Tag |
Content |
WERAM ID |
WERAM-Mum-0197 |
Ensembl Protein ID |
ENSMUSP00000066789.4 |
Uniprot Accession |
B2RWS6; EP300_MOUSE; E9PYJ8 |
Genbank Protein ID |
NP_808489.4 |
Protein Name |
Histone acetyltransferase p300 |
Genbank Nucleotide ID |
NM_177821.6 |
Gene Name |
EP300;KAT3B;P300 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Ac_Reader |
Bromodomain |
Bromodomain |
H1.4K74; H2AK5; H2AK15; H2AK36; H2BK43; H2BK46; H3K56; H3K79; H3K115; H3K122; H4K5; H4K20; H4K44 |
K |
24704920; 22464331 |
HAT |
p300_CBP |
CBP/p300-type HAT |
H1.4K74; H2AK5; H2AK15; H2AK36; H2BK43; H2BK46; H3K56; H3K79; H3K115; H3K122; H4K5; H4K20; H4K44 |
K |
24480624; 24704920; 22464331 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HAT |
p300_CBP |
1.10e-176 |
589.7 |
338 |
1703 |
Ac_Reader |
Bromodomain |
2.50e-25 |
89.8 |
1067 |
1138 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:14645221, PubMed:9512516). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates MEF2D (By similarity). |
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:14645221, PubMed:9512516). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates MEF2D (By similarity).
|
Domain Profile |
HAT p300_CBP
CBP.txt 299 llmeklgetilpkk...kdkilvelqksn.kkksklvvsgnrwvcekcknlqlcdkcyeaeq 356 l+ ++l ++ +k +++ e++++n ++ +++++ n+ +c++ + c+ ++ a ENSMUSP00000066789.4 338 LIQQQLVLLLHAHKcqrREQANGEVRQCNlPHCRTMKNVLNH--MTHCQSGKSCQVAHCASS 397 455554444443331112233333444442578888888887..667777666666555544 PP CBP.txt 1 klgakkLpetkLskfleqrlfkklkkerqerarlqgksyeevpeaeelvvrvvassdktlevkkrlkerfveen.fpeefpyrskal 86 kl+ak+Lp+t+L++fle+r++++l+++++ pe++e++vrvv++sdkt+evk+++k+rfv+++ ++e+fpyr+kal ENSMUSP00000066789.4 1286 KLSAKRLPSTRLGTFLENRVNDFLRRQNH-------------PESGEVTVRVVHASDKTVEVKPGMKARFVDSGeMAESFPYRTKAL 1359 579*************************9.............********************************************* PP CBP.txt 87 llfekidgvdvClfglyvqefGsecsaPnqrrvyisyLdsvkyfrPevrtvagealrtavyheiLiGyleyvkklGfttayiWaCPP 173 ++fe+idgvd+C+fg++vqe+Gs+c++PnqrrvyisyLdsv++frP ++lrtavyheiLiGyleyvkklG+tt++iWaCPP ENSMUSP00000066789.4 1360 FAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRP-------KCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPP 1439 **********************************************.......********************************** PP CBP.txt 174 seGddyilychPedqkiPktkkLreWykkmLekavkerivvevtnlykdifkqaeedrlvtaarLPyfeGdfWpnvleelikeleqe 260 seGddyi++chP+dqkiPk+k+L+eWykkmL+kav+eriv++ ykdi+kqa+edrl++a++LPyfeGdfWpnvlee+ikeleqe ENSMUSP00000066789.4 1440 SEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHD----YKDILKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQE 1522 ******************************************....***************************************** PP CBP.txt 261 eeerkkkekkaaskkkvkkralkaegqldlsknakkklllmeklgetilpkkkdkilvelqksnkkksklvvsgnrwvcekcknlql 347 eeerk++e++++++++v+k ++sknakkk ++kk++k++++l++ nkkk+ +++++n+ ENSMUSP00000066789.4 1523 EEERKREENTSNESTDVTK---------GDSKNAKKK-----------NNKKTSKNKSSLSRGNKKKPGMPNVSND----------- 1578 ****************988.........89*******...........9***************************........... PP CBP.txt 348 cdkcyeaeqerlseklyatmekekevlfvvrlkdvpa....aeiedkdellesdlldgrdafLtlardkhyefssLrrakhsslmll 430 ls+klyatmek+kev+fv+rl ++pa ++i+d+d+l+ +dl+dgrdafLtlardkh+efssLrra++s++++l ENSMUSP00000066789.4 1579 -----------LSQKLYATMEKHKEVFFVIRLIACPApnslPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCML 1654 ...........99***********************999999********************************************* PP CBP.txt 431 yeLhnqtk 438 +eLh+q++ ENSMUSP00000066789.4 1655 VELHTQSQ 1662 *****985 PP CBP.txt 324 nkkksklvvsgnrwvcekcknlqlcdkcyeaeqerls 360 ++++ + + rw c c++++lc +cy+++++ + ENSMUSP00000066789.4 1669 CNECK--HHVETRWHCTVCEDYDLCITCYNTKNHDHK 1703 44444..467889****************99876554 PP
Ac_Reader Bromodomain
BROMO.txt 2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 + ++s pFr+pvdpq l ipdY+di+k PmdLstik++l++g+Y++p + ++D++l+fnNa yn++ s v+ ENSMUSP00000066789.4 1067 QDPESLPFRQPVDPQlLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVY 1138 56899**************************************************************99887 PP
|
Protein Sequence (Fasta) | MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD 60 ISQLQTSLGI VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQAMASQAQQ NSPGLSLINS 120 MVKSPMAQTG LTSPNMGIGS SGPNQGPTQS PAGMMNSPVN QPAMGMNTGM NAGMNPGMLA 180 AGNGQGIMPN QVMNGSIGAG RGRPNMQYPN AGMGNAGSLL TEPLQQGSPQ MGGQPGLRGP 240 QPLKMGMMNN PSPYGSPYTQ NSGQQIGASG LGLQIQTKTV LPNNLSPFAM DKKAVPGGGM 300 PSMGQQPTPS VQQPGLVTPV AAGMGSGAHT ADPEKRKLIQ QQLVLLLHAH KCQRREQANG 360 EVRQCNLPHC RTMKNVLNHM THCQSGKSCQ VAHCASSRQI ISHWKNCTRH DCPVCLPLKN 420 AGDKRNQQSI LTGAPVGLGN PSSLGVGQQS TPSLSTVSQI DPSSIERAYA ALGLPYQVNQ 480 IPPQPQVQAK NQQSQPSGQS PQGMRSVNNM SASPMGVNGG VGVQTPNLLS DSMLHSTINS 540 QNPMMSENAG VASLGPLPTA AQPSSTGIRK QWHEDITQDL RNHLVHKLVQ AIFPTPDPAA 600 LKDRRMENLV AYARKVEGDM YESANNRAEY YHLLAEKIYK IQKELEEKRR TRLQKQNMLP 660 NAPGMGPVPM NTGSNMGQQP TGMTTNGPVP DPSMIRGSVP NHMMPRMTPQ PGLNQFGQMN 720 MPQPPIGPRQ PSPLQHHGQL AQSGSLNPPM GYGPRMQQAS GQNQFLSQTQ FTSQGMNVTN 780 MPLAPSSGQA PVSQAQMSSS SCPVNSPIMP PGSQGSHIHC PTLPQQAHQN SPSPVPSRTP 840 TPHHTPPSIG NQPPPATAIP TPVPTPPAIP PGPQPPSLHP SSRQTPTPPT HLPPQVQPSL 900 PAAPSADQSQ QQPRSQQSTA VSVPTPTAPL LPPQPSTPLS QPAVSIEGQV SNPPSTSSTE 960 VNSQTIPEKQ PSQEVKMESK MEVDKPEPAD AQPEDTKEAK GEDVKVEPTE MEERGPELKT 1020 DGKEEEEQPS TSATQSSPAP GQSKKKIFKP EELRQALMPT LEALYRQDPE SLPFRQPVDP 1080 QLLGIPDYFD IVKSPMDLST IKRKLDTGQY QEPWQYIDDI WLMFNNAWLY NRKTSRVYKY 1140 CSKLSEVFEQ EIDPVMQSLG YCCGRKLEFS PQTLCCYGKQ LCTIPRDATY YSYQNRYHFC 1200 EKCFNEIQGE SVSLGDDPSQ PQTTINKEQF SKRKNDTLDP ELFVECTECG RKMHQICVLH 1260 HEIIWPSGFV CDGCLKKTAR TRKENKLSAK RLPSTRLGTF LENRVNDFLR RQNHPESGEV 1320 TVRVVHASDK TVEVKPGMKA RFVDSGEMAE SFPYRTKALF AFEEIDGVDL CFFGMHVQEY 1380 GSDCPPPNQR RVYISYLDSV HFFRPKCLRT AVYHEILIGY LEYVKKLGYT TGHIWACPPS 1440 EGDDYIFHCH PPDQKIPKPK RLQEWYKKML DKAVSERIVH DYKDILKQAT EDRLTSAKEL 1500 PYFEGDFWPN VLEESIKELE QEEEERKREE NTSNESTDVT KGDSKNAKKK NNKKTSKNKS 1560 SLSRGNKKKP GMPNVSNDLS QKLYATMEKH KEVFFVIRLI ACPAPNSLPP IVDPDPLIPC 1620 DLMDGRDAFL TLARDKHLEF SSLRRAQWST MCMLVELHTQ SQDRFVYTCN ECKHHVETRW 1680 HCTVCEDYDL CITCYNTKNH DHKMEKLGLG LDDESNNQQA AATQSPGDSR RLSIQRCIQS 1740 LVHACQCRNA NCSLPSCQKM KRVVQHTKGC KRKTNGGCPI CKQLIALCCY HAKHCQENKC 1800 PVPFCLNIKQ KLRQQQLQHR LQQAQMLRRR MASMQRTGVA GQQQGLPSPT PATPTTPTGQ 1860 QPATPQTPQP QPTSQPQPTP PNNMTPYLPR TQTTGPVSQG KAPGQVTPPT PPQTAQAPLP 1920 GPPPAAVEMA MQIQRAAETQ RQMAHVQIFQ RPIQHQMPQM SPMAPMGMNP PPMARGPGGH 1980 LDPGIGPAGM QQQPPWAQGG MPQPQQMQSG MPRPAMMSVA QHGQPLNMAP QPGLGQVGVS 2040 PLKPGTVSQQ ALQNLLRTLR SPSSPLQQQQ VLSILHANPQ LLAAFIKQRA AKYANPNPQP 2100 LPGQPGMTQG QPGLQPPTMP GQQGVHSNPA LQNMNPLQAG VQRAGLPQQQ PQQQLQPPMG 2160 AMSPQAQQMN MNHNTMPSQF RDILRRQMMQ QQGAGPGIGP GMANQFQQPQ GIGYPPQQQQ 2220 QQRMQHHMQQ MQQGNMGQMG QLPQALGAEA GASLQAYQQR LLQQQMGSPA QPNPMSPQQH 2280 MLPNQAQSPH LQGQQIPNSL SNQVRSPQPV PSPRPQSQPP HSSPSPRMQP QPSPHHVSPQ 2340 TSSPHPGLVA AQAANPMEQG HFASPDQNSM LSQLASNPGM ANLHGASATD LGLSSDNADL 2400 NSNLSQSTLD IH 2412Protein Fasta Sequence
>ENSMUSP00000066789.4|EP300;KAT3B;P300|Mus musculus MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDISQLQTSLGIVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQAMASQAQQNSPGLSLINSMVKSPMAQTGLTSPNMGIGSSGPNQGPTQSPAGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRPNMQYPNAGMGNAGSLLTEPLQQGSPQMGGQPGLRGPQPLKMGMMNNPSPYGSPYTQNSGQQIGASGLGLQIQTKTVLPNNLSPFAMDKKAVPGGGMPSMGQQPTPSVQQPGLVTPVAAGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQSILTGAPVGLGNPSSLGVGQQSTPSLSTVSQIDPSSIERAYAALGLPYQVNQIPPQPQVQAKNQQSQPSGQSPQGMRSVNNMSASPMGVNGGVGVQTPNLLSDSMLHSTINSQNPMMSENAGVASLGPLPTAAQPSSTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAPGMGPVPMNTGSNMGQQPTGMTTNGPVPDPSMIRGSVPNHMMPRMTPQPGLNQFGQMNMPQPPIGPRQPSPLQHHGQLAQSGSLNPPMGYGPRMQQASGQNQFLSQTQFTSQGMNVTNMPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPTLPQQAHQNSPSPVPSRTPTPHHTPPSIGNQPPPATAIPTPVPTPPAIPPGPQPPSLHPSSRQTPTPPTHLPPQVQPSLPAAPSADQSQQQPRSQQSTAVSVPTPTAPLLPPQPSTPLSQPAVSIEGQVSNPPSTSSTEVNSQTIPEKQPSQEVKMESKMEVDKPEPADAQPEDTKEAKGEDVKVEPTEMEERGPELKTDGKEEEEQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPSGFVCDGCLKKTARTRKENKLSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDILKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIACPAPNSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVAGQQQGLPSPTPATPTTPTGQQPATPQTPQPQPTSQPQPTPPNNMTPYLPRTQTTGPVSQGKAPGQVTPPTPPQTAQAPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPQMSPMAPMGMNPPPMARGPGGHLDPGIGPAGMQQQPPWAQGGMPQPQQMQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGVSPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANPNPQPLPGQPGMTQGQPGLQPPTMPGQQGVHSNPALQNMNPLQAGVQRAGLPQQQPQQQLQPPMGAMSPQAQQMNMNHNTMPSQFRDILRRQMMQQQGAGPGIGPGMANQFQQPQGIGYPPQQQQQQRMQHHMQQMQQGNMGQMGQLPQALGAEAGASLQAYQQRLLQQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQAANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSSDNADLNSNLSQSTLDIH
|
Nucleotide Sequence (Fasta) | CTTGTTTGTG TGCTAGCCTG TGGGGGGGGT GGGGGGAGGA GGAGAGAGAG CGGAGAGGGA 60 CCGGGAGAGA GAGAGTGGGG CAAGCGGGAC GCCCGGCTGA GTGCGAACTG CGCGAGCAGG 120 GAGTGAGGAG GGTACCTGGC TGGAGAGCAG CGGCCGGGAC CGAGACAGTG GTTGGGGGCC 180 CCGGGGCGCA AAGGCTGAGG CGACCCTCAG TCCCCTCCTT GCCCGCACAC ACCCCCACCG 240 CAGCCCGGGC CGGCGTCGAC GCCTAAGGGG GGGAAACCAT TACATAAGCC CGCGCCCCGC 300 GGCGCCTCTG CCCGCCGTCC GAGGCGGCCC CCGAGCCGAG CCCCCGGCAG GCACCTGGCT 360 GCCGGGGGGG TGAGGGCCAG GGAGGCGGCC GGACTGATTT CTCCTCCCCG GGCTTGCGAG 420 TGGAGGCGGA GAAGCGCGGC GCGCGGAGAG GCCGCGTCGG TGGGCTCGGC GTCAGCGCGG 480 GCTTGCGGGC GGACGGCCCT GCTTGGCCCG GCCCGGCCCC CCTGGCCCTT CGGGCCGGCG 540 AGCTCCACGC TCGGCGTCGT CGCTGCTGCG CCTCTGCTTG TCCGCTGCGC GATGTGAGGC 600 GGCCCCGGCG CCAGTCTGGC TCTCGGCTCG GCTGAGCTCA GTGTGGCCAT TAGGGGCCGG 660 TGCGGCAGCG GCGGCGCGGA GCGCAGCGGC AGGAGGAGGA GGAGGGCGGC TCTCAGGGTG 720 GGGGCGCAGG CCCGGGAGGG GGCACCGGGA GGAGGTGAGT GTCTCTGGTC GCCTCCTCCT 780 CTCCCCCTTT TTCGCCCCCG CCTCCTTGTG GCGATGAGAA GGAGGAGGAC AGCGCCGAGG 840 AGGAAGAAGC TGATGGCGGC GGCGGAGCTC CGAGAGACCT CGGCTGGGCA GGGGCTCGCC 900 GTGGCGGGCT GGGGACTGCG TCTGTAGAGC TGTGAGTTCC CGAGAATTCG CTGCAGCGGA 960 CGTGCTCGTG GGATCAGTGT TGCTGTACCC TCCTCCCGGC CTGGTTTAGG CCCGGCCCCT 1020 CGCACTTGCC CCTACCATTT CTGTTGAGTC CGCATCCCTC TCCGGCCACC GCAACCAGGC 1080 GAAGAGAAAA AGGAACTTCC CCCCACCCCT GTTGGGTGGC GGCGGAGCTC CGGAGCCCAC 1140 CCTTAGGAGC GGGGCGGGGA CCCCGTTTCG GAGAAGAGAT TTCCTCAGGA TTCTCGTTTT 1200 TTTCCTCGGT TGTATCTCCG AAAGAATTAA AAATGGCCGA GAATGTGGTG GAACCCGGGC 1260 CGCCTTCAGC CAAGCGGCCT AAACTCTCAT CTCCGGCCCT CTCGGCGTCC GCCAGCGATG 1320 GCACAGATTT TGGTTCACTG TTTGACCTGG AACATGACTT ACCAGATGAA TTAATCAACT 1380 CTACAGAATT GGGACTAACC AATGGTGGCG ATATCAGTCA GCTTCAGACA AGTCTTGGCA 1440 TAGTACAAGA TGCAGCCTCG AAACATAAAC AGCTGTCAGA ACTGCTGAGG TCTGGTAGCT 1500 CCCCAAACCT CAACATGGGA GTCGGTGGCC CAGGCCAAGC GATGGCCAGC CAGGCCCAAC 1560 AGAACAGCCC TGGATTAAGT TTGATAAATA GCATGGTCAA AAGCCCAATG GCACAGACAG 1620 GCTTGACTTC TCCAAACATG GGGATTGGCA GTAGTGGACC AAATCAGGGT CCTACTCAGT 1680 CCCCAGCAGG TATGATGAAC AGTCCAGTGA ACCAGCCTGC CATGGGAATG AACACAGGGA 1740 TGAATGCTGG CATGAATCCT GGAATGTTGG CTGCAGGCAA TGGACAAGGG ATAATGCCCA 1800 ATCAAGTCAT GAACGGTTCC ATTGGAGCAG GCCGGGGACG GCCAAACATG CAGTACCCAA 1860 ATGCAGGCAT GGGCAATGCT GGCAGTTTAT TGACTGAGCC ACTACAGCAG GGCTCTCCTC 1920 AGATGGGAGG ACAGCCAGGA TTGAGAGGCC CCCAACCACT TAAGATGGGA ATGATGAACA 1980 ATCCCAGTCC TTATGGTTCA CCATACACTC AGAATTCTGG ACAGCAGATT GGAGCAAGTG 2040 GCCTTGGTCT CCAAATTCAG ACAAAGACTG TTCTACCAAA TAACTTATCT CCATTTGCAA 2100 TGGACAAAAA GGCAGTTCCT GGTGGGGGAA TGCCCAGTAT GGGCCAGCAG CCTACCCCAT 2160 CGGTCCAGCA GCCAGGCCTG GTGACTCCAG TTGCCGCAGG AATGGGTTCT GGAGCACACA 2220 CAGCTGATCC AGAGAAGCGC AAGCTCATCC AGCAGCAGCT TGTTCTCCTT TTACATGCTC 2280 ACAAGTGCCA GCGCCGGGAG CAAGCTAATG GGGAAGTGAG GCAGTGCAAC CTTCCTCACT 2340 GTCGTACCAT GAAAAATGTC CTAAACCATA TGACACATTG CCAGTCAGGC AAATCCTGCC 2400 AAGTGGCACA TTGTGCATCT TCTCGACAAA TCATTTCACA CTGGAAAAAT TGCACAAGGC 2460 ATGATTGTCC TGTGTGTCTT CCTCTCAAAA ATGCTGGGGA TAAGCGAAAT CAACAGTCAA 2520 TTTTGACTGG AGCACCAGTT GGGCTTGGAA ACCCTAGCTC TCTAGGAGTG GGGCAGCAGT 2580 CCACTCCTAG CCTAAGCACT GTTAGTCAGA TTGACCCCAG CTCTATAGAG CGAGCTTACG 2640 CTGCTCTTGG ACTACCCTAT CAAGTAAACC AGATTCCACC ACAACCCCAG GTACAAGCAA 2700 AGAATCAACA AAGCCAGCCA TCTGGACAGT CTCCCCAGGG CATGCGGTCT GTGAACAACA 2760 TGAGTGCTAG TCCTATGGGT GTAAATGGAG GTGTTGGGGT TCAGACGCCA AATCTTCTTT 2820 CTGACTCCAT GTTGCATTCA ACTATAAATT CTCAAAACCC AATGATGAGT GAAAATGCTG 2880 GTGTGGCCTC CCTGGGTCCT TTGCCAACAG CAGCTCAGCC ATCTAGTACT GGAATTCGAA 2940 AACAGTGGCA TGAAGATATT ACTCAGGATC TTCGAAACCA CCTTGTTCAT AAACTTGTTC 3000 AAGCCATATT TCCCACTCCG GATCCTGCTG CTTTAAAAGA CCGACGGATG GAAAATCTTG 3060 TTGCATATGC TCGTAAAGTG GAAGGGGACA TGTATGAATC TGCAAACAAT AGAGCGGAAT 3120 ACTATCACCT CCTAGCCGAG AAGATCTATA AGATCCAGAA GGAACTAGAA GAGAAACGAA 3180 GGACTAGACT ACAGAAACAG AACATGCTAC CGAATGCTCC TGGCATGGGT CCAGTTCCTA 3240 TGAATACTGG GTCGAACATG GGGCAGCAAC CAACAGGAAT GACTACCAAT GGTCCTGTAC 3300 CTGACCCGTC TATGATCCGT GGCAGTGTGC CGAACCACAT GATGCCTCGG ATGACTCCAC 3360 AGCCTGGTTT GAATCAATTT GGGCAGATGA ATATGCCACA GCCCCCTATT GGACCCCGGC 3420 AACCCTCTCC TCTTCAGCAC CATGGACAAT TGGCTCAGTC TGGGTCACTC AATCCGCCTA 3480 TGGGCTATGG ACCTCGCATG CAGCAGGCTT CCGGCCAGAA CCAGTTCCTC TCCCAGACTC 3540 AGTTCACATC CCAAGGAATG AATGTAACAA ACATGCCTTT GGCTCCATCC AGCGGTCAAG 3600 CACCAGTGTC TCAAGCACAA ATGTCCAGTT CTTCTTGCCC AGTGAACTCT CCTATAATGC 3660 CTCCAGGGTC TCAAGGGAGC CACATTCACT GTCCTACTCT GCCTCAACAA GCTCATCAGA 3720 ATTCACCTTC TCCTGTTCCT AGCCGCACCC CTACTCCTCA TCATACCCCC CCAAGCATAG 3780 GGAATCAACC ACCACCAGCA ACAGCAATTC CAACACCTGT TCCTACACCT CCTGCCATAC 3840 CACCTGGACC ACAGCCCCCA TCTCTGCATC CCTCATCTAG ACAAACACCT ACACCACCAA 3900 CACATCTGCC TCCCCAAGTG CAGCCTTCAC TTCCTGCTGC TCCTTCTGCT GACCAGTCCC 3960 AGCAACAGCC TCGGTCACAG CAGAGCACAG CAGTTTCTGT TCCTACCCCA ACAGCACCAT 4020 TGCTGCCTCC TCAGCCTTCC ACTCCGCTTT CTCAGCCAGC TGTGAGCATT GAAGGCCAGG 4080 TCTCAAACCC TCCATCTACT AGTAGCACCG AAGTGAATTC TCAGACCATT CCTGAGAAGC 4140 AGCCTTCACA GGAAGTGAAA ATGGAGTCTA AAATGGAGGT GGATAAGCCA GAACCAGCAG 4200 ATGCTCAACC TGAGGATACA AAGGAGGCTA AAGGTGAGGA TGTTAAAGTA GAACCTACAG 4260 AAATGGAGGA GAGAGGCCCT GAGTTAAAAA CTGATGGGAA AGAGGAGGAA GAACAGCCAA 4320 GCACCTCTGC TACCCAGTCC TCCCCAGCTC CTGGACAGTC AAAGAAGAAG ATTTTCAAAC 4380 CAGAGGAATT ACGACAGGCT CTGATGCCAA CATTGGAGGC ACTTTACCGG CAGGACCCAG 4440 AATCTCTTCC CTTTCGTCAG CCTGTGGACC CGCAGCTTCT AGGAATCCCT GATTACTTTG 4500 ATATTGTGAA GAGCCCCATG GATCTTTCTA CAATCAAGAG GAAGTTAGAT ACTGGACAAT 4560 ACCAAGAGCC CTGGCAATAT ATAGATGATA TTTGGCTTAT GTTCAACAAT GCCTGGTTAT 4620 ATAACCGTAA AACTTCAAGG GTATACAAAT ATTGCTCTAA ACTTTCTGAA GTATTTGAAC 4680 AAGAAATTGA CCCTGTCATG CAAAGCCTTG GATACTGTTG TGGCAGAAAG TTGGAGTTTT 4740 CTCCACAGAC TCTTTGTTGC TATGGGAAAC AGTTATGCAC AATCCCCCGT GATGCTACTT 4800 ACTACAGTTA CCAGAACAGG TATCATTTCT GTGAGAAGTG TTTCAATGAA ATCCAAGGGG 4860 AGAGCGTTTC TTTGGGTGAT GACCCTTCCC AACCTCAAAC TACAATAAAT AAAGAACAGT 4920 TTTCCAAGAG AAAAAATGAC ACGTTGGATC CTGAACTGTT TGTTGAGTGC ACAGAGTGTG 4980 GAAGAAAGAT GCACCAGATC TGTGTCCTTC ACCACGAGAT CATCTGGCCA TCTGGGTTTG 5040 TCTGTGATGG CTGTTTAAAG AAAACTGCAC GAACTAGGAA AGAAAATAAG CTTTCTGCTA 5100 AAAGATTGCC ATCTACCAGA CTTGGGACCT TTCTGGAGAA TCGAGTGAAT GACTTTCTGA 5160 GGCGACAAAA TCACCCTGAA TCAGGAGAGG TCACTGTTCG GGTTGTTCAT GCTTCTGACA 5220 AAACTGTGGA AGTGAAACCA GGCATGAAAG CAAGGTTTGT AGATAGTGGA GAGATGGCAG 5280 AATCTTTTCC ATACCGAACA AAGGCCCTGT TTGCCTTTGA AGAAATTGAT GGTGTTGACT 5340 TGTGTTTCTT CGGCATGCAT GTTCAAGAAT ATGGCTCTGA CTGCCCCCCT CCCAACCAGA 5400 GGAGGGTATA CATATCTTAC CTCGATAGTG TTCATTTCTT CCGTCCTAAA TGCTTGCGGA 5460 CTGCAGTCTA TCATGAAATT CTAATTGGAT ATTTGGAATA TGTCAAGAAA TTAGGATACA 5520 CAACAGGGCA CATCTGGGCC TGTCCACCCA GTGAAGGGGA TGACTATATC TTCCATTGCC 5580 ATCCACCTGA TCAGAAGATA CCAAAGCCCA AGCGCCTGCA AGAATGGTAC AAAAAGATGC 5640 TTGACAAGGC TGTATCAGAA CGTATTGTCC ATGACTACAA GGATATTTTA AAACAAGCTA 5700 CTGAAGATCG ATTAACAAGT GCAAAGGAAC TACCCTACTT TGAAGGTGAT TTCTGGCCCA 5760 ATGTTCTAGA AGAAAGCATC AAGGAGCTTG AACAGGAAGA GGAAGAGAGG AAACGGGAAG 5820 AGAACACCAG CAACGAGAGT ACTGATGTAA CAAAAGGAGA CAGCAAAAAT GCTAAGAAGA 5880 AGAATAACAA GAAAACCAGC AAAAACAAGA GCAGCCTGAG TAGGGGCAAT AAGAAGAAGC 5940 CTGGTATGCC CAATGTGTCT AATGACCTTT CTCAGAAACT GTATGCCACC ATGGAAAAGC 6000 ATAAAGAGGT TTTCTTTGTG ATCCGCCTCA TCGCTTGTCC TGCTCCCAAT TCCCTGCCTC 6060 CCATTGTTGA TCCTGACCCT CTCATCCCCT GTGACCTGAT GGACGGTAGA GATGCATTTC 6120 TCACCCTTGC AAGGGACAAG CACCTGGAGT TCTCTTCACT TCGAAGAGCC CAGTGGTCTA 6180 CCATGTGCAT GCTGGTGGAG CTCCATACAC AGAGTCAGGA TCGCTTTGTC TACACCTGCA 6240 ACGAGTGCAA GCACCACGTG GAGACACGCT GGCATTGCAC TGTGTGTGAG GATTATGACC 6300 TGTGCATCAC TTGTTATAAC ACTAAAAATC ATGACCACAA AATGGAGAAA CTAGGCCTTG 6360 GCTTAGATGA TGAGAGCAAT AACCAGCAAG CTGCAGCTAC ACAGAGCCCA GGAGACTCCC 6420 GCCGCCTGAG CATCCAACGC TGCATCCAGT CTCTGGTGCA TGCCTGTCAG TGCCGCAACG 6480 CCAACTGCTC CCTGCCTTCC TGCCAGAAGA TGAAGAGGGT TGTGCAGCAC ACCAAAGGCT 6540 GCAAACGGAA AACCAATGGT GGGTGCCCCA TTTGCAAACA GCTTATTGCC CTCTGCTGCT 6600 ATCATGCCAA GCACTGCCAG GAGAACAAGT GCCCGGTGCC ATTTTGCCTC AACATCAAGC 6660 AAAAGCTCCG GCAGCAACAG CTGCAGCACC GGCTCCAACA GGCTCAGATG CTCCGTAGGA 6720 GGATGGCCAG CATGCAACGA ACTGGTGTGG CGGGGCAGCA GCAGGGCCTG CCGTCCCCAA 6780 CTCCTGCTAC ACCAACTACC CCTACTGGCC AACAGCCAGC CACCCCACAG ACACCCCAGC 6840 CCCAACCCAC CTCTCAACCA CAGCCCACTC CTCCCAACAA CATGACACCC TACTTACCCA 6900 GGACTCAGAC TACTGGCCCT GTGTCCCAGG GTAAGGCACC AGGCCAGGTG ACCCCACCTA 6960 CCCCACCTCA GACTGCTCAG GCCCCCCTTC CAGGGCCTCC ACCTGCAGCA GTAGAAATGG 7020 CAATGCAAAT TCAGAGGGCA GCAGAGACAC AGCGCCAGAT GGCCCATGTA CAGATTTTCC 7080 AAAGGCCAAT CCAGCACCAG ATGCCCCAGA TGTCACCCAT GGCCCCTATG GGCATGAACC 7140 CACCTCCTAT GGCCAGAGGT CCTGGTGGGC ATTTGGATCC AGGAATAGGT CCAGCAGGAA 7200 TGCAGCAACA GCCACCTTGG GCCCAAGGAG GAATGCCTCA GCCCCAGCAG ATGCAGTCAG 7260 GGATGCCAAG GCCAGCCATG ATGTCAGTGG CCCAGCATGG TCAGCCTTTA AACATGGCTC 7320 CACAACCAGG ATTGGGCCAA GTGGGTGTGA GCCCTCTCAA GCCAGGCACT GTGTCTCAAC 7380 AAGCCTTACA AAACCTTTTG CGGACTCTCA GGTCTCCCAG TTCTCCCTTA CAGCAGCAAC 7440 AGGTGCTTAG TATCCTTCAT GCCAACCCCC AACTGTTGGC TGCATTCATC AAGCAGCGGG 7500 CTGCCAAGTA TGCCAACCCT AATCCACAGC CTCTCCCTGG ACAGCCTGGC ATGACCCAGG 7560 GACAGCCAGG GCTGCAGCCA CCTACCATGC CTGGCCAGCA AGGTGTCCAC TCCAACCCAG 7620 CCTTGCAGAA CATGAATCCT CTGCAGGCAG GTGTCCAGAG AGCTGGCCTG CCCCAGCAGC 7680 AGCCGCAGCA GCAGCTCCAG CCACCCATGG GAGCAATGAG TCCCCAAGCT CAGCAAATGA 7740 ACATGAATCA CAATACCATG CCTTCACAGT TCAGAGACAT CTTAAGACGG CAGATGATGC 7800 AACAGCAGGG AGCAGGGCCA GGAATCGGCC CTGGAATGGC CAACCAGTTC CAGCAGCCCC 7860 AAGGAATTGG CTATCCACCG CAGCAGCAGC AGCAGCAGCG AATGCAGCAT CACATGCAGC 7920 AAATGCAGCA AGGAAATATG GGACAAATGG GTCAGCTTCC CCAGGCTCTG GGGGCTGAGG 7980 CAGGAGCCAG TCTACAGGCC TATCAGCAGC GACTTCTTCA ACAACAGATG GGGTCTCCTG 8040 CTCAGCCCAA CCCTATGAGC CCACAGCAGC ACATGCTCCC AAATCAGGCA CAGTCCCCAC 8100 ACCTACAAGG TCAACAAATC CCTAATTCTC TCTCCAATCA AGTGCGCTCT CCCCAGCCTG 8160 TCCCTTCTCC TCGACCACAG TCTCAGCCCC CCCATTCCAG CCCATCTCCG AGGATGCAGC 8220 CTCAGCCTTC TCCACACCAT GTTTCTCCAC AGACCAGTTC CCCACATCCT GGACTGGTAG 8280 CTGCCCAGGC TGCCAACCCT ATGGAACAAG GGCATTTTGC CAGCCCAGAC CAGAATTCAA 8340 TGCTTTCACA GCTCGCTAGC AATCCTGGCA TGGCAAACCT CCACGGGGCA AGTGCCACGG 8400 ACCTGGGACT GAGCAGCGAT AATGCAGACT TGAATTCAAA CCTCTCACAG AGTACACTAG 8460 ACATACACTA GAGACACCTT GTAGTATTTT GGAAGCAAAA GATTATTTTC TCTTAACAAG 8520 ACTTTTTGTA CTGAAAACAA TTTTTTTGAA TCTTTCTTAG CCTAAAAGAC CCATTTTCCT 8580 TGGAACATGT AAGAACTGTG CAGTAGCCAT TTATGGTTTA AAGTAAACAG GCCAGATGAA 8640 CCTGAGGGAT AATAGATTAC AAAGAATATA TTTTTGTTAT GGCTGGTTAC CCCAGCTCTT 8700 TTTCCCCTTG TGTGTGTGGT TCAAGTGTGC ACTGGGAGGC AACTGAGGTC TGAAGCCAAC 8760 CATATGCTCC TGCCTTGCCG ATAGGTTTTA TTATTTTTTT TAAATTAATG AAAATATGTA 8820 ATATTAATAG TTATTATTTA CTGGTGCAGA TGGTTGACAT TTTTCCCTAT TTTCCTCACT 8880 TTATGAAAGA ATTTAAATAA AAAAAAAGAA CATTTCTAAA ACCAGAGGAC AAAAGGGGTT 8940 AATGTTACGT AAAATTACAT TATATATATA TATATATATA AATATATATA AATATATTAA 9000 AATACCAATT TTTTTCTCTG GGTGCAAAGA TGTTCATTCT TTTAAAAACA TTTAAAAAAT 9060 AAAATAAAAA GCCTCCTCTT TCCATCCCTC AAGTCAACTT TTGTGCTCCA GAAAATTTTC 9120 TATTCTGTAA GTCTAAGGGT AAAACTTCAA GTATTAAGAT AATTTGTACA TGTAGAGAAA 9180 AAAATGACTT TTTCATAATA TACAGGGGCA GCTGCCAAAT TGATGTATTA TAATATTGTG 9240 GTTTCTGTTT CTTGAGAAAA ATTTTTTGTT ATTTTTACAT CTAACAGAGG AAAAAAAATT 9300 TAAAAAGAGG GTAAGAAATG ACTCCAGTGG GGTGATTTTA ACATGCAAAT GTCTGAGATT 9360 TCTTCACTTG CTTTCTTCCT TACTCTGCCC CACACACGTA CACTTTCTGT AAAACTTGAA 9420 AATAGAAAGC AAAAACCCTC AACTGTTGTA AATCATGCAA TTAAGGTTGA TTACTTATAA 9480 ATATGAACTT TGGATCACTG TATAGACTGT TAAATTTGAT TTCTTATTAC CTATTGTTAA 9540 ATAAACTGTG TGAGACAGAC ACCTGA
9567Nucleotide Fasta Sequence
>ENSMUSP00000066789.4|Bromodomain|Mus musculus CTTGTTTGTGTGCTAGCCTGTGGGGGGGGTGGGGGGAGGAGGAGAGAGAGCGGAGAGGGACCGGGAGAGAGAGAGTGGGGCAAGCGGGACGCCCGGCTGAGTGCGAACTGCGCGAGCAGGGAGTGAGGAGGGTACCTGGCTGGAGAGCAGCGGCCGGGACCGAGACAGTGGTTGGGGGCCCCGGGGCGCAAAGGCTGAGGCGACCCTCAGTCCCCTCCTTGCCCGCACACACCCCCACCGCAGCCCGGGCCGGCGTCGACGCCTAAGGGGGGGAAACCATTACATAAGCCCGCGCCCCGCGGCGCCTCTGCCCGCCGTCCGAGGCGGCCCCCGAGCCGAGCCCCCGGCAGGCACCTGGCTGCCGGGGGGGTGAGGGCCAGGGAGGCGGCCGGACTGATTTCTCCTCCCCGGGCTTGCGAGTGGAGGCGGAGAAGCGCGGCGCGCGGAGAGGCCGCGTCGGTGGGCTCGGCGTCAGCGCGGGCTTGCGGGCGGACGGCCCTGCTTGGCCCGGCCCGGCCCCCCTGGCCCTTCGGGCCGGCGAGCTCCACGCTCGGCGTCGTCGCTGCTGCGCCTCTGCTTGTCCGCTGCGCGATGTGAGGCGGCCCCGGCGCCAGTCTGGCTCTCGGCTCGGCTGAGCTCAGTGTGGCCATTAGGGGCCGGTGCGGCAGCGGCGGCGCGGAGCGCAGCGGCAGGAGGAGGAGGAGGGCGGCTCTCAGGGTGGGGGCGCAGGCCCGGGAGGGGGCACCGGGAGGAGGTGAGTGTCTCTGGTCGCCTCCTCCTCTCCCCCTTTTTCGCCCCCGCCTCCTTGTGGCGATGAGAAGGAGGAGGACAGCGCCGAGGAGGAAGAAGCTGATGGCGGCGGCGGAGCTCCGAGAGACCTCGGCTGGGCAGGGGCTCGCCGTGGCGGGCTGGGGACTGCGTCTGTAGAGCTGTGAGTTCCCGAGAATTCGCTGCAGCGGACGTGCTCGTGGGATCAGTGTTGCTGTACCCTCCTCCCGGCCTGGTTTAGGCCCGGCCCCTCGCACTTGCCCCTACCATTTCTGTTGAGTCCGCATCCCTCTCCGGCCACCGCAACCAGGCGAAGAGAAAAAGGAACTTCCCCCCACCCCTGTTGGGTGGCGGCGGAGCTCCGGAGCCCACCCTTAGGAGCGGGGCGGGGACCCCGTTTCGGAGAAGAGATTTCCTCAGGATTCTCGTTTTTTTCCTCGGTTGTATCTCCGAAAGAATTAAAAATGGCCGAGAATGTGGTGGAACCCGGGCCGCCTTCAGCCAAGCGGCCTAAACTCTCATCTCCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGTTCACTGTTTGACCTGGAACATGACTTACCAGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGCGATATCAGTCAGCTTCAGACAAGTCTTGGCATAGTACAAGATGCAGCCTCGAAACATAAACAGCTGTCAGAACTGCTGAGGTCTGGTAGCTCCCCAAACCTCAACATGGGAGTCGGTGGCCCAGGCCAAGCGATGGCCAGCCAGGCCCAACAGAACAGCCCTGGATTAAGTTTGATAAATAGCATGGTCAAAAGCCCAATGGCACAGACAGGCTTGACTTCTCCAAACATGGGGATTGGCAGTAGTGGACCAAATCAGGGTCCTACTCAGTCCCCAGCAGGTATGATGAACAGTCCAGTGAACCAGCCTGCCATGGGAATGAACACAGGGATGAATGCTGGCATGAATCCTGGAATGTTGGCTGCAGGCAATGGACAAGGGATAATGCCCAATCAAGTCATGAACGGTTCCATTGGAGCAGGCCGGGGACGGCCAAACATGCAGTACCCAAATGCAGGCATGGGCAATGCTGGCAGTTTATTGACTGAGCCACTACAGCAGGGCTCTCCTCAGATGGGAGGACAGCCAGGATTGAGAGGCCCCCAACCACTTAAGATGGGAATGATGAACAATCCCAGTCCTTATGGTTCACCATACACTCAGAATTCTGGACAGCAGATTGGAGCAAGTGGCCTTGGTCTCCAAATTCAGACAAAGACTGTTCTACCAAATAACTTATCTCCATTTGCAATGGACAAAAAGGCAGTTCCTGGTGGGGGAATGCCCAGTATGGGCCAGCAGCCTACCCCATCGGTCCAGCAGCCAGGCCTGGTGACTCCAGTTGCCGCAGGAATGGGTTCTGGAGCACACACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAGCAGCTTGTTCTCCTTTTACATGCTCACAAGTGCCAGCGCCGGGAGCAAGCTAATGGGGAAGTGAGGCAGTGCAACCTTCCTCACTGTCGTACCATGAAAAATGTCCTAAACCATATGACACATTGCCAGTCAGGCAAATCCTGCCAAGTGGCACATTGTGCATCTTCTCGACAAATCATTTCACACTGGAAAAATTGCACAAGGCATGATTGTCCTGTGTGTCTTCCTCTCAAAAATGCTGGGGATAAGCGAAATCAACAGTCAATTTTGACTGGAGCACCAGTTGGGCTTGGAAACCCTAGCTCTCTAGGAGTGGGGCAGCAGTCCACTCCTAGCCTAAGCACTGTTAGTCAGATTGACCCCAGCTCTATAGAGCGAGCTTACGCTGCTCTTGGACTACCCTATCAAGTAAACCAGATTCCACCACAACCCCAGGTACAAGCAAAGAATCAACAAAGCCAGCCATCTGGACAGTCTCCCCAGGGCATGCGGTCTGTGAACAACATGAGTGCTAGTCCTATGGGTGTAAATGGAGGTGTTGGGGTTCAGACGCCAAATCTTCTTTCTGACTCCATGTTGCATTCAACTATAAATTCTCAAAACCCAATGATGAGTGAAAATGCTGGTGTGGCCTCCCTGGGTCCTTTGCCAACAGCAGCTCAGCCATCTAGTACTGGAATTCGAAAACAGTGGCATGAAGATATTACTCAGGATCTTCGAAACCACCTTGTTCATAAACTTGTTCAAGCCATATTTCCCACTCCGGATCCTGCTGCTTTAAAAGACCGACGGATGGAAAATCTTGTTGCATATGCTCGTAAAGTGGAAGGGGACATGTATGAATCTGCAAACAATAGAGCGGAATACTATCACCTCCTAGCCGAGAAGATCTATAAGATCCAGAAGGAACTAGAAGAGAAACGAAGGACTAGACTACAGAAACAGAACATGCTACCGAATGCTCCTGGCATGGGTCCAGTTCCTATGAATACTGGGTCGAACATGGGGCAGCAACCAACAGGAATGACTACCAATGGTCCTGTACCTGACCCGTCTATGATCCGTGGCAGTGTGCCGAACCACATGATGCCTCGGATGACTCCACAGCCTGGTTTGAATCAATTTGGGCAGATGAATATGCCACAGCCCCCTATTGGACCCCGGCAACCCTCTCCTCTTCAGCACCATGGACAATTGGCTCAGTCTGGGTCACTCAATCCGCCTATGGGCTATGGACCTCGCATGCAGCAGGCTTCCGGCCAGAACCAGTTCCTCTCCCAGACTCAGTTCACATCCCAAGGAATGAATGTAACAAACATGCCTTTGGCTCCATCCAGCGGTCAAGCACCAGTGTCTCAAGCACAAATGTCCAGTTCTTCTTGCCCAGTGAACTCTCCTATAATGCCTCCAGGGTCTCAAGGGAGCCACATTCACTGTCCTACTCTGCCTCAACAAGCTCATCAGAATTCACCTTCTCCTGTTCCTAGCCGCACCCCTACTCCTCATCATACCCCCCCAAGCATAGGGAATCAACCACCACCAGCAACAGCAATTCCAACACCTGTTCCTACACCTCCTGCCATACCACCTGGACCACAGCCCCCATCTCTGCATCCCTCATCTAGACAAACACCTACACCACCAACACATCTGCCTCCCCAAGTGCAGCCTTCACTTCCTGCTGCTCCTTCTGCTGACCAGTCCCAGCAACAGCCTCGGTCACAGCAGAGCACAGCAGTTTCTGTTCCTACCCCAACAGCACCATTGCTGCCTCCTCAGCCTTCCACTCCGCTTTCTCAGCCAGCTGTGAGCATTGAAGGCCAGGTCTCAAACCCTCCATCTACTAGTAGCACCGAAGTGAATTCTCAGACCATTCCTGAGAAGCAGCCTTCACAGGAAGTGAAAATGGAGTCTAAAATGGAGGTGGATAAGCCAGAACCAGCAGATGCTCAACCTGAGGATACAAAGGAGGCTAAAGGTGAGGATGTTAAAGTAGAACCTACAGAAATGGAGGAGAGAGGCCCTGAGTTAAAAACTGATGGGAAAGAGGAGGAAGAACAGCCAAGCACCTCTGCTACCCAGTCCTCCCCAGCTCCTGGACAGTCAAAGAAGAAGATTTTCAAACCAGAGGAATTACGACAGGCTCTGATGCCAACATTGGAGGCACTTTACCGGCAGGACCCAGAATCTCTTCCCTTTCGTCAGCCTGTGGACCCGCAGCTTCTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCATGGATCTTTCTACAATCAAGAGGAAGTTAGATACTGGACAATACCAAGAGCCCTGGCAATATATAGATGATATTTGGCTTATGTTCAACAATGCCTGGTTATATAACCGTAAAACTTCAAGGGTATACAAATATTGCTCTAAACTTTCTGAAGTATTTGAACAAGAAATTGACCCTGTCATGCAAAGCCTTGGATACTGTTGTGGCAGAAAGTTGGAGTTTTCTCCACAGACTCTTTGTTGCTATGGGAAACAGTTATGCACAATCCCCCGTGATGCTACTTACTACAGTTACCAGAACAGGTATCATTTCTGTGAGAAGTGTTTCAATGAAATCCAAGGGGAGAGCGTTTCTTTGGGTGATGACCCTTCCCAACCTCAAACTACAATAAATAAAGAACAGTTTTCCAAGAGAAAAAATGACACGTTGGATCCTGAACTGTTTGTTGAGTGCACAGAGTGTGGAAGAAAGATGCACCAGATCTGTGTCCTTCACCACGAGATCATCTGGCCATCTGGGTTTGTCTGTGATGGCTGTTTAAAGAAAACTGCACGAACTAGGAAAGAAAATAAGCTTTCTGCTAAAAGATTGCCATCTACCAGACTTGGGACCTTTCTGGAGAATCGAGTGAATGACTTTCTGAGGCGACAAAATCACCCTGAATCAGGAGAGGTCACTGTTCGGGTTGTTCATGCTTCTGACAAAACTGTGGAAGTGAAACCAGGCATGAAAGCAAGGTTTGTAGATAGTGGAGAGATGGCAGAATCTTTTCCATACCGAACAAAGGCCCTGTTTGCCTTTGAAGAAATTGATGGTGTTGACTTGTGTTTCTTCGGCATGCATGTTCAAGAATATGGCTCTGACTGCCCCCCTCCCAACCAGAGGAGGGTATACATATCTTACCTCGATAGTGTTCATTTCTTCCGTCCTAAATGCTTGCGGACTGCAGTCTATCATGAAATTCTAATTGGATATTTGGAATATGTCAAGAAATTAGGATACACAACAGGGCACATCTGGGCCTGTCCACCCAGTGAAGGGGATGACTATATCTTCCATTGCCATCCACCTGATCAGAAGATACCAAAGCCCAAGCGCCTGCAAGAATGGTACAAAAAGATGCTTGACAAGGCTGTATCAGAACGTATTGTCCATGACTACAAGGATATTTTAAAACAAGCTACTGAAGATCGATTAACAAGTGCAAAGGAACTACCCTACTTTGAAGGTGATTTCTGGCCCAATGTTCTAGAAGAAAGCATCAAGGAGCTTGAACAGGAAGAGGAAGAGAGGAAACGGGAAGAGAACACCAGCAACGAGAGTACTGATGTAACAAAAGGAGACAGCAAAAATGCTAAGAAGAAGAATAACAAGAAAACCAGCAAAAACAAGAGCAGCCTGAGTAGGGGCAATAAGAAGAAGCCTGGTATGCCCAATGTGTCTAATGACCTTTCTCAGAAACTGTATGCCACCATGGAAAAGCATAAAGAGGTTTTCTTTGTGATCCGCCTCATCGCTTGTCCTGCTCCCAATTCCCTGCCTCCCATTGTTGATCCTGACCCTCTCATCCCCTGTGACCTGATGGACGGTAGAGATGCATTTCTCACCCTTGCAAGGGACAAGCACCTGGAGTTCTCTTCACTTCGAAGAGCCCAGTGGTCTACCATGTGCATGCTGGTGGAGCTCCATACACAGAGTCAGGATCGCTTTGTCTACACCTGCAACGAGTGCAAGCACCACGTGGAGACACGCTGGCATTGCACTGTGTGTGAGGATTATGACCTGTGCATCACTTGTTATAACACTAAAAATCATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAATAACCAGCAAGCTGCAGCTACACAGAGCCCAGGAGACTCCCGCCGCCTGAGCATCCAACGCTGCATCCAGTCTCTGGTGCATGCCTGTCAGTGCCGCAACGCCAACTGCTCCCTGCCTTCCTGCCAGAAGATGAAGAGGGTTGTGCAGCACACCAAAGGCTGCAAACGGAAAACCAATGGTGGGTGCCCCATTTGCAAACAGCTTATTGCCCTCTGCTGCTATCATGCCAAGCACTGCCAGGAGAACAAGTGCCCGGTGCCATTTTGCCTCAACATCAAGCAAAAGCTCCGGCAGCAACAGCTGCAGCACCGGCTCCAACAGGCTCAGATGCTCCGTAGGAGGATGGCCAGCATGCAACGAACTGGTGTGGCGGGGCAGCAGCAGGGCCTGCCGTCCCCAACTCCTGCTACACCAACTACCCCTACTGGCCAACAGCCAGCCACCCCACAGACACCCCAGCCCCAACCCACCTCTCAACCACAGCCCACTCCTCCCAACAACATGACACCCTACTTACCCAGGACTCAGACTACTGGCCCTGTGTCCCAGGGTAAGGCACCAGGCCAGGTGACCCCACCTACCCCACCTCAGACTGCTCAGGCCCCCCTTCCAGGGCCTCCACCTGCAGCAGTAGAAATGGCAATGCAAATTCAGAGGGCAGCAGAGACACAGCGCCAGATGGCCCATGTACAGATTTTCCAAAGGCCAATCCAGCACCAGATGCCCCAGATGTCACCCATGGCCCCTATGGGCATGAACCCACCTCCTATGGCCAGAGGTCCTGGTGGGCATTTGGATCCAGGAATAGGTCCAGCAGGAATGCAGCAACAGCCACCTTGGGCCCAAGGAGGAATGCCTCAGCCCCAGCAGATGCAGTCAGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAGCATGGTCAGCCTTTAAACATGGCTCCACAACCAGGATTGGGCCAAGTGGGTGTGAGCCCTCTCAAGCCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGACTCTCAGGTCTCCCAGTTCTCCCTTACAGCAGCAACAGGTGCTTAGTATCCTTCATGCCAACCCCCAACTGTTGGCTGCATTCATCAAGCAGCGGGCTGCCAAGTATGCCAACCCTAATCCACAGCCTCTCCCTGGACAGCCTGGCATGACCCAGGGACAGCCAGGGCTGCAGCCACCTACCATGCCTGGCCAGCAAGGTGTCCACTCCAACCCAGCCTTGCAGAACATGAATCCTCTGCAGGCAGGTGTCCAGAGAGCTGGCCTGCCCCAGCAGCAGCCGCAGCAGCAGCTCCAGCCACCCATGGGAGCAATGAGTCCCCAAGCTCAGCAAATGAACATGAATCACAATACCATGCCTTCACAGTTCAGAGACATCTTAAGACGGCAGATGATGCAACAGCAGGGAGCAGGGCCAGGAATCGGCCCTGGAATGGCCAACCAGTTCCAGCAGCCCCAAGGAATTGGCTATCCACCGCAGCAGCAGCAGCAGCAGCGAATGCAGCATCACATGCAGCAAATGCAGCAAGGAAATATGGGACAAATGGGTCAGCTTCCCCAGGCTCTGGGGGCTGAGGCAGGAGCCAGTCTACAGGCCTATCAGCAGCGACTTCTTCAACAACAGATGGGGTCTCCTGCTCAGCCCAACCCTATGAGCCCACAGCAGCACATGCTCCCAAATCAGGCACAGTCCCCACACCTACAAGGTCAACAAATCCCTAATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCTCGACCACAGTCTCAGCCCCCCCATTCCAGCCCATCTCCGAGGATGCAGCCTCAGCCTTCTCCACACCATGTTTCTCCACAGACCAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCTGCCAACCCTATGGAACAAGGGCATTTTGCCAGCCCAGACCAGAATTCAATGCTTTCACAGCTCGCTAGCAATCCTGGCATGGCAAACCTCCACGGGGCAAGTGCCACGGACCTGGGACTGAGCAGCGATAATGCAGACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAGAGACACCTTGTAGTATTTTGGAAGCAAAAGATTATTTTCTCTTAACAAGACTTTTTGTACTGAAAACAATTTTTTTGAATCTTTCTTAGCCTAAAAGACCCATTTTCCTTGGAACATGTAAGAACTGTGCAGTAGCCATTTATGGTTTAAAGTAAACAGGCCAGATGAACCTGAGGGATAATAGATTACAAAGAATATATTTTTGTTATGGCTGGTTACCCCAGCTCTTTTTCCCCTTGTGTGTGTGGTTCAAGTGTGCACTGGGAGGCAACTGAGGTCTGAAGCCAACCATATGCTCCTGCCTTGCCGATAGGTTTTATTATTTTTTTTAAATTAATGAAAATATGTAATATTAATAGTTATTATTTACTGGTGCAGATGGTTGACATTTTTCCCTATTTTCCTCACTTTATGAAAGAATTTAAATAAAAAAAAAGAACATTTCTAAAACCAGAGGACAAAAGGGGTTAATGTTACGTAAAATTACATTATATATATATATATATATAAATATATATAAATATATTAAAATACCAATTTTTTTCTCTGGGTGCAAAGATGTTCATTCTTTTAAAAACATTTAAAAAATAAAATAAAAAGCCTCCTCTTTCCATCCCTCAAGTCAACTTTTGTGCTCCAGAAAATTTTCTATTCTGTAAGTCTAAGGGTAAAACTTCAAGTATTAAGATAATTTGTACATGTAGAGAAAAAAATGACTTTTTCATAATATACAGGGGCAGCTGCCAAATTGATGTATTATAATATTGTGGTTTCTGTTTCTTGAGAAAAATTTTTTGTTATTTTTACATCTAACAGAGGAAAAAAAATTTAAAAAGAGGGTAAGAAATGACTCCAGTGGGGTGATTTTAACATGCAAATGTCTGAGATTTCTTCACTTGCTTTCTTCCTTACTCTGCCCCACACACGTACACTTTCTGTAAAACTTGAAAATAGAAAGCAAAAACCCTCAACTGTTGTAAATCATGCAATTAAGGTTGATTACTTATAAATATGAACTTTGGATCACTGTATAGACTGTTAAATTTGATTTCTTATTACCTATTGTTAAATAAACTGTGTGAGACAGACACCTGA
|
Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0012--Acyltransferase KW-0090--Biological rhythms KW-0103--Bromodomain KW-0131--Cell cycle KW-0164--Citrullination KW-0175--Coiled coil KW-0181--Complete proteome KW-0963--Cytoplasm KW-0221--Differentiation KW-1017--Isopeptide bond KW-0479--Metal-binding KW-0488--Methylation KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0804--Transcription KW-0805--Transcription regulation KW-0808--Transferase KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
|
Interpro |
IPR001487--Bromodomain IPR018359--Bromodomain_CS IPR031162--CBP_P300_HAT IPR010303--DUF902_CREBbp IPR013178--Histone_AcTrfase_Rtt109/CBP IPR003101--KIX_dom IPR009110--Nuc_rcpt_coact IPR014744--Nuc_rcpt_coact_CREBbp IPR000197--Znf_TAZ IPR000433--Znf_ZZ
|
PROSITE |
PS00633--BROMODOMAIN_1 PS50014--BROMODOMAIN_2 PS51727--CBP_P300_HAT PS50952--KIX PS50134--ZF_TAZ PS01357--ZF_ZZ_1 PS50135--ZF_ZZ_2
|
Pfam |
PF00439--Bromodomain PF09030--Creb_binding PF06001--DUF902 PF08214--HAT_KAT11 PF02172--KIX PF02135--zf-TAZ PF00569--ZZ
|
Gene Ontology |
GO:0000785--C:chromatin GO:0005737--C:cytoplasm GO:0000123--C:histone acetyltransferase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0032993--C:protein-DNA complex GO:0005667--C:transcription factor complex GO:0016407--F:acetyltransferase activity GO:0033613--F:activating transcription factor binding GO:0050681--F:androgen receptor binding GO:0003823--F:antigen binding GO:0008013--F:beta-catenin binding GO:0003682--F:chromatin binding GO:0031490--F:chromatin DNA binding GO:0001047--F:core promoter binding GO:0003684--F:damaged DNA binding GO:0003677--F:DNA binding GO:0004402--F:histone acetyltransferase activity GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0035257--F:nuclear hormone receptor binding GO:0002039--F:p53 binding GO:0097157--F:pre-mRNA intronic binding GO:0008022--F:protein C-terminus binding GO:0001102--F:RNA polymerase II activating transcription factor binding GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding GO:0001085--F:RNA polymerase II transcription factor binding GO:0003713--F:transcription coactivator activity GO:0008134--F:transcription factor binding GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0016746--F:transferase activity, transferring acyl groups GO:0008270--F:zinc ion binding GO:0006915--P:apoptotic process GO:0030183--P:B cell differentiation GO:0051216--P:cartilage development GO:0007049--P:cell cycle GO:0071320--P:cellular response to cAMP GO:0071549--P:cellular response to dexamethasone stimulus GO:0035690--P:cellular response to drug GO:0071333--P:cellular response to glucose stimulus GO:0070301--P:cellular response to hydrogen peroxide GO:0071389--P:cellular response to mineralocorticoid stimulus GO:1990090--P:cellular response to nerve growth factor stimulus GO:0071300--P:cellular response to retinoic acid GO:0035984--P:cellular response to trichostatin A GO:0034644--P:cellular response to UV GO:0007623--P:circadian rhythm GO:0048565--P:digestive tract development GO:0045444--P:fat cell differentiation GO:0007507--P:heart development GO:0043969--P:histone H2B acetylation GO:0043966--P:histone H3 acetylation GO:0043967--P:histone H4 acetylation GO:0018393--P:internal peptidyl-lysine acetylation GO:0006475--P:internal protein amino acid acetylation GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0001889--P:liver development GO:0030324--P:lung development GO:0035855--P:megakaryocyte development GO:0007613--P:memory GO:0018076--P:N-terminal peptidyl-lysine acetylation GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:2000629--P:negative regulation of miRNA metabolic process GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0007219--P:Notch signaling pathway GO:0009887--P:organ morphogenesis GO:0030220--P:platelet formation GO:0043923--P:positive regulation by host of viral transcription GO:0045773--P:positive regulation of axon extension GO:0010942--P:positive regulation of cell death GO:0045793--P:positive regulation of cell size GO:0032967--P:positive regulation of collagen biosynthetic process GO:0043388--P:positive regulation of DNA binding GO:0010628--P:positive regulation of gene expression GO:0010560--P:positive regulation of glycoprotein biosynthetic process GO:0035066--P:positive regulation of histone acetylation GO:0014737--P:positive regulation of muscle atrophy GO:0032092--P:positive regulation of protein binding GO:0033160--P:positive regulation of protein import into nucleus, translocation GO:0001934--P:positive regulation of protein phosphorylation GO:0050714--P:positive regulation of protein secretion GO:0045862--P:positive regulation of proteolysis GO:0060298--P:positive regulation of sarcomere organization GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0045893--P:positive regulation of transcription, DNA-templated GO:0045727--P:positive regulation of translation GO:0006473--P:protein acetylation GO:0043491--P:protein kinase B signaling GO:0050821--P:protein stabilization GO:0065004--P:protein-DNA complex assembly GO:0060765--P:regulation of androgen receptor signaling pathway GO:0060177--P:regulation of angiotensin metabolic process GO:0006355--P:regulation of transcription, DNA-templated GO:0090043--P:regulation of tubulin deacetylation GO:0051592--P:response to calcium ion GO:0032025--P:response to cobalt ion GO:0043627--P:response to estrogen GO:0045471--P:response to ethanol GO:0070542--P:response to fatty acid GO:0001666--P:response to hypoxia GO:0034612--P:response to tumor necrosis factor GO:0007519--P:skeletal muscle tissue development GO:0001756--P:somitogenesis GO:0006366--P:transcription from RNA polymerase II promoter
|
Orthology |
|
Created Date |
25-Jun-2016 |