Tag |
Content |
WERAM ID |
WERAM-Mum-0097 |
Ensembl Protein ID |
ENSMUSP00000038229.9 |
Uniprot Accession |
Q6P1G2; KDM2B_MOUSE; Q3V396; Q6PFD0; Q6ZPE8; Q9CSF7; Q9QZN6 |
Genbank Protein ID |
NP_001003953.1; NP_038938.1 |
Protein Name |
Lysine-specific demethylase 2B |
Genbank Nucleotide ID |
NM_001003953.2; NM_013910.2 |
Gene Name |
KDM2B;Fbxl10;JHDM1B;NDY1 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
JHDM1 |
Jmjc |
H3K36me2; H3K4me3 |
K |
26984996; 18838535 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
JHDM1 |
1.10e-95 |
319.4 |
147 |
315 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). |
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).
|
Domain Profile |
HDM JHDM1
JHDM1.txt 1 fsktkleelvkkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPp 89 fs+tkle+lvk+p+vv+ +d+vdn+Wp++lkekqte+tnal+emkyPkv+kyclmsvk+c+tdfhidfgGtsv+yhv++G+k+fwliPp ENSMUSP00000038229.9 147 FSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPP 235 8**************************************************************************************** PP JHDM1.txt 90 teknlelyeewvlsgkqsdiflgdrvekcqrvelkagdtlliPsGwihavytPvdslvfgGnflhslniktqlkiyeied 169 t +nl+lyeewvlsgkqsdiflgdrve+cqr+elk+g+t++iPsGwihavytPvdslvfgGn+lhs+n+++ql+iyeied ENSMUSP00000038229.9 236 TLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIED 315 ******************************************************************************97 PP
|
Protein Sequence (Fasta) | MEAEKDSGRR LRAIDRQRYD ENEDLSDVEE IVSVRGFSLE EKLRSQLYQG DFVHAMEGKD 60 FNYEYVQREA LRVPLVFRDK DGLGIKMPDP DFTVRDVKLL VGSRRLVDVM DVNTQKGTEM 120 SMSQFVRYYE TPEAQRDKLY NVISLEFSHT KLEHLVKRPT VVDLVDWVDN MWPQHLKEKQ 180 TEATNALAEM KYPKVKKYCL MSVKGCFTDF HIDFGGTSVW YHVFRGGKIF WLIPPTLHNL 240 ALYEEWVLSG KQSDIFLGDR VERCQRIELK QGYTFFIPSG WIHAVYTPVD SLVFGGNILH 300 SFNVPMQLRI YEIEDRTRVQ PKFRYPFYYE MCWYVLERYV YCVTQRSYLT QEYQRELMLI 360 DAPRKTSVDG FSSDSWLDME EESCEQQPQE EEEEEEDKEE EGDGADKTPK PPTDDPTSPT 420 STPPEDQDST GKKPKAPAIR FLKRTLSNES EESVKSTSMP TDDPKTPTGS PATEVSTKWT 480 HLTEFELKGL KALVEKLESL PENKKCVPEG IEDPQALLEG VKNVLKEHVD DDPTLAITGV 540 PVVSWPKKTA KNRVVGRPKG KLGPASAVKL AANRTTAGAR RRRTRCRKCE ACLRTECGEC 600 HFCKDMKKFG GPGRMKQSCI MRQCIAPVLP HTAVCLVCGE AGKEDTVEEE EGKFNLMLME 660 CSICNEIIHP GCLKIKESEG VVNDELPNCW ECPKCNHAGK TGKQKRGPGF KYASNLPGSL 720 LKEQKMNRDN KEGQEPAKRR SECEEAPRRR SDEHPKKVPA DGILRRKSDD VHLRRKRKYE 780 KPQELSGRKR ASSLQTSPGS SSHLSPRPPL GSSLSPWWRS SLTYFQQQLK PGKEDKLFRK 840 KRRSWKNAED RLSLANKPLR RFKQEPEDDL PEAPPKTRES DQSRSSSPTA GPSTEGAEGP 900 EEKKKVKMRR KRRLVNKELS KELSKELNHE IQKTESTLAH ESQQPIKSEP ESENDEPKRP 960 LSHCERPHRF SKGLNGTPRE LRHSLGPGLR SPPRVMSRPP PSASPPKCIQ MERHVIRPPP 1020 ISPPPDSLPL DDGAAHVMHR EVWMAVFSYL SHRDLCVCMR VCRTWNRWCC DKRLWTRIDL 1080 NRCKSITPLM LSGIIRRQPV SLDLSWTNIS KKQLSWLINR LPGLRDLVLS GCSWIAVSAL 1140 CSSSCPLLRT LDVQWVEGLK DAQMRDLLSP PTDNRPGQMD NRSKLRNIVE LRLAGLDITD 1200 VSLRLIIRHM PLLSKLQLSY CNHINDQSIN LLTAVGTTTR DSLTEVNLSD CNKVTDLCLS 1260 FFKRCGNICH IDLRYCKQVT KEGCEQFIAE MSVSVQFGQV EEKLLQKLS 1309Protein Fasta Sequence
>ENSMUSP00000038229.9|KDM2B;Fbxl10;JHDM1B;NDY1|Mus musculus MEAEKDSGRRLRAIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSYLTQEYQRELMLIDAPRKTSVDGFSSDSWLDMEEESCEQQPQEEEEEEEDKEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPKAPAIRFLKRTLSNESEESVKSTSMPTDDPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHVDDDPTLAITGVPVVSWPKKTAKNRVVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLVNKELSKELSKELNHEIQKTESTLAHESQQPIKSEPESENDEPKRPLSHCERPHRFSKGLNGTPRELRHSLGPGLRSPPRVMSRPPPSASPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCCDKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDVSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAVGTTTRDSLTEVNLSDCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
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Nucleotide Sequence (Fasta) | AACTGCTGAA AATGGTTTCC TAGGACTTTG CAAACGGATC TGCTTAAGTG TTGGTGCAAA 60 ACTTTGTAGA TATCGGCTCT GGCTTGCTCT ATTTATTTAT TTTTTTGCTT TCTTTTCTTT 120 GGTCTTCCCT CCTTTCCCCC TCCGCCAAAA TGCAGGGGGC AGGAGTGTTG ACAATTAATT 180 GGTGAACTCT CCTAAAAAAA TGGAGGCAGA GAAAGACTCT GGAAGAAGAT TGCGTGCGAT 240 TGACCGCCAG AGATACGACG AGAACGAAGA CTTGTCGGAC GTGGAGGAAA TTGTCAGCGT 300 CCGTGGCTTC AGCCTGGAGG AGAAGCTACG TAGCCAGTTA TACCAGGGGG ACTTCGTGCA 360 TGCTATGGAA GGCAAAGATT TTAACTATGA GTACGTACAG AGAGAAGCTC TCAGGGTCCC 420 CCTGGTTTTT CGGGACAAGG ATGGACTAGG GATCAAGATG CCAGACCCTG ATTTCACAGT 480 CCGAGACGTC AAACTCCTGG TGGGGAGCCG CCGTTTGGTG GATGTCATGG ACGTCAACAC 540 CCAGAAGGGT ACCGAGATGA GCATGTCCCA GTTTGTGCGC TACTACGAGA CACCAGAGGC 600 ACAGCGGGAT AAACTGTACA ACGTCATCAG CCTCGAGTTC AGCCATACGA AGCTGGAGCA 660 TCTGGTCAAG CGTCCCACTG TGGTGGACCT GGTCGACTGG GTGGACAACA TGTGGCCTCA 720 GCATCTAAAG GAAAAGCAGA CAGAAGCCAC CAATGCCCTT GCAGAGATGA AGTACCCCAA 780 AGTGAAAAAG TACTGTCTGA TGAGCGTGAA GGGCTGTTTC ACTGACTTCC ACATTGACTT 840 TGGAGGCACC TCCGTGTGGT ACCATGTGTT CCGTGGTGGC AAGATCTTTT GGCTGATCCC 900 TCCAACCCTG CACAACTTGG CTTTGTACGA GGAGTGGGTG CTGTCTGGCA AACAGAGCGA 960 CATCTTTCTG GGAGACCGCG TGGAACGCTG CCAAAGAATT GAGCTGAAGC AAGGCTACAC 1020 CTTTTTCATC CCTTCCGGTT GGATCCATGC GGTTTATACG CCTGTGGACT CTCTGGTGTT 1080 CGGCGGGAAC ATCCTGCATA GCTTCAACGT GCCCATGCAG CTGCGGATCT ACGAGATCGA 1140 GGACAGGACC CGGGTTCAGC CCAAGTTCCG TTACCCCTTC TACTATGAGA TGTGCTGGTA 1200 TGTCTTGGAG AGATATGTGT ACTGTGTGAC CCAGCGCTCC TACCTCACTC AGGAATACCA 1260 GAGAGAATTA ATGCTTATTG ATGCCCCAAG AAAAACCAGT GTAGACGGCT TTTCATCCGA 1320 CTCCTGGCTG GACATGGAGG AGGAGTCCTG CGAGCAGCAG CCACAGGAGG AAGAGGAGGA 1380 GGAGGAGGAC AAGGAGGAGG AAGGAGATGG TGCAGATAAA ACACCCAAGC CACCCACCGA 1440 TGACCCCACC TCACCCACCA GCACCCCGCC CGAAGACCAG GACAGCACAG GGAAGAAGCC 1500 TAAAGCCCCT GCCATACGGT TCCTCAAGAG GACGTTGTCC AATGAGTCAG AGGAAAGTGT 1560 CAAGTCGACC TCGATGCCCA CGGACGATCC CAAGACGCCC ACGGGCTCCC CGGCCACCGA 1620 GGTTTCTACC AAGTGGACTC ACCTTACCGA ATTTGAACTG AAGGGCTTGA AAGCCCTGGT 1680 TGAAAAGCTA GAGTCCCTTC CGGAGAATAA GAAGTGTGTC CCTGAGGGAA TCGAGGACCC 1740 CCAGGCCCTC CTGGAAGGTG TAAAGAATGT ACTGAAAGAG CACGTGGATG ACGACCCCAC 1800 CCTGGCCATC ACCGGGGTCC CTGTGGTCAG CTGGCCAAAG AAAACTGCAA AGAACCGGGT 1860 GGTGGGTCGG CCTAAGGGCA AGTTGGGCCC GGCCTCAGCG GTGAAGTTGG CTGCCAACCG 1920 AACAACAGCA GGAGCTCGCA GGCGCCGGAC GCGATGCCGC AAGTGCGAGG CCTGCCTGCG 1980 GACGGAGTGT GGAGAGTGCC ACTTTTGCAA GGACATGAAG AAGTTTGGAG GTCCTGGGCG 2040 CATGAAGCAG AGCTGCATCA TGCGGCAGTG CATCGCGCCA GTGCTGCCCC ACACCGCCGT 2100 GTGCCTTGTG TGTGGCGAGG CAGGGAAGGA GGACACAGTG GAAGAGGAAG AAGGCAAGTT 2160 TAACCTCATG CTCATGGAAT GCTCCATCTG CAACGAGATC ATCCACCCTG GATGCCTTAA 2220 GATTAAGGAA TCGGAGGGTG TGGTCAACGA TGAGCTTCCC AACTGCTGGG AGTGTCCGAA 2280 GTGTAACCAT GCCGGCAAGA CCGGGAAACA AAAGCGTGGC CCTGGCTTTA AGTATGCCTC 2340 CAACCTGCCT GGCTCCTTGC TCAAGGAGCA GAAGATGAAC CGGGACAACA AGGAAGGGCA 2400 AGAGCCTGCC AAGCGGAGAA GTGAGTGTGA AGAGGCTCCC CGTCGGAGGT CAGACGAGCA 2460 CCCCAAAAAG GTGCCTGCAG ATGGCATCCT CCGCCGAAAG TCTGATGATG TGCACCTGAG 2520 GAGGAAGCGG AAATACGAGA AGCCCCAAGA GCTGAGTGGA CGCAAGCGAG CCTCGTCGCT 2580 TCAAACGTCC CCCGGTTCCT CCTCTCACCT CTCGCCGAGG CCCCCTCTAG GCAGCAGTCT 2640 CAGCCCTTGG TGGAGATCCA GTCTCACTTA CTTCCAGCAG CAGCTAAAAC CTGGCAAAGA 2700 AGATAAGCTT TTCAGGAAAA AGCGGCGGTC CTGGAAGAAC GCTGAGGATC GTCTGTCACT 2760 GGCCAACAAG CCCCTTCGGC GCTTTAAGCA GGAACCGGAG GACGATCTGC CTGAGGCACC 2820 TCCTAAGACC CGGGAGAGTG ATCAGTCACG TTCCAGCTCA CCCACTGCTG GTCCCAGCAC 2880 TGAGGGAGCT GAAGGCCCAG AAGAGAAGAA AAAGGTGAAG ATGCGCCGGA AGCGGCGACT 2940 TGTTAACAAG GAGCTGAGCA AAGAGCTAAG CAAGGAGCTC AACCATGAGA TCCAAAAGAC 3000 GGAGAGCACC CTGGCTCACG AGAGCCAGCA GCCCATCAAG TCAGAGCCTG AGAGCGAGAA 3060 CGACGAGCCC AAGAGGCCCT TAAGCCACTG CGAGCGCCCC CACCGCTTCA GCAAAGGGCT 3120 CAACGGCACA CCTCGGGAGC TGCGGCACTC GCTGGGACCT GGCCTGCGTA GTCCACCTCG 3180 TGTTATGTCC CGGCCCCCGC CCTCTGCATC CCCACCCAAG TGCATCCAGA TGGAGCGTCA 3240 CGTGATCCGG CCACCGCCCA TCAGCCCCCC ACCTGACTCG CTGCCCCTGG ATGATGGAGC 3300 AGCCCACGTC ATGCATAGGG AGGTGTGGAT GGCAGTCTTC AGCTACCTCA GCCACCGAGA 3360 CCTGTGTGTC TGCATGCGGG TCTGCAGGAC CTGGAACCGC TGGTGCTGCG ATAAGCGGTT 3420 GTGGACCCGC ATCGACCTGA ACCGCTGCAA GTCCATCACA CCCCTGATGC TGAGCGGTAT 3480 CATCCGGCGA CAGCCTGTCT CCCTTGACCT CAGTTGGACC AACATCTCCA AGAAGCAGCT 3540 GAGTTGGCTC ATCAACCGGT TGCCTGGGCT CCGAGACTTG GTGCTGTCAG GCTGCTCATG 3600 GATCGCTGTC TCAGCCCTCT GTAGCTCCAG TTGTCCATTG CTCCGGACCC TGGATGTCCA 3660 GTGGGTAGAA GGACTAAAGG ATGCCCAGAT GAGGGATCTC CTGTCTCCAC CCACAGACAA 3720 CAGGCCAGGT CAGATGGACA ATCGGAGCAA GCTCCGGAAC ATTGTAGAGC TGCGCCTAGC 3780 TGGCCTGGAC ATCACAGATG TCTCCCTGCG GCTCATTATT CGCCATATGC CCCTGCTCTC 3840 GAAGCTCCAA CTCAGTTACT GTAACCACAT CAATGACCAG TCCATCAACC TGCTCACTGC 3900 CGTCGGCACC ACCACCCGAG ACTCGCTGAC AGAGGTCAAC CTATCAGACT GTAATAAGGT 3960 AACTGACCTG TGCCTGTCCT TCTTCAAACG CTGTGGAAAT ATCTGTCATA TTGACCTGAG 4020 GTACTGCAAG CAAGTCACCA AGGAAGGCTG TGAGCAATTC ATAGCTGAAA TGTCTGTGAG 4080 TGTCCAATTT GGGCAAGTGG AAGAGAAACT CCTGCAAAAA CTAAGTTAGT TCCAGGACAA 4140 GTATGTAAAT ATGGAGGGTT GGGGGGAATA CAACCAGGAA GGGTGAAAGA CTGCAAAATC 4200 AAGTGGGCCT ATTATTTCCC TTTGGAATTT GAAACAAGAG ACTACAGGAC ACAGTTCTGT 4260 TTTGCAAATC TTGCCAAGGG GGAAGCCATT CAACCACCCA TTTTGGGATG AGTGAGCCAG 4320 ATGTTTTCCT TTGCTCTTTC TGCATCGTAA CTGCACTGCT TTCTGGACCA TTTCTAAGGC 4380 GGCCTTTAGA AGACATTCCA ATTGGAAAGG AAGATGAGCT TTGGAGAAAT CCTCTTAGAA 4440 GCCTAAGCTT GGTGTTTTTA TCAGTAGTTT TTGTTTGGGG CACTTGTTCC TTGCAATGCT 4500 GAGGCTTCTG GCGTCAACAT GGAGTGGACC ACACACACAC CATCTGCAGC CGTCGTTGAT 4560 ACATTTTGTT TAGTTGGTTT TGTTACATCT TACATTATGC AGAACTATTT TTGTATAAAT 4620 TGTTTAAAAA TTATTTATGG GAGATTTGAA TGCATACCAG TGTTTTTATT ATTTAGATTG 4680 CCAACTGTCC TTCAGGTAGG AGAGTTAACC TGTACTATGT CAGCATAAAA AGCCCATCTC 4740 CAGATGTGCC CAGGTGTGAC AGGGGGCTAT GACCTTCCAC TTAAAAAGCA TGTTTAACTG 4800 GATGCTGAGA GCCTACTGTG TATGTCAAGA AGCTACACAA GCATGTTGTG GATATGTGTA 4860 AAGTATAGTC CAGGTAAAAC ACTTTGCCAA GTTTCAATAG ACTTCACCTC TCCCTCAGAC 4920 TTGAGCCTTT ACACTCAGGA GGGTTTGCTC CAAGCATGAG CTCTTGTATT CTACTTACAT 4980 AGGTCTAATT TATACCAAGA ATCAGGTAGA ATAAATGTGC CCACACCCTC TCCTTTGTCC 5040 TCCTCCTCTC AAGTGTTCAG TTCTCACTTT AGTTGGTAAG TTCTGCATCC CTTGTTGTTT 5100 GGTGGTGTTT CCTAACCTTT CCCTGATGCA GTTTGACCTT TGTTGGATTT ATATAAACAA 5160 TTGTACAAAA AAAAAAATCT
5181Nucleotide Fasta Sequence
>ENSMUSP00000038229.9|JHDM1|Mus musculus AACTGCTGAAAATGGTTTCCTAGGACTTTGCAAACGGATCTGCTTAAGTGTTGGTGCAAAACTTTGTAGATATCGGCTCTGGCTTGCTCTATTTATTTATTTTTTTGCTTTCTTTTCTTTGGTCTTCCCTCCTTTCCCCCTCCGCCAAAATGCAGGGGGCAGGAGTGTTGACAATTAATTGGTGAACTCTCCTAAAAAAATGGAGGCAGAGAAAGACTCTGGAAGAAGATTGCGTGCGATTGACCGCCAGAGATACGACGAGAACGAAGACTTGTCGGACGTGGAGGAAATTGTCAGCGTCCGTGGCTTCAGCCTGGAGGAGAAGCTACGTAGCCAGTTATACCAGGGGGACTTCGTGCATGCTATGGAAGGCAAAGATTTTAACTATGAGTACGTACAGAGAGAAGCTCTCAGGGTCCCCCTGGTTTTTCGGGACAAGGATGGACTAGGGATCAAGATGCCAGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTGGTGGGGAGCCGCCGTTTGGTGGATGTCATGGACGTCAACACCCAGAAGGGTACCGAGATGAGCATGTCCCAGTTTGTGCGCTACTACGAGACACCAGAGGCACAGCGGGATAAACTGTACAACGTCATCAGCCTCGAGTTCAGCCATACGAAGCTGGAGCATCTGGTCAAGCGTCCCACTGTGGTGGACCTGGTCGACTGGGTGGACAACATGTGGCCTCAGCATCTAAAGGAAAAGCAGACAGAAGCCACCAATGCCCTTGCAGAGATGAAGTACCCCAAAGTGAAAAAGTACTGTCTGATGAGCGTGAAGGGCTGTTTCACTGACTTCCACATTGACTTTGGAGGCACCTCCGTGTGGTACCATGTGTTCCGTGGTGGCAAGATCTTTTGGCTGATCCCTCCAACCCTGCACAACTTGGCTTTGTACGAGGAGTGGGTGCTGTCTGGCAAACAGAGCGACATCTTTCTGGGAGACCGCGTGGAACGCTGCCAAAGAATTGAGCTGAAGCAAGGCTACACCTTTTTCATCCCTTCCGGTTGGATCCATGCGGTTTATACGCCTGTGGACTCTCTGGTGTTCGGCGGGAACATCCTGCATAGCTTCAACGTGCCCATGCAGCTGCGGATCTACGAGATCGAGGACAGGACCCGGGTTCAGCCCAAGTTCCGTTACCCCTTCTACTATGAGATGTGCTGGTATGTCTTGGAGAGATATGTGTACTGTGTGACCCAGCGCTCCTACCTCACTCAGGAATACCAGAGAGAATTAATGCTTATTGATGCCCCAAGAAAAACCAGTGTAGACGGCTTTTCATCCGACTCCTGGCTGGACATGGAGGAGGAGTCCTGCGAGCAGCAGCCACAGGAGGAAGAGGAGGAGGAGGAGGACAAGGAGGAGGAAGGAGATGGTGCAGATAAAACACCCAAGCCACCCACCGATGACCCCACCTCACCCACCAGCACCCCGCCCGAAGACCAGGACAGCACAGGGAAGAAGCCTAAAGCCCCTGCCATACGGTTCCTCAAGAGGACGTTGTCCAATGAGTCAGAGGAAAGTGTCAAGTCGACCTCGATGCCCACGGACGATCCCAAGACGCCCACGGGCTCCCCGGCCACCGAGGTTTCTACCAAGTGGACTCACCTTACCGAATTTGAACTGAAGGGCTTGAAAGCCCTGGTTGAAAAGCTAGAGTCCCTTCCGGAGAATAAGAAGTGTGTCCCTGAGGGAATCGAGGACCCCCAGGCCCTCCTGGAAGGTGTAAAGAATGTACTGAAAGAGCACGTGGATGACGACCCCACCCTGGCCATCACCGGGGTCCCTGTGGTCAGCTGGCCAAAGAAAACTGCAAAGAACCGGGTGGTGGGTCGGCCTAAGGGCAAGTTGGGCCCGGCCTCAGCGGTGAAGTTGGCTGCCAACCGAACAACAGCAGGAGCTCGCAGGCGCCGGACGCGATGCCGCAAGTGCGAGGCCTGCCTGCGGACGGAGTGTGGAGAGTGCCACTTTTGCAAGGACATGAAGAAGTTTGGAGGTCCTGGGCGCATGAAGCAGAGCTGCATCATGCGGCAGTGCATCGCGCCAGTGCTGCCCCACACCGCCGTGTGCCTTGTGTGTGGCGAGGCAGGGAAGGAGGACACAGTGGAAGAGGAAGAAGGCAAGTTTAACCTCATGCTCATGGAATGCTCCATCTGCAACGAGATCATCCACCCTGGATGCCTTAAGATTAAGGAATCGGAGGGTGTGGTCAACGATGAGCTTCCCAACTGCTGGGAGTGTCCGAAGTGTAACCATGCCGGCAAGACCGGGAAACAAAAGCGTGGCCCTGGCTTTAAGTATGCCTCCAACCTGCCTGGCTCCTTGCTCAAGGAGCAGAAGATGAACCGGGACAACAAGGAAGGGCAAGAGCCTGCCAAGCGGAGAAGTGAGTGTGAAGAGGCTCCCCGTCGGAGGTCAGACGAGCACCCCAAAAAGGTGCCTGCAGATGGCATCCTCCGCCGAAAGTCTGATGATGTGCACCTGAGGAGGAAGCGGAAATACGAGAAGCCCCAAGAGCTGAGTGGACGCAAGCGAGCCTCGTCGCTTCAAACGTCCCCCGGTTCCTCCTCTCACCTCTCGCCGAGGCCCCCTCTAGGCAGCAGTCTCAGCCCTTGGTGGAGATCCAGTCTCACTTACTTCCAGCAGCAGCTAAAACCTGGCAAAGAAGATAAGCTTTTCAGGAAAAAGCGGCGGTCCTGGAAGAACGCTGAGGATCGTCTGTCACTGGCCAACAAGCCCCTTCGGCGCTTTAAGCAGGAACCGGAGGACGATCTGCCTGAGGCACCTCCTAAGACCCGGGAGAGTGATCAGTCACGTTCCAGCTCACCCACTGCTGGTCCCAGCACTGAGGGAGCTGAAGGCCCAGAAGAGAAGAAAAAGGTGAAGATGCGCCGGAAGCGGCGACTTGTTAACAAGGAGCTGAGCAAAGAGCTAAGCAAGGAGCTCAACCATGAGATCCAAAAGACGGAGAGCACCCTGGCTCACGAGAGCCAGCAGCCCATCAAGTCAGAGCCTGAGAGCGAGAACGACGAGCCCAAGAGGCCCTTAAGCCACTGCGAGCGCCCCCACCGCTTCAGCAAAGGGCTCAACGGCACACCTCGGGAGCTGCGGCACTCGCTGGGACCTGGCCTGCGTAGTCCACCTCGTGTTATGTCCCGGCCCCCGCCCTCTGCATCCCCACCCAAGTGCATCCAGATGGAGCGTCACGTGATCCGGCCACCGCCCATCAGCCCCCCACCTGACTCGCTGCCCCTGGATGATGGAGCAGCCCACGTCATGCATAGGGAGGTGTGGATGGCAGTCTTCAGCTACCTCAGCCACCGAGACCTGTGTGTCTGCATGCGGGTCTGCAGGACCTGGAACCGCTGGTGCTGCGATAAGCGGTTGTGGACCCGCATCGACCTGAACCGCTGCAAGTCCATCACACCCCTGATGCTGAGCGGTATCATCCGGCGACAGCCTGTCTCCCTTGACCTCAGTTGGACCAACATCTCCAAGAAGCAGCTGAGTTGGCTCATCAACCGGTTGCCTGGGCTCCGAGACTTGGTGCTGTCAGGCTGCTCATGGATCGCTGTCTCAGCCCTCTGTAGCTCCAGTTGTCCATTGCTCCGGACCCTGGATGTCCAGTGGGTAGAAGGACTAAAGGATGCCCAGATGAGGGATCTCCTGTCTCCACCCACAGACAACAGGCCAGGTCAGATGGACAATCGGAGCAAGCTCCGGAACATTGTAGAGCTGCGCCTAGCTGGCCTGGACATCACAGATGTCTCCCTGCGGCTCATTATTCGCCATATGCCCCTGCTCTCGAAGCTCCAACTCAGTTACTGTAACCACATCAATGACCAGTCCATCAACCTGCTCACTGCCGTCGGCACCACCACCCGAGACTCGCTGACAGAGGTCAACCTATCAGACTGTAATAAGGTAACTGACCTGTGCCTGTCCTTCTTCAAACGCTGTGGAAATATCTGTCATATTGACCTGAGGTACTGCAAGCAAGTCACCAAGGAAGGCTGTGAGCAATTCATAGCTGAAATGTCTGTGAGTGTCCAATTTGGGCAAGTGGAAGAGAAACTCCTGCAAAAACTAAGTTAGTTCCAGGACAAGTATGTAAATATGGAGGGTTGGGGGGAATACAACCAGGAAGGGTGAAAGACTGCAAAATCAAGTGGGCCTATTATTTCCCTTTGGAATTTGAAACAAGAGACTACAGGACACAGTTCTGTTTTGCAAATCTTGCCAAGGGGGAAGCCATTCAACCACCCATTTTGGGATGAGTGAGCCAGATGTTTTCCTTTGCTCTTTCTGCATCGTAACTGCACTGCTTTCTGGACCATTTCTAAGGCGGCCTTTAGAAGACATTCCAATTGGAAAGGAAGATGAGCTTTGGAGAAATCCTCTTAGAAGCCTAAGCTTGGTGTTTTTATCAGTAGTTTTTGTTTGGGGCACTTGTTCCTTGCAATGCTGAGGCTTCTGGCGTCAACATGGAGTGGACCACACACACACCATCTGCAGCCGTCGTTGATACATTTTGTTTAGTTGGTTTTGTTACATCTTACATTATGCAGAACTATTTTTGTATAAATTGTTTAAAAATTATTTATGGGAGATTTGAATGCATACCAGTGTTTTTATTATTTAGATTGCCAACTGTCCTTCAGGTAGGAGAGTTAACCTGTACTATGTCAGCATAAAAAGCCCATCTCCAGATGTGCCCAGGTGTGACAGGGGGCTATGACCTTCCACTTAAAAAGCATGTTTAACTGGATGCTGAGAGCCTACTGTGTATGTCAAGAAGCTACACAAGCATGTTGTGGATATGTGTAAAGTATAGTCCAGGTAAAACACTTTGCCAAGTTTCAATAGACTTCACCTCTCCCTCAGACTTGAGCCTTTACACTCAGGAGGGTTTGCTCCAAGCATGAGCTCTTGTATTCTACTTACATAGGTCTAATTTATACCAAGAATCAGGTAGAATAAATGTGCCCACACCCTCTCCTTTGTCCTCCTCCTCTCAAGTGTTCAGTTCTCACTTTAGTTGGTAAGTTCTGCATCCCTTGTTGTTTGGTGGTGTTTCCTAACCTTTCCCTGATGCAGTTTGACCTTTGTTGGATTTATATAAACAATTGTACAAAAAAAAAAATCT
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Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0175--Coiled coil KW-0181--Complete proteome KW-0223--Dioxygenase KW-0408--Iron KW-1017--Isopeptide bond KW-0433--Leucine-rich repeat KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0694--RNA-binding KW-0699--rRNA-binding KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0833--Ubl conjugation pathway KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR001810--F-box_dom IPR003347--JmjC_dom IPR032675--L_dom-like IPR006553--Leu-rich_rpt_Cys-con_subtyp IPR002857--Znf_CXXC IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR019787--Znf_PHD-finger IPR013083--Znf_RING/FYVE/PHD
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PROSITE |
PS51184--JMJC PS51058--ZF_CXXC PS50016--ZF_PHD_2
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Pfam |
PF00646--F-box PF02373--JmjC PF16866--PHD_4 PF02008--zf-CXXC
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Gene Ontology |
GO:0005730--C:nucleolus GO:0031519--C:PcG protein complex GO:0032452--F:histone demethylase activity GO:0051864--F:histone demethylase activity (H3-K36 specific) GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding GO:0019843--F:rRNA binding GO:0008270--F:zinc ion binding GO:0048596--P:embryonic camera-type eye morphogenesis GO:0030900--P:forebrain development GO:0021592--P:fourth ventricle development GO:0030902--P:hindbrain development GO:0035518--P:histone H2A monoubiquitination GO:0070544--P:histone H3-K36 demethylation GO:0021993--P:initiation of neural tube closure GO:0021670--P:lateral ventricle development GO:0030901--P:midbrain development GO:0021555--P:midbrain-hindbrain boundary morphogenesis GO:2000178--P:negative regulation of neural precursor cell proliferation GO:0043524--P:negative regulation of neuron apoptotic process GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0030307--P:positive regulation of cell growth GO:1902459--P:positive regulation of stem cell population maintenance GO:0007283--P:spermatogenesis GO:0021678--P:third ventricle development GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |