WERAM Information

Tag Content
WERAM ID WERAM-Mum-0073
Ensembl Protein ID ENSMUSP00000026865.8
Gene Name Jade1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025764.14 ENSMUST00000026865.14 ENSMUSP00000026865.8
ENSMUSG00000025764.14 ENSMUST00000170711.7 ENSMUSP00000127113.1
ENSMUSG00000025764.14 ENSMUST00000163764.7 ENSMUSP00000128152.1
ENSMUSG00000025764.14 ENSMUST00000168086.6 ENSMUSP00000131441.1
ENSMUSG00000025764.14 ENSMUST00000191952.1 ENSMUSP00000141499.1
Status Unreviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 3.00e-11 44.8 205 370
Organism Mus musculus
Domain Profile
  Me_Reader PHD
               PHD.txt   2 tiClvCg.kddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                            +C vC+  d+e+ +emv Cd+C+  +H+ C+++   ++peg sw+C++C 
  ENSMUSP00000026865.8 205 VVCDVCQsPDGEDGNEMVFCDKCNICVHQACYGIL--KVPEG-SWLCRTCA 252
                           58****6444444556*******************..*****.*******5 PP
               PHD.txt   4 ClvCgkddegekemvqCdeCddwfHlkCv 32 
                           Cl+C  ++ g+  m    ++ +w+H++C 
  ENSMUSP00000026865.8 259 CLLC-PKKGGA--MKPTRSGTKWVHVSCA 284
                           8888.333331..44456699*******6 PP
               PHD.txt   3 iClvCgkddegekemvqCde..CddwfHlkCvklp.......lsslpeg.....kswyCpsCk 51 
                           +C +C ++++g+   +qC+   C+++fH++C           l    ++      + yCp++ 
  ENSMUSP00000026865.8 315 VCSLC-NEKFGA--SIQCSVknCRTAFHVTCAFDRglemktiL----AEndevkFKSYCPKHS 370
                           7999*.788886..6***9899*********977755443221....1134544446788886 PP
Protein Sequence
(Fasta)		MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR TDLITAMKLH 60
DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR VVSEEKSLMF IRPKKYIASS 120
GSEPPALGYV DIRTLADSVC RYDLNDMDAA WLEVTNEEFK EMGMPELDEY TMERVLEEFE 180
QRCYDNMNHA IETEEGLGIE YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK 240
VPEGSWLCRT CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP 300
ITKVSHIPSS RWALVCSLCN EKFGASIQCS VKNCRTAFHV TCAFDRGLEM KTILAENDEV 360
KFKSYCPKHS SHRKPEEGLG EGAAQENGAP ESSPQSPLEP YGSLEPNREE AHRVSVRKQK 420
LQQLEDEFYT FVNLLDVARA LRLPEEVVDF LYQYWKLKRK INFNKPLITP KKDEEDNLAK 480
REQDVLFRRL QLFTHLRQDL ERVRNLTYMV TRREKIKRSV CKVQEQIFTQ YTKLLEQEKV 540
SGVPSSCSSA LENMLFFNSP SVGPNAPKIE DLKWHSAFFR KQMGTSLVHP LKKSHKRDAV 600
QNSSGTEGKT SHKQPGLCGR REGLEVSESL LSLEKTFAEA RLLSSAQQKN GVVTPDHGKR 660
RDNRFHCDLV KGDLKDKSFK QSHKPLRSTD TSQRHLDNTR AATSPGVGQS APGTRKEIVP 720
KCNGSLVKVP ITPASPVKSW GGFRIPKKGE RQQQGEAHDG ACHQHSDCSH LGVSRAPAKE 780
RAKSRLRADS ENDGYAPDGE MSDSESEASE KKCIHASSTI SRRTDIIRRS ILAS 834
Nucleotide Sequence
(Fasta)		TGCTCTTTGG GTTCTAGAAG GCAGAAGACA TCCTTGTCCG CTCGCCTGCT ACCTCTGAGG 60
AAACTCGGGG CTCTACTCAA AGTGCTGAGG CTGCCTGCTG TCTCCCGGGG AGATCATGAA 120
ACGAGGTCGC CTTCCCAGCA GCAGTGAGGA TTCTGACGAC AATGGCAGCT TGTCAACGAC 180
ATGGTCCCAG CATTCTCGAT CCCAGCATGG GAGGAGTAGT ACCTGCTCTA GACCTGAAGA 240
TCGAAAGCCT TCTGAGGTGT TTAGGACCGA CCTGATCACT GCCATGAAGT TGCATGACTC 300
CTACCAGCTG AACCCGGATG ACTACTACGT GCTGGCTGAT CCCTGGAGAC AGGAGTGGGA 360
GAAAGGGGTC CAGGTGCCTG TGAGCCCAGG GACCATCCCA CAGCCTGTGG CCAGGGTTGT 420
GTCTGAAGAG AAGTCTCTCA TGTTCATCAG GCCCAAGAAG TACATCGCGT CGTCCGGCTC 480
TGAGCCCCCA GCGTTAGGCT ACGTCGATAT CCGGACTCTG GCAGACAGTG TGTGTCGGTA 540
TGACCTCAAT GATATGGATG CTGCGTGGCT GGAAGTAACC AATGAAGAAT TTAAGGAGAT 600
GGGGATGCCG GAGCTGGACG AGTACACCAT GGAAAGGGTC TTGGAGGAAT TCGAACAGCG 660
ATGCTATGAC AATATGAATC ATGCCATAGA GACAGAAGAG GGCTTGGGGA TTGAATACGA 720
CGAAGACGTT GTCTGCGATG TCTGCCAGTC ACCTGATGGC GAGGACGGCA ACGAGATGGT 780
GTTCTGTGAC AAGTGTAACA TCTGTGTGCA CCAGGCTTGC TATGGGATCC TCAAGGTGCC 840
AGAGGGCAGT TGGCTATGTC GTACATGTGC CCTGGGAGTT CAGCCAAAAT GTTTGCTGTG 900
TCCCAAGAAA GGCGGAGCTA TGAAGCCGAC CCGCAGCGGA ACCAAGTGGG TCCACGTCAG 960
CTGTGCCCTG TGGATCCCTG AGGTAAGCAT TGGCAGCCCT GAGAAGATGG AGCCCATCAC 1020
AAAAGTGTCT CACATTCCCA GCAGCCGGTG GGCGCTTGTG TGCAGCCTCT GCAATGAGAA 1080
ATTCGGGGCC TCCATACAGT GCTCTGTGAA GAACTGCCGG ACAGCCTTCC ACGTGACTTG 1140
TGCTTTTGAC CGTGGCCTGG AGATGAAGAC CATATTGGCA GAGAATGATG AAGTCAAATT 1200
CAAGTCCTAC TGCCCAAAGC ACAGCTCACA CAGGAAACCC GAGGAGGGCC TGGGTGAAGG 1260
AGCAGCCCAG GAGAATGGGG CCCCTGAGAG TTCTCCCCAG AGCCCTCTGG AGCCCTATGG 1320
TAGTCTGGAG CCGAATCGAG AGGAGGCCCA CCGGGTGAGT GTTCGCAAGC AGAAGCTACA 1380
GCAGCTGGAG GATGAGTTCT ACACCTTTGT CAACCTGCTG GATGTGGCCA GGGCGCTGCG 1440
GCTGCCTGAG GAAGTGGTGG ATTTCCTGTA CCAGTACTGG AAGTTGAAGA GGAAGATCAA 1500
CTTCAACAAG CCCCTCATCA CCCCAAAGAA AGACGAAGAG GACAATCTAG CCAAGCGGGA 1560
GCAGGATGTC TTGTTTAGGA GGCTGCAGCT GTTCACGCAC CTGCGGCAGG ACCTGGAGAG 1620
GGTTCGGAAC CTCACTTACA TGGTGACCCG CAGGGAAAAG ATTAAACGGT CTGTGTGCAA 1680
AGTCCAGGAA CAAATTTTCA CTCAGTACAC TAAGCTCTTG GAGCAAGAAA AAGTTTCAGG 1740
TGTGCCTTCT TCCTGCTCCT CCGCACTGGA GAACATGCTT TTTTTCAACA GTCCTTCTGT 1800
GGGCCCCAAT GCTCCCAAGA TAGAGGACTT GAAATGGCAT TCTGCATTCT TCAGGAAACA 1860
AATGGGCACT TCCTTGGTTC ATCCACTGAA AAAGTCCCAT AAACGAGATG CAGTGCAGAA 1920
TAGTTCTGGG ACCGAGGGCA AGACCTCGCA TAAGCAGCCA GGTCTTTGTG GTAGAAGGGA 1980
GGGGCTGGAG GTCTCAGAAA GCTTGCTGAG CTTAGAAAAG ACTTTTGCAG AAGCACGTCT 2040
CCTATCATCA GCACAACAGA AAAATGGTGT GGTGACCCCA GACCATGGGA AAAGAAGAGA 2100
CAATCGTTTT CATTGTGATC TCGTTAAAGG AGACTTAAAG GACAAATCTT TTAAGCAGAG 2160
TCACAAGCCT CTCAGGTCCA CAGACACATC CCAGAGGCAT CTGGACAACA CAAGAGCTGC 2220
CACCTCCCCT GGAGTAGGGC AGTCAGCACC TGGCACCAGG AAGGAGATTG TGCCCAAGTG 2280
CAATGGCTCC CTAGTCAAAG TGCCTATAAC ACCTGCCAGC CCAGTGAAAA GCTGGGGAGG 2340
ATTCCGGATT CCAAAGAAGG GGGAGCGGCA GCAGCAAGGA GAAGCCCATG ATGGGGCCTG 2400
CCACCAGCAC TCAGACTGCT CCCATCTGGG TGTAAGCCGA GCTCCAGCCA AGGAGAGAGC 2460
GAAGAGCAGG TTAAGAGCTG ACAGTGAGAA TGATGGGTAC GCCCCTGATG GGGAAATGAG 2520
TGACTCAGAG AGCGAGGCAT CAGAGAAGAA ATGTATCCAT GCCAGCAGCA CCATCAGCAG 2580
GAGGACAGAT ATCATCAGGC GAAGCATCTT GGCCTCTTGA TGAAACAGCC GGTGTGGAAG 2640
CACATGGCTT GTTGCCGTGT GCTGAGGAGA GCTCTGATAA TAGGGGCAAG CAAATACCCA 2700
TTGTTTCTGA GCTACAGACA TACTTCCTTG CAATTCAGAT TGAATTTTTT TCCAGAGTCA 2760
TTTATAAATC ATTGTGAGAA GTTTGTGTTA TTTGCAACTT GTTGAGGAAA CAGAAGAGTA 2820
GACTGTAACC ATAAGACACT AAGATTAGAA CCTGAACTAA ACACTATAAA AAAAAAACCA 2880
ACAAATGAAG TAACTTTGCA GAGGGCCAGG CTTGAATAGC ACCATGTATT ATTGCCCTCT 2940
ACATTCTCCC CAAAGCACAA ACTCTTGAAT ACTCACTCTT ACAGAATCAT AGAATTCTGT 3000
GTGGTGAACA AGTCCTATTT CTAGAAGCCC TCATGTACCA TTTATAGCCC ACAAAGCTTA 3060
TTTTCTAGGA ATGGTAAATG CTGACGGCAT TTGGCTCCCA GGCTGTGTGG TATGAGGAGC 3120
TGAGGTTCTG AAGCTTCACA ACACTGGGAT CTTGCACATG TGGCATCCAG GGGAAGAGTT 3180
TACACAACAG GCATTGCTGG AAGGCTGCAG GGACAGAGCA GAGCTGCTGC ACTGAGATTT 3240
GGGGCCCGTG TAGCAAGGTC CCGAAGCCCT GAGTGGGCTG TGGACACAGG ACGGGTGGAG 3300
GAAAAGTTGT CCAGAAACTT CTGTGAGACA GGGCAGCTGA GGCCCAGGTG TTACTAGTCC 3360
GCTTGACCTT CCTCTTTCCT AACTGCTGGC CTTTGGATCC AAATGGGATT TCCCTGGCTA 3420
CTGCCAGTAC TTGGCCATCT GGCTTCCAAT AATACAATGG TTATTCAAGT TCAAGTGATG 3480
AACTTCTGGT GACTCTCACT CTACAGAGTC AACCACTAGT GCATATTTGG GAAATCCAGG 3540
CTTCCACCAT GAGTGGATTC CTTAAGCAAA AAGGAAAACA AAAAGCAAAA TAGGTTATAT 3600
TTTAAAATAT AGAAAGGCAA TAAGTTGCAT CAAGGTTATA CAGGAAAGAA TTCAAAGTGT 3660
ATCCTTGAAT AGGTTTCTGG AGTTGGAGTT CTAAACTCTG ATTTGTAACT TGGACTTTCG 3720
AATTGCAAAT GGCAATAACT AGTAAGTTAT CAGCAATAAT AAATTTAGCA TTAAATTTGA 3780
GTATAATGTT CTGTTTTTGC ACTCCTCATA TAGTGCATAT GTATTCAGAC AAGTGGATAG 3840
TGTTAAAGTC CTGTTATTTT CTTTGGAATT CAATGTAGTT GTGAATCAAA ATTAAGAGAA 3900
GGGAAGTTTC ATTAGCAATG AGATTTAGAA TTAAGGGCAT TTGGAATAAG CCCAGTTTCC 3960
CCTAAATTAC CCTTAGTTTA TTAATATCAA TGTTCAGATT CCTGACTCAT TTATACATCT 4020
GTTTCCATGT GGCAGGGACA TTCTGATATT TAATGAGCAA TGCTTTGAGT TTGTAGAAGC 4080
TTTCAAGTCT TCCAGATGAT TGTCAACAAC AGAAAAGGCT TATTGAATTC CATCTTGCTA 4140
TGCAAGTTTT ATCAGATGAT CAAATGACAG ATCTGATGCA TCTCATCGTA TGTATGACAT 4200
TTTCAAACTA AGTCTTAACT TCTCAAGTAC ATTGTAGTAG CTAATTCAGG GGAGGGGAAA 4260
GGATGACCCA GGTTTTAGAT TGACTATTTT TTGAGCTATG GAGCTCCTTT GAGACTGCTG 4320
TCCAGATCAG CTCGTTGCTA CTGGTATTCG AAGATTCTCA GGAGTCCAAG TTGTACTTTT 4380
GCTTGTAGCC TAATTTAAAA ATGAGATGTT TTGCATCTGA GCAAAAACCT TTTGCTGGAT 4440
ACAGGAAAAG GCTGGACTCT GATCTAGTTA TCTTTTGATT ACAGCAACAG CTCTGGGTGA 4500
GAATAGAATT TATAGAGGAA TAATCTGTGA AGCCATAGAA AGAAACCCTA AATTAATCTA 4560
GTGAGTATAT GGCCTCTCAC CATTTTAGGA GGCACCAGAT TCATTTGCAC TATTAGGAAT 4620
GCTAGTTTTG TGCAAAAATA AATGCCTTAC CTGTTTCCCC CCACATTTAG GTTGAAAAGC 4680
TTTCAAATGT TCCAAGTTAT GCTGAACCAA AAACAAATAA AACAAAATGA AAAAAAAAAA 4740
AAAAAATAAT AATAAAAAAT TTCCCCCACA AAAACATAAC AAAAAAAAAA AAAGCCCACA 4800
CGTTTAATTA CTGCTTTGAA ATGCAATGGT ATAGAGCACG GTTTCTGACA GTGTAATGAT 4860
AGCTTTGTAA GTTAGTTCAT GTCATGCTGG GAACTCTGTA TGAGGCGGCC ACAGGCAGCA 4920
GCAGCCCACC TACCTACCCA CTTGCATTCT ATTAGTATTG AGCTTTTTTG TTTGTTTGTT 4980
TGTTCTTTTG AATCTTCCTT GTGCATCCTG ACCAAGAAAT ATCTTTGATT ATGATCAATG 5040
TATTATGTCA AAATGTAGGC TAGTTGAACT TTTGTAAAGT TGCCTGGAAT GTCATTTGTT 5100
AGGTTATAAA CACAAAATTT AAATGAAGGG TTTTATGTGT TGTGTACAAA TCTTAATTAT 5160
TTTAAAATGG ACAGACTTGT CATTACATTT GTAACCTTGT ACAGAGGATT TTTCACTATG 5220
TGCCTAGCTT GGTGTCCATT CAACTAAAAT TGAAAAAAAA AAGGTGCATG AAGAGTTAAA 5280
ATCAGAAGTT AAACAAAGTC TATGTAGAGA TGACTATTTT ATATTACATG GCCCAATCCT 5340
GTATTTATTT CTACCCCCTT TTTGAAAGTA TTTATAAAAC TAGTTGAAGA CAGCTGTATT 5400
TTTTTGTTGA ACTATTTAGT AGAATTTGTG CCTTTTTGTC TGTATGTGAA TAAATGCTGT 5460
ACATTTTGCA ATACATTTTA A 5482
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0090 ENSRNOP00000018872.6 Rattus norvegicus 95 0.0 1564
WERAM-Poa-0131 ENSPPYP00000016826.2 Pongo abelii 92 0.0 1529
WERAM-Paa-0112 ENSPANP00000004588.1 Papio anubis 92 0.0 1517
WERAM-Pat-0133 ENSPTRP00000028231.4 Pan troglodytes 92 0.0 1517
WERAM-Hos-0034 ENSP00000226319.6 Homo sapiens 92 0.0 1517
WERAM-Chs-0041 ENSCSAP00000014486.1 Chlorocebus sabaeus 92 0.0 1516
WERAM-Mam-0014 ENSMMUP00000002861.2 Macaca mulatta 91 0.0 1516
WERAM-Nol-0159 ENSNLEP00000016918.1 Nomascus leucogenys 91 0.0 1515
WERAM-Gog-0025 ENSGGOP00000002307.2 Gorilla gorilla 92 0.0 1515
WERAM-Caj-0033 ENSCJAP00000006021.1 Callithrix jacchus 91 0.0 1511
WERAM-Cap-0026 ENSCPOP00000002047.2 Cavia porcellus 91 0.0 1502
WERAM-Orc-0038 ENSOCUP00000003905.3 Oryctolagus cuniculus 90 0.0 1501
WERAM-Loa-0013 ENSLAFP00000000853.3 Loxodonta africana 91 0.0 1499
WERAM-Dan-0003 ENSDNOP00000000420.3 Dasypus novemcinctus 90 0.0 1495
WERAM-Otg-0064 ENSOGAP00000004615.2 Otolemur garnettii 90 0.0 1493
WERAM-Tut-0092 ENSTTRP00000007733.1 Tursiops truncatus 90 0.0 1492
WERAM-Aim-0116 ENSAMEP00000011097.1 Ailuropoda melanoleuca 90 0.0 1489
WERAM-Bot-0158 ENSBTAP00000032057.4 Bos taurus 90 0.0 1488
WERAM-Sus-0062 ENSSSCP00000009680.2 Sus scrofa 89 0.0 1485
WERAM-Fec-0183 ENSFCAP00000019233.1 Felis catus 90 0.0 1484
WERAM-Ova-0164 ENSOARP00000016229.1 Ovis aries 89 0.0 1481
WERAM-Ict-0193 ENSSTOP00000016953.1 Ictidomys tridecemlineatus 89 0.0 1472
WERAM-Caf-0045 ENSCAFP00000005680.3 Canis familiaris 89 0.0 1464
WERAM-Mup-0200 ENSMPUP00000017251.1 Mustela putorius furo 90 0.0 1425
WERAM-Ptv-0080 ENSPVAP00000007411.1 Pteropus vampyrus 88 0.0 1374
WERAM-Mod-0185 ENSMODP00000025962.3 Monodelphis domestica 79 0.0 1316
WERAM-Fia-0102 ENSFALP00000008419.1 Ficedula albicollis 79 0.0 1292
WERAM-Anp-0139 ENSAPLP00000015050.1 Anas platyrhynchos 78 0.0 1278
WERAM-Tag-0030 ENSTGUP00000002178.1 Taeniopygia guttata 78 0.0 1276
WERAM-Anc-0065 ENSACAP00000006214.3 Anolis carolinensis 77 0.0 1264
WERAM-Gaga-0104 ENSGALP00000016588.4 Gallus gallus 78 0.0 1259
WERAM-Pes-0104 ENSPSIP00000012865.1 Pelodiscus sinensis 77 0.0 1237
WERAM-Meg-0050 ENSMGAP00000004710.2 Meleagris gallopavo 78 0.0 1234
