT 3060
CGTCGCCTAC ACAAAGTTCT GCGGCCCTTC CTGCTGCGGC GGCTCAAGAA GGAAGTTGAA 3120
GCCCAGCTCC CTGAGAAGGT AGAGTATGTC ATCAAATGCG ACATGTCAGC CCTGCAGCGT 3180
GTGCTGTACC GTCACATGCA GGCCAAAGGT GTGCTGCTGA CTGACGGCTC CGAGAAGGAC 3240
AAGAAGGGCA AAGGTGGCAC CAAGACACTG ATGAACACTA TTATGCAACT GCGTAAGATC 3300
TGCAACCACC CCTACATGTT CCAGCACATC GAGGAGTCCT TTTCTGAGCA CTTGGGGTTC 3360
ACCGGCGGCA TCGTGCAAGG ATTGGACCTT TACCGTGCCT CAGGGAAATT TGAACTTCTT 3420
GATAGAATTC TACCCAAACT CCGTGCAACG AACCATAAAG TGCTCCTCTT TTGCCAAATG 3480
ACCTCCCTCA TGACCATCAT GGAAGACTAC TTTGCATACC GTGGCTTCAA ATACCTCAGG 3540
CTTGATGGAA CCACAAAAGC AGAAGACCGG GGCATGCTGT TGAAAACCTT TAATGAACCT 3600
GGCTCTGAGT ATTTCATTTT CCTGCTCAGT ACCCGTGCTG GGGGGCTGGG CCTGAATCTG 3660
CAGTCAGCTG ACACTGTGAT CATCTTTGAC AGTGACTGGA ATCCCCACCA GGACCTGCAA 3720
GCACAGGATC GAGCCCATCG CATTGGACAG CAGAATGAGG TGCGTGTTCT TCGCCTGTGC 3780
ACGGTCAACA GTGTGGAAGA GAAGATACTG GCTGCTGCCA AATACAAACT CAATGTGGAT 3840
CAGAAGGTGA TCCAGGCAGG CATGTTCGAC CAGAAGTCGT CCAGCCATGA GAGGCGTGCC 3900
TTCCTGCAGG CCATCCTGGA GCACGAGGAG CAGGATGAGG AGGAAGATGA GGTGCCTGAT 3960
GATGAGACCG TCAACCAGAT GATTGCCCGG CACGAAGAAG AGTTTGACCT CTTCATGCGC 4020
ATGGACTTGG ACCGCCGGCG TGAAGAAGCC CGCAACCCCA AGCGGAAGCC ACGCCTGATG 4080
GAAGAGGATG AGCTCCCATC CTGGATCATC AAGGATGATG CCGAGGTGGA GCGGCTGACA 4140
TGTGAAGAGG AAGAGGAGAA GATGTTCGGC CGTGGTTCTC GCCACCGCAA GGAGGTAGAC 4200
TACAGCGACT CACTGACAGA GAAGCAGTGG CTCAAGGCTA TCGAGGAGGG CACGCTGGAG 4260
GAGATCGAAG AGGAGGTCCG GCAGAAGAAA TCTTCACGTA AGCGTAAGCG AGACAGCGAG 4320
GCCGGCTCCT CCACCCCGAC CACCAGCACC CGCAGCCGTG ACAAGGATGA GGAGAGCAAG 4380
AAGCAGAAGA AACGTGGGCG GCCACCTGCT GAGAAGCTGT CCCCAAACCC ACCTAACCTC 4440
ACCAAGAAGA TGAAGAAGAT CGTGGATGCT GTGATCAAGT ACAAAGACAG CAGTGGACGT 4500
CAGCTCAGCG AGGTGTTCAT CCAGCTCCCC TCTCGCAAGG AGCTTCCTGA GTACTATGAG 4560
CTCATCCGAA AGCCTGTGGA CTTCAAGAAG ATCAAGGAAC GCATCCGAAA CCACAAGTAC 4620
CGCAGCCTCA ATGACCTGGA GAAGGATGTG ATGCTGCTGT GCCAGAACGC TCAGACGTTC 4680
AACCTCGAGG GTTCCCTGAT CTATGAGGAC TCCATCGTCC TGCAGTCTGT CTTCACCAGC 4740
GTACGGCAGA AGATTGAGAA GGAGGACGAC AGTGAAGGCG AGGAAAGCGA GGAGGAGGAG 4800
GAGGGCGAGG AGGAAGGCTC CGAGTCTGAG TCCCGCTCCG TCAAGGTGAA GATCAAGCTG 4860
GGCCGCAAGG AGAAGGCCCA GGACCGACTC AAGGGGGGCC GCCGGCGGCC AAGCCGGGGA 4920
TCCCGGGCCA AGCCGGTTGT GAGTGACGAT GACAGTGAGG AGGAGCAGGA GGAGGACCGC 4980
TCAGGAAGTG GCAGTGAGGA AGACTGAACC AGACATTCCT GAGTCCTGAC CCCGAGGCGC 5040
