WERAM Information

Tag Content
WERAM ID WERAM-Mum-0214
Ensembl Protein ID ENSMUSP00000079226.2
Uniprot Accession Q9ESK4; ING2_MOUSE; Q4VAD7; Q80VI5; Q8BGU8
Genbank Protein ID NP_075992.2
Protein Name Inhibitor of growth protein 2
Genbank Nucleotide ID NM_023503.3
Gene Name ING2;Ing1l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000063049.4 ENSMUST00000080353.2 ENSMUSP00000079226.2
ENSMUSG00000063049.4 ENSMUST00000146625.2 ENSMUSP00000124454.1
ENSMUSG00000063049.4 ENSMUST00000125536.1 ENSMUSP00000124792.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 16728977
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 1.50e-12 49 119 260
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).
Domain Profile
  Me_Reader PHD
               PHD.txt  25 dwfHlkCvklplssl 39 
                           +  H +C + p +s 
  ENSMUSP00000079226.2 119 MELHSQCFQDPAESE 133
                           568****99984443 PP
               PHD.txt   2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCk 51 
                           t+Cl C+++++ge  m+ Cd+  C+ +wfH +Cv+l+    p+g +wyCp+C+
  ENSMUSP00000079226.2 214 TYCL-CNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT--YKPKG-KWYCPKCR 260
                           89*9.*******6..**********************..*****.*******8 PP
Protein Sequence
(Fasta)		MLGQQQQQQL YSSAALLTGE RSRLLSCYVQ DYLECVESLP HDMQRNVSVL RELDNKYQET 60
LKEIDDVYEK YKKEDDSNQK KRLQQHLQRA LINSQELGDE KIQIVTQMLE LVENRARQME 120
LHSQCFQDPA ESERASDKSK MDSSQPERSS RRPRRQRTSE SRDLCHMTNG IDDCDDQPPK 180
EKRSKSAKKK KRSKAKQERE ASPVEFAIDP NEPTYCLCNQ VSYGEMIGCD NEQCPIEWFH 240
FSCVSLTYKP KGKWYCPKCR GDNEKTMDKS TEKTKKERRA R 281
Nucleotide Sequence
(Fasta)		GACTAGTCCT GTGAGACTCC GACAGGCACG GAGGCTGATA GAGAGGCGAG AGGGTAGCGA 60
GGGGCTTGTC ACGGGGATCC GGGCGACCGG GCAGCCCCGG TAGTGTCTGG GGAGTCCCCG 120
GGGGGGACAG CCAGCGTCGC TGCCTGGGAG CCCCGGCGCC ATCGGCCGCG GGGAACCCCG 180
CTGCTCGCTC TCCTAGAGAG GGAGGGGGCC GGAGGGAGCC CCGGTCTCGC CCCGCCCCTG 240
GGCTTGTTAC CGCGGGGGCG GGGAGTAAGG GCTTCTTCTT GGGGGAGTGG AGATCGGGGG 300
ACTCGGCGGT GCCCTCTCGA GCGGCGGCCG TGTCCCCGCG GCGCCGGGCT GCCGAGCGGA 360
GGAGCGGCGG TCGTGGCTGT TGCATGTGTG GCTGCTGGAT GCGGAGGCGG CGGCGGCGGC 420
GGCGGCGAGG AGCAGCAGCA GCGGCGGCGG CGGCGGTGGT GGTGGTGGCG GCGGCAGGAT 480
GTTAGGGCAG CAGCAGCAGC AGCAGCTGTA CTCGTCGGCC GCGCTCCTGA CCGGAGAGCG 540
GAGCCGGCTG CTCTCCTGCT ACGTGCAGGA CTACCTGGAG TGTGTGGAGT CGCTGCCCCA 600
CGACATGCAG AGGAACGTGT CGGTGCTGCG GGAGCTGGAC AACAAATACC AAGAAACGTT 660
AAAGGAAATT GATGATGTCT ATGAAAAATA TAAGAAAGAA GATGATTCCA ACCAGAAAAA 720
ACGCCTACAG CAGCATCTCC AGAGAGCGTT AATCAATAGC CAAGAATTGG GAGATGAAAA 780
AATTCAGATT GTCACCCAGA TGCTCGAATT GGTGGAGAAC CGAGCGAGAC AAATGGAGCT 840
GCATTCACAG TGTTTCCAGG ATCCTGCTGA AAGTGAGCGA GCCTCAGACA AGTCGAAGAT 900
GGATTCCAGT CAACCGGAAA GATCTTCTAG AAGACCTCGA AGACAGAGGA CCAGTGAGAG 960
CCGTGACTTA TGTCACATGA CAAACGGGAT TGACGACTGT GATGATCAAC CACCGAAAGA 1020
AAAGAGATCC AAGTCCGCCA AGAAGAAGAA GCGCTCCAAG GCCAAGCAGG AGAGGGAGGC 1080
ATCCCCTGTC GAGTTTGCCA TCGATCCCAA TGAGCCCACC TACTGCTTGT GTAACCAAGT 1140
GTCCTACGGG GAGATGATAG GCTGTGACAA TGAACAGTGT CCCATTGAAT GGTTTCACTT 1200
TTCATGTGTT TCACTCACCT ATAAACCCAA GGGGAAATGG TATTGCCCAA AGTGTAGGGG 1260
AGACAATGAG AAAACCATGG ACAAAAGTAC CGAAAAGACA AAAAAGGAGA GAAGAGCGAG 1320
GTAGTGAAGG CCATCGGTTT TAAAGGGTTC TTTGTCTTTT ATAGAATTGC TTTACTTTCA 1380
GAAAATGTTT TAGGGTAACT GCATAAGACT ATGCAATAAT TTTTAATCAT TAGTATTGAT 1440
GGTGTATTAA AAGTTGTTGT ACTTTGTCTG TGACCTTAAT TTTCTGCACT GAATTACCAA 1500
ATATTTTCAG CCAGGTAGTC TCTGTGAGGA CCTAATGAAA GGAGCAGGCA GAGAGGCGTA 1560
TGAACGAACT GCAAGCAGCT TCCCAAGCCA CGCCTATTCC ACCCCCACCT TCAACTCTCA 1620
TGCTGTTTGG GGGTGGGGGG TAAACCCAAA AAGTTTTGCT AACATTTTAT TTTAGTTCTG 1680
TGTGCTTAAG AATTTTATGT ATTGTTGGAT TTCTGTGTCA AATTCTCTTG GTGATTTCAA 1740
ACATGAACAC TATTCTGTTT AGAGATTCTT ATTGCCTCCA TGTCTTCAGA CACTTGTTAA 1800
ATCTCTAGTC TCCCAGAAAT TCCAGGAACT AGAGACAACA GTACCCATGC TCCCACATGG 1860
ACTAGTGCGC TCTTCCTGGA GTGTCCACTG CGTATTTTCT TGGTAGCTTT TGTTACCTGT 1920
CAGTTGTAGC GTCTGTAAAA GCCCCTGCTT CTTCAGAACA GACACACCTC ATCTAGTGTT 1980
TAATAAGGGA CTCATTTTGA TCAGGACACG TAAGACTAGT TAGAAATACC AAATAATGTT 2040
GCCGCTGCCT CATATTGGCA AGATGTGGAT TATTCAGCAT CATGGTTCAA GGTTGAACAA 2100
TTTAAAGGTG TGTCTTAATA TTTTCTATGT GACCCACTGC TGGGATGTTT AGCCACAGAC 2160
CCGTCAGTGG GAAAAGGGCA TAGATTAGTC TTTAAATAAT GCCTTTTCTG TCAAACAGTT 2220
ATTTTAAATA GTTCTTTTCT GGGGGCTAGA GTTTATTTTT ACCCCCCAAT GAGTAATTAT 2280
ACATTATTTT AAATAATAGT ATATTTACCT TAACCTCCTG GTATTGGTGC TGTTTGATGT 2340
TTTCATGTTT ATTGAACTAA TTTCATTATA ATAATACGAT TAATAATGTA TTTGTAAATT 2400
GAATTTTCCA AGATTTTGAT ATTTTAAGGT TAAGCATCTT GGTGGAGCTG TGACCATGTG 2460
TGGGAGCAGT TTTTGGTTAT GGAGAGCAGC AGACGGACTA GTCCTTTAAC CTCTCATGCA 2520
GCTTCTGTCT TAGTTGTCAT CTTTTCTTCC TAATCTGATA ATCTTGGTTC TTGTTGATTA 2580
ACATGTGAAA AATCCTATCT GCTTGTTTGG AAAAAAAAAA AAAGAAAGAT GTTTTTTTCC 2640
TCTTCAAGCT CTCTGTGTGA CTTAGGCCCT GTCATTTCAC CTTACCTGAA TGTTGGGTGA 2700
TGGATCAACC TAGAAAATGA GTTGGCTTAA CCATCTGCAA GGGCCTTTTG AAATTTCAGT 2760
GTTGTGCCGT GGTGAACGAT TTTAACAATG AAATGGCTTG CTTTTCTCTT TC 2813
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0035091--F:phosphatidylinositol binding
GO:0032403--F:protein complex binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0043065--P:positive regulation of apoptotic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0072520--P:seminiferous tubule development
GO:0030317--P:sperm motility
GO:0007286--P:spermatid development
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0086 ENSRNOP00000018689.4 Rattus norvegicus 98 5e-120 427
WERAM-Sus-0166 ENSSSCP00000028185.1 Sus scrofa 98 2e-119 426
WERAM-Ptv-0141 ENSPVAP00000011934.1 Pteropus vampyrus 97 2e-119 425
WERAM-Bot-0224 ENSBTAP00000054457.1 Bos taurus 98 3e-119 425
WERAM-Ict-0126 ENSSTOP00000012796.2 Ictidomys tridecemlineatus 97 8e-119 423
WERAM-Orc-0119 ENSOCUP00000010152.3 Oryctolagus cuniculus 97 1e-118 422
WERAM-Fec-0192 ENSFCAP00000019449.1 Felis catus 97 1e-118 422
WERAM-Aim-0091 ENSAMEP00000008687.1 Ailuropoda melanoleuca 96 5e-118 421
WERAM-Dio-0155 ENSDORP00000014378.1 Dipodomys ordii 96 7e-118 420
WERAM-Eqc-0120 ENSECAP00000013009.1 Equus caballus 97 9e-118 420
WERAM-Caf-0090 ENSCAFP00000011661.2 Canis familiaris 96 1e-117 419
WERAM-Ova-0072 ENSOARP00000007677.1 Ovis aries 97 1e-117 419
WERAM-Vip-0056 ENSVPAP00000005332.1 Vicugna pacos 96 1e-117 419
WERAM-Dan-0032 ENSDNOP00000003012.2 Dasypus novemcinctus 96 1e-117 419
WERAM-Mim-0014 ENSMICP00000001205.1 Microcebus murinus 97 2e-117 419
WERAM-Paa-0070 ENSPANP00000001839.1 Papio anubis 96 6e-117 417
WERAM-Mam-0072 ENSMMUP00000011648.2 Macaca mulatta 96 6e-117 417
WERAM-Hos-0190 ENSP00000307183.3 Homo sapiens 96 6e-117 417
WERAM-Chs-0033 ENSCSAP00000015014.1 Chlorocebus sabaeus 96 6e-117 417
WERAM-Cap-0134 ENSCPOP00000010891.2 Cavia porcellus 95 8e-117 417
WERAM-Poa-0135 ENSPPYP00000017012.2 Pongo abelii 96 2e-116 415
WERAM-Otg-0175 ENSOGAP00000014951.2 Otolemur garnettii 97 2e-116 415
WERAM-Ect-0001 ENSETEP00000000063.1 Echinops telfairi 95 3e-115 412
WERAM-Gog-0204 ENSGGOP00000017999.1 Gorilla gorilla 95 2e-111 399
WERAM-Sah-0143 ENSSHAP00000014993.1 Sarcophilus harrisii 91 6e-110 394
WERAM-Mod-0032 ENSMODP00000005181.3 Monodelphis domestica 91 7e-110 394
WERAM-Mae-0079 ENSMEUP00000007772.1 Macropus eugenii 90 3e-108 388
WERAM-Prc-0101 ENSPCAP00000009149.1 Procavia capensis 94 1e-104 376
WERAM-Mup-0125 ENSMPUP00000010954.1 Mustela putorius furo 96 2e-97 352
WERAM-Lac-0118 ENSLACP00000014384.1 Latimeria chalumnae 79 3e-91 332
WERAM-Tut-0111 ENSTTRP00000009087.1 Tursiops truncatus 98 3e-90 328
WERAM-Loa-0132 ENSLAFP00000012180.2 Loxodonta africana 97 5e-89 324
WERAM-Ere-0043 ENSEEUP00000003677.1 Erinaceus europaeus 97 7e-89 324
WERAM-Tas-0017 ENSTSYP00000002061.1 Tarsius syrichta 97 5e-88 321
WERAM-Anc-0071 ENSACAP00000006812.3 Anolis carolinensis 81 5e-88 321
WERAM-Caj-0059 ENSCJAP00000010218.2 Callithrix jacchus 97 1e-87 320
WERAM-Pat-0135 ENSPTRP00000028526.3 Pan troglodytes 97 1e-87 320
WERAM-Soa-0115 ENSSARP00000010879.1 Sorex araneus 95 4e-87 318
WERAM-Nol-0114 ENSNLEP00000013029.1 Nomascus leucogenys 96 8e-87 317
WERAM-Asm-0005 ENSAMXP00000000685.1 Astyanax mexicanus 74 3e-82 302
WERAM-Xet-0119 ENSXETP00000041302.3 Xenopus tropicalis 70 8e-81 297
WERAM-Anp-0003 ENSAPLP00000000292.1 Anas platyrhynchos 81 3e-80 295
WERAM-Gaga-0105 ENSGALP00000017323.5 Gallus gallus 80 6e-80 294
WERAM-Tag-0099 ENSTGUP00000006752.1 Taeniopygia guttata 90 7e-80 294
WERAM-Meg-0069 ENSMGAP00000006505.2 Meleagris gallopavo 89 1e-79 293
WERAM-Fia-0171 ENSFALP00000015237.1 Ficedula albicollis 89 2e-79 293
WERAM-Dar-0238 ENSDARP00000134787.1 Danio rerio 70 2e-77 286
WERAM-Gam-0075 ENSGMOP00000008031.1 Gadus morhua 61 3e-77 285
WERAM-Pof-0169 ENSPFOP00000014200.1 Poecilia formosa 66 7e-76 280
WERAM-Xim-0083 ENSXMAP00000007731.1 Xiphophorus maculatus 66 2e-75 280
WERAM-Orn-0189 ENSONIP00000019769.1 Oreochromis niloticus 64 2e-75 279
WERAM-Gaa-0007 ENSGACP00000001097.1 Gasterosteus aculeatus 61 4e-75 278
WERAM-Ten-0001 ENSTNIP00000000290.1 Tetraodon nigroviridis 63 2e-71 266
WERAM-Tar-0165 ENSTRUP00000035350.1 Takifugu rubripes 59 1e-67 253
WERAM-Pes-0156 ENSPSIP00000018616.1 Pelodiscus sinensis 59 2e-66 249
WERAM-Ora-0131 ENSOANP00000024605.3 Ornithorhynchus anatinus 58 3e-64 242
WERAM-Leo-0081 ENSLOCP00000011043.1 Lepisosteus oculatus 59 2e-59 226
WERAM-Myl-0071 ENSMLUP00000005816.2 Myotis lucifugus 54 2e-59 226
WERAM-Chh-0082 ENSCHOP00000008858.1 Choloepus hoffmanni 55 2e-51 200
WERAM-Orla-0129 ENSORLP00000015380.1 Oryzias latipes 89 3e-42 169
WERAM-Ocp-0050 ENSOPRP00000004396.1 Ochotona princeps 79 1e-36 150
WERAM-Pem-0082 ENSPMAP00000008755.1 Petromyzon marinus 68 5e-30 128
WERAM-Tub-0041 ENSTBEP00000005072.1 Tupaia belangeri 32 5e-28 122
WERAM-Drm-0046 FBpp0080103 Drosophila melanogaster 74 4e-27 119
WERAM-Cii-0086 ENSCINP00000002250.3 Ciona intestinalis 73 2e-25 113
WERAM-Cis-0005 ENSCSAVP00000000824.1 Ciona savignyi 72 5e-25 112
Created Date 25-Jun-2016