Tag |
Content |
WERAM ID |
WERAM-Mum-0086 |
Ensembl Protein ID |
ENSMUSP00000072761.3 |
Uniprot Accession |
O88509; DNM3B_MOUSE; O88510; O88511 |
Genbank Protein ID |
NP_001003960.2; NP_001003961.2; NP_001258673.1; NP_001258674.1; NP_001258676.1; NP_034198.3 |
Protein Name |
DNA (cytosine-5)-methyltransferase 3B |
Genbank Nucleotide ID |
NM_001003960.4; NM_001003961.4; NM_001271744.1; NM_001271745.1; NM_001271747.1; NM_010068.5 |
Gene Name |
DNM3B |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Me_Reader |
ADD |
ADD |
H3K4; H3K9 |
K |
18814855 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Me_Reader |
ADD |
4.60e-61 |
206.2 |
428 |
560 |
Me_Reader |
PWWP |
9.10e-17 |
62.4 |
232 |
288 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity). |
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).
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Domain Profile |
Me_Reader ADD
ADD.txt 1 evkrnednlediciacGkkdsilrhPlleggicknckdkfleaaisydddGyqsycticaeGrelllcgndsctrafcvecvdrlvGrg 89 ev++n+ nled+c++cGkk+++++hPl+egg+c++c+d+fle +++yd+dGyqsyct+c+eGrelllc+n+sc+r+fcvec+++lvG+g ENSMUSP00000072761.3 428 EVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAG 516 799************************************************************************************** PP ADD.txt 90 eaekikkeenWvcylclpesllgllrrrkdvkerleqllqqnkd 133 +ae++k +e+W+cy+clp++++g+lrrrkd+++rl++++++++d ENSMUSP00000072761.3 517 TAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPD 560 ****************************************9875 PP
Me_Reader PWWP
PWWP.txt 1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpys 62 +gdLVw+K+kg++wWPa+v+s++ ++k++ a+ ++++V++Fg + +++ ++++klv+++ ENSMUSP00000072761.3 232 IGDLVWGKIKGFSWWPAMVVSWKATSKRQ----AMPGMRWVQWFG-DGKFSEISADKLVALG 288 69***************************....************.*************986 PP
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Protein Sequence (Fasta) | MKGDSRHLNE EEGASGYEEC IIVNGNFSDQ SSDTKDAPSP PVLEAICTEP VCTPETRGRR 60 SSSRLSKREV SSLLNYTQDM TGDGDRDDEV DDGNGSDILM PKLTRETKDT RTRSESPAVR 120 TRHSNGTSSL ERQRASPRIT RGRQGRHHVQ EYPVEFPATR SRRRRASSSA STPWSSPASV 180 DFMEEVTPKS VSTPSVDLSQ DGDQEGMDTT QVDAESRDGD STEYQDDKEF GIGDLVWGKI 240 KGFSWWPAMV VSWKATSKRQ AMPGMRWVQW FGDGKFSEIS ADKLVALGLF SQHFNLATFN 300 KLVSYRKAMY HTLEKARVRA GKTFSSSPGE SLEDQLKPML EWAHGGFKPT GIEGLKPNKK 360 QPVVNKSKVR RSDSRNLEPR RRENKSRRRT TNDSAASESP PPKRLKTNSY GGKDRGEDEE 420 SRERMASEVT NNKGNLEDRC LSCGKKNPVS FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ 480 SYCTVCCEGR ELLLCSNTSC CRCFCVECLE VLVGAGTAED AKLQEPWSCY MCLPQRCHGV 540 LRRRKDWNMR LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKEL 600 GIKVEKYIAS EVCAESIAVG TVKHEGQIKY VNDVRKITKK NIEEWGPFDL VIGGSPCNDL 660 SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW MFENVVAMKV NDKKDISRFL 720 ACNPVMIDAI KVSAAHRARY FWGNLPGMNR PVMASKNDKL ELQDCLEFSR TAKLKKVQTI 780 TTKSNSIRQG KNQLFPVVMN GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW 840 SVPVIRHLFA PLKDYFACE 859Protein Fasta Sequence
>ENSMUSP00000072761.3|DNM3B|Mus musculus MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
|
Nucleotide Sequence (Fasta) | ACCCACTCCC GTGCGCGCCC GGCCCGTAGC GTCCTCGTCG CCGCCCCTCG TCTCGCAGCC 60 GCAGCCCGCG TGGACGCTCT CGCCTGAGCG CCGCGGACTA GCCCGGGTGG CCCACTGGCG 120 CGCGGGCGAG CGCACGGGCG CTCCAGTCCG GCAGCGCCGG GGTTAAGCGG CCCAAGTAAA 180 CGTAGCGCAG CGATCGGCGC CGGAGATTCG CGAACCCGAC ACTCCGCGCC GCCCGCCGGC 240 CAGGACCCGC GGCGCGATCG CGGCGCCGCG CTACAGCCAG CCTCACGACA GGAAACAATG 300 AAGGGAGACA GCAGACATCT GAATGAAGAA GAGGGTGCCA GCGGGTATGA GGAGTGCATT 360 ATCGTTAATG GGAACTTCAG TGACCAGTCC TCAGACACGA AGGATGCTCC CTCACCCCCA 420 GTCTTGGAGG CAATCTGCAC AGAGCCAGTC TGCACACCAG AGACCAGAGG CCGCAGGTCA 480 AGCTCCCGGC TGTCTAAGAG GGAGGTCTCC AGCCTTCTGA ATTACACGCA GGACATGACA 540 GGAGATGGAG ACAGAGATGA TGAAGTAGAT GATGGGAATG GCTCTGATAT TCTAATGCCA 600 AAGCTCACCC GTGAGACCAA GGACACCAGG ACGCGCTCTG AAAGCCCGGC TGTCCGAACC 660 CGACATAGCA ATGGGACCTC CAGCTTGGAG AGGCAAAGAG CCTCCCCCAG AATCACCCGA 720 GGTCGGCAGG GCCGCCACCA TGTGCAGGAG TACCCTGTGG AGTTTCCGGC TACCAGGTCT 780 CGGAGACGTC GAGCATCATC TTCAGCAAGC ACGCCATGGT CATCCCCTGC CAGCGTCGAC 840 TTCATGGAAG AAGTGACACC TAAGAGCGTC AGTACCCCAT CAGTTGACTT GAGCCAGGAT 900 GGAGATCAGG AGGGTATGGA TACCACACAG GTGGATGCAG AGAGCAGAGA TGGAGACAGC 960 ACAGAGTATC AGGATGATAA AGAGTTTGGA ATAGGTGACC TCGTGTGGGG AAAGATCAAG 1020 GGCTTCTCCT GGTGGCCTGC CATGGTGGTG TCCTGGAAAG CCACCTCCAA GCGACAGGCC 1080 ATGCCCGGAA TGCGCTGGGT ACAGTGGTTT GGTGATGGCA AGTTTTCTGA GATCTCTGCT 1140 GACAAACTGG TGGCTCTGGG GCTGTTCAGC CAGCACTTTA ATCTGGCTAC CTTCAATAAG 1200 CTGGTTTCTT ATAGGAAGGC CATGTACCAC ACTCTGGAGA AAGCCAGGGT TCGAGCTGGC 1260 AAGACCTTCT CCAGCAGTCC TGGAGAGTCA CTGGAGGACC AGCTGAAGCC CATGCTGGAG 1320 TGGGCCCACG GTGGCTTCAA GCCTACTGGG ATCGAGGGCC TCAAACCCAA CAAGAAGCAA 1380 CCAGTGGTTA ATAAGTCGAA GGTGCGTCGT TCAGACAGTA GGAACTTAGA ACCCAGGAGA 1440 CGCGAGAACA AAAGTCGAAG ACGCACAACC AATGACTCTG CTGCTTCTGA GTCCCCCCCA 1500 CCCAAGCGCC TCAAGACAAA TAGCTATGGC GGGAAGGACC GAGGGGAGGA TGAGGAGAGC 1560 CGAGAACGGA TGGCTTCTGA AGTCACCAAC AACAAGGGCA ATCTGGAAGA CCGCTGTTTG 1620 TCCTGTGGAA AGAAGAACCC TGTGTCCTTC CACCCCCTCT TTGAGGGTGG GCTCTGTCAG 1680 AGTTGCCGGG ATCGCTTCCT AGAGCTCTTC TACATGTATG ATGAGGACGG CTATCAGTCC 1740 TACTGCACCG TGTGCTGTGA GGGCCGTGAA CTGCTGCTGT GCAGTAACAC AAGCTGCTGC 1800 AGATGCTTCT GTGTGGAGTG TCTGGAGGTG CTGGTGGGCG CAGGCACAGC TGAGGATGCC 1860 AAGCTGCAGG AACCCTGGAG CTGCTATATG TGCCTCCCTC AGCGCTGCCA TGGGGTCCTC 1920 CGACGCAGGA AAGATTGGAA CATGCGCCTG CAAGACTTCT TCACTACTGA TCCTGACCTG 1980 GAAGAATTTG AGCCACCCAA GTTGTACCCA GCAATTCCTG CAGCCAAAAG GAGGCCCATT 2040 AGAGTCCTGT CTCTGTTTGA TGGAATTGCA ACGGGGTACT TGGTGCTCAA GGAGTTGGGT 2100 ATTAAAGTGG AAAAGTACAT TGCCTCCGAA GTCTGTGCAG AGTCCATCGC TGTGGGAACT 2160 GTTAAGCATG AAGGCCAGAT CAAATATGTC AATGACGTCC GGAAAATCAC CAAGAAAAAT 2220 ATTGAAGAGT GGGGCCCGTT CGACTTGGTG ATTGGTGGAA GCCCATGCAA TGATCTCTCT 2280 AACGTCAATC CTGCCCGCAA AGGTTTATAT GAGGGCACAG GAAGGCTCTT CTTCGAGTTT 2340 TACCACTTGC TGAATTATAC CCGCCCCAAG GAGGGCGACA ACCGTCCATT CTTCTGGATG 2400 TTCGAGAATG TTGTGGCCAT GAAAGTGAAT GACAAGAAAG ACATCTCAAG ATTCCTGGCA 2460 TGTAACCCAG TGATGATCGA TGCCATCAAG GTGTCTGCTG CTCACAGGGC CCGGTACTTC 2520 TGGGGTAACC TACCCGGAAT GAACAGGCCC GTGATGGCTT CAAAGAATGA TAAGCTCGAG 2580 CTGCAGGACT GCCTGGAGTT CAGTAGGACA GCAAAGTTAA AGAAAGTGCA GACAATAACC 2640 ACCAAGTCGA ACTCCATCAG ACAGGGCAAA AACCAGCTTT TCCCTGTAGT CATGAATGGC 2700 AAGGACGACG TTTTGTGGTG CACTGAGCTC GAAAGGATCT TCGGCTTCCC TGCTCACTAC 2760 ACGGACGTGT CCAACATGGG CCGCGGCGCC CGTCAGAAGC TGCTGGGCAG GTCCTGGAGT 2820 GTACCGGTCA TCAGACACCT GTTTGCCCCC TTGAAGGACT ACTTTGCCTG TGAATAGTTC 2880 TACCCAGGAC TGGGGAGCTC TCGGTCAGAG CCAGTGCCCA GAGTCACCCC TCCCTGAAGG 2940 CACCTCACCT GTCCCCTTTT TAGCTCACCT GTGTGGGGCC TCACATCACT GTACCTCAGC 3000 TTTCTCCTGC TCAGTGGGAG CAGAGCCTCC TGGCCCTTGC AGGGGAGCCC CGGTGCTCCC 3060 TCCGTGTGCA CAGCTCAGAC CTGGCTGCTT AGAGTAGCCC GGCATGGTGC TCATGTTCTC 3120 TTACCCTGAA ACTTTAAAAC TTGAAGTAGG TAGTAAGATG GCTTTCTTTT ACCCTCCTGA 3180 GTTTATCACT CAGAAGTGAT GGCTAAGATA CCAAAAAAAC AAACAAAAAC AGAAACAAAA 3240 AACAAAAAAA AAACCTCAAC AGCTCTCTTA GTACTCAGGT TCATGCTGCA AAATCACTTG 3300 AGATTTTGTT TTTAAGTAAC CCGTGCTCCA CATTTGCTGG AGGATGCTAT TGTGAATGTG 3360 GGCTCAGATG AGCAAGGTCA AGGGGCCAAA AAAAATTCCC CCTCTCCCCC CAGGAGTATT 3420 TGAAGATGAT GTTTATGGTT TAAGTCTTCC TGGCACCTTC CCCTTGCTTT GGTACAAGGG 3480 CTGAAGTCCT GTTGGTCTTG TAGCATTTCC CAGGATGATG ATGTCAGCAG GGATGACATC 3540 ATCACCTTTA GGGCTTTTCC CTGGCAGGGG CCCATGTGGC TAGTCCTCAC GAAGACTGGA 3600 GTAGAATGTT TGGAGCTCAG GAAGGGTGGG TGGAGTGGCC CTCTTCCAGG TGTGAGGGAT 3660 ACGAAGGAGG AAGCTTAGGG AAATCCATTC CCCACTCCCT CTTGCCAAAT GAGGGGCCCA 3720 GTCCCCAACA GCTCAGGTCC CCAGAACCCC CTAGTTCCTC ATGAGAAGCT AGGACCAGAA 3780 GCACATCGTT CCCCTTATCT GAGCAGTGTT TGGGGAACTA CAGTGAAAAC CTTCTGGAGA 3840 TGTTAAAAGC TTTTTACCCC ACGATAGATT GTGTTTTTAA GGGGTGCTTT TTTTAGGGGC 3900 ATCACTGGAG ATAAGAAAGC TGCATTTCAG AAATGCCATC GTAATGGTTT TTAAACACCT 3960 TTTACCTAAT TACAGGTGCT ATTTTATAGA AGCAGACAAC ACTTCTTTTT ATGACTCTCA 4020 GACTTCTATT TTCATGTTAC CATTTTTTTT GTAACTCGCA AGGTGTGGGC TTTTGTAACT 4080 TCACAGGTGT GGGGAGAGAC TGCCTTGTTT CAACAGTTTG TCTCCACTGG TTTCTAATTT 4140 TTAGGTGCAA AGATGACAGA TGCCCAGAGT TTACCTTTCT GGTTGATTAA AGTTGTATTT 4200 CTCTATAA
4209Nucleotide Fasta Sequence
>ENSMUSP00000072761.3|PWWP|Mus musculus ACCCACTCCCGTGCGCGCCCGGCCCGTAGCGTCCTCGTCGCCGCCCCTCGTCTCGCAGCCGCAGCCCGCGTGGACGCTCTCGCCTGAGCGCCGCGGACTAGCCCGGGTGGCCCACTGGCGCGCGGGCGAGCGCACGGGCGCTCCAGTCCGGCAGCGCCGGGGTTAAGCGGCCCAAGTAAACGTAGCGCAGCGATCGGCGCCGGAGATTCGCGAACCCGACACTCCGCGCCGCCCGCCGGCCAGGACCCGCGGCGCGATCGCGGCGCCGCGCTACAGCCAGCCTCACGACAGGAAACAATGAAGGGAGACAGCAGACATCTGAATGAAGAAGAGGGTGCCAGCGGGTATGAGGAGTGCATTATCGTTAATGGGAACTTCAGTGACCAGTCCTCAGACACGAAGGATGCTCCCTCACCCCCAGTCTTGGAGGCAATCTGCACAGAGCCAGTCTGCACACCAGAGACCAGAGGCCGCAGGTCAAGCTCCCGGCTGTCTAAGAGGGAGGTCTCCAGCCTTCTGAATTACACGCAGGACATGACAGGAGATGGAGACAGAGATGATGAAGTAGATGATGGGAATGGCTCTGATATTCTAATGCCAAAGCTCACCCGTGAGACCAAGGACACCAGGACGCGCTCTGAAAGCCCGGCTGTCCGAACCCGACATAGCAATGGGACCTCCAGCTTGGAGAGGCAAAGAGCCTCCCCCAGAATCACCCGAGGTCGGCAGGGCCGCCACCATGTGCAGGAGTACCCTGTGGAGTTTCCGGCTACCAGGTCTCGGAGACGTCGAGCATCATCTTCAGCAAGCACGCCATGGTCATCCCCTGCCAGCGTCGACTTCATGGAAGAAGTGACACCTAAGAGCGTCAGTACCCCATCAGTTGACTTGAGCCAGGATGGAGATCAGGAGGGTATGGATACCACACAGGTGGATGCAGAGAGCAGAGATGGAGACAGCACAGAGTATCAGGATGATAAAGAGTTTGGAATAGGTGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCTGCCATGGTGGTGTCCTGGAAAGCCACCTCCAAGCGACAGGCCATGCCCGGAATGCGCTGGGTACAGTGGTTTGGTGATGGCAAGTTTTCTGAGATCTCTGCTGACAAACTGGTGGCTCTGGGGCTGTTCAGCCAGCACTTTAATCTGGCTACCTTCAATAAGCTGGTTTCTTATAGGAAGGCCATGTACCACACTCTGGAGAAAGCCAGGGTTCGAGCTGGCAAGACCTTCTCCAGCAGTCCTGGAGAGTCACTGGAGGACCAGCTGAAGCCCATGCTGGAGTGGGCCCACGGTGGCTTCAAGCCTACTGGGATCGAGGGCCTCAAACCCAACAAGAAGCAACCAGTGGTTAATAAGTCGAAGGTGCGTCGTTCAGACAGTAGGAACTTAGAACCCAGGAGACGCGAGAACAAAAGTCGAAGACGCACAACCAATGACTCTGCTGCTTCTGAGTCCCCCCCACCCAAGCGCCTCAAGACAAATAGCTATGGCGGGAAGGACCGAGGGGAGGATGAGGAGAGCCGAGAACGGATGGCTTCTGAAGTCACCAACAACAAGGGCAATCTGGAAGACCGCTGTTTGTCCTGTGGAAAGAAGAACCCTGTGTCCTTCCACCCCCTCTTTGAGGGTGGGCTCTGTCAGAGTTGCCGGGATCGCTTCCTAGAGCTCTTCTACATGTATGATGAGGACGGCTATCAGTCCTACTGCACCGTGTGCTGTGAGGGCCGTGAACTGCTGCTGTGCAGTAACACAAGCTGCTGCAGATGCTTCTGTGTGGAGTGTCTGGAGGTGCTGGTGGGCGCAGGCACAGCTGAGGATGCCAAGCTGCAGGAACCCTGGAGCTGCTATATGTGCCTCCCTCAGCGCTGCCATGGGGTCCTCCGACGCAGGAAAGATTGGAACATGCGCCTGCAAGACTTCTTCACTACTGATCCTGACCTGGAAGAATTTGAGCCACCCAAGTTGTACCCAGCAATTCCTGCAGCCAAAAGGAGGCCCATTAGAGTCCTGTCTCTGTTTGATGGAATTGCAACGGGGTACTTGGTGCTCAAGGAGTTGGGTATTAAAGTGGAAAAGTACATTGCCTCCGAAGTCTGTGCAGAGTCCATCGCTGTGGGAACTGTTAAGCATGAAGGCCAGATCAAATATGTCAATGACGTCCGGAAAATCACCAAGAAAAATATTGAAGAGTGGGGCCCGTTCGACTTGGTGATTGGTGGAAGCCCATGCAATGATCTCTCTAACGTCAATCCTGCCCGCAAAGGTTTATATGAGGGCACAGGAAGGCTCTTCTTCGAGTTTTACCACTTGCTGAATTATACCCGCCCCAAGGAGGGCGACAACCGTCCATTCTTCTGGATGTTCGAGAATGTTGTGGCCATGAAAGTGAATGACAAGAAAGACATCTCAAGATTCCTGGCATGTAACCCAGTGATGATCGATGCCATCAAGGTGTCTGCTGCTCACAGGGCCCGGTACTTCTGGGGTAACCTACCCGGAATGAACAGGCCCGTGATGGCTTCAAAGAATGATAAGCTCGAGCTGCAGGACTGCCTGGAGTTCAGTAGGACAGCAAAGTTAAAGAAAGTGCAGACAATAACCACCAAGTCGAACTCCATCAGACAGGGCAAAAACCAGCTTTTCCCTGTAGTCATGAATGGCAAGGACGACGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTCGGCTTCCCTGCTCACTACACGGACGTGTCCAACATGGGCCGCGGCGCCCGTCAGAAGCTGCTGGGCAGGTCCTGGAGTGTACCGGTCATCAGACACCTGTTTGCCCCCTTGAAGGACTACTTTGCCTGTGAATAGTTCTACCCAGGACTGGGGAGCTCTCGGTCAGAGCCAGTGCCCAGAGTCACCCCTCCCTGAAGGCACCTCACCTGTCCCCTTTTTAGCTCACCTGTGTGGGGCCTCACATCACTGTACCTCAGCTTTCTCCTGCTCAGTGGGAGCAGAGCCTCCTGGCCCTTGCAGGGGAGCCCCGGTGCTCCCTCCGTGTGCACAGCTCAGACCTGGCTGCTTAGAGTAGCCCGGCATGGTGCTCATGTTCTCTTACCCTGAAACTTTAAAACTTGAAGTAGGTAGTAAGATGGCTTTCTTTTACCCTCCTGAGTTTATCACTCAGAAGTGATGGCTAAGATACCAAAAAAACAAACAAAAACAGAAACAAAAAACAAAAAAAAAACCTCAACAGCTCTCTTAGTACTCAGGTTCATGCTGCAAAATCACTTGAGATTTTGTTTTTAAGTAACCCGTGCTCCACATTTGCTGGAGGATGCTATTGTGAATGTGGGCTCAGATGAGCAAGGTCAAGGGGCCAAAAAAAATTCCCCCTCTCCCCCCAGGAGTATTTGAAGATGATGTTTATGGTTTAAGTCTTCCTGGCACCTTCCCCTTGCTTTGGTACAAGGGCTGAAGTCCTGTTGGTCTTGTAGCATTTCCCAGGATGATGATGTCAGCAGGGATGACATCATCACCTTTAGGGCTTTTCCCTGGCAGGGGCCCATGTGGCTAGTCCTCACGAAGACTGGAGTAGAATGTTTGGAGCTCAGGAAGGGTGGGTGGAGTGGCCCTCTTCCAGGTGTGAGGGATACGAAGGAGGAAGCTTAGGGAAATCCATTCCCCACTCCCTCTTGCCAAATGAGGGGCCCAGTCCCCAACAGCTCAGGTCCCCAGAACCCCCTAGTTCCTCATGAGAAGCTAGGACCAGAAGCACATCGTTCCCCTTATCTGAGCAGTGTTTGGGGAACTACAGTGAAAACCTTCTGGAGATGTTAAAAGCTTTTTACCCCACGATAGATTGTGTTTTTAAGGGGTGCTTTTTTTAGGGGCATCACTGGAGATAAGAAAGCTGCATTTCAGAAATGCCATCGTAATGGTTTTTAAACACCTTTTACCTAATTACAGGTGCTATTTTATAGAAGCAGACAACACTTCTTTTTATGACTCTCAGACTTCTATTTTCATGTTACCATTTTTTTTGTAACTCGCAAGGTGTGGGCTTTTGTAACTTCACAGGTGTGGGGAGAGACTGCCTTGTTTCAACAGTTTGTCTCCACTGGTTTCTAATTTTTAGGTGCAAAGATGACAGATGCCCAGAGTTTACCTTTCTGGTTGATTAAAGTTGTATTTCTCTATAA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0010--Activator KW-0025--Alternative splicing KW-0164--Citrullination KW-0181--Complete proteome KW-0238--DNA-binding KW-0479--Metal-binding KW-0489--Methyltransferase KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0678--Repressor KW-0949--S-adenosyl-L-methionine KW-0808--Transferase KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR025766--ADD IPR018117--C5_DNA_meth_AS IPR001525--C5_MeTfrase IPR030488--DNMT3B IPR000313--PWWP_dom IPR029063--SAM-dependent_MTases IPR011011--Znf_FYVE_PHD
|
PROSITE |
PS51533--ADD PS00094--C5_MTASE_1 PS50812--PWWP PS51679--SAM_MT_C5
|
Pfam |
PF00145--DNA_methylase PF00855--PWWP
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Gene Ontology |
GO:0000775--C:chromosome, centromeric region GO:0000792--C:heterochromatin GO:0043231--C:intracellular membrane-bounded organelle GO:0005720--C:nuclear heterochromatin GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0003886--F:DNA (cytosine-5-)-methyltransferase activity GO:0051719--F:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates GO:0003677--F:DNA binding GO:0046872--F:metal ion binding GO:0008168--F:methyltransferase activity GO:0003714--F:transcription corepressor activity GO:0090116--P:C-5 methylation of cytosine GO:0071230--P:cellular response to amino acid stimulus GO:0000183--P:chromatin silencing at rDNA GO:0006306--P:DNA methylation GO:0043045--P:DNA methylation involved in embryo development GO:0032776--P:DNA methylation on cytosine GO:0060821--P:inactivation of X chromosome by DNA methylation GO:0006346--P:methylation-dependent chromatin silencing GO:0045814--P:negative regulation of gene expression, epigenetic GO:0051573--P:negative regulation of histone H3-K9 methylation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0010628--P:positive regulation of gene expression GO:0051571--P:positive regulation of histone H3-K4 methylation GO:0031503--P:protein complex localization GO:0006349--P:regulation of gene expression by genetic imprinting
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Orthology |
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Created Date |
25-Jun-2016 |