WERAM Information

Tag Content
WERAM ID WERAM-Mum-0032
Ensembl Protein ID ENSMUSP00000020991.8
Uniprot Accession O88508; DNM3A_MOUSE; Q3TZK8; Q3UH24; Q8CJ60; Q922J0; Q9CSE1
Genbank Protein ID NP_001258682.1; NP_031898.1; NP_714965.1; XP_006515016.1; XP_006515017.1; XP_006515018.1; XP_006515019.1; XP_011242111.1; XP_011242112.1
Protein Name DNA (cytosine-5)-methyltransferase 3A
Genbank Nucleotide ID NM_001271753.1; NM_007872.4; NM_153743.4; XM_006514953.2; XM_006514954.2; XM_006514955.2; XM_006514956.2; XM_011243809.1; XM_011243810.1
Gene Name DNM3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020661.15 ENSMUST00000020991.14 ENSMUSP00000020991.8
ENSMUSG00000020661.15 ENSMUST00000111186.7 ENSMUSP00000106817.1
ENSMUSG00000020661.15 ENSMUST00000172689.7 ENSMUSP00000133543.1
ENSMUSG00000020661.15 ENSMUST00000172509.7 ENSMUSP00000133869.1
ENSMUSG00000020661.15 ENSMUST00000174817.7 ENSMUSP00000134009.1
ENSMUSG00000020661.15 ENSMUST00000174774.7 ENSMUSP00000134529.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader ADD ADD H3K4; H3K9 K 20547484
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader ADD 3.80e-61 206.5 478 610
Me_Reader PWWP 5.50e-17 63.1 288 345
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Domain Profile
  Me_Reader ADD
               ADD.txt   1 evkrnednlediciacGkkdsilrhPlleggicknckdkfleaaisydddGyqsycticaeGrelllcgndsctrafcvecvdrlvGrg 89 
                           ev+++++n+edici+cG+++++l+hPl+ gg+c+nck++fle+a++ydddGyqsyctic++Gre+l+cgn++c+r+fcvecvd lvG+g
  ENSMUSP00000020991.8 478 EVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPG 566
                           79*************************************************************************************** PP
               ADD.txt  90 eaekikkeenWvcylclpesllgllrrrkdvkerleqllqqnkd 133
                           +a++++ke++W+cy+c ++ ++gllrrr+d+ +rl++++++n+d
  ENSMUSP00000020991.8 567 AAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHD 610
                           *****************************************986 PP
  Me_Reader PWWP
              PWWP.txt   1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpyse 63 
                           +g+LVw+Kl+g++wWP++++s+++++++     a e++++V++Fg + ++++v+++kl+p+s+
  ENSMUSP00000020991.8 288 IGELVWGKLRGFSWWPGRIVSWWMTGRSR----AAEGTRWVMWFG-DGKFSVVCVEKLMPLSS 345
                           59***************************....************.**************986 PP
Protein Sequence
(Fasta)		MPSSGPGDTS SSSLEREDDR KEGEEQEENR GKEERQEPSA TARKVGRPGR KRKHPPVESS 60
DTPKDPAVTT KSQPMAQDSG PSDLLPNGDL EKRSEPQPEE GSPAAGQKGG APAEGEGTET 120
PPEASRAVEN GCCVTKEGRG ASAGEGKEQK QTNIESMKME GSRGRLRGGL GWESSLRQRP 180
MPRLTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NAVEENQASG ESQKVEEASP 240
PAVQQPTDPA SPTVATTPEP VGGDAGDKNA TKAADDEPEY EDGRGFGIGE LVWGKLRGFS 300
WWPGRIVSWW MTGRSRAAEG TRWVMWFGDG KFSVVCVEKL MPLSSFCSAF HQATYNKQPM 360
YRKAIYEVLQ VASSRAGKLF PACHDSDESD SGKAVEVQNK QMIEWALGGF QPSGPKGLEP 420
PEEEKNPYKE VYTDMWVEPE AAAYAPPPPA KKPRKSTTEK PKVKEIIDER TRERLVYEVR 480
QKCRNIEDIC ISCGSLNVTL EHPLFIGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR 540
EVLMCGNNNC CRCFCVECVD LLVGPGAAQA AIKEDPWNCY MCGHKGTYGL LRRREDWPSR 600
LQMFFANNHD QEFDPPKVYP PVPAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVDRYIASE 660
VCEDSITVGM VRHQGKIMYV GDVRSVTQKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY 720
EGTGRLFFEF YRLLHDARPK EGDDRPFFWL FENVVAMGVS DKRDISRFLE SNPVMIDAKE 780
VSAAHRARYF WGNLPGMNRP LASTVNDKLE LQECLEHGRI AKFSKVRTIT TRSNSIKQGK 840
DQHFPVFMNE KEDILWCTEM ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP 900
LKEYFACV 908
Nucleotide Sequence
(Fasta)		GGCGCGGGCG GCGGCGCGAG CAGAGGACGA GCCGGGACGC GGCGCCGCGG CAGCAGGGCG 60
AGCCGGGCCG CCCGACCCGC CGGGCCACAC GGCAGAGCCG CCTGAAGCCC AGCGCTGAGG 120
CTGCACTTTT CCGAGGGCTT GACATCAGGG TCTATGTTTA AGTCTTAGCT CTTGCTTACA 180
AAGACCACGG CAATTCCTTC TCTGAAGCCC TCGCAGCCCC ACAGCGCCCT CGCAGCCCCA 240
GCCTGCCGCC TACTGCCCAG CAATGCCCTC CAGCGGCCCC GGGGACACCA GCAGCTCCTC 300
TCTGGAGCGG GAGGATGATC GAAAGGAAGG AGAGGAACAG GAGGAGAACC GTGGCAAGGA 360
AGAGCGCCAG GAGCCCAGCG CCACGGCCCG GAAGGTGGGG AGGCCTGGCC GGAAGCGCAA 420
GCACCCACCG GTGGAAAGCA GTGACACCCC CAAGGACCCA GCAGTGACCA CCAAGTCTCA 480
GCCCATGGCC CAGGACTCTG GCCCCTCAGA TCTGCTACCC AATGGAGACT TGGAGAAGCG 540
GAGTGAACCC CAACCTGAGG AGGGGAGCCC AGCTGCAGGG CAGAAGGGTG GGGCCCCAGC 600
TGAAGGAGAG GGAACTGAGA CCCCACCAGA AGCCTCCAGA GCTGTGGAGA ATGGCTGCTG 660
TGTGACCAAG GAAGGCCGTG GAGCCTCTGC AGGAGAGGGC AAAGAACAGA AGCAGACCAA 720
CATCGAATCC ATGAAAATGG AGGGCTCCCG GGGCCGACTG CGAGGTGGCT TGGGCTGGGA 780
GTCCAGCCTC CGTCAGCGAC CCATGCCAAG ACTCACCTTC CAGGCAGGGG ACCCCTACTA 840
CATCAGCAAA CGGAAACGGG ATGAGTGGCT GGCACGTTGG AAAAGGGAGG CTGAGAAGAA 900
AGCCAAGGTA ATTGCAGTAA TGAATGCTGT GGAAGAGAAC CAGGCCTCTG GAGAGTCTCA 960
GAAGGTGGAG GAGGCCAGCC CTCCTGCTGT GCAGCAGCCC ACGGACCCTG CTTCTCCGAC 1020
TGTGGCCACC ACCCCTGAGC CAGTAGGAGG GGATGCTGGG GACAAGAATG CTACCAAAGC 1080
AGCCGACGAT GAGCCTGAGT ATGAGGATGG CCGGGGCTTT GGCATTGGAG AGCTGGTGTG 1140
GGGGAAACTT CGGGGCTTCT CCTGGTGGCC AGGCCGAATT GTGTCTTGGT GGATGACAGG 1200
CCGGAGCCGA GCAGCTGAAG GCACTCGCTG GGTCATGTGG TTCGGAGATG GCAAGTTCTC 1260
AGTGGTGTGT GTGGAGAAGC TCATGCCGCT GAGCTCCTTC TGCAGTGCAT TCCACCAGGC 1320
CACCTACAAC AAGCAGCCCA TGTACCGCAA AGCCATCTAC GAAGTCCTCC AGGTGGCCAG 1380
CAGCCGTGCC GGGAAGCTGT TTCCAGCTTG CCATGACAGT GATGAAAGTG ACAGTGGCAA 1440
GGCTGTGGAA GTGCAGAACA AGCAGATGAT TGAATGGGCC CTCGGTGGCT TCCAGCCCTC 1500
GGGTCCTAAG GGCCTGGAGC CACCAGAAGA AGAGAAGAAT CCTTACAAGG AAGTTTACAC 1560
CGACATGTGG GTGGAGCCTG AAGCAGCTGC TTACGCCCCA CCCCCACCAG CCAAGAAACC 1620
CAGAAAGAGC ACAACAGAGA AACCTAAGGT CAAGGAGATC ATTGATGAGC GCACAAGGGA 1680
GCGGCTGGTG TATGAGGTGC GCCAGAAGTG CAGAAACATC GAGGACATTT GTATCTCATG 1740
TGGGAGCCTC AATGTCACCC TGGAGCACCC ACTCTTCATT GGAGGCATGT GCCAGAACTG 1800
TAAGAACTGC TTCTTGGAGT GTGCTTACCA GTATGACGAC GATGGGTACC AGTCCTATTG 1860
CACCATCTGC TGTGGGGGGC GTGAAGTGCT CATGTGTGGG AACAACAACT GCTGCAGGTG 1920
CTTTTGTGTC GAGTGTGTGG ATCTCTTGGT GGGGCCAGGA GCTGCTCAGG CAGCCATTAA 1980
GGAAGACCCC TGGAACTGCT ACATGTGCGG GCATAAGGGC ACCTATGGGC TGCTGCGAAG 2040
ACGGGAAGAC TGGCCTTCTC GACTCCAGAT GTTCTTTGCC AATAACCATG ACCAGGAATT 2100
TGACCCCCCA AAGGTTTACC CACCTGTGCC AGCTGAGAAG AGGAAGCCCA TCCGCGTGCT 2160
GTCTCTCTTT GATGGGATTG CTACAGGGCT CCTGGTGCTG AAGGACCTGG GCATCCAAGT 2220
GGACCGCTAC ATTGCCTCCG AGGTGTGTGA GGACTCCATC ACGGTGGGCA TGGTGCGGCA 2280
CCAGGGAAAG ATCATGTACG TCGGGGACGT CCGCAGCGTC ACACAGAAGC ATATCCAGGA 2340
GTGGGGCCCA TTCGACCTGG TGATTGGAGG CAGTCCCTGC AATGACCTCT CCATTGTCAA 2400
CCCTGCCCGC AAGGGACTTT ATGAGGGTAC TGGCCGCCTC TTCTTTGAGT TCTACCGCCT 2460
CCTGCATGAT GCGCGGCCCA AGGAGGGAGA TGATCGCCCC TTCTTCTGGC TCTTTGAGAA 2520
TGTGGTGGCC ATGGGCGTTA GTGACAAGAG GGACATCTCG CGATTTCTTG AGTCTAACCC 2580
CGTGATGATT GACGCCAAAG AAGTGTCTGC TGCACACAGG GCCCGTTACT TCTGGGGTAA 2640
CCTTCCTGGC ATGAACAGGC CTTTGGCATC CACTGTGAAT GATAAGCTGG AGCTGCAAGA 2700
GTGTCTGGAG CACGGCAGAA TAGCCAAGTT CAGCAAAGTG AGGACCATTA CCACCAGGTC 2760
AAACTCTATA AAGCAGGGCA AAGACCAGCA TTTCCCCGTC TTCATGAACG AGAAGGAGGA 2820
CATCCTGTGG TGCACTGAAA TGGAAAGGGT GTTTGGCTTC CCCGTCCACT ACACAGACGT 2880
CTCCAACATG AGCCGCTTGG CGAGGCAGAG ACTGCTGGGC CGATCGTGGA GCGTGCCGGT 2940
CATCCGCCAC CTCTTCGCTC CGCTGAAGGA ATATTTTGCT TGTGTGTAAG GGACATGGGG 3000
GCAAACTGAA GTAGTGATGA TAAAAAAGTT AAACAAACAA ACAAACAAAA AACAