| Tag |
Content |
| WERAM ID |
WERAM-Mum-0110 |
| Ensembl Protein ID |
ENSMUSP00000102853.1 |
| Uniprot Accession |
Q921E6; EED_MOUSE; P97462
|
| Genbank Protein ID |
NP_068676.1
|
| Protein Name |
Polycomb protein EED |
| Genbank Nucleotide ID |
NM_021876.3
|
| Gene Name |
EED |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
WD40 |
WD1-7 |
H3K9; H3K27 |
K |
15516932
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
WD40 |
1.60e-152 |
509.1 |
91 |
439 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain. |
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
|
| Domain Profile |
Me_Reader WD40
WD40.txt 1 dhekelsavkfepaseegaslvaatvgseavtvydcqtqgeikllqky..kghdeefysvawtadsnkrhslLasAgdrglirlldvea 87
dh+++l++v+f+++s+eg++lv+atvgs++vt+y+c++qgei+llq+y +++de+fy++awt+dsn++h+lLa+Ag+rg+ir++++++
ENSMUSP00000102853.1 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYvdADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT 179
8***********************************************9999************************************* PP
WD40.txt 88 gqcikvlvgHknaiaelkFsPkdenlllsaSfdkrvrlWdiktdklkkif...eahsdevldvdydlrgslivScgmdgslkiWdvrsk 173
+qcik++vgH+nai+elkF+P+d+nllls+S+d+++rlW+i+td+l++if e+h+devl++dydl g++i+Scgmd+slk+W+++sk
ENSMUSP00000102853.1 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268
***************************************************************************************** PP
WD40.txt 174 rrvcevklvddenpeksnrr....................VdcvrfsngdlilsgsldntivlW.......dirkikqsevavvvLkrf 235
r+++++k+++d+np+k+nr+ Vdcvr+ +gdlils+s++n+iv+W di+kik+se++v++L+rf
ENSMUSP00000102853.1 269 RMMNAIKESYDYNPNKTNRPfisqkihfpdfstrdihrnyVDCVRW-LGDLILSKSCENAIVCWkpgkmedDIDKIKPSESNVTILGRF 356
**********************************************.****************************************** PP
WD40.txt 236 eyskteiyyislsfsvdn.kkilvsgdedgkvyvwdlsveaalkakelllklgkvtakimqtsvspnesiiiltaltddnivkiWdr 321
+ys+++i+y+ +fs+d+ +k+l++g+++gk+yvwdl+ve+++kak+++l+++k++a+i+qts+s+++si+i a++dd+++++Wdr
ENSMUSP00000102853.1 357 DYSQCDIWYM--RFSMDFwQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILI--AVCDDASIWRWDR 439
**********..************************************************************..************8 PP
|
Protein Sequence
(Fasta) | MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 60
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 120
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM 180
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL 240
SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS 300
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ 360
CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR 420
DSSILIAVCD DASIWRWDRL R 441Protein Fasta Sequence
>ENSMUSP00000102853.1|EED|Mus musculus
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR |
Nucleotide Sequence
(Fasta) | GTTTGCAGCG GGTCGGAGAT CGAAGGATTG AGCCAATTGC GGATGAAACG TCTTGGCCAG 60
GAAGGGGGTG AGGGAGCAGC CCTTTGAGTT CCGCCTCGTC TCTAGGCGCT GGTGGGGAAG 120
GGGGACGTAG GAAACCCCTG CCCTCTGAGC CAGCAGATCC GACGCCTCGG TGCAAAGTGT 180
CGAGAGGGCG GCGGGAAAAC CGCCCGCCCG GACCAAGGGA CGGGAAGCAG CCGGGAAGCC 240
GTGCGGGAGG GCGCGCGCGT GCGCGCCCCT TTTTCAGCAG TGTGGCGGGG TCGCACGCAC 300
GCCCGCCTCG GCGGCTGGGC GCGATTTGCG ACAGTGGGGG GGGCGGCGGC GGTGGCGGCG 360
CCGGCAGCTT TGCGGCAGGC TCGGGCCGGG CGTGCTTGAC GGCGGTGTGG CGGAGGCCCC 420
GCCCGAGGCG GCAAGAACCT GGAGGGAGGC GGAGGAACAT GTCCGAGAGG GAAGTGTCGA 480
CTGCGCCGGC GGGAACAGAC ATGCCCGCGG CCAAGAAGCA GAAGTTGAGC AGCGACGAGA 540
ACAGCAACCC GGACCTCTCG GGAGACGAAA ATGACGATGC TGTCAGTATT GAGAGTGGCA 600
CAAACACAGA ACGCCCGGAC ACGCCCACAA ATACGCCAAA TGCACCAGGA AGGAAAAGCT 660
GGGGAAAGGG AAAATGGAAG TCAAAGAAAT GCAAATATTC TTTCAAATGT GTGAACAGCC 720
TCAAGGAAGA TCATAACCAG CCATTGTTTG GAGTTCAGTT TAACTGGCAC AGTAAAGAAG 780
GAGACCCTCT GGTGTTTGCA ACTGTGGGAA GCAACAGAGT AACCTTATAC GAATGCCATT 840
CACAGGGGGA GATACGGTTA TTGCAGTCCT ATGTAGATGC TGATGCAGAT GAAAACTTTT 900
ACACTTGTGC ATGGACCTAT GATAGCAACA CCAGCCACCC TCTATTAGCA GTTGCTGGAT 960
CTAGAGGCAT TATAAGAATA ATTAATCCTA TAACAATGCA GTGTATAAAG CACTATGTTG 1020
GCCATGGAAA TGCTATCAAT GAGCTGAAAT TCCACCCACG AGACCCAAAC CTTCTCCTGT 1080
CAGTAAGTAA AGATCATGCT TTACGGTTAT GGAATATCCA AACAGACACT CTTGTGGCAA 1140
TATTCGGAGG TGTGGAAGGG CACAGAGATG AAGTTCTGAG TGCTGATTAT GATCTTTTGG 1200
GTGAAAAAAT AATGTCCTGT GGTATGGATC ACTCTCTTAA ACTGTGGAGA ATCAACTCAA 1260
AGAGGATGAT GAATGCAATT AAGGAGTCTT ATGATTATAA CCCAAACAAA ACTAACAGGC 1320
CATTTATTTC CCAGAAAATC CACTTTCCTG ACTTTTCTAC CAGAGACATA CATAGGAATT 1380
ATGTTGATTG TGTGCGATGG TTAGGCGATT TGATACTTTC CAAGTCTTGT GAAAATGCCA 1440
TTGTATGCTG GAAACCTGGC AAAATGGAGG ATGATATAGA TAAAATTAAA CCTAGTGAGT 1500
CTAATGTGAC TATTCTTGGG CGATTTGATT ACAGCCAGTG TGACATTTGG TACATGAGGT 1560
TTTCTATGGA TTTCTGGCAA AAGATGCTTG CATTGGGCAA TCAGGTTGGC AAACTGTATG 1620
TTTGGGATTT AGAAGTAGAA GATCCTCATA AAGCCAAATG CACAACACTG ACCCATCATA 1680
AATGTGGCGC GGCTATTCGA CAAACCAGTT TCAGTAGGGA TAGCAGCATC CTCATAGCTG 1740
TCTGCGATGA TGCCAGCATT TGGCGATGGG ATCGACTTCG ATAAACTATT TTTTCCTAGT 1800
AAAAATTAGT CTGTTGTCTG TAAAATAGAA GTAATGTATC TTGCTAGTAA GGGCACATAG 1860
AGCATTTAGA CTTGTTTTTC AGCATTCGAT CAGGCTGAGC TGAATGTAGT GATGTTCACA 1920
TTGTTTACAT TCTTTGTACT GTCTTCCTGC TCGGACTTTA CTGCTTTTAA TAAAAATTTA 1980
TTTTTGTAAA GCTGTGTTAT TTTTATTGTG ATGGAAACAA ACTGGAAGAA ATAAAGTTGT 2040
ACCATATCTT TTTGTAATGT TTACTTT
2068Nucleotide Fasta Sequence
>ENSMUSP00000102853.1|WD40|Mus musculus
GTTTGCAGCGGGTCGGAGATCGAAGGATTGAGCCAATTGCGGATGAAACGTCTTGGCCAGGAAGGGGGTGAGGGAGCAGCCCTTTGAGTTCCGCCTCGTCTCTAGGCGCTGGTGGGGAAGGGGGACGTAGGAAACCCCTGCCCTCTGAGCCAGCAGATCCGACGCCTCGGTGCAAAGTGTCGAGAGGGCGGCGGGAAAACCGCCCGCCCGGACCAAGGGACGGGAAGCAGCCGGGAAGCCGTGCGGGAGGGCGCGCGCGTGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGGGCGGCGGCGGTGGCGGCGCCGGCAGCTTTGCGGCAGGCTCGGGCCGGGCGTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCGAGGCGGCAAGAACCTGGAGGGAGGCGGAGGAACATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCCGCGGCCAAGAAGCAGAAGTTGAGCAGCGACGAGAACAGCAACCCGGACCTCTCGGGAGACGAAAATGACGATGCTGTCAGTATTGAGAGTGGCACAAACACAGAACGCCCGGACACGCCCACAAATACGCCAAATGCACCAGGAAGGAAAAGCTGGGGAAAGGGAAAATGGAAGTCAAAGAAATGCAAATATTCTTTCAAATGTGTGAACAGCCTCAAGGAAGATCATAACCAGCCATTGTTTGGAGTTCAGTTTAACTGGCACAGTAAAGAAGGAGACCCTCTGGTGTTTGCAACTGTGGGAAGCAACAGAGTAACCTTATACGAATGCCATTCACAGGGGGAGATACGGTTATTGCAGTCCTATGTAGATGCTGATGCAGATGAAAACTTTTACACTTGTGCATGGACCTATGATAGCAACACCAGCCACCCTCTATTAGCAGTTGCTGGATCTAGAGGCATTATAAGAATAATTAATCCTATAACAATGCAGTGTATAAAGCACTATGTTGGCCATGGAAATGCTATCAATGAGCTGAAATTCCACCCACGAGACCCAAACCTTCTCCTGTCAGTAAGTAAAGATCATGCTTTACGGTTATGGAATATCCAAACAGACACTCTTGTGGCAATATTCGGAGGTGTGGAAGGGCACAGAGATGAAGTTCTGAGTGCTGATTATGATCTTTTGGGTGAAAAAATAATGTCCTGTGGTATGGATCACTCTCTTAAACTGTGGAGAATCAACTCAAAGAGGATGATGAATGCAATTAAGGAGTCTTATGATTATAACCCAAACAAAACTAACAGGCCATTTATTTCCCAGAAAATCCACTTTCCTGACTTTTCTACCAGAGACATACATAGGAATTATGTTGATTGTGTGCGATGGTTAGGCGATTTGATACTTTCCAAGTCTTGTGAAAATGCCATTGTATGCTGGAAACCTGGCAAAATGGAGGATGATATAGATAAAATTAAACCTAGTGAGTCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAGGTTGGCAAACTGTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGCACAACACTGACCCATCATAAATGTGGCGCGGCTATTCGACAAACCAGTTTCAGTAGGGATAGCAGCATCCTCATAGCTGTCTGCGATGATGCCAGCATTTGGCGATGGGATCGACTTCGATAAACTATTTTTTCCTAGTAAAAATTAGTCTGTTGTCTGTAAAATAGAAGTAATGTATCTTGCTAGTAAGGGCACATAGAGCATTTAGACTTGTTTTTCAGCATTCGATCAGGCTGAGCTGAATGTAGTGATGTTCACATTGTTTACATTCTTTGTACTGTCTTCCTGCTCGGACTTTACTGCTTTTAATAAAAATTTATTTTTGTAAAGCTGTGTTATTTTTATTGTGATGGAAACAAACTGGAAGAAATAAAGTTGTACCATATCTTTTTGTAATGTTTACTTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0024--Alternative initiation
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
--
|
| Interpro |
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF00400--WD40
|
| Gene Ontology |
GO:0035098--C:ESC/E(Z) complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045120--C:pronucleus
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0042802--F:identical protein binding
GO:0016571--P:histone methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0021510--P:spinal cord development
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