TCGTCCCAGC CAAGATGGAG TAGCCCTTAG CAGTGATGGG TAGCACCAGA TGTAGTTTCG 5100
AACTTGGAGA ACTGTACACA TGCAATCTTC CACATTTTTA GGCAGAGAAG TATAGGCCTG 5160
TCTGTCGGCC CTGGCCTGGC CTCGAGTCTC TACCAGCATT AACTGTCTAG AGAGGGGACC 5220
TCCTGGGAGC ACCATCCACC TCCCCAGGCC CCAGTCACTG TAGCTCAGTG GATGCATGCG 5280
CGTGCCGGCC GCTCCTTGTA CTGTATCTTA CTGGACAGGG CCAGCTCTCC AGGAGGCTCA 5340
CAGGCCCAGC GGGTATGTCA GTGTCACTGG AGTCAGACAG TAATAAATTA AAGCAATGAC 5400
AAGCC
5406Nucleotide Fasta Sequence
>ENSMUSP00000133922.1|Bromodomain|Mus musculus
AGGCTTTCCCACTCGCTTGGCAGCGGCGGAGACGGCTTCTTTGTTTCCTGAGGAGAAGCGAGACGCCCACTCTGTCCCCGACCCCTCGTGGAGGGTTGGGGGCGGCGCCAGGAAGGTTACGGCGCCGTTACCTCCAGGAGACCAGTGCCTGTAGCTCCAGTAAAGATGTCTACTCCAGACCCACCCTTGGGTGGGACTCCTCGGCCTGGTCCTTCCCCAGGCCCTGGTCCTTCACCTGGTGCAATGCTGGGTCCTAGCCCTGGCCCCTCACCAGGTTCTGCCCACAGCATGATGGGGCCAAGCCCAGGACCTCCTTCAGCAGGACATCCCATGCCCACCCAGGGGCCTGGAGGGTACCCCCAGGACAACATGCATCAGATGCACAAGCCTATGGAGTCCATGCACGAGAAGGGCATGCCTGATGACCCACGATACAACCAGATGAAAGGGATGGGCATGCGGTCAGGGGCCCACACAGGCATGGCACCTCCACCTAGTCCCATGGACCAGCATTCTCAAGGTTACCCCTCACCCCTCGGCGGCTCTGAACATGCCTCCAGTCCTGTCCCAGCCAGTGGCCCATCTTCAGGCCCCCAGATGTCCTCTGGGCCAGGAGGGGCCCCACTAGATGGTTCTGATCCCCAGGCCTTGGGACAGCAAAACAGAGGCCCAACCCCATTTAACCAGAACCAGCTGCATCAACTCAGAGCTCAGATAATGGCCTACAAGATGTTGGCCAGGGGCCAGCCATTGCCCGACCACCTGCAGATGGCCGTGCAAGGCAAGCGGCCGATGCCTGGAATGCAGCAACAGATGCCAACACTACCTCCACCCTCAGTGTCCGCCACAGGACCCGGACCTGGACCCGGCCCTGGCCCTGGCCCTGGCCCAGGACCAGCCCCTCCAAATTACAGTAGACCCCATGGTATGGGAGGGCCCAACATGCCTCCCCCAGGACCCTCAGGTGTGCCCCCCGGGATGCCTGGTCAGCCGCCTGGAGGGCCTCCCAAGCCATGGCCTGAAGGACCCATGGCCAATGCTGCTGCCCCCACAAGCACCCCACAGAAGCTGATTCCTCCGCAACCAACAGGCCGTCCTTCACCTGCACCTCCTGCTGTCCCGCCTGCTGCCTCACCTGTAATGCCACCACAAACACAGTCCCCAGGGCAGCCAGCCCAGCCTGCTCCATTGGTGCCACTGCACCAGAAGCAGAGCCGAATCACCCCCATCCAGAAGCCCCGAGGCCTTGACCCTGTGGAGATCCTACAAGAGCGGGAGTACAGGCTTCAGGCTCGAATCGCACACAGAATTCAGGAACTTGAAAACCTCCCTGGGTCCCTGGCTGGGGACCTTCGAACCAAAGCAACCATCGAACTCAAGGCCCTTAGGTTGCTGAACTTCCAGAGGCAGCTGCGCCAGGAGGTGGTGGTGTGCATGCGAAGAGACACAGCCCTGGAGACAGCCCTCAATGCCAAGGCCTACAAGCGCAGCAAACGTCAGTCACTACGGGAGGCCCGCATCACTGAGAAGTTGGAGAAGCAGCAGAAGATTGAACAGGAGCGCAAGCGCCGCCAGAAGCACCAGGAGTACCTCAACAGCATTCTGCAGCATGCCAAGGACTTCAGGGAGTATCACAGATCAGTCACAGGCAAACTCCAGAAACTCACCAAGGCTGTGGCCACCTACCATGCCAACACTGAGCGGGAGCAGAAGAAAGAAAATGAGCGCATTGAGAAGGAGCGAATGCGGAGGCTTATGGCTGAAGATGAGGAGGGCTACCGCAAACTCATTGACCAGAAGAAGGACAAGCGCCTGGCCTACCTTCTGCAGCAGACAGATGAGTATGTGGCCAACCTCACAGAGCTGGTGCGGCAGCACAAAGCTGCCCAGGTTGCCAAGGAGAAGAAGAAGAAAAAGAAAAAGAAGAAGGCAGAAAATGCTGAAGGACAGACACCTGCTATTGGACCAGATGGTGAGCCTCTGGATGAGACCAGCCAGATGAGTGACCTCCCTGTGAAGGTGATCCACGTGGAGAGTGGCAAGATCCTCACTGGCACAGATGCCCCAAAAGCCGGGCAGCTGGAAGCCTGGCTTGAAATGAACCCAGGGTATGAAGTAGCCCCCAGGTCAGACAGTGAAGAAAGTGGCTCTGAAGAGGAGGAGGAGGAGGAGGAAGAGGAGCAGCCTCAGCCCGCACAGCCCCCTACACTGCCTGTGGAAGAAAAGAAGAAGATTCCAGACCCAGACAGCGATGATGTCTCTGAGGTGGACGCCCGACACATTATTGAGAACGCCAAGCAAGATGTGGACGATGAGTACGGTGTGTCCCAGGCCCTTGCTCGTGGCCTGCAGTCTTACTATGCTGTGGCCCATGCAGTCACAGAGAGAGTAGATAAGCAGTCCGCCCTCATGGTCAACGGTGTCCTCAAACAGTACCAGATCAAGGGTTTGGAGTGGCTGGTGTCCCTGTACAACAACAACCTGAATGGCATCCTGGCTGATGAGATGGGGCTGGGGAAGACCATCCAGACCATCGCGCTCATCACATACCTCATGGAGCACAAGCGCATCAACGGGCCTTTCCTCATCATCGTGCCTCTCTCGACACTGTCAAACTGGGCGTATGAATTTGACAAGTGGGCCCCCTCTGTGGTGAAGGTTTCTTACAAGGGCTCTCCAGCTGCAAGGCGAGCTTTTGTCCCACAGCTTCGCAGTGGGAAGTTCAACGTCTTACTGACCACCTATGAATATATCATCAAAGACAAGCATATCCTAGCCAAGATCCGCTGGAAGTACATGATTGTGGATGAAGGCCACCGCATGAAAAACCACCACTGCAAGTTGACGCAGGTCCTTAACACACACTACGTGGCCCCTCGGCGCCTGCTTCTTACAGGCACACCACTGCAGAACAAGCTACCGGAGCTCTGGGCCCTGCTTAACTTCCTGCTCCCCACTATCTTCAAGAGCTGCAGCACCTTCGAACAGTGGTTCAATGCACCCTTTGCCATGACTGGAGAAAAGGTGGACCTGAATGAAGAGGAGACTATCCTCATTATTCGTCGCCTACACAAAGTTCTGCGGCCCTTCCTGCTGCGGCGGCTCAAGAAGGAAGTTGAAGCCCAGCTCCCTGAGAAGGTAGAGTATGTCATCAAATGCGACATGTCAGCCCTGCAGCGTGTGCTGTACCGTCACATGCAGGCCAAAGGTGTGCTGCTGACTGACGGCTCCGAGAAGGACAAGAAGGGCAAAGGTGGCACCAAGACACTGATGAACACTATTATGCAACTGCGTAAGATCTGCAACCACCCCTACATGTTCCAGCACATCGAGGAGTCCTTTTCTGAGCACTTGGGGTTCACCGGCGGCATCGTGCAAGGATTGGACCTTTACCGTGCCTCAGGGAAATTTGAACTTCTTGATAGAATTCTACCCAAACTCCGTGCAACGAACCATAAAGTGCTCCTCTTTTGCCAAATGACCTCCCTCATGACCATCATGGAAGACTACTTTGCATACCGTGGCTTCAAATACCTCAGGCTTGATGGAACCACAAAAGCAGAAGACCGGGGCATGCTGTTGAAAACCTTTAATGAACCTGGCTCTGAGTATTTCATTTTCCTGCTCAGTACCCGTGCTGGGGGGCTGGGCCTGAATCTGCAGTCAGCTGACACTGTGATCATCTTTGACAGTGACTGGAATCCCCACCAGGACCTGCAAGCACAGGATCGAGCCCATCGCATTGGACAGCAGAATGAGGTGCGTGTTCTTCGCCTGTGCACGGTCAACAGTGTGGAAGAGAAGATACTGGCTGCTGCCAAATACAAACTCAATGTGGATCAGAAGGTGATCCAGGCAGGCATGTTCGACCAGAAGTCGTCCAGCCATGAGAGGCGTGCCTTCCTGCAGGCCATCCTGGAGCACGAGGAGCAGGATGAGGAGGAAGATGAGGTGCCTGATGATGAGACCGTCAACCAGATGATTGCCCGGCACGAAGAAGAGTTTGACCTCTTCATGCGCATGGACTTGGACCGCCGGCGTGAAGAAGCCCGCAACCCCAAGCGGAAGCCACGCCTGATGGAAGAGGATGAGCTCCCATCCTGGATCATCAAGGATGATGCCGAGGTGGAGCGGCTGACATGTGAAGAGGAAGAGGAGAAGATGTTCGGCCGTGGTTCTCGCCACCGCAAGGAGGTAGACTACAGCGACTCACTGACAGAGAAGCAGTGGCTCAAGGCTATCGAGGAGGGCACGCTGGAGGAGATCGAAGAGGAGGTCCGGCAGAAGAAATCTTCACGTAAGCGTAAGCGAGACAGCGAGGCCGGCTCCTCCACCCCGACCACCAGCACCCGCAGCCGTGACAAGGATGAGGAGAGCAAGAAGCAGAAGAAACGTGGGCGGCCACCTGCTGAGAAGCTGTCCCCAAACCCACCTAACCTCACCAAGAAGATGAAGAAGATCGTGGATGCTGTGATCAAGTACAAAGACAGCAGTGGACGTCAGCTCAGCGAGGTGTTCATCCAGCTCCCCTCTCGCAAGGAGCTTCCTGAGTACTATGAGCTCATCCGAAAGCCTGTGGACTTCAAGAAGATCAAGGAACGCATCCGAAACCACAAGTACCGCAGCCTCAATGACCTGGAGAAGGATGTGATGCTGCTGTGCCAGAACGCTCAGACGTTCAACCTCGAGGGTTCCCTGATCTATGAGGACTCCATCGTCCTGCAGTCTGTCTTCACCAGCGTACGGCAGAAGATTGAGAAGGAGGACGACAGTGAAGGCGAGGAAAGCGAGGAGGAGGAGGAGGGCGAGGAGGAAGGCTCCGAGTCTGAGTCCCGCTCCGTCAAGGTGAAGATCAAGCTGGGCCGCAAGGAGAAGGCCCAGGACCGACTCAAGGGGGGCCGCCGGCGGCCAAGCCGGGGATCCCGGGCCAAGCCGGTTGTGAGTGACGATGACAGTGAGGAGGAGCAGGAGGAGGACCGCTCAGGAAGTGGCAGTGAGGAAGACTGAACCAGACATTCCTGAGTCCTGACCCCGAGGCGCTCGTCCCAGCCAAGATGGAGTAGCCCTTAGCAGTGATGGGTAGCACCAGATGTAGTTTCGAACTTGGAGAACTGTACACATGCAATCTTCCACATTTTTAGGCAGAGAAGTATAGGCCTGTCTGTCGGCCCTGGCCTGGCCTCGAGTCTCTACCAGCATTAACTGTCTAGAGAGGGGACCTCCTGGGAGCACCATCCACCTCCCCAGGCCCCAGTCACTGTAGCTCAGTGGATGCATGCGCGTGCCGGCCGCTCCTTGTACTGTATCTTACTGGACAGGGCCAGCTCTCCAGGAGGCTCACAGGCCCAGCGGGTATGTCAGTGTCACTGGAGTCAGACAGTAATAAATTAAAGCAATGACAAGCC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR030100--BRG1
IPR006576--BRK_domain
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR014978--Gln-Leu-Gln_QLQ
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014012--HSA_dom
IPR027417--P-loop_NTPase
IPR029295--SnAC
IPR000330--SNF2_N
|
| PROSITE |
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51204--HSA
PS51666--QLQ
|
| Pfam |
PF07533--BRK
PF00439--Bromodomain
PF00271--Helicase_C
PF07529--HSA
PF08880--QLQ
PF14619--SnAC
PF00176--SNF2_N
|
| Gene Ontology |
GO:0090544--C:BAF-type complex
GO:0005615--C:extracellular space
GO:0000792--C:heterochromatin
GO:0016020--C:membrane
GO:0071565--C:nBAF complex
GO:0071564--C:npBAF complex
GO:0000790--C:nuclear chromatin
GO:0005719--C:nuclear euchromatin
GO:0005634--C:nucleus
GO:0005726--C:perichromatin fibrils
GO:0043234--C:protein complex
GO:0016514--C:SWI/SNF complex
GO:0050681--F:androgen receptor binding
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003682--F:chromatin binding
GO:0070182--F:DNA polymerase binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0004386--F:helicase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0047485--F:protein N-terminus binding
GO:0001164--F:RNA polymerase I CORE element sequence-specific DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0030957--F:Tat protein binding
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0035904--P:aorta development
GO:0035887--P:aortic smooth muscle cell differentiation
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0001832--P:blastocyst growth
GO:0001835--P:blastocyst hatching
GO:0001568--P:blood vessel development
GO:0000902--P:cell morphogenesis
GO:0006338--P:chromatin remodeling
GO:0060976--P:coronary vasculature development
GO:0060318--P:definitive erythrocyte differentiation
GO:0010424--P:DNA methylation on cytosine within a CG sequence
GO:0035116--P:embryonic hindlimb morphogenesis
GO:0048562--P:embryonic organ morphogenesis
GO:0048730--P:epidermis morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0030900--P:forebrain development
GO:0007403--P:glial cell fate determination
GO:0007507--P:heart development
GO:0060347--P:heart trabecula formation
GO:0030902--P:hindbrain development
GO:0043966--P:histone H3 acetylation
GO:0001701--P:in utero embryonic development
GO:0030216--P:keratinocyte differentiation
GO:0070307--P:lens fiber cell development
GO:0001889--P:liver development
GO:0006346--P:methylation-dependent chromatin silencing
GO:0060766--P:negative regulation of androgen receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0022008--P:neurogenesis
GO:0006334--P:nucleosome assembly
GO:0006337--P:nucleosome disassembly
GO:0003151--P:outflow tract morphogenesis
GO:0061626--P:pharyngeal arch artery morphogenesis
GO:0043923--P:positive regulation by host of viral transcription
GO:0045597--P:positive regulation of cell differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:0043388--P:positive regulation of DNA binding
GO:1902661--P:positive regulation of glucose mediated signaling pathway
GO:1902895--P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1901838--P:positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0030334--P:regulation of cell migration
GO:0019827--P:stem cell population maintenance
GO:0001570--P:vasculogenesis
GO:0003281--P:ventricular septum development
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
