WERAM Information

Tag Content
WERAM ID WERAM-Mum-0111
Ensembl Protein ID ENSMUSP00000032956.8
Uniprot Accession Q9DA08; SGF29_MOUSE; Q8R0I6
Genbank Protein ID NP_083615.3
Protein Name SAGA-associated factor 29
Genbank Nucleotide ID NM_029339.3
Gene Name Sgf29;Ccdc101
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030714.14 ENSMUST00000032956.9 ENSMUSP00000032956.8
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader TTD SGF29C-terminal H3K4me2/3 K 15489334
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader TTD 3.40e-49 168 153 293
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation (By similarity).
Domain Profile
  Me_Reader TTD
               TTD.txt   2 dasievGakvaakdr....deewyqaevvkvsaettkyevd..feegkeredlskeyivpleklklrpegdpeaefqkgekVlarypdt 84 
                           d+++++G+kvaa+++    de+w++aevv++s++t+kyevd  +eegker++ls+++i+pl+++k++pe+dpea+fqk+++Vla+yp+t
  ENSMUSP00000032956.8 153 DYVAKPGDKVAARVKavegDEQWILAEVVSYSHATNKYEVDdiDEEGKERHTLSRRRIIPLPQWKANPETDPEALFQKEQLVLALYPQT 241
                           89***************************************999********************************************* PP
               TTD.txt  85 t.fYpAkvia..skkdgtysvkFe.....Dgssevvkraqvyalskeenkkk 128
                           t fY+A++++  ++++++ysv Fe     Dg+s+++++aq+y+++++e+kkk
  ENSMUSP00000032956.8 242 TcFYRALIHTppQRPQDDYSVLFEdtsyaDGYSPPLNVAQRYVVACKEPKKK 293
                           *************************************************886 PP
Protein Sequence
(Fasta)		MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR 60
GLYTTAKTDA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM 120
TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVAKPGD KVAARVKAVE GDEQWILAEV 180
VSYSHATNKY EVDDIDEEGK ERHTLSRRRI IPLPQWKANP ETDPEALFQK EQLVLALYPQ 240
TTCFYRALIH TPPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK 293
Nucleotide Sequence
(Fasta)		GTCCTCCGCG CTCGACCGCG CTCATAAGAG AAACAGCGTG TGTGGTTCTT GACGCGCCGC 60
GAACCTTCGA ACGCAAGTGC GAGACTACCC TGTGAGGAAA CGTTCCAGGG ATTCGCCTGT 120
TCCCGCCATC GCAGTTACCA GCGCGACGTG CTGTTTCTTC CTGTGCTCGA TGCCCTTCCC 180
AGGCCCGTCC CATGGCCCTT GTGTCTGCTG ATTCTCGAAT TGCAGAGCTT CTCACAGAGC 240
TCCATCAGCT GATCAAGCAA ACCCAGGAAG AGCGGTCGAG AAGTGAGCAC AACTTGGTGA 300
ACATCCAGAA AACCCACGAG CGGATGCAGA CAGAGAACAA GATTTCTCCT TATTACCGGA 360
CAAAGCTTCG AGGCCTCTAC ACAACCGCCA AGACTGATGC GGAGGCCGAG TGCAACATCC 420
TCCGCAAAGC GCTGGATAAG ATAGCTGAGA TCAAGTCTCT GTTGGAAGAG AGGCGGATTG 480
CGGCCAAGAT CGCAGGTCTC TACAATGACT CAGAGCCCCC ACGGAAGACC ATGCGCAGAG 540
GGGTGCTGAT GACACTGCTG CAGCAGTCCG CCATGACCCT GCCCCTCTGG ATCGGGAAAC 600
CTGGTGACAA GCCCCCACCC CTCTGTGGAG CCATTCCAGC CTCAGGGGAC TATGTGGCCA 660
AACCTGGAGA CAAGGTGGCT GCTAGGGTGA AGGCTGTGGA AGGGGATGAA CAGTGGATCC 720
TAGCTGAAGT AGTCAGTTAC AGCCATGCTA CCAACAAGTA TGAGGTAGAC GACATTGATG 780
AAGAAGGCAA AGAGAGACAC ACCCTGAGCC GTCGGCGCAT CATCCCACTG CCCCAGTGGA 840
AAGCTAACCC TGAGACAGAC CCTGAGGCCT TGTTCCAGAA GGAGCAGCTG GTGCTGGCCC 900
TATATCCCCA GACCACCTGC TTCTACCGTG CCCTGATCCA CACCCCACCA CAGAGGCCTC 960
AGGATGACTA CTCAGTCCTG TTTGAAGACA CCTCTTATGC AGATGGCTAC TCCCCTCCCC 1020
TCAATGTGGC CCAGAGGTAC GTGGTGGCTT GTAAGGAGCC CAAGAAAAAG TGAATCGGGC 1080
TGGTAGGCTT GAATCTGCCA CTGCCAACCT CATGGGAGAA GGCTACAAAG GAGTTCCTAT 1140
GATCAAATAA ATACTCTTCC CTCTCACCAT GTCTCCTGGG CCTCACTACG TCAGACCCTC 1200
TTGCCATCCT CCATCAGGCA CGTGGGATTG ATGGTCGCAA GAGGGAGAAG GTCCAGTCAG 1260
CTCCCAGTGG CATTTATTTG TTCAGGTAAA ATACAGTTTA TCTTACTATT TT 1313
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR010750--SGF29_tudor-like_dom
PROSITE

PS51518--SGF29_C
Pfam

PF07039--DUF1325
Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0070461--C:SAGA-type complex
GO:0035064--F:methylated histone binding
GO:0043966--P:histone H3 acetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0126 ENSRNOP00000026146.4 Rattus norvegicus 100 6e-173 603
WERAM-Dan-0201 ENSDNOP00000030563.1 Dasypus novemcinctus 99 2e-172 602
WERAM-Ova-0024 ENSOARP00000003438.1 Ovis aries 99 2e-172 602
WERAM-Myl-0192 ENSMLUP00000017362.1 Myotis lucifugus 99 2e-172 602
WERAM-Mup-0144 ENSMPUP00000012575.1 Mustela putorius furo 99 2e-172 602
WERAM-Loa-0206 ENSLAFP00000020801.1 Loxodonta africana 99 2e-172 602
WERAM-Ict-0117 ENSSTOP00000011884.2 Ictidomys tridecemlineatus 99 2e-172 602
WERAM-Fec-0124 ENSFCAP00000011410.3 Felis catus 99 2e-172 602
WERAM-Eqc-0075 ENSECAP00000009386.1 Equus caballus 99 2e-172 602
WERAM-Ocp-0094 ENSOPRP00000008519.1 Ochotona princeps 99 8e-172 599
WERAM-Cap-0219 ENSCPOP00000018704.1 Cavia porcellus 98 2e-171 598
WERAM-Poa-0064 ENSPPYP00000008178.2 Pongo abelii 98 2e-171 598
WERAM-Paa-0137 ENSPANP00000012534.1 Papio anubis 98 2e-171 598
WERAM-Pat-0061 ENSPTRP00000013546.3 Pan troglodytes 98 2e-171 598
WERAM-Mam-0096 ENSMMUP00000014921.2 Macaca mulatta 98 2e-171 598
WERAM-Hos-0209 ENSP00000316114.3 Homo sapiens 98 2e-171 598
WERAM-Caj-0075 ENSCJAP00000012147.2 Callithrix jacchus 98 2e-171 598
WERAM-Gog-0011 ENSGGOP00000000797.2 Gorilla gorilla 98 8e-171 596
WERAM-Sah-0126 ENSSHAP00000013194.1 Sarcophilus harrisii 98 1e-170 596
WERAM-Mod-0138 ENSMODP00000019525.2 Monodelphis domestica 97 3e-170 594
WERAM-Xet-0181 ENSXETP00000063382.1 Xenopus tropicalis 96 5e-168 587
WERAM-Anc-0068 ENSACAP00000006479.1 Anolis carolinensis 97 1e-167 586
WERAM-Caf-0182 ENSCAFP00000025225.3 Canis familiaris 99 4e-165 577
WERAM-Nol-0017 ENSNLEP00000001893.1 Nomascus leucogenys 95 1e-164 575
WERAM-Meg-0120 ENSMGAP00000012819.2 Meleagris gallopavo 94 2e-164 575
WERAM-Gaga-0162 ENSGALP00000037055.2 Gallus gallus 94 2e-164 575
WERAM-Dar-0002 ENSDARP00000002714.7 Danio rerio 91 5e-161 563
WERAM-Pof-0115 ENSPFOP00000010049.1 Poecilia formosa 92 5e-160 560
WERAM-Xim-0132 ENSXMAP00000010959.1 Xiphophorus maculatus 92 6e-160 560
WERAM-Chs-0071 ENSCSAP00000002544.1 Chlorocebus sabaeus 92 1e-159 559
WERAM-Orc-0193 ENSOCUP00000017486.1 Oryctolagus cuniculus 99 8e-159 556
WERAM-Ten-0017 ENSTNIP00000004385.1 Tetraodon nigroviridis 91 2e-158 555
WERAM-Orn-0114 ENSONIP00000011784.1 Oreochromis niloticus 91 2e-158 555
WERAM-Otg-0167 ENSOGAP00000014142.2 Otolemur garnettii 92 5e-158 553
WERAM-Ere-0082 ENSEEUP00000007748.1 Erinaceus europaeus 99 7e-158 553
WERAM-Dio-0065 ENSDORP00000006564.1 Dipodomys ordii 91 9e-155 543
WERAM-Mim-0098 ENSMICP00000009094.1 Microcebus murinus 92 6e-154 540
WERAM-Gam-0004 ENSGMOP00000000324.1 Gadus morhua 89 1e-153 539
WERAM-Asm-0027 ENSAMXP00000003470.1 Astyanax mexicanus 92 2e-135 479
WERAM-Tas-0029 ENSTSYP00000003034.1 Tarsius syrichta 97 1e-122 436
WERAM-Mae-0060 ENSMEUP00000005683.1 Macropus eugenii 98 2e-86 315
WERAM-Amt-0061 ERN13844 Amborella trichopoda 28 7e-14 75.1
WERAM-Osl-0023 ABO96036 Ostreococcus lucimarinus 35 8e-12 68.2
WERAM-Orr-0122 ORUFI12G10040.1 Oryza rufipogon 27 1e-10 64.3
WERAM-Orni-0121 ONIVA12G08890.1 Oryza nivara 28 1e-10 64.3
WERAM-Orgl-0118 OGLUM12G10350.1 Oryza glumaepatula 27 1e-10 64.3
WERAM-Php-0040 PP1S19_93V6.3 Physcomitrella patens 35 1e-08 58.2
WERAM-Pot-0012 POPTR_0001s35610.1 Populus trichocarpa 31 6e-08 55.5
Created Date 25-Jun-2016