WERAM Information

Tag Content
WERAM ID WERAM-Mum-0060
Ensembl Protein ID ENSMUSP00000025444.6
Uniprot Accession Q9CWW7; CXXC1_MOUSE
Genbank Protein ID NP_083144.1
Protein Name CXXC-type zinc finger protein 1
Genbank Nucleotide ID NM_028868.3
Gene Name CXXC1;Cgbp;Pccx1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024560.6 ENSMUST00000025444.6 ENSMUSP00000025444.6
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 23201125
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 6.70e-12 46.9 28 75
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
Domain Profile
  Me_Reader PHD
               PHD.txt  3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52
                          +C+ C+k+d +  +m+ Cd+C++wfH++C+ ++++ +++ ++wyC++C+e
  ENSMUSP00000025444.6 28 YCI-CRKPDINC-FMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECRE 75
                          8*9.******95.6*******************666665589******98 PP
Protein Sequence
(Fasta)		MEGDGSDLEP PDAGDDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF HGDCIRITEK 60
MAKAIREWYC RECREKDPKL EIRYRHKKCR ERDGSERAGS EPRDEGGGRK RPASDPELQR 120
RAGSGTGVGA MLARGSASPH KSSPQPLVAT PSQHHHQQQQ QQQQQIKRSA RMCGECEACR 180
RTEDCGHCDF CRDMKKFGGP NKIRQKCRLR QCQLRARESY KYFPSSLSPV TPSEALPRPR 240
RPPPTQQQPQ QSQKLGRIRE DEGTVLSSVV KEPPEATATP EPLSDEDLAL DPDLYQDFCA 300
GAFDDHGLPW MSDAEESPFL DPALRKRAVK VKHVKRREKK SEKKKEERYK RHRQKQKHKD 360
KWKHPERADA KDPASLPQCL GPGCVRAAQP GSKYCSDDCG MKLAANRIYE ILPQRIQQWQ 420
QSPCIAEEHG KKLLERIRRE QQSARTRLQE MERRFHELEA IILRAKQQAV REDEENNEND 480
SDDTDLQIFC VSCGHPINPR VALRHMERCY AKYESQTSFG SMYPTRIEGA TRLFCDVYNP 540
QSKTYCKRLQ VLCPEHSRDP KVPADEVCGC PLVRDVFELT GDFCRLPKRQ CNRHYCWEKL 600
RRAEVDLERV RVWYKLDELF EQERNVRTAM TNRAGLLALM LHQTIQHDPL TTDLRSSADR 660
Nucleotide Sequence
(Fasta)		GGACTTGGCT GACAAGGTGG CGGCGCGCTC GGAGGACCTG AACTGTAGGC GCGGCCATGC 60
TTCCCGGAAC GTATGGTCTC CGCTGTCTTA CGGACTCGAT GGTCAAGATG GCGGCGACAG 120
AGAGACCTTC GCGGCTCTAG GTGGGAGACC TATTTGTTTG CCGCTAAAGC CGTCGCGCCG 180
GGCGTGAGGA GTTAAAGAGT GCGGGGCCGC GGAGGCGGGA CCAGTGGCGG AAGTAGTTGC 240
GGGCGCCTTT GCGGGCGCCT TTGCTCCCGC CGCGGACGCT GCCGGGGAGC TCGTTCGGCT 300
TCGCGGGTTG TTGCACGGGG TCCAGAGCGG GCGCTCTGTG AGCGGAGATA TGGAAGGAGA 360
TGGCTCAGAC CTGGAACCTC CGGATGCCGG GGACGACAGC AAGTCTGAGA ATGGGGAGAA 420
CGCTCCCATC TACTGCATCT GTCGCAAACC GGACATCAAT TGCTTCATGA TTGGATGTGA 480
CAACTGCAAC GAGTGGTTCC ATGGAGACTG CATCCGGATC ACTGAGAAGA TGGCCAAGGC 540
CATCCGGGAA TGGTACTGTC GGGAGTGCCG AGAGAAGGAC CCGAAGCTGG AGATTCGTTA 600
CCGCCACAAA AAGTGCCGGG AGAGGGATGG CAGTGAGCGG GCCGGCAGTG AGCCCCGGGA 660
TGAGGGAGGA GGGCGCAAGA GGCCGGCTTC AGATCCAGAG CTGCAGCGCC GGGCAGGGTC 720
AGGGACAGGG GTTGGGGCCA TGCTTGCTCG GGGCTCTGCT TCCCCCCACA AATCTTCTCC 780
ACAGCCCTTG GTGGCCACAC CTAGCCAGCA CCACCACCAA CAGCAGCAGC AGCAGCAGCA 840
GCAAATCAAA CGATCAGCTC GGATGTGTGG TGAGTGCGAG GCCTGCCGAC GCACTGAGGA 900
CTGTGGCCAC TGTGACTTCT GCCGTGACAT GAAGAAGTTT GGGGGCCCCA ACAAGATCCG 960
GCAGAAGTGC CGGCTTCGTC AGTGTCAGCT GCGGGCACGG GAATCGTACA AGTACTTCCC 1020
TTCCTCGCTC TCGCCGGTGA CACCCTCAGA GGCCCTGCCA AGGCCCCGCC GGCCACCACC 1080
CACTCAACAG CAGCCACAGC AGTCCCAGAA GCTGGGGCGT ATTCGTGAAG ATGAGGGGAC 1140
AGTGTTGTCA TCAGTGGTTA AGGAGCCACC AGAGGCTACA GCAACACCTG AGCCACTTTC 1200
AGATGAGGAC CTAGCACTGG ACCCCGATCT GTACCAGGAC TTCTGTGCTG GGGCCTTTGA 1260
TGATCACGGC CTACCCTGGA TGAGCGATGC AGAAGAGTCC CCGTTCCTGG ATCCTGCACT 1320
GAGGAAGCGG GCGGTGAAGG TGAAGCACGT GAAGCGCCGG GAGAAGAAGT CCGAGAAGAA 1380
GAAGGAGGAG AGGTACAAAC GGCATCGACA GAAGCAGAAA CATAAAGACA AATGGAAACA 1440
CCCAGAGAGG GCTGATGCCA AGGACCCTGC ATCTCTCCCG CAGTGCCTGG GGCCTGGCTG 1500
TGTGCGGGCT GCCCAGCCTG GGTCCAAGTA TTGTTCAGAT GACTGTGGCA TGAAGCTGGC 1560
AGCCAACCGA ATCTATGAGA TCCTCCCCCA GCGCATCCAG CAGTGGCAGC AAAGCCCCTG 1620
CATCGCTGAA GAGCACGGCA AGAAGCTACT TGAGCGGATC CGCCGTGAGC AGCAGAGCGC 1680
CCGCACCCGC CTTCAGGAAA TGGAGCGCAG ATTCCACGAG CTTGAGGCCA TCATTCTTCG 1740
CGCTAAGCAG CAAGCTGTGC GAGAGGATGA GGAGAACAAC GAGAACGACA GTGATGACAC 1800
AGATCTGCAG ATCTTCTGCG TCTCCTGCGG GCATCCCATC AACCCACGAG TTGCCTTGCG 1860
TCACATGGAA CGTTGCTATG CTAAGTATGA GAGCCAGACG TCTTTTGGGT CCATGTACCC 1920
CACACGCATC GAGGGGGCTA CCCGACTCTT CTGTGATGTC TACAATCCTC AGAGCAAGAC 1980
ATATTGTAAG CGGCTCCAGG TGCTGTGTCC TGAGCACTCC CGGGACCCCA AAGTGCCAGC 2040
TGATGAGGTC TGTGGGTGTC CACTTGTACG TGATGTCTTT GAGCTCACAG GTGACTTCTG 2100
CCGCCTGCCC AAGCGCCAGT GTAATCGCCA TTATTGCTGG GAGAAGCTTC GGCGTGCAGA 2160
AGTGGACTTG GAGCGCGTGC GGGTGTGGTA CAAGCTGGAC GAGCTCTTTG AGCAGGAACG 2220
TAATGTACGC ACAGCCATGA CCAACAGAGC AGGGCTACTT GCCCTGATGC TTCACCAAAC 2280
GATCCAACAC GATCCACTCA CTACCGACCT TCGCTCTAGT GCCGACCGCT GACTTCACCA 2340
GCCCAGAGCC TCTCGGCCCT GCATTCAGTT AGGGGAGAGG CCCTGCATTG CCAGCTGTCC 2400
GTTCCTCCAT TCATCTGTTT CTTCTGCTGC CCTTAGTTTG ATCCTCACCA TCCACGTTTT 2460
GGCTTCCGTT TGCCCTTATC AAAGGGTCTC TGCTTTCCCT TTGTCACCGT CTGTCTCCTC 2520
TTTCCATAGT CAGGGCTGGG GTGAGACTCA AACTTACTCA TCCTTGCCTA TACCCACCCC 2580
CCAAAAACAG GTTTTATTAA TAAAAAATGT GAAGAACC 2619
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR022056--CpG-bd_C
IPR019786--Zinc_finger_PHD-type_CS
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
PF12269--zf-CpG_bind_C
PF02008--zf-CXXC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035097--C:histone methyltransferase complex
GO:0016363--C:nuclear matrix
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0051568--P:histone H3-K4 methylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0096 ENSRNOP00000020472.4 Rattus norvegicus 99 0.0 1085
WERAM-Ict-0206 ENSSTOP00000021043.1 Ictidomys tridecemlineatus 96 0.0 1069
WERAM-Mup-0092 ENSMPUP00000008761.1 Mustela putorius furo 96 0.0 1068
WERAM-Chs-0213 ENSCSAP00000014093.1 Chlorocebus sabaeus 96 0.0 1067
WERAM-Mam-0075 ENSMMUP00000011869.2 Macaca mulatta 96 0.0 1067
WERAM-Caf-0194 ENSCAFP00000027880.3 Canis familiaris 96 0.0 1066
WERAM-Hos-0165 ENSP00000285106.6 Homo sapiens 96 0.0 1065
WERAM-Orc-0197 ENSOCUP00000023194.2 Oryctolagus cuniculus 96 0.0 1065
WERAM-Eqc-0138 ENSECAP00000015570.1 Equus caballus 96 0.0 1065
WERAM-Gog-0192 ENSGGOP00000016570.2 Gorilla gorilla 95 0.0 1063
WERAM-Otg-0225 ENSOGAP00000021460.1 Otolemur garnettii 96 0.0 1063
WERAM-Fec-0065 ENSFCAP00000005703.2 Felis catus 96 0.0 1063
WERAM-Pat-0083 ENSPTRP00000017038.5 Pan troglodytes 93 0.0 1060
WERAM-Paa-0069 ENSPANP00000000581.1 Papio anubis 93 0.0 1060
WERAM-Nol-0124 ENSNLEP00000014342.1 Nomascus leucogenys 93 0.0 1059
WERAM-Sus-0030 ENSSSCP00000004872.2 Sus scrofa 96 0.0 1057
WERAM-Aim-0004 ENSAMEP00000000290.1 Ailuropoda melanoleuca 94 0.0 1056
WERAM-Bot-0188 ENSBTAP00000029172.3 Bos taurus 95 0.0 1056
WERAM-Tut-0175 ENSTTRP00000014718.1 Tursiops truncatus 95 0.0 1054
WERAM-Caj-0058 ENSCJAP00000052060.1 Callithrix jacchus 91 0.0 1046
WERAM-Myl-0201 ENSMLUP00000021844.1 Myotis lucifugus 95 0.0 1042
WERAM-Ova-0034 ENSOARP00000004613.1 Ovis aries 88 0.0 954
WERAM-Mae-0018 ENSMEUP00000001345.1 Macropus eugenii 80 0.0 878
WERAM-Sah-0038 ENSSHAP00000004511.1 Sarcophilus harrisii 79 0.0 850
WERAM-Mod-0085 ENSMODP00000013227.2 Monodelphis domestica 78 0.0 840
WERAM-Ora-0117 ENSOANP00000022988.1 Ornithorhynchus anatinus 79 0.0 835
WERAM-Anc-0059 ENSACAP00000005932.2 Anolis carolinensis 73 0.0 820
WERAM-Ptv-0169 ENSPVAP00000014716.1 Pteropus vampyrus 94 0.0 776
WERAM-Xet-0139 ENSXETP00000047467.2 Xenopus tropicalis 68 0.0 744
WERAM-Lac-0009 ENSLACP00000001551.1 Latimeria chalumnae 68 0.0 743
WERAM-Ten-0091 ENSTNIP00000010129.1 Tetraodon nigroviridis 61 0.0 689
WERAM-Asm-0177 ENSAMXP00000017441.1 Astyanax mexicanus 61 0.0 674
WERAM-Dar-0215 ENSDARP00000132286.1 Danio rerio 61 0.0 657
WERAM-Orn-0238 ENSONIP00000025567.1 Oreochromis niloticus 62 0.0 650
WERAM-Orla-0152 ENSORLP00000017766.1 Oryzias latipes 57 3e-177 619
WERAM-Prc-0020 ENSPCAP00000001625.1 Procavia capensis 86 6e-165 578
WERAM-Loa-0215 ENSLAFP00000022842.1 Loxodonta africana 88 2e-164 577
WERAM-Leo-0152 ENSLOCP00000018078.1 Lepisosteus oculatus 84 2e-153 540
WERAM-Xim-0066 ENSXMAP00000005658.1 Xiphophorus maculatus 86 8e-147 518
WERAM-Pof-0085 ENSPFOP00000007727.2 Poecilia formosa 86 2e-146 516
WERAM-Gaa-0126 ENSGACP00000016061.1 Gasterosteus aculeatus 76 1e-145 514
WERAM-Gam-0026 ENSGMOP00000002893.1 Gadus morhua 73 7e-143 505
WERAM-Tar-0155 ENSTRUP00000033845.1 Takifugu rubripes 84 3e-141 499
WERAM-Dio-0004 ENSDORP00000000837.1 Dipodomys ordii 100 2e-140 497
WERAM-Tub-0096 ENSTBEP00000011303.1 Tupaia belangeri 83 9e-118 421
WERAM-Cis-0022 ENSCSAVP00000004511.1 Ciona savignyi 54 1e-88 325
WERAM-Drm-0036 FBpp0071262 Drosophila melanogaster 51 2e-84 310
WERAM-Scj-0009 EEB06282 Schizosaccharomyces japonicus 40 2e-11 68.9
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 37 5e-11 67.0
WERAM-Scp-0047 SPCC594.05c.1:pep Schizosaccharomyces pombe 41 9e-11 66.2
WERAM-Spr-0013 CBQ68026 Sporisorium reilianum 41 2e-10 65.5
WERAM-Tag-0055 ENSTGUP00000003831.1 Taeniopygia guttata 29 4e-10 64.3
WERAM-Caa-0003 KGT72513 Candida albicans 44 7e-10 63.5
WERAM-Crn-0026 AAW44599 Cryptococcus neoformans 33 7e-10 63.5
WERAM-Phn-0028 SNOT_14703 Phaeosphaeria nodorum 46 1e-09 62.4
WERAM-Fia-0091 ENSFALP00000007322.1 Ficedula albicollis 28 1e-09 62.4
WERAM-Asni-0006 CADANGAP00002236 Aspergillus niger 49 2e-09 62.4
WERAM-Kll-0016 CAH00481 Kluyveromyces lactis 47 2e-09 62.4
WERAM-Yal-0012 CAG81489 Yarrowia lipolytica 40 2e-09 62.0
WERAM-Asf-0010 CADAFLAP00002425 Aspergillus flavus 49 2e-09 62.0
WERAM-Mim-0056 ENSMICP00000005678.1 Microcebus murinus 47 2e-09 62.0
WERAM-Chg-0026 EAQ89690 Chaetomium globosum 39 2e-09 61.6
WERAM-Map-0007 MAPG_02504T0 Magnaporthe poae 35 2e-09 61.6
WERAM-Cap-0052 ENSCPOP00000004396.2 Cavia porcellus 40 3e-09 61.6
WERAM-Gaga-0056 ENSGALP00000008273.4 Gallus gallus 34 3e-09 61.6
WERAM-Asg-0005 AAS51341 Ashbya gossypii 40 3e-09 61.6
WERAM-Cii-0050 ENSCINP00000019842.3 Ciona intestinalis 42 3e-09 61.2
WERAM-Poa-0094 ENSPPYP00000012535.2 Pongo abelii 47 3e-09 61.2
WERAM-Meg-0066 ENSMGAP00000006074.2 Meleagris gallopavo 47 3e-09 61.2
WERAM-Pyt-0009 EFQ93938 Pyrenophora teres 37 3e-09 61.2
WERAM-Vip-0022 ENSVPAP00000002066.1 Vicugna pacos 45 5e-09 60.5
WERAM-Ect-0020 ENSETEP00000001250.1 Echinops telfairi 45 6e-09 60.5
WERAM-Chh-0058 ENSCHOP00000006628.1 Choloepus hoffmanni 43 8e-09 60.1
WERAM-Anp-0046 ENSAPLP00000005022.1 Anas platyrhynchos 47 8e-09 60.1
WERAM-Tas-0113 ENSTSYP00000011554.1 Tarsius syrichta 45 9e-09 59.7
WERAM-Dan-0127 ENSDNOP00000023585.1 Dasypus novemcinctus 45 1e-08 59.7
WERAM-Cag-0032 CAG62435 Candida glabrata 38 1e-08 59.7
WERAM-Coi-0019 EAS32695 Coccidioides immitis 47 1e-08 59.3
WERAM-Pytr-0001 EDU39597 Pyrenophora triticirepentis 39 1e-08 59.3
WERAM-Pes-0034 ENSPSIP00000005572.1 Pelodiscus sinensis 43 2e-08 58.9
WERAM-Sac-0049 YPL138C Saccharomyces cerevisiae 37 2e-08 58.5
Created Date 25-Jun-2016