Tag |
Content |
WERAM ID |
WERAM-Mum-0151 |
Ensembl Protein ID |
ENSMUSP00000047308.7 |
Uniprot Accession |
Q9WTU0; PHF2_MOUSE; Q6A023; Q80WA8 |
Genbank Protein ID |
NP_035208.2 |
Protein Name |
Lysine-specific demethylase PHF2 |
Genbank Nucleotide ID |
NM_011078.3 |
Gene Name |
PHF2;Kiaa0662 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
PHF2_PHF8 |
Jmjc |
H3K9; H4K20me3 |
K |
25266703; 22921934 |
Me_Reader |
PHD |
PHD-type |
H3K4me3 |
K |
23201125 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
PHF2_PHF8 |
4.40e-92 |
307.5 |
197 |
353 |
Me_Reader |
PHD |
9.10e-14 |
52.9 |
6 |
261 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). |
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).
|
Domain Profile |
HDM PHF2_PHF8
PHF2.txt 1 fsdtklselveppdivkklslvenlwpdeavlekpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyeawe 89 fsdt++s++veppdivkkls+ven+wpd+a+l+kpkv+kycli+vkdsytdfhid+ggas++yhvlkgekifylirp++an++lye+w+ ENSMUSP00000047308.7 197 FSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWR 285 79*************************************************************************************** PP PHF2.txt 90 sssdqsevffgdkvdkaykvvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157 s+s++se+ff+d+vd++yk++vkqgqtl+ip+gwi+a+ltpvdclaf+g+flhsl++emq+raye+e+ ENSMUSP00000047308.7 286 SASNHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVER 353 ******************************************************************96 PP
Me_Reader PHD
PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 +C+ C+ +++ +++m++Cd C+dwfH++Cv+++++++p+ + ++Cp+C++ ENSMUSP00000047308.7 6 VYCV-CRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEK 55 69*9.**********************************7758******86 PP PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHl 29 ++Cl+C kd++ + +++ + + w+H+ ENSMUSP00000047308.7 235 KYCLICVKDSYTD-FHIDSGGASAWYHV 261 79****7777774.79999999999996 PP
|
Protein Sequence (Fasta) | MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 60 TLKKKRTWHK HGPGPTPDVK PVQNGSQLFI KELRSRTFPS AEDVVSRVPG SQLTVGYMEE 120 HGFTEPILVP KKDGLGLAVP APTFYVSDVE NYVGPERSVD VTDVTKQKDC KMKLKEFVDY 180 YYSTNRKRVL NVTNLEFSDT RMSSFVEPPD IVKKLSWVEN YWPDDALLAK PKVTKYCLIC 240 VKDSYTDFHI DSGGASAWYH VLKGEKIFYL IRPASANISL YERWRSASNH SEMFFADQVD 300 RCYKCTVKQG QTLFIPSGWI YATLTPVDCL AFAGHFLHSL SVEMQMRAYE VERRLKLGSL 360 TQFPNFETAC WYMGKHLLEA FKGSHKSGKQ LPPHLVQGAK ILNGAFRSWT KKQALAEHED 420 ELPEHFRPSQ LIKDLAKEIR LSENASKTVR PEVNAAASSD EVCDGDREKE EPPSPVETTP 480 PRSLLEKVSK KKTSKTVKMP KPSKIPKPPK SPKPPKTLKL KDGSKKKGKK CKESASPTIP 540 NLDLLEAHTK EALTKMEPPK KGKTPKSVLS VPNKDTVHTQ NDMERLEIRE QTKSKSEAKW 600 KYKNSKPDSL LKMEEEQRLE KSPLAGNKDK FSFSFSNRKL LGSKALRPPS SPGVFGALQS 660 FKEDKAKPVR DEYEYVSDDG ELKIDEFPIR RKKSAPKRDL SFLLDKKEAL LMPTSKPKLD 720 SAVYKSDDSS DEGSLHIDTD TKPGRNAKVK KESGSSAAGI LDLLQASEEV GALEYNPNSQ 780 PPASPSTQEA IQGMLSMANL QASDSCLQTT WGTGQAKGGS LAAHGARKIG GGNKGTGKRL 840 LKRTAKNSVD LEDYEEQDHL DACFKDSDYV YPSLESDEDN PVFKSRSKKR KGSDDAPYSP 900 TARVGPSVPR QDRPVREGTR VASIETGLAA AAAKLSQQEE QKNRKKKNTK RKPAPNTASP 960 SISTSASAST GTTSASTTPA STTPASTTPA STTPASTSTA SSQASQEGSS PEPPPESHSS 1020 SLADHEYTAA GTFSGSQAGR ASQPMAPGVF LTQRRPSASS PNNTAAKGKR TKKGMATAKQ 1080 RLGKILKIHR NGKLLL 1096Protein Fasta Sequence
>ENSMUSP00000047308.7|PHF2;Kiaa0662|Mus musculus MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGPTPDVKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWRSASNHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAAASSDEVCDGDREKEEPPSPVETTPPRSLLEKVSKKKTSKTVKMPKPSKIPKPPKSPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDMERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKALRPPSSPGVFGALQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKSAPKRDLSFLLDKKEALLMPTSKPKLDSAVYKSDDSSDEGSLHIDTDTKPGRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKIGGGNKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPAPNTASPSISTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFSGSQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
|
Nucleotide Sequence (Fasta) | CCGTCCGCTC CGGCCGCGGC GCCCGCGCCC GCCGCCCCCG CCGCCCTCGC CGCGCGGCCC 60 CCGGCCCGGC CCGGCCCGAC CCGGGCAGCG CAGCGGCGGG GCGAGCGGCG GCGCGGCAAC 120 ATGGCGACGG TGCCCGTGTA CTGCGTCTGC CGGCTGCCCT ACGACGTTAC CCGCTTTATG 180 ATCGAGTGCG ATGCCTGCAA GGACTGGTTC CACGGCAGCT GTGTTGGGGT GGAAGAGGAA 240 GAGGCACCAG ACATCGACAT TTACCACTGC CCGAACTGCG AGAAAACCCA TGGCAAGTCC 300 ACACTCAAGA AAAAGCGGAC TTGGCACAAA CACGGCCCTG GGCCAACACC GGACGTGAAA 360 CCAGTGCAGA ATGGCAGTCA GCTGTTCATC AAGGAGCTGC GGAGCCGAAC CTTCCCCAGT 420 GCTGAAGACG TGGTGTCCCG TGTGCCAGGT AGCCAGCTCA CCGTGGGCTA CATGGAGGAG 480 CATGGCTTCA CTGAGCCCAT CCTTGTCCCC AAGAAAGATG GCCTGGGCTT AGCTGTCCCT 540 GCCCCAACAT TCTACGTGAG TGATGTGGAG AACTATGTGG GGCCGGAGAG GAGTGTGGAT 600 GTGACAGACG TTACCAAACA GAAAGACTGC AAAATGAAGC TGAAAGAATT CGTGGACTAT 660 TACTATAGCA CGAACCGCAA GCGTGTTCTC AACGTGACCA ACCTCGAGTT CTCAGACACC 720 AGAATGTCCA GCTTTGTGGA GCCACCTGAC ATTGTGAAGA AACTATCGTG GGTGGAAAAC 780 TACTGGCCCG ATGACGCGCT GCTGGCCAAG CCCAAGGTGA CCAAGTACTG CCTGATCTGT 840 GTGAAGGACA GCTACACCGA CTTCCACATT GACTCTGGAG GTGCCTCAGC GTGGTACCAT 900 GTCCTCAAGG GGGAGAAGAT CTTCTATCTC ATCCGGCCAG CCTCAGCCAA CATCTCCCTA 960 TATGAGCGCT GGCGGTCAGC CTCCAACCAC AGCGAGATGT TCTTCGCCGA CCAGGTGGAC 1020 AGGTGCTATA AATGCACTGT CAAGCAGGGC CAGACCCTCT TCATCCCCTC AGGCTGGATC 1080 TATGCCACAC TCACCCCCGT GGACTGCCTG GCCTTCGCTG GACATTTCCT CCACAGCCTC 1140 AGTGTGGAGA TGCAGATGAG GGCATACGAG GTGGAAAGGA GGTTAAAACT TGGCAGCCTG 1200 ACTCAGTTTC CCAACTTTGA AACTGCCTGC TGGTACATGG GAAAGCACCT ATTGGAAGCG 1260 TTCAAAGGTT CTCACAAGTC TGGGAAACAG CTGCCCCCAC ACTTAGTTCA AGGAGCTAAA 1320 ATTCTCAATG GTGCTTTTAG GTCATGGACG AAGAAGCAGG CTTTGGCAGA GCATGAGGAC 1380 GAACTCCCAG AGCACTTCAG GCCCTCACAG CTCATCAAGG ACCTGGCCAA AGAGATCAGG 1440 CTCAGTGAGA ATGCCTCCAA AACTGTCCGA CCTGAAGTAA ACGCTGCCGC CTCCTCAGAT 1500 GAGGTCTGTG ATGGAGACCG GGAGAAGGAA GAACCGCCAT CTCCTGTTGA GACTACCCCA 1560 CCTCGATCCC TCCTGGAGAA AGTGTCCAAA AAAAAGACTT CCAAGACTGT GAAGATGCCC 1620 AAGCCATCCA AAATTCCCAA GCCCCCCAAA TCCCCCAAGC CCCCCAAAAC TCTGAAGCTC 1680 AAAGATGGGA GCAAGAAGAA AGGGAAGAAG TGCAAGGAGT CAGCCTCACC CACCATCCCC 1740 AACCTAGACC TGCTTGAGGC TCACACAAAG GAGGCGCTGA CCAAGATGGA GCCACCGAAG 1800 AAAGGGAAGA CCCCAAAGAG CGTCCTGAGT GTTCCCAATA AGGACACAGT CCACACGCAG 1860 AATGACATGG AAAGGCTGGA AATTCGAGAG CAAACAAAGA GCAAGTCAGA AGCCAAGTGG 1920 AAATACAAGA ACAGCAAACC TGACTCGTTA CTGAAGATGG AGGAGGAGCA GAGGCTGGAG 1980 AAGTCGCCCC TGGCTGGGAA CAAGGACAAG TTTTCCTTTT CTTTCTCCAA CAGAAAACTC 2040 CTGGGCTCCA AGGCCCTCAG GCCCCCGAGC AGCCCTGGTG TGTTCGGCGC CTTGCAGAGC 2100 TTCAAGGAGG ACAAGGCCAA GCCCGTGCGC GATGAGTATG AGTACGTATC AGATGATGGG 2160 GAGCTGAAGA TAGACGAGTT TCCCATCAGG AGGAAGAAGA GCGCCCCCAA AAGGGACTTG 2220 TCCTTCTTGT TAGACAAGAA GGAGGCTCTC CTCATGCCCA CCTCGAAGCC AAAGCTGGAT 2280 TCTGCGGTGT ACAAGAGCGA TGACTCCTCT GACGAGGGCT CTCTGCACAT CGACACGGAC 2340 ACCAAGCCAG GCAGAAATGC CAAAGTGAAG AAGGAGAGTG GGAGCTCCGC GGCCGGCATC 2400 CTGGACCTGC TGCAGGCCAG CGAGGAGGTT GGCGCACTCG AGTACAACCC CAACAGCCAG 2460 CCCCCTGCCT CCCCCAGCAC ACAGGAAGCC ATTCAGGGAA TGCTCTCCAT GGCCAATCTG 2520 CAGGCCTCTG ACTCTTGCCT GCAGACCACA TGGGGCACGG GGCAGGCCAA GGGTGGCTCA 2580 CTGGCAGCCC ATGGTGCCCG GAAGATTGGT GGTGGCAACA AAGGCACAGG CAAGCGCCTG 2640 CTGAAGAGGA CTGCCAAGAA CAGTGTGGAT CTGGAGGACT ACGAGGAGCA GGATCACCTG 2700 GATGCCTGCT TCAAGGACTC AGACTATGTT TACCCCTCAC TGGAGTCTGA CGAAGATAAC 2760 CCCGTCTTCA AGTCCCGGTC AAAGAAGAGG AAAGGCTCAG ACGATGCTCC GTACAGCCCC 2820 ACAGCCAGGG TCGGTCCATC GGTGCCAAGA CAAGACAGGC CTGTGCGTGA GGGGACCAGA 2880 GTGGCCTCCA TTGAGACGGG GCTGGCAGCT GCTGCAGCCA AGCTGTCCCA GCAGGAGGAG 2940 CAGAAAAACA GGAAGAAGAA GAACACCAAA AGGAAGCCGG CTCCTAACAC TGCCTCCCCC 3000 TCCATCTCCA CCTCTGCCTC CGCCTCCACG GGTACCACCT CGGCCTCCAC CACCCCAGCA 3060 TCCACCACCC CGGCCTCCAC CACCCCAGCA TCCACCACCC CGGCCTCCAC CAGCACAGCC 3120 AGCAGCCAGG CCTCACAGGA GGGCAGCTCA CCTGAGCCCC CACCTGAATC ACACAGCAGT 3180 AGCCTGGCTG ACCACGAATA TACAGCAGCC GGCACATTCT CGGGGTCCCA GGCTGGCCGT 3240 GCCTCCCAGC CCATGGCCCC TGGAGTCTTT CTCACACAGA GGCGGCCTTC TGCATCATCC 3300 CCCAACAACA CTGCTGCCAA AGGAAAACGT ACAAAAAAGG GCATGGCCAC CGCCAAGCAA 3360 AGGCTTGGAA AGATCTTGAA GATCCATCGG AACGGGAAAC TGCTCCTCTA AGGCTTGGGA 3420 AGCCAGGATC CTTCTGCTCT GCTCAGGACC CCCGGAGCCC CGCTACATCC ACCCCTCCCA 3480 GGACGGTGGC TGTGCTGCCT GGCCCAGGGA GGGCCTCGCC TCCTCCCAGC CACCTCTCCC 3540 CAATGCGAGC ATCTGTCCCT TGAGCAGGTG GAGCGAGCGA GCGAGCGGAG CATGGCCGTC 3600 CCTTGTTGTG AACACGGACA TCCTTTCTCG AGTTGCTCAG AGTGACCTGA AAGTGGCCCC 3660 GCCGACTTAA GGATCATTCT GGTTTCAGAA CAGCCTCCAG GCTCCCCACT GGAGCGGCTC 3720 TGCTTAGGAG CATGAGGCCT TCAAGGAAGG TGCAGTGAGC CACGCTCACC AGCCCGAGTC 3780 CGAGCTGGCC CCAGGCTGGC AGCCTCCAAA GGCGTAAAAC AAGGCAAAGG ACACAGAAAG 3840 GAGCTGTGGG GTATTGAATG TCCCCACCCA CCTCTTCCTG AGCGAGGCTT ACATCACTTG 3900 ACCAGTGAGG AAGAGGTTAC CCCAGCTCCC TGGCTGGCAG GTAGCAGGCT AGGTAATGGG 3960 TGTCACACAC ATCCCAAATG CCTAGGGACA TTTGGGCTTG TCAGGACCCA CAGTTAGGTT 4020 GGTGTGTTAG TGGGTTGGAG GAGCCACTGT GGGGGTCACA GGGGAAGGGT GACAGCTCAG 4080 CCACGTCTTC GGGTCCGGGG GACCCAGGCT AAGCCACGTG GAGGGGCCCC ACTCTGAAAC 4140 AGCACTTCTA GGCCAAGGCA CCCTGCCCTG AGTGGGCAGA CAGGTGAGCA GGGCCACAGG 4200 GCTGGAGCCA GCACGGCAGC GCTTGTCTGA GCCCCTGGGT GGCGTCATGA GTGTGGGCCA 4260 TCTCAGGTGG TGGTGTCCAC CCATCGACAC GGAGGGGCTG GGTTTGTTTC TCAGGCAATC 4320 CTGTATTTTC ATTTTAGATG TATTTCCGGA AGCATATTTT TCATAGAATG TAGCGTGTAA 4380 ATAGCTTTTT AAATGACTTC TTTTTTACAA GAGCAAAAGT ATCTCTAGGA ATTTCTTTCT 4440 ATAGAGTCCT TCATTAACCT TTATACGAGT TTTTGCTCCC CCACCCCCTT CTCTGATGGA 4500 TGGTCGGGTT CTGGCCCCCC ACCCCCTTTT CTTTCCTTTC CTTTTGTTAC TCCTTCTTAT 4560 TTTCCTCTTA GGAACTAAGG TATTGCCTGA AAAACAACGG CGCCTGCGCG GCCTTACACT 4620 CCGCCTCTCA GAGCGGACAG TACAGAGGCC CCTCCCACTC GCCCCGAAAG CCGCGTCTCC 4680 AGTCTCACAC CAGCTCTTCG GTCCTCTTCC TTGTATGGCG AGGGTCAGGG ATGCAGTTAC 4740 TTTGCTAGCA CCTTGTGAAG TATTTGTGTT TCGTGATGCT GTAATTTATT AATGTTTGTA 4800 GCTTTTTATA TTTGTACATT TCTTATGAGG TTTGTTTCTA CACCCGTTAC CCGGATGTGT 4860 TGTCCACGAG GAGATGCAGC TTGGCGGAGG CCTTATCCAC TCCCACTTGA CCTGTTTGGA 4920 GGGACGCCAT CCCCAGGGCC CGGGGCTGGG AGAGGGGCAT CGTGCAGGCC CCAGGCTTAC 4980 TCAGAACTGG TGTTTTTAAA AGTTTTCCTT GACCCTGTCC TTGTGAACAT TTCTATAATC 5040 TTAACCCGGG CATCAAGCTG TTCTCTCTCT CTCTCTCTCT CTCTTTCTCT TTTTAATTTT 5100 ATTATTATTT TGGCGACATG TACATTTCTA ACAAAGTTTA TCGTGGCTAT TAAAGTGTTC 5160 TATTTCCCAG TTCATATTAC TCTTGTATCG AGTCCATGAG GTCTAAGGCA ACTTAGACCA 5220 AAGTTTTAAA AAAGTAAAAA TATTTCAGGT TTTGTACAGA
5261Nucleotide Fasta Sequence
>ENSMUSP00000047308.7|PHD|Mus musculus CCGTCCGCTCCGGCCGCGGCGCCCGCGCCCGCCGCCCCCGCCGCCCTCGCCGCGCGGCCCCCGGCCCGGCCCGGCCCGACCCGGGCAGCGCAGCGGCGGGGCGAGCGGCGGCGCGGCAACATGGCGACGGTGCCCGTGTACTGCGTCTGCCGGCTGCCCTACGACGTTACCCGCTTTATGATCGAGTGCGATGCCTGCAAGGACTGGTTCCACGGCAGCTGTGTTGGGGTGGAAGAGGAAGAGGCACCAGACATCGACATTTACCACTGCCCGAACTGCGAGAAAACCCATGGCAAGTCCACACTCAAGAAAAAGCGGACTTGGCACAAACACGGCCCTGGGCCAACACCGGACGTGAAACCAGTGCAGAATGGCAGTCAGCTGTTCATCAAGGAGCTGCGGAGCCGAACCTTCCCCAGTGCTGAAGACGTGGTGTCCCGTGTGCCAGGTAGCCAGCTCACCGTGGGCTACATGGAGGAGCATGGCTTCACTGAGCCCATCCTTGTCCCCAAGAAAGATGGCCTGGGCTTAGCTGTCCCTGCCCCAACATTCTACGTGAGTGATGTGGAGAACTATGTGGGGCCGGAGAGGAGTGTGGATGTGACAGACGTTACCAAACAGAAAGACTGCAAAATGAAGCTGAAAGAATTCGTGGACTATTACTATAGCACGAACCGCAAGCGTGTTCTCAACGTGACCAACCTCGAGTTCTCAGACACCAGAATGTCCAGCTTTGTGGAGCCACCTGACATTGTGAAGAAACTATCGTGGGTGGAAAACTACTGGCCCGATGACGCGCTGCTGGCCAAGCCCAAGGTGACCAAGTACTGCCTGATCTGTGTGAAGGACAGCTACACCGACTTCCACATTGACTCTGGAGGTGCCTCAGCGTGGTACCATGTCCTCAAGGGGGAGAAGATCTTCTATCTCATCCGGCCAGCCTCAGCCAACATCTCCCTATATGAGCGCTGGCGGTCAGCCTCCAACCACAGCGAGATGTTCTTCGCCGACCAGGTGGACAGGTGCTATAAATGCACTGTCAAGCAGGGCCAGACCCTCTTCATCCCCTCAGGCTGGATCTATGCCACACTCACCCCCGTGGACTGCCTGGCCTTCGCTGGACATTTCCTCCACAGCCTCAGTGTGGAGATGCAGATGAGGGCATACGAGGTGGAAAGGAGGTTAAAACTTGGCAGCCTGACTCAGTTTCCCAACTTTGAAACTGCCTGCTGGTACATGGGAAAGCACCTATTGGAAGCGTTCAAAGGTTCTCACAAGTCTGGGAAACAGCTGCCCCCACACTTAGTTCAAGGAGCTAAAATTCTCAATGGTGCTTTTAGGTCATGGACGAAGAAGCAGGCTTTGGCAGAGCATGAGGACGAACTCCCAGAGCACTTCAGGCCCTCACAGCTCATCAAGGACCTGGCCAAAGAGATCAGGCTCAGTGAGAATGCCTCCAAAACTGTCCGACCTGAAGTAAACGCTGCCGCCTCCTCAGATGAGGTCTGTGATGGAGACCGGGAGAAGGAAGAACCGCCATCTCCTGTTGAGACTACCCCACCTCGATCCCTCCTGGAGAAAGTGTCCAAAAAAAAGACTTCCAAGACTGTGAAGATGCCCAAGCCATCCAAAATTCCCAAGCCCCCCAAATCCCCCAAGCCCCCCAAAACTCTGAAGCTCAAAGATGGGAGCAAGAAGAAAGGGAAGAAGTGCAAGGAGTCAGCCTCACCCACCATCCCCAACCTAGACCTGCTTGAGGCTCACACAAAGGAGGCGCTGACCAAGATGGAGCCACCGAAGAAAGGGAAGACCCCAAAGAGCGTCCTGAGTGTTCCCAATAAGGACACAGTCCACACGCAGAATGACATGGAAAGGCTGGAAATTCGAGAGCAAACAAAGAGCAAGTCAGAAGCCAAGTGGAAATACAAGAACAGCAAACCTGACTCGTTACTGAAGATGGAGGAGGAGCAGAGGCTGGAGAAGTCGCCCCTGGCTGGGAACAAGGACAAGTTTTCCTTTTCTTTCTCCAACAGAAAACTCCTGGGCTCCAAGGCCCTCAGGCCCCCGAGCAGCCCTGGTGTGTTCGGCGCCTTGCAGAGCTTCAAGGAGGACAAGGCCAAGCCCGTGCGCGATGAGTATGAGTACGTATCAGATGATGGGGAGCTGAAGATAGACGAGTTTCCCATCAGGAGGAAGAAGAGCGCCCCCAAAAGGGACTTGTCCTTCTTGTTAGACAAGAAGGAGGCTCTCCTCATGCCCACCTCGAAGCCAAAGCTGGATTCTGCGGTGTACAAGAGCGATGACTCCTCTGACGAGGGCTCTCTGCACATCGACACGGACACCAAGCCAGGCAGAAATGCCAAAGTGAAGAAGGAGAGTGGGAGCTCCGCGGCCGGCATCCTGGACCTGCTGCAGGCCAGCGAGGAGGTTGGCGCACTCGAGTACAACCCCAACAGCCAGCCCCCTGCCTCCCCCAGCACACAGGAAGCCATTCAGGGAATGCTCTCCATGGCCAATCTGCAGGCCTCTGACTCTTGCCTGCAGACCACATGGGGCACGGGGCAGGCCAAGGGTGGCTCACTGGCAGCCCATGGTGCCCGGAAGATTGGTGGTGGCAACAAAGGCACAGGCAAGCGCCTGCTGAAGAGGACTGCCAAGAACAGTGTGGATCTGGAGGACTACGAGGAGCAGGATCACCTGGATGCCTGCTTCAAGGACTCAGACTATGTTTACCCCTCACTGGAGTCTGACGAAGATAACCCCGTCTTCAAGTCCCGGTCAAAGAAGAGGAAAGGCTCAGACGATGCTCCGTACAGCCCCACAGCCAGGGTCGGTCCATCGGTGCCAAGACAAGACAGGCCTGTGCGTGAGGGGACCAGAGTGGCCTCCATTGAGACGGGGCTGGCAGCTGCTGCAGCCAAGCTGTCCCAGCAGGAGGAGCAGAAAAACAGGAAGAAGAAGAACACCAAAAGGAAGCCGGCTCCTAACACTGCCTCCCCCTCCATCTCCACCTCTGCCTCCGCCTCCACGGGTACCACCTCGGCCTCCACCACCCCAGCATCCACCACCCCGGCCTCCACCACCCCAGCATCCACCACCCCGGCCTCCACCAGCACAGCCAGCAGCCAGGCCTCACAGGAGGGCAGCTCACCTGAGCCCCCACCTGAATCACACAGCAGTAGCCTGGCTGACCACGAATATACAGCAGCCGGCACATTCTCGGGGTCCCAGGCTGGCCGTGCCTCCCAGCCCATGGCCCCTGGAGTCTTTCTCACACAGAGGCGGCCTTCTGCATCATCCCCCAACAACACTGCTGCCAAAGGAAAACGTACAAAAAAGGGCATGGCCACCGCCAAGCAAAGGCTTGGAAAGATCTTGAAGATCCATCGGAACGGGAAACTGCTCCTCTAAGGCTTGGGAAGCCAGGATCCTTCTGCTCTGCTCAGGACCCCCGGAGCCCCGCTACATCCACCCCTCCCAGGACGGTGGCTGTGCTGCCTGGCCCAGGGAGGGCCTCGCCTCCTCCCAGCCACCTCTCCCCAATGCGAGCATCTGTCCCTTGAGCAGGTGGAGCGAGCGAGCGAGCGGAGCATGGCCGTCCCTTGTTGTGAACACGGACATCCTTTCTCGAGTTGCTCAGAGTGACCTGAAAGTGGCCCCGCCGACTTAAGGATCATTCTGGTTTCAGAACAGCCTCCAGGCTCCCCACTGGAGCGGCTCTGCTTAGGAGCATGAGGCCTTCAAGGAAGGTGCAGTGAGCCACGCTCACCAGCCCGAGTCCGAGCTGGCCCCAGGCTGGCAGCCTCCAAAGGCGTAAAACAAGGCAAAGGACACAGAAAGGAGCTGTGGGGTATTGAATGTCCCCACCCACCTCTTCCTGAGCGAGGCTTACATCACTTGACCAGTGAGGAAGAGGTTACCCCAGCTCCCTGGCTGGCAGGTAGCAGGCTAGGTAATGGGTGTCACACACATCCCAAATGCCTAGGGACATTTGGGCTTGTCAGGACCCACAGTTAGGTTGGTGTGTTAGTGGGTTGGAGGAGCCACTGTGGGGGTCACAGGGGAAGGGTGACAGCTCAGCCACGTCTTCGGGTCCGGGGGACCCAGGCTAAGCCACGTGGAGGGGCCCCACTCTGAAACAGCACTTCTAGGCCAAGGCACCCTGCCCTGAGTGGGCAGACAGGTGAGCAGGGCCACAGGGCTGGAGCCAGCACGGCAGCGCTTGTCTGAGCCCCTGGGTGGCGTCATGAGTGTGGGCCATCTCAGGTGGTGGTGTCCACCCATCGACACGGAGGGGCTGGGTTTGTTTCTCAGGCAATCCTGTATTTTCATTTTAGATGTATTTCCGGAAGCATATTTTTCATAGAATGTAGCGTGTAAATAGCTTTTTAAATGACTTCTTTTTTACAAGAGCAAAAGTATCTCTAGGAATTTCTTTCTATAGAGTCCTTCATTAACCTTTATACGAGTTTTTGCTCCCCCACCCCCTTCTCTGATGGATGGTCGGGTTCTGGCCCCCCACCCCCTTTTCTTTCCTTTCCTTTTGTTACTCCTTCTTATTTTCCTCTTAGGAACTAAGGTATTGCCTGAAAAACAACGGCGCCTGCGCGGCCTTACACTCCGCCTCTCAGAGCGGACAGTACAGAGGCCCCTCCCACTCGCCCCGAAAGCCGCGTCTCCAGTCTCACACCAGCTCTTCGGTCCTCTTCCTTGTATGGCGAGGGTCAGGGATGCAGTTACTTTGCTAGCACCTTGTGAAGTATTTGTGTTTCGTGATGCTGTAATTTATTAATGTTTGTAGCTTTTTATATTTGTACATTTCTTATGAGGTTTGTTTCTACACCCGTTACCCGGATGTGTTGTCCACGAGGAGATGCAGCTTGGCGGAGGCCTTATCCACTCCCACTTGACCTGTTTGGAGGGACGCCATCCCCAGGGCCCGGGGCTGGGAGAGGGGCATCGTGCAGGCCCCAGGCTTACTCAGAACTGGTGTTTTTAAAAGTTTTCCTTGACCCTGTCCTTGTGAACATTTCTATAATCTTAACCCGGGCATCAAGCTGTTCTCTCTCTCTCTCTCTCTCTCTTTCTCTTTTTAATTTTATTATTATTTTGGCGACATGTACATTTCTAACAAAGTTTATCGTGGCTATTAAAGTGTTCTATTTCCCAGTTCATATTACTCTTGTATCGAGTCCATGAGGTCTAAGGCAACTTAGACCAAAGTTTTAAAAAAGTAAAAATATTTCAGGTTTTGTACAGA
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Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0010--Activator KW-0137--Centromere KW-0156--Chromatin regulator KW-0158--Chromosome KW-0181--Complete proteome KW-0223--Dioxygenase KW-0408--Iron KW-0995--Kinetochore KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc KW-0863--Zinc-finger --
|
Interpro |
IPR003347--JmjC_dom IPR019786--Zinc_finger_PHD-type_CS IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR019787--Znf_PHD-finger IPR013083--Znf_RING/FYVE/PHD
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PROSITE |
PS51184--JMJC PS01359--ZF_PHD_1 PS50016--ZF_PHD_2
|
Pfam |
PF02373--JmjC PF00628--PHD
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Gene Ontology |
GO:0000777--C:condensed chromosome kinetochore GO:0005737--C:cytoplasm GO:0005730--C:nucleolus GO:0005634--C:nucleus GO:0051213--F:dioxygenase activity GO:0032454--F:histone demethylase activity (H3-K9 specific) GO:0005506--F:iron ion binding GO:0035064--F:methylated histone binding GO:0003713--F:transcription coactivator activity GO:0008270--F:zinc ion binding GO:0033169--P:histone H3-K9 demethylation GO:0061188--P:negative regulation of chromatin silencing at rDNA GO:0006482--P:protein demethylation GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |