WERAM Information

Tag Content
WERAM ID WERAM-Mum-0080
Ensembl Protein ID ENSMUSP00000028232.3
Uniprot Accession Q9CXG9; PHF19_MOUSE
Genbank Protein ID NP_082992.1; XP_006498442.1
Protein Name PHD finger protein 19
Genbank Nucleotide ID NM_028716.4; XM_006498379.2
Gene Name Phf19;Pcl3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026873.9 ENSMUST00000028232.6 ENSMUSP00000028232.3
ENSMUSG00000026873.9 ENSMUST00000202907.1 ENSMUSP00000143954.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3K36me2/3 K 23104054
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 1.80e-12 48.8 39 89
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2).
Domain Profile
  Me_Reader Tudor
             Tudor.txt  3 kvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlre 60
                          ++G++V+++w+ dG++Y gki    +rv+s ++ +++++ed++k+++  L+k+++++ 
  ENSMUSP00000028232.3 39 TEGQFVLCRWT-DGLYYLGKI----KRVSSPKQSCLVTFEDNSKYWV--LWKDIQHAG 89
                          68*********.*********....**********************..9***99875 PP
Protein Sequence
(Fasta)		METQALEPGT LEAFGATSPN KGGLSKTKKN FKDLMSKVTE GQFVLCRWTD GLYYLGKIKR 60
VSSPKQSCLV TFEDNSKYWV LWKDIQHAGV PGEEPKCDVC MGKTSGPMNE ILICGKCGLG 120
YHQQCHIPIA VDANWPLLTH WFCRRCIFAL AVRKGGALKK GAIAKTLQAV KMVLSYQPEE 180
LDWDSPHRTN QQQCYCYCGG PGEWYLRMLQ CYRCRQWFHE ACTQCLSEPM VFGDRFYLFF 240
CSVCNQGPEY IERLPLRWVD IVHLALYNLG VQSKKRYFDF EEILAFVNHH WELLQLGKLT 300
STPMTERGPH LLNALNSYKS RFLCGKEIKK KKCIFRLRIR VPPAPPGKLL PDRALMPSDK 360
GTSELLRKKG KSKPGLLPQE PQQQKRRVYR RKRSKFLLED AIPSSDFTSA WSTDHHLASI 420
FDFTLDEIQS LKSGSSGQTF FSDVDSTDAA STSGSASTSL SYDSRWTVGS RKRKLTAKVH 480
RPLRAKQRAA ELEGRCASDS NAEGAVGPEQ PDEGIDSHTL ESISGDDSSL SHLKSSITNY 540
FGAAGRLACG EKYRVLARRV TPEGKVQYLL EWEGTTPY 578
Nucleotide Sequence
(Fasta)		GACTCCAAGT GGGACCGGCT GACGCGCTGC CTCGCGAAGC TAATGGAGAC TCAAGCTCTG 60
GAACCAGGGA CTCTGGAAGC CTTTGGTGCC ACCAGTCCTA ACAAGGGGGG CCTGTCTAAG 120
ACCAAAAAGA ACTTCAAAGA CTTGATGTCT AAGGTGACAG AGGGACAGTT CGTGCTATGC 180
AGGTGGACAG ACGGGCTATA TTACCTTGGC AAGATCAAGC GGGTCAGCAG TCCTAAGCAA 240
AGCTGCCTTG TGACTTTTGA AGATAATTCC AAATACTGGG TCCTGTGGAA GGACATCCAG 300
CATGCTGGTG TTCCGGGAGA GGAGCCCAAG TGTGACGTCT GCATGGGGAA GACTTCAGGG 360
CCTATGAACG AGATCCTCAT CTGTGGGAAG TGTGGCCTGG GTTACCACCA ACAGTGCCAC 420
ATCCCCATCG CAGTTGATGC CAACTGGCCC CTCCTCACTC ATTGGTTCTG CCGACGCTGC 480
ATTTTCGCAC TGGCTGTGAG GAAAGGTGGC GCTTTGAAGA AAGGCGCCAT CGCCAAGACG 540
CTGCAGGCAG TGAAAATGGT GCTGTCCTAC CAGCCGGAGG AACTCGATTG GGACTCGCCC 600
CATCGCACTA ACCAGCAGCA ATGCTACTGC TACTGCGGCG GGCCTGGAGA GTGGTACCTT 660
CGGATGCTAC AGTGCTACCG GTGTAGGCAG TGGTTCCATG AGGCTTGCAC ACAGTGCCTT 720
AGTGAGCCTA TGGTGTTTGG AGACCGCTTC TACCTGTTCT TCTGCTCCGT GTGTAACCAA 780
GGCCCAGAGT ATATTGAGAG GCTGCCCTTG CGATGGGTGG ATATAGTTCA CCTGGCTCTC 840
TATAACTTGG GAGTACAGAG CAAGAAGCGG TACTTTGACT TTGAGGAGAT CCTGGCCTTT 900
GTCAACCATC ACTGGGAGCT CCTGCAGCTT GGCAAGCTCA CCAGCACCCC CATGACAGAA 960
CGAGGGCCAC ATCTCCTCAA CGCTCTCAAC AGTTACAAGA GCCGGTTCCT GTGTGGCAAG 1020
GAAATTAAGA AGAAGAAATG CATCTTCCGA CTGCGCATCC GAGTCCCGCC TGCCCCTCCA 1080
GGAAAACTGC TTCCCGACAG GGCGTTGATG CCAAGTGACA AAGGGACCTC CGAGCTGCTT 1140
CGTAAGAAAG GAAAGAGCAA GCCTGGTTTG TTGCCTCAGG AACCCCAGCA GCAGAAAAGG 1200
CGAGTTTATA GAAGAAAAAG ATCAAAGTTT TTGCTGGAAG ATGCTATTCC CAGTAGTGAC 1260
TTCACCTCAG CCTGGAGCAC AGACCACCAC CTAGCCAGTA TATTCGACTT CACACTGGAT 1320
GAAATTCAGA GTTTAAAAAG TGGCAGCTCA GGCCAGACCT TCTTCTCAGA TGTGGATTCT 1380
ACCGACGCAG CCAGCACCTC GGGGTCTGCC TCCACCAGCC TCTCCTACGA CTCCAGATGG 1440
ACGGTAGGCA GCCGCAAGAG GAAGCTGACA GCCAAAGTGC ACAGGCCCCT GCGAGCAAAG 1500
CAAAGGGCGG CGGAGCTGGA GGGGCGCTGC GCCTCAGACA GCAATGCAGA GGGAGCTGTG 1560
GGTCCTGAGC AGCCGGATGA AGGCATCGAC AGCCACACAC TTGAAAGCAT CAGTGGAGAC 1620
GACTCGTCCC TGTCCCACCT CAAGTCCTCT ATCACCAACT ACTTTGGTGC AGCTGGGCGG 1680
TTGGCCTGCG GGGAAAAATA TCGGGTGTTG GCGCGGAGGG TCACTCCAGA AGGCAAGGTT 1740
CAGTACCTGT TGGAATGGGA GGGGACCACC CCTTACTGAT TACCCTCAGA GGCTGCCCAG 1800
ATCCCTGCAA ACCAAAGGAG GGGCAGAAGA GGCCACTGGG TCCCTGTTTT CGCCAGGCTT 1860
GGGGTGGTGG TGGTGAAACA GGACATCCTG CCTGTGGCCC CTGCCTGCTG CCTGCCAGGC 1920
CAAGGCCTGT GTGCTGCTGT ACCTGAGTCT CTGAGACCCC ATTGGTATTC TCTCGTTGTC 1980
AATACTACAC TCCACACCCC TCAAACTTTT TATTGGTTCC TCTGACAGTA TCCTGGCTCC 2040
AACCCCTGGA TCTGTTTTTT GTTGTCCCCA ATTCTCCATC TTCTGCCCTC TCACCCCTTT 2100
CAGGTGTTTT GTGTGGACAC ACATCTTCCA CGGGCATACA CCCATCTGTC CCTCACTGGG 2160
CATGCTTCAC TGGGTCCTCA CTAGGACCAC AGTGAGGGAA GGGAACCTTG GGGGTCTTCT 2220
GCTTTCTCAC TAGTACCCCT CACCCCAGGA AGGTAGGGGG TGCCTGAGAA AGTTTAGGAT 2280
GCCTAGGACC CAGAGTCTGG GGAGTGGTGA GCTGGGTCTC TGCAGAAGGG ACAAGAATCA 2340
GGGTCTTTTA TTGAGGAGGG GAGACTAAGG AAGTCAGGCA GGGCCAAGGT TTCCAGAAGT 2400
TTGCCTGTCC CAGCAACAAC CCTTTACTGT TGTCAAGGAT TGGGACCTGG CCCTGCTGCA 2460
TAGACGTGTC TTAAACACAC AGATCTGGGA GGAAAGGATG GGGAAGAAGA CTAAGCCAGA 2520
TTAAATCCCA TCCCAAACAC TGTGTGTACA GCCACCACCT ACTCCTGCCA GGGCCCCCTG 2580
GCCCCCCGTC CTTGGCCTCT TCCAGGGATA CATGCTGCAG TTAAATGTGA GAACCAAACC 2640
CCTGCCTCCT CTGGCCTGTG AAGCAGCCTT GGCCCCACAG AGAAGCACAA AATATACCCC 2700
TCTCCTGCAT GGCTCCTGCC TTGCCCTGGA GCTGACAATC ACTTTGGGGA CAGGTTTGGA 2760
GTTTACAAGG GCCTGAATCG TTGGTTCCCT TCAGAAAGGA AGGCTTTGTC ATCAATGGTA 2820
CAAATAGAAT TCTTAGAATG GTCAAGCTTA GCCGTGTCTG GGGAGAAACC AGGAGGTGGG 2880
CAGGGAGCCC TTACTTTGCC TACAGAAACA GAAATTGACT CACTCAGTTG GAGAAATGGA 2940
AAGAACTGCC ATTGAAGTGG GAGGCAAGGG CACCAGACTG AGACTAGCCT CCCTGACTGC 3000
TGCTGTAGCT TCCAGCTGGG GGTGGGAAGA TGGACCACAT GGTGACATCA GACTATACCA 3060
AAGGTGCTGA TATTCCCATG ACTAGGTCTG ACCCCTTCAC ACCTTCCCGT GAGCATTAAG 3120
GAGGGTCCCT GCAGTAGGTT AGATGTCCCC TGCCTTAAAC CTCAGCCACC ATGGTGCCTT 3180
GCAAAGAAAC CTCGCCTCTC ATAGACACAG CTACCTACTT CCCTCTGCCT TCCTGTCTGG 3240
GCTCAGGCAG GGATAAGCAG ATGGACACTG GGCCCAGTTG TCAGTCCCAC AGCTGCCGCC 3300
ACTGAGGTCC CAAAGTGGGG CCTGGTGGAA GGAGAGTTGG GAAGCCAACT CCTAGGCTTG 3360
TGGGAACTGG GGTCAAATTT GTGGCTTCCT GTTGGCTTCA GTGAACATGG CAACCTCCAA 3420
CACGTGTTTT CCAGGCCACT GGGGAAGCCA GAGTTAGGAT GGCTATCTGT ACATCTGCCC 3480
CTCCTCTGCT GTGCCCCAGA AGCTCTGGGC CTGAGGAGCA GGAAGGCAGG AGGGGTGCCC 3540
GTCCCGTTGG GGATCCTAGC ACAAGGCCTG ACCAGGTCCC TGGACTTCCC ATGGCAGCAT 3600
TTCACTCCTA CAAAATAATA GCTGCATTAC TGCCAACTGA TGGTATAACC CTGTGCACCT 3660
TTGAAAAGAT TTTGGTTTTA AATTGCTGCT TTTAATAATA TTTGTTATAT TAAAGTTATA 3720
ATTGATGTGT CTGGTTTACA A 3742
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0120 ENSRNOP00000025528.5 Rattus norvegicus 96 0.0 1048
WERAM-Eqc-0194 ENSECAP00000021073.1 Equus caballus 89 0.0 971
WERAM-Poa-0185 ENSPPYP00000021915.2 Pongo abelii 89 0.0 971
WERAM-Nol-0187 ENSNLEP00000020703.1 Nomascus leucogenys 89 0.0 969
WERAM-Gog-0023 ENSGGOP00000002247.2 Gorilla gorilla 89 0.0 969
WERAM-Paa-0212 ENSPANP00000018930.1 Papio anubis 89 0.0 968
WERAM-Mam-0088 ENSMMUP00000013924.2 Macaca mulatta 89 0.0 968
WERAM-Hos-0098 ENSP00000483946.1 Homo sapiens 89 0.0 968
WERAM-Chs-0159 ENSCSAP00000009370.1 Chlorocebus sabaeus 89 0.0 968
WERAM-Otg-0215 ENSOGAP00000022602.1 Otolemur garnettii 89 0.0 968
WERAM-Bot-0152 ENSBTAP00000022557.4 Bos taurus 88 0.0 965
WERAM-Loa-0055 ENSLAFP00000004073.3 Loxodonta africana 85 0.0 964
WERAM-Fec-0007 ENSFCAP00000000596.3 Felis catus 88 0.0 964
WERAM-Orc-0051 ENSOCUP00000004910.3 Oryctolagus cuniculus 88 0.0 962
WERAM-Cap-0025 ENSCPOP00000002036.2 Cavia porcellus 88 0.0 956
WERAM-Myl-0055 ENSMLUP00000004589.2 Myotis lucifugus 88 0.0 956
WERAM-Mup-0083 ENSMPUP00000007596.1 Mustela putorius furo 88 0.0 951
WERAM-Aim-0016 ENSAMEP00000001231.1 Ailuropoda melanoleuca 85 0.0 920
WERAM-Caj-0214 ENSCJAP00000042819.1 Callithrix jacchus 88 0.0 911
WERAM-Sah-0188 ENSSHAP00000020428.1 Sarcophilus harrisii 84 0.0 901
WERAM-Dio-0090 ENSDORP00000009372.1 Dipodomys ordii 85 0.0 889
WERAM-Ptv-0127 ENSPVAP00000011106.1 Pteropus vampyrus 89 0.0 872
WERAM-Tut-0075 ENSTTRP00000006294.1 Tursiops truncatus 85 0.0 855
WERAM-Fia-0031 ENSFALP00000001875.1 Ficedula albicollis 77 0.0 815
WERAM-Meg-0036 ENSMGAP00000003133.1 Meleagris gallopavo 77 0.0 810
WERAM-Gaga-0017 ENSGALP00000002418.5 Gallus gallus 80 0.0 803
WERAM-Mod-0183 ENSMODP00000024495.2 Monodelphis domestica 79 0.0 798
WERAM-Ect-0026 ENSETEP00000001872.1 Echinops telfairi 78 0.0 794
WERAM-Ova-0055 ENSOARP00000006044.1 Ovis aries 88 0.0 773
WERAM-Ict-0115 ENSSTOP00000011704.2 Ictidomys tridecemlineatus 88 0.0 772
WERAM-Lac-0136 ENSLACP00000015753.1 Latimeria chalumnae 73 0.0 767
WERAM-Mae-0050 ENSMEUP00000004804.1 Macropus eugenii 70 0.0 756
WERAM-Leo-0057 ENSLOCP00000007767.1 Lepisosteus oculatus 69 0.0 709
WERAM-Caf-0039 ENSCAFP00000005324.3 Canis familiaris 70 0.0 704
WERAM-Xet-0124 ENSXETP00000042382.3 Xenopus tropicalis 73 0.0 701
WERAM-Anp-0069 ENSAPLP00000008395.1 Anas platyrhynchos 71 0.0 690
WERAM-Ere-0085 ENSEEUP00000008196.1 Erinaceus europaeus 81 0.0 686
WERAM-Dar-0179 ENSDARP00000101389.2 Danio rerio 64 0.0 683
WERAM-Anc-0034 ENSACAP00000018499.2 Anolis carolinensis 78 0.0 651
WERAM-Orn-0009 ENSONIP00000001041.1 Oreochromis niloticus 58 5e-171 598
WERAM-Soa-0088 ENSSARP00000008397.1 Sorex araneus 73 7e-171 597
WERAM-Ten-0022 ENSTNIP00000005027.1 Tetraodon nigroviridis 57 2e-165 579
WERAM-Tar-0222 ENSTRUP00000046767.1 Takifugu rubripes 56 8e-165 577
WERAM-Gaa-0109 ENSGACP00000014147.1 Gasterosteus aculeatus 56 3e-164 575
WERAM-Prc-0046 ENSPCAP00000004178.1 Procavia capensis 71 3e-163 572
WERAM-Mim-0032 ENSMICP00000003002.1 Microcebus murinus 74 4e-159 558
WERAM-Sus-0036 ENSSSCP00000005906.2 Sus scrofa 85 2e-158 556
WERAM-Xim-0088 ENSXMAP00000008107.1 Xiphophorus maculatus 55 3e-154 542
WERAM-Pof-0138 ENSPFOP00000011590.2 Poecilia formosa 56 1e-153 541
WERAM-Gam-0002 ENSGMOP00000000180.1 Gadus morhua 56 3e-153 539
WERAM-Tag-0098 ENSTGUP00000006728.1 Taeniopygia guttata 88 8e-152 534
WERAM-Orla-0194 ENSORLP00000022012.1 Oryzias latipes 54 2e-145 513
WERAM-Asm-0130 ENSAMXP00000012810.1 Astyanax mexicanus 55 2e-140 496
WERAM-Ora-0006 ENSOANP00000000893.2 Ornithorhynchus anatinus 80 1e-122 437
WERAM-Ocp-0073 ENSOPRP00000006411.1 Ochotona princeps 80 5e-111 399
WERAM-Pes-0077 ENSPSIP00000009455.1 Pelodiscus sinensis 55 1e-106 384
WERAM-Pat-0008 ENSPTRP00000052062.2 Pan troglodytes 55 6e-106 382
WERAM-Tas-0127 ENSTSYP00000013465.1 Tarsius syrichta 55 2e-102 370
WERAM-Pem-0006 ENSPMAP00000000578.1 Petromyzon marinus 58 3e-98 356
WERAM-Tub-0048 ENSTBEP00000005679.1 Tupaia belangeri 51 2e-84 310
WERAM-Dan-0184 ENSDNOP00000013781.3 Dasypus novemcinctus 57 3e-84 310
WERAM-Chh-0106 ENSCHOP00000011829.1 Choloepus hoffmanni 48 1e-80 298
WERAM-Vip-0124 ENSVPAP00000011690.1 Vicugna pacos 90 8e-72 268
WERAM-Drm-0007 FBpp0085914 Drosophila melanogaster 32 9e-46 182
WERAM-Cis-0011 ENSCSAVP00000001651.1 Ciona savignyi 43 4e-19 94.0
WERAM-Cii-0087 ENSCINP00000031571.1 Ciona intestinalis 40 3e-18 90.9
WERAM-Gag-0024 GGTG_08466T0 Gaeumannomyces graminis 43 4e-06 50.4
Created Date 25-Jun-2016