WERAM Information

Tag Content
WERAM ID WERAM-Mum-0206
Ensembl Protein ID ENSMUSP00000074707.6
Uniprot Accession Q9WTK2; CDYL_MOUSE; Q3U0W2; Q6P6N3
Genbank Protein ID NP_001116858.1; NP_034011.1
Protein Name Chromodomain Y-like protein
Genbank Nucleotide ID NM_001123386.1; NM_009881.3
Gene Name CDYL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000059288.13 ENSMUST00000075220.12 ENSMUSP00000074707.6
ENSMUSG00000059288.13 ENSMUST00000163595.2 ENSMUSP00000131784.2
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromodomain Chromo H3K27me3; H3K9me2 K 24144980
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromodomain 1.10e-24 87.7 57 115
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation.
Domain Profile
  Me_Reader Chromodomain
      Chromodomain.txt   2 everivdkkelrkgeveYlVrWkGynksddtWepeenLl.ckelleefekkkekkkkqg 59 
                           +ve+ivdk++++kg++eYlVrWkGy+++ddtWepe++L+ c+e++++f++++++++k+g
  ENSMUSP00000074707.6  57 QVESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVnCEEYIHDFNRRHNERQKEG 115
                           79******************************************************998 PP
Protein Sequence
(Fasta)		MGIGNSQPNS QEAQLCTLPE KAEQPTDDNT CQQNNVVPAT VSEPDQASPA IQDAETQVES 60
IVDKRKNKKG KTEYLVRWKG YDSEDDTWEP EQHLVNCEEY IHDFNRRHNE RQKEGSLARA 120
SRASPSNARK QISRSTHSTL SKTNSKALVV GKDHESKSSQ LLAASQKFRK NPAPSLANRK 180
NMDLAKSGIK ILVPKSPVKG RTSVDGFQGE SPEKLDPVDQ GAEDTVAPEV TAEKPTGALL 240
GPGAERARMG SRPRIHPLVP QVSGPVTAAM ATGLAVNGKG TSPFMDALAA NGTVTIQTSV 300
TGVTAGKRKF IDDRRDQPFD KRLRFSVRQT ESAYRYRDIV VRKQDGFTHI LLSTKSSENN 360
SLNPEVMKEV QSALSTAAAD DSKLVLLSAV GSVFCCGLDF IYFIRRLTDD RKRESTKMAD 420
AIRNFVNTFI QFKKPIIVAV NGPAIGLGAS ILPLCDVVWA NEKAWFQTPY TTFGQSPDGC 480
STVMFPKIMG GASANEMLFS GRKLTAQEAC GKGLVSQVFW PGTFTQEVMV RIKELASCNP 540
VVLEESKALV RCNMKMELEQ ANERECEVLK KIWGSAQGMD SMLKYLQRKI DEF 593
Nucleotide Sequence
(Fasta)		ATGATGGAGG CGATCTTGCT TTGAGGTGGT TTAGCATCCC ACTTGTTCCT TGAGGACATC 60
TGTTCCTACC TAAGAGCACT CACCTGAGAT GCTCAAAGGT CCAGAAGAAA CACTTCTCGG 120
GTGACAAAGC AGGTGGTGAC CAGAGAACAG AGGCCCCCCA AAAATTTTAT GGCATTCAAG 180
GCAAAGCACA GCCAACCCGG AGGGAAAGCA AGAGTCCAGC CTGGAAATAC ATAGCCCAAC 240
CCGAAGGTTA TCTCTGAAGG AAAACAATGG GCATAGGCAA TAGCCAGCCT AATTCACAGG 300
AAGCCCAGCT CTGCACACTT CCAGAGAAAG CTGAACAACC TACTGATGAT AACACCTGCC 360
AGCAAAATAA TGTGGTTCCT GCAACAGTCT CAGAACCCGA TCAAGCGTCC CCTGCAATTC 420
AAGACGCGGA GACTCAGGTG GAAAGTATCG TTGACAAAAG GAAAAACAAG AAAGGGAAGA 480
CAGAATATCT GGTGCGGTGG AAAGGCTATG ACAGTGAGGA TGACACGTGG GAGCCTGAGC 540
AGCACCTGGT GAACTGTGAG GAATACATCC ATGACTTCAA CCGGCGCCAC AACGAGAGGC 600
AAAAGGAAGG TAGCCTGGCT CGTGCCAGCA GAGCCTCCCC CAGCAACGCC CGGAAGCAGA 660
TTTCCAGGTC CACCCACAGC ACTCTCTCCA AGACCAACTC CAAAGCACTT GTGGTAGGCA 720
AAGATCATGA GTCCAAAAGC AGCCAGCTGT TGGCTGCCAG CCAGAAGTTC AGGAAAAACC 780
CAGCCCCATC TCTTGCAAAC CGCAAGAACA TGGACCTCGC CAAGTCAGGG ATCAAAATTC 840
TCGTGCCTAA GAGCCCCGTT AAGGGCAGGA CCTCGGTTGA TGGCTTTCAG GGGGAGAGCC 900
CCGAGAAGCT GGACCCTGTG GATCAGGGTG CCGAGGACAC TGTAGCCCCA GAGGTGACTG 960
CAGAGAAGCC CACTGGGGCT TTGCTGGGCC CTGGTGCGGA GCGAGCCAGG ATGGGGAGCA 1020
GGCCCCGAAT ACATCCACTA GTGCCTCAGG TTTCTGGCCC CGTGACTGCT GCCATGGCCA 1080
CAGGCTTAGC TGTTAATGGA AAAGGTACAT CTCCATTCAT GGATGCGCTA GCAGCCAACG 1140
GAACAGTCAC CATACAGACA TCCGTAACAG GAGTGACAGC CGGGAAAAGG AAATTTATTG 1200
ACGACAGAAG AGACCAACCT TTTGACAAGC GGTTGCGTTT CAGTGTGAGG CAGACAGAGA 1260
GTGCCTACAG ATACAGAGAT ATTGTCGTCA GGAAGCAAGA TGGCTTCACC CACATCTTGT 1320
TATCCACAAA ATCGTCAGAG AATAACTCAC TAAACCCAGA GGTGATGAAA GAAGTGCAGA 1380
GCGCCCTGAG CACAGCTGCA GCCGACGACA GCAAGCTGGT TCTGCTCAGC GCCGTGGGCA 1440
GCGTCTTCTG CTGTGGTCTG GACTTTATTT ATTTTATTCG GCGCCTCACA GATGACCGAA 1500
AGAGAGAAAG CACTAAAATG GCAGACGCTA TCAGAAACTT CGTGAATACT TTCATTCAGT 1560
TTAAGAAGCC TATTATTGTA GCTGTTAATG GCCCAGCCAT TGGACTAGGA GCATCCATAT 1620
TGCCTCTTTG TGATGTGGTT TGGGCTAACG AAAAGGCTTG GTTTCAAACA CCCTATACCA 1680
CCTTCGGACA GAGTCCAGAT GGCTGCTCTA CCGTTATGTT TCCCAAGATT ATGGGAGGAG 1740
CATCTGCGAA TGAAATGCTG TTCAGTGGGC GGAAGTTGAC GGCACAGGAG GCCTGTGGCA 1800
AGGGTCTGGT CTCCCAGGTG TTTTGGCCAG GAACCTTCAC ACAGGAAGTC ATGGTTCGAA 1860
TCAAGGAGCT GGCTTCATGT AACCCAGTTG TCCTGGAGGA ATCCAAAGCC CTGGTGCGCT 1920
GCAATATGAA GATGGAGCTA GAGCAGGCCA ATGAGAGAGA ATGTGAAGTG CTGAAGAAGA 1980
TCTGGGGCTC CGCCCAGGGC ATGGACTCCA TGTTAAAGTA CTTACAGAGG AAAATCGATG 2040
AGTTCTGATG GGCAGGCTGA GCAGGACATC GGTGGCTCCC ACTTGCTACG TCGTCCTGCA 2100
GTGGCTCGTG CTTGGAGGCA GAACTGGAAA CATCCGAGCT ATTTATTGCC GCGGAGTTTT 2160
TAAGTACTGT AACTTTAAAA TAACTACAAA GCTTCTTTGT CTAAGCGTCT TTATTTTATA 2220
CTCATGTATA CACAAGTATA AAAATGTAAT TGAGCACTAG GCTGCTCTTG GAAGCTCTAA 2280
TTTTCTTGTA AGCTAGTTGT GGATTTTTGT TTTGTTTTTG TTTTTAAAAG GAATTATGTT 2340
TTCATTTTGG GTGACAGAAG AGTTTGAAAT AATGTTTGTT TTACTCTTTT TTTTTTTCCT 2400
TAAATCTAGA TCACAGACCC TCAAGAATAC TAGCCAGCCT TCTCCCCCTC CCTCTACTGA 2460
AACATGTAGA AATACTTAAA CATGTTCCTG CCTCTAGGGG GGAGGGGGAG GTGTGAGTAC 2520
CTCAATGCTG AAAACAGTTC TGATCAAACT TAAGACCAAC CTGGTAGAAA AAGCATCACT 2580
GATGGAAAAT CCCACCCACG GGGGCGTGGG TTTCTGCTGA AATGCCCGCC GCTCTACCTT 2640
TCTTACTGTC CCATTCTTAC CCAGCCACCG TGAAGAGCCC AGTGTCTGGA GGAAAGCAGG 2700
TGGTCCAGTG TCTGTGAGTC ACTCCGTAGC TCGAGTGTTA CTTGCTAAGT TATGAATTAG 2760
CATTAGTGGG TTTAAATAGT TTTTCTGACC CTTTTTGAAA AATAACTACA TAAGTACTCC 2820
TTGTGGCTGG GTGAGAAATA CTACTTTGCA TAGTTTTGTT TGTCTATCTG CAGATATGAT 2880
TGCTGTATTA CACCAAAAGT ATTTTTTATG TTTATAAAGT GTAATTTTTA GGTTCACTTA 2940
GAATATATTT TATTTAATTT AAAATTCTCT TGGCACACTA TTAAATACGT AAACTCCTTT 3000
CAGAACAGAA AAGAACTACC TTATATTTGA CATTTATTAT CCAGTCTCTG CTCTTATGTC 3060
TGCCATATAT TGCGCACGGT TTCGTGTTCA CGAGTACCCC ATGGTGTGGG GACTAACTTC 3120
AGATGCCTAT TATGACTAAG GCTTCTAGGT TTGCAATCAT ATTGAATGTA TGAAGACTGA 3180
AATAAAATAA AAAACCTTAT TTTTGTACAG TTTTGAAGTT TATACTCAGA ACTGACGCCT 3240
CCCCGGCCAT GTGGAGCGCT GTGCAGTGTG TACATCTGTC TTTACCTTGG ATGGATTGGT 3300
ACAGTATTTT TGCATCTGTG GGACCTTCTC TTTGGTTCAG TAGTTTGAAC TATATATATA 3360
AACTGTACAC TCTGTAAAGT TTTTATAGAA TAAATATTCA GCTGTGAAAA CTGGTTAAAT 3420
AAAACTAATA TTTCTTAACA CA 3443
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR029045--ClpP/crotonase-like_dom
IPR001753--Crotonase_core_superfam
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
Pfam

PF00385--Chromo
PF00378--ECH_1
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004402--F:histone acetyltransferase activity
GO:0035064--F:methylated histone binding
GO:0003714--F:transcription corepressor activity
GO:1903507--P:negative regulation of nucleic acid-templated transcription
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0178 ENSRNOP00000048651.3 Rattus norvegicus 93 0.0 1122
WERAM-Loa-0167 ENSLAFP00000015437.3 Loxodonta africana 93 0.0 1037
WERAM-Otg-0168 ENSOGAP00000014264.2 Otolemur garnettii 93 0.0 1034
WERAM-Hos-0161 ENSP00000330512.5 Homo sapiens 89 0.0 1034
WERAM-Pat-0144 ENSPTRP00000030202.3 Pan troglodytes 89 0.0 1031
WERAM-Gog-0199 ENSGGOP00000022358.1 Gorilla gorilla 89 0.0 1030
WERAM-Caj-0223 ENSCJAP00000039775.2 Callithrix jacchus 92 0.0 1030
WERAM-Chs-0087 ENSCSAP00000003568.1 Chlorocebus sabaeus 93 0.0 1030
WERAM-Nol-0120 ENSNLEP00000013918.1 Nomascus leucogenys 89 0.0 1029
WERAM-Poa-0144 ENSPPYP00000018112.2 Pongo abelii 93 0.0 1028
WERAM-Mup-0005 ENSMPUP00000000515.1 Mustela putorius furo 93 0.0 1027
WERAM-Myl-0005 ENSMLUP00000000450.2 Myotis lucifugus 92 0.0 1027
WERAM-Mam-0034 ENSMMUP00000006579.2 Macaca mulatta 93 0.0 1026
WERAM-Caf-0104 ENSCAFP00000013867.3 Canis familiaris 93 0.0 1026
WERAM-Tas-0043 ENSTSYP00000004340.1 Tarsius syrichta 93 0.0 1025
WERAM-Ptv-0179 ENSPVAP00000015848.1 Pteropus vampyrus 93 0.0 1023
WERAM-Aim-0145 ENSAMEP00000013615.1 Ailuropoda melanoleuca 93 0.0 1023
WERAM-Eqc-0104 ENSECAP00000011853.1 Equus caballus 92 0.0 1020
WERAM-Fec-0185 ENSFCAP00000017712.1 Felis catus 93 0.0 1015
WERAM-Cap-0071 ENSCPOP00000005275.2 Cavia porcellus 92 0.0 1013
WERAM-Ict-0097 ENSSTOP00000010036.2 Ictidomys tridecemlineatus 92 0.0 1011
WERAM-Dan-0073 ENSDNOP00000007459.3 Dasypus novemcinctus 91 0.0 1001
WERAM-Bot-0151 ENSBTAP00000021803.5 Bos taurus 91 0.0 995
WERAM-Prc-0113 ENSPCAP00000009984.1 Procavia capensis 92 0.0 991
WERAM-Ocp-0100 ENSOPRP00000009200.2 Ochotona princeps 90 0.0 983
WERAM-Ova-0001 ENSOARP00000000051.1 Ovis aries 90 0.0 969
WERAM-Mod-0080 ENSMODP00000012255.3 Monodelphis domestica 87 0.0 968
WERAM-Sah-0088 ENSSHAP00000010186.1 Sarcophilus harrisii 87 0.0 966
WERAM-Orc-0035 ENSOCUP00000003807.3 Oryctolagus cuniculus 83 0.0 960
WERAM-Anp-0051 ENSAPLP00000005516.1 Anas platyrhynchos 86 0.0 953
WERAM-Gaga-0119 ENSGALP00000020866.4 Gallus gallus 86 0.0 948
WERAM-Ora-0013 ENSOANP00000001917.2 Ornithorhynchus anatinus 85 0.0 948
WERAM-Pes-0070 ENSPSIP00000008652.1 Pelodiscus sinensis 85 0.0 939
WERAM-Fia-0161 ENSFALP00000013732.1 Ficedula albicollis 85 0.0 934
WERAM-Tag-0032 ENSTGUP00000002323.1 Taeniopygia guttata 85 0.0 933
WERAM-Anc-0139 ENSACAP00000013040.3 Anolis carolinensis 84 0.0 919
WERAM-Ere-0138 ENSEEUP00000014340.1 Erinaceus europaeus 90 0.0 901
WERAM-Dio-0023 ENSDORP00000002640.1 Dipodomys ordii 84 0.0 899
WERAM-Tut-0047 ENSTTRP00000003953.1 Tursiops truncatus 83 0.0 897
WERAM-Xet-0170 ENSXETP00000058332.1 Xenopus tropicalis 80 0.0 879
WERAM-Ect-0115 ENSETEP00000012627.1 Echinops telfairi 82 0.0 843
WERAM-Leo-0112 ENSLOCP00000014301.1 Lepisosteus oculatus 74 0.0 801
WERAM-Mim-0107 ENSMICP00000010255.1 Microcebus murinus 71 0.0 749
WERAM-Mae-0082 ENSMEUP00000008225.1 Macropus eugenii 78 0.0 749
WERAM-Meg-0040 ENSMGAP00000003834.2 Meleagris gallopavo 71 0.0 733
WERAM-Dar-0088 ENSDARP00000073586.2 Danio rerio 62 0.0 684
WERAM-Asm-0012 ENSAMXP00000001823.1 Astyanax mexicanus 63 0.0 650
WERAM-Tub-0103 ENSTBEP00000011867.1 Tupaia belangeri 88 0.0 650
WERAM-Orn-0171 ENSONIP00000017623.1 Oreochromis niloticus 58 6e-179 624
WERAM-Chh-0092 ENSCHOP00000010408.1 Choloepus hoffmanni 85 4e-178 622
WERAM-Gaa-0021 ENSGACP00000003221.1 Gasterosteus aculeatus 60 4e-176 615
WERAM-Orla-0077 ENSORLP00000009659.1 Oryzias latipes 59 5e-174 608
WERAM-Gam-0207 ENSGMOP00000020036.1 Gadus morhua 59 6e-170 595
WERAM-Pof-0152 ENSPFOP00000012380.2 Poecilia formosa 56 2e-157 553
WERAM-Lac-0092 ENSLACP00000011748.1 Latimeria chalumnae 49 3e-143 506
WERAM-Paa-0107 ENSPANP00000003836.1 Papio anubis 50 4e-137 485
WERAM-Xim-0223 ENSXMAP00000018601.1 Xiphophorus maculatus 64 2e-130 463
WERAM-Pem-0021 ENSPMAP00000002854.1 Petromyzon marinus 45 3e-122 436
WERAM-Ten-0110 ENSTNIP00000000668.1 Tetraodon nigroviridis 61 4e-112 402
WERAM-Tar-0221 ENSTRUP00000046743.1 Takifugu rubripes 61 4e-110 396
WERAM-Vip-0001 ENSVPAP00000000085.1 Vicugna pacos 70 8e-52 202
WERAM-Cii-0059 ENSCINP00000026937.2 Ciona intestinalis 51 1e-09 62.4
WERAM-Sus-0066 ENSSSCP00000010219.2 Sus scrofa 53 3e-09 61.2
WERAM-Drm-0069 FBpp0083702 Drosophila melanogaster 43 5e-08 57.0
WERAM-Cae-0010 K01G5.2a Caenorhabditis elegans 39 5e-07 53.9
Created Date 25-Jun-2016