| Tag |
Content |
| WERAM ID |
WERAM-Mum-0191 |
| Ensembl Protein ID |
ENSMUSP00000105244.1 |
| Uniprot Accession |
Q8VDS3; CBX7_MOUSE
|
| Genbank Protein ID |
NP_659060.1
|
| Protein Name |
Chromobox protein homolog 7 |
| Genbank Nucleotide ID |
NM_144811.3
|
| Gene Name |
CBX7;D15Ertd417e |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
Chromodomain |
Chromo |
H3K27me3 |
K |
24525102
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
Chromodomain |
2.70e-23 |
83.3 |
11 |
101 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
|
| Domain Profile |
Me_Reader Chromodomain
Chromodomain.txt 1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkekkkkqg 59
F+ve+i kk++rkg+veYlV+WkG++++++tWepee++l+++l++++e+k+e+++++g
ENSMUSP00000105244.1 11 FAVESIR-KKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASG 68
99*****.***********************************************9987 PP
Chromodomain.txt 33 Wepeen 38
Wep e+
ENSMUSP00000105244.1 96 WEPMEQ 101
999875 PP
|
Protein Sequence
(Fasta) | MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK 60
EERDRASGYR KRGPKPRRLL LQESAAPDVV QTPGDWEPME QAPEEEAEAD LTNGPPPWTP 120
TLPSSEVTVT DITANSVTVT FREAQAAEGF FRDRNEKL 158Protein Fasta Sequence
>ENSMUSP00000105244.1|CBX7;D15Ertd417e|Mus musculus
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPRRLLLQESAAPDVVQTPGDWEPMEQAPEEEAEADLTNGPPPWTPTLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRNEKL |
Nucleotide Sequence
(Fasta) | GGGCCCACTC GCCCGCCGCC CCGCATGGAG CTGTCAGCCA TAGGCGAGCA GGTGTTTGCG 60
GTGGAGAGCA TCCGGAAGAA GCGCGTGCGG AAGGGCAAAG TTGAATATCT GGTGAAGTGG 120
AAAGGATGGC CCCCCAAGTA TAGCACCTGG GAGCCAGAGG AGCACATCTT GGACCCTCGC 180
CTTGTCATGG CCTACGAGGA GAAGGAGGAG AGAGACCGAG CCTCGGGGTA TAGGAAGAGA 240
GGTCCGAAAC CCAGGCGGCT TCTGCTACAG GAGTCAGCAG CCCCAGACGT TGTGCAGACC 300
CCCGGAGACT GGGAGCCTAT GGAGCAAGCC CCCGAGGAGG AGGCAGAAGC AGACCTGACC 360
AATGGGCCGC CTCCCTGGAC ACCCACGCTC CCCTCAAGTG AAGTTACCGT GACTGACATC 420
ACCGCCAACT CCGTCACCGT CACCTTCCGC GAGGCTCAAG CCGCCGAGGG CTTCTTCCGA 480
GACCGCAACG AGAAGCTGTG AATAGCGGCT TCCCCTCTTA AAACTGTGCT TCTTGGGGCT 540
TGGGTGAGGA TTTCCAGAGA CAGGAGGGGC TGGGAGCAGG GTAAATATTT TTATTTTTTA 600
AAAAAGTAGA AGCACGGGGA AGACCCCAGC ACCCGCCCTT GCTCCCCGAC GGTTGTTTAC 660
AAAGAGGCCT CAGAAACAGG GGGGGAAGGC CAGTGTTGTC TGGGTCTCAT
711Nucleotide Fasta Sequence
>ENSMUSP00000105244.1|Chromodomain|Mus musculus
GGGCCCACTCGCCCGCCGCCCCGCATGGAGCTGTCAGCCATAGGCGAGCAGGTGTTTGCGGTGGAGAGCATCCGGAAGAAGCGCGTGCGGAAGGGCAAAGTTGAATATCTGGTGAAGTGGAAAGGATGGCCCCCCAAGTATAGCACCTGGGAGCCAGAGGAGCACATCTTGGACCCTCGCCTTGTCATGGCCTACGAGGAGAAGGAGGAGAGAGACCGAGCCTCGGGGTATAGGAAGAGAGGTCCGAAACCCAGGCGGCTTCTGCTACAGGAGTCAGCAGCCCCAGACGTTGTGCAGACCCCCGGAGACTGGGAGCCTATGGAGCAAGCCCCCGAGGAGGAGGCAGAAGCAGACCTGACCAATGGGCCGCCTCCCTGGACACCCACGCTCCCCTCAAGTGAAGTTACCGTGACTGACATCACCGCCAACTCCGTCACCGTCACCTTCCGCGAGGCTCAAGCCGCCGAGGGCTTCTTCCGAGACCGCAACGAGAAGCTGTGAATAGCGGCTTCCCCTCTTAAAACTGTGCTTCTTGGGGCTTGGGTGAGGATTTCCAGAGACAGGAGGGGCTGGGAGCAGGGTAAATATTTTTATTTTTTAAAAAAGTAGAAGCACGGGGAAGACCCCAGCACCCGCCCTTGCTCCCCGACGGTTGTTTACAAAGAGGCCTCAGAAACAGGGGGGGAAGGCCAGTGTTGTCTGGGTCTCAT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
|
| Pfam |
PF00385--Chromo
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0003727--F:single-stranded RNA binding
GO:0016568--P:chromatin modification
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042493--P:response to drug
GO:0048733--P:sebaceous gland development
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
