WERAM Information

Tag Content
WERAM ID WERAM-Mum-0084
Ensembl Protein ID ENSMUSP00000028408.2
Uniprot Accession Q8BY71; HAT1_MOUSE;
Genbank Protein ID NP_080391.2;
Protein Name Histone acetyltransferase 1;
Genbank Nucleotide ID NM_026115.4;
Gene Name HAT1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027018.11 ENSMUST00000028408.2 ENSMUSP00000028408.2
ENSMUSG00000027018.11 ENSMUST00000112122.8 ENSMUSP00000107750.2
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HAT1 H2AK5; H4K5; H4K12 K 25865065
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HAT1 2.30e-62 211.4 22 402
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.
Domain Profile
  HAT HAT1
              HAT1.txt   1 rvveanevielllveakeeidtdistfkpeilyqlfgddetifGYkdlkvtvhylaksldeyidvkYsskinkekgscleaddveskle 89 
                           +++++n++iel+lv+++e++++di+tf+pe+++qlfgddet+fGYk+lk+ ++y+a+sl++ ++v+Yssk+ +e+++c+eaddve+k++
  ENSMUSP00000028408.2  22 YKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTLFRVEYSSKV-DENFDCVEADDVEGKIR 109
                           589********************************************************************.***************** PP
              HAT1.txt  90 qkiteetivdnkeeFlqlldkqddFkpfgelihkyrklgkd......feiykaedlsdeflellerlqtlelfFie 159
                           q i+++++++n+++Fl+ll+k+++Fkpfg+l+h+y++ +++      f+i+ka++++++f+e++erlqt++++Fie
  ENSMUSP00000028408.2 110 Q-IIPPGFCTNTNDFLSLLEKETNFKPFGTLLHTYTVPSQTggetftFQIHKADMTCRGFREYHERLQTFLMWFIE 184
                           *.*************************************************************************8 PP
              HAT1.txt  78 cleaddveskleqkiteetivdn..keeFlql 107
                           cl+++ + ++++q  +e+++  +  +e F++l
  ENSMUSP00000028408.2 373 CLRPEELTNQMNQ--IEISVQHEqlEERFQEL 402
                           6777777777777..33333332113455554 PP
Protein Sequence
(Fasta)		MAALEKFLVE YKSAVEKKLA EYKCNTNTAI ELKLVRFPED LENDIRTFFP EYTHQLFGDD 60
ETAFGYKGLK ILLYYIAGSL STLFRVEYSS KVDENFDCVE ADDVEGKIRQ IIPPGFCTNT 120
NDFLSLLEKE TNFKPFGTLL HTYTVPSQTG GETFTFQIHK ADMTCRGFRE YHERLQTFLM 180
WFIETASFID VDDERWHYFL VFEKYNKDGA TLFATVGYMT VYNYYVYPDK TRPRVSQMLI 240
LTPFQGQGHG AQLLETVHRY YISFPTVLDI TAEDPSRSYL KLRDFVLVKF CQFLPSFSRE 300
RLLQGFSEDM AIQAQQMFKI NKQHARRVYE ILRLLVTDMS DAEQYRSYRL DIKRRLISPY 360
KKKQRDLAKM KKCLRPEELT NQMNQIEISV QHEQLEERFQ ELVEDYRRVI ERLAQE 416
Nucleotide Sequence
(Fasta)		TTTGTCCTTC CTCAGCTGCG GGCGCTCGGA GCTCGGAAAT GGCGGCCTTG GAGAAATTTC 60
TGGTGGAGTA TAAGAGTGCC GTGGAGAAGA AACTAGCAGA GTACAAGTGT AACACCAACA 120
CAGCAATCGA GCTGAAACTA GTTCGTTTTC CTGAAGATCT TGAGAATGAC ATTAGAACTT 180
TCTTTCCTGA ATATACCCAT CAGCTCTTTG GGGATGATGA AACTGCTTTC GGTTACAAGG 240
GCCTGAAGAT CTTGCTGTAC TATATTGCTG GTAGCCTGTC AACACTGTTC CGTGTTGAAT 300
ATTCATCTAA AGTTGATGAG AACTTTGATT GTGTGGAGGC AGATGATGTT GAAGGCAAAA 360
TCAGACAAAT CATTCCACCT GGGTTTTGCA CAAACACAAA TGATTTTCTT TCCTTGCTGG 420
AAAAGGAAAC TAATTTCAAG CCTTTTGGAA CCCTCCTCCA TACATACACA GTTCCTAGTC 480
AGACAGGAGG TGAAACCTTT ACTTTCCAGA TCCACAAGGC TGACATGACA TGTAGAGGCT 540
TTCGAGAATA TCATGAAAGG CTTCAGACCT TTTTGATGTG GTTTATTGAA ACTGCTAGCT 600
TTATTGACGT GGATGATGAA AGATGGCACT ACTTTCTAGT ATTTGAGAAG TATAATAAGG 660
ATGGAGCTAC GCTCTTTGCG ACCGTAGGCT ACATGACAGT CTATAATTAC TATGTGTACC 720
CAGACAAAAC CCGGCCACGT GTAAGTCAGA TGCTGATACT GACTCCATTT CAAGGTCAGG 780
GCCACGGTGC TCAACTTCTT GAAACAGTTC ATAGATACTA CATTTCATTT CCTACAGTTC 840
TTGATATTAC AGCGGAAGAT CCGTCCAGAA GCTATTTGAA ACTAAGAGAC TTTGTGCTTG 900
TGAAGTTTTG TCAATTTTTG CCCAGTTTCT CCCGGGAAAG ATTACTGCAA GGATTCAGTG 960
AAGATATGGC AATACAGGCA CAGCAAATGT TCAAAATAAA TAAGCAACAT GCTAGAAGGG 1020
TTTATGAAAT TCTTCGACTG CTGGTGACTG ACATGAGCGA TGCTGAGCAA TACAGAAGCT 1080
ACAGACTGGA TATTAAAAGA AGACTAATTA GCCCTTACAA GAAAAAGCAG AGGGATCTTG 1140
CCAAGATGAA GAAATGCCTG AGACCAGAAG AGCTGACAAA TCAGATGAAC CAGATAGAAA 1200
TAAGTGTGCA GCATGAGCAG CTGGAAGAGA GATTTCAGGA GCTGGTGGAG GACTACCGGC 1260
GTGTCATTGA GCGACTTGCT CAAGAGTGAA GCCCTTGTTC CCCAGAATAC CTGCAGATTT 1320
CTGTGCATCG TGCTGTGAAC CTCTGATGAC CCTAAAGTTA TCTATGTTCT CCTTAGTGGA 1380
ATATTTCCTT TTGAGAGATT GTATATTTTA AAATACTGTC TAGAGTTTAT GAACATATAT 1440
TGCATTAATA AAAGATGGCT TGTGAAATAC CACCGCCCAC TGCTTTCTTC TTAAACAGTA 1500
AAATAAATGA TTGGTTGTAG TATATTAAGT TATAATGTGG TGCTTAAGGC TTTAGGATAA 1560
ATATTTTGAG TTACAC 1577
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR019467--Hat1_N
IPR017380--Hist_AcTrfase_B-typ_cat-su
PROSITE
Pfam

PF10394--Hat1_N
Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0006348--P:chromatin silencing at telomere
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0043967--P:histone H4 acetylation
GO:0007584--P:response to nutrient
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ova-0012 ENSOARP00000001849.1 Ovis aries 94 0.0 818
WERAM-Poa-0112 ENSPPYP00000014436.2 Pongo abelii 94 0.0 816
WERAM-Nol-0056 ENSNLEP00000006694.2 Nomascus leucogenys 94 0.0 816
WERAM-Soa-0052 ENSSARP00000005106.1 Sorex araneus 94 0.0 815
WERAM-Bot-0100 ENSBTAP00000013355.2 Bos taurus 94 0.0 815
WERAM-Pat-0100 ENSPTRP00000021597.3 Pan troglodytes 94 0.0 815
WERAM-Gog-0106 ENSGGOP00000009140.2 Gorilla gorilla 94 0.0 815
WERAM-Chs-0180 ENSCSAP00000010905.1 Chlorocebus sabaeus 94 0.0 815
WERAM-Ran-0015 ENSRNOP00000002085.5 Rattus norvegicus 94 0.0 814
WERAM-Vip-0017 ENSVPAP00000001693.1 Vicugna pacos 93 0.0 814
WERAM-Sus-0118 ENSSSCP00000016904.2 Sus scrofa 93 0.0 814
WERAM-Paa-0093 ENSPANP00000018512.1 Papio anubis 93 0.0 813
WERAM-Hos-0115 ENSP00000264108.4 Homo sapiens 93 0.0 813
WERAM-Aim-0094 ENSAMEP00000008940.1 Ailuropoda melanoleuca 93 0.0 812
WERAM-Eqc-0073 ENSECAP00000009282.1 Equus caballus 93 0.0 811
WERAM-Fec-0026 ENSFCAP00000002278.3 Felis catus 93 0.0 811
WERAM-Ptv-0121 ENSPVAP00000010680.1 Pteropus vampyrus 93 0.0 811
WERAM-Caj-0083 ENSCJAP00000013707.2 Callithrix jacchus 93 0.0 811
WERAM-Otg-0107 ENSOGAP00000009328.2 Otolemur garnettii 93 0.0 811
WERAM-Caf-0137 ENSCAFP00000018999.3 Canis familiaris 94 0.0 810
WERAM-Loa-0101 ENSLAFP00000008558.3 Loxodonta africana 92 0.0 809
WERAM-Dan-0092 ENSDNOP00000009190.3 Dasypus novemcinctus 93 0.0 806
WERAM-Orc-0047 ENSOCUP00000004608.2 Oryctolagus cuniculus 91 0.0 803
WERAM-Myl-0187 ENSMLUP00000015650.2 Myotis lucifugus 91 0.0 791
WERAM-Mam-0057 ENSMMUP00000009587.2 Macaca mulatta 93 0.0 782
WERAM-Cap-0017 ENSCPOP00000001664.2 Cavia porcellus 89 0.0 758
WERAM-Ocp-0137 ENSOPRP00000014189.1 Ochotona princeps 88 0.0 751
WERAM-Mod-0069 ENSMODP00000011048.3 Monodelphis domestica 82 0.0 724
WERAM-Gaga-0098 ENSGALP00000015492.3 Gallus gallus 81 0.0 703
WERAM-Anp-0011 ENSAPLP00000002164.1 Anas platyrhynchos 81 0.0 701
WERAM-Meg-0104 ENSMGAP00000010389.2 Meleagris gallopavo 81 0.0 695
WERAM-Fia-0035 ENSFALP00000002091.1 Ficedula albicollis 80 0.0 691
WERAM-Tag-0111 ENSTGUP00000008605.1 Taeniopygia guttata 79 0.0 687
WERAM-Pes-0131 ENSPSIP00000015233.1 Pelodiscus sinensis 80 0.0 687
WERAM-Lac-0041 ENSLACP00000006166.2 Latimeria chalumnae 77 0.0 664
WERAM-Orn-0101 ENSONIP00000010967.1 Oreochromis niloticus 73 0.0 635
WERAM-Mup-0007 ENSMPUP00000000831.1 Mustela putorius furo 93 1e-180 630
WERAM-Orla-0189 ENSORLP00000021710.1 Oryzias latipes 73 2e-180 629
WERAM-Sah-0179 ENSSHAP00000018728.1 Sarcophilus harrisii 82 3e-180 628
WERAM-Ten-0201 ENSTNIP00000002170.1 Tetraodon nigroviridis 72 7e-179 624
WERAM-Drm-0060 FBpp0078318 Drosophila melanogaster 40 3e-82 303
WERAM-Cae-0071 M03C11.4.2 Caenorhabditis elegans 34 1e-61 234
WERAM-Scp-0004 SPAC139.06.1:pep Schizosaccharomyces pombe 30 3e-31 133
WERAM-Art-0144 AT5G56740.1 Arabidopsis thaliana 25 7e-26 115
WERAM-Sac-0045 YPL001W Saccharomyces cerevisiae 25 1e-25 114
Created Date 25-Jun-2016