WERAM-Myl-0092 ENSMLUP00000007591.2 Myotis lucifugus 87 0.0 1219
WERAM-Sah-0172 ENSSHAP00000017983.1 Sarcophilus harrisii 85 0.0 1113
WERAM-Lac-0141 ENSLACP00000016147.1 Latimeria chalumnae 66 0.0 1059
WERAM-Xet-0146 ENSXETP00000048721.3 Xenopus tropicalis 65 0.0 1037
WERAM-Leo-0098 ENSLOCP00000013043.1 Lepisosteus oculatus 60 0.0 950
WERAM-Eqc-0204 ENSECAP00000021894.1 Equus caballus 92 0.0 934
WERAM-Orla-0196 ENSORLP00000022489.1 Oryzias latipes 55 0.0 807
WERAM-Xim-0091 ENSXMAP00000008163.1 Xiphophorus maculatus 53 0.0 803
WERAM-Mae-0046 ENSMEUP00000004225.1 Macropus eugenii 75 0.0 785
WERAM-Dar-0071 ENSDARP00000042059.3 Danio rerio 68 0.0 785
WERAM-Tar-0057 ENSTRUP00000012601.1 Takifugu rubripes 69 0.0 776
WERAM-Ten-0148 ENSTNIP00000015370.1 Tetraodon nigroviridis 68 0.0 771
WERAM-Pof-0049 ENSPFOP00000003730.2 Poecilia formosa 72 0.0 769
WERAM-Orn-0149 ENSONIP00000015594.1 Oreochromis niloticus 70 0.0 761
WERAM-Gaa-0042 ENSGACP00000006044.1 Gasterosteus aculeatus 69 0.0 755
WERAM-Gam-0056 ENSGMOP00000005486.1 Gadus morhua 66 0.0 697
WERAM-Vip-0050 ENSVPAP00000004441.1 Vicugna pacos 62 0.0 675
WERAM-Tas-0052 ENSTSYP00000004657.1 Tarsius syrichta 61 0.0 675
WERAM-Asm-0133 ENSAMXP00000012915.1 Astyanax mexicanus 60 0.0 666
WERAM-Ora-0072 ENSOANP00000010690.2 Ornithorhynchus anatinus 59 0.0 665
WERAM-Ocp-0139 ENSOPRP00000014469.2 Ochotona princeps 62 0.0 657
WERAM-Ect-0092 ENSETEP00000010853.1 Echinops telfairi 62 0.0 655
WERAM-Tub-0076 ENSTBEP00000009310.1 Tupaia belangeri 59 0.0 635
WERAM-Prc-0031 ENSPCAP00000002422.1 Procavia capensis 60 2e-169 593
WERAM-Soa-0019 ENSSARP00000001963.1 Sorex araneus 69 8e-165 578
WERAM-Dio-0117 ENSDORP00000011462.1 Dipodomys ordii 90 4e-164 576
WERAM-Mim-0021 ENSMICP00000002262.1 Microcebus murinus 61 3e-160 563
WERAM-Chh-0117 ENSCHOP00000012308.1 Choloepus hoffmanni 97 1e-154 544
WERAM-Cii-0023 ENSCINP00000009171.2 Ciona intestinalis 51 3e-151 533
WERAM-Cis-0030 ENSCSAVP00000006409.1 Ciona savignyi 50 5e-147 519
WERAM-Drm-0055 FBpp0072431 Drosophila melanogaster 45 3e-140 496
WERAM-Ere-0108 ENSEEUP00000011601.1 Erinaceus europaeus 87 6e-117 419
WERAM-Miv-0018 MVLG_02627T0 Microbotryum violaceum 31 2e-57 221
WERAM-Crn-0022 AAW44024 Cryptococcus neoformans 29 3e-55 214
Created Date 25-Jun-2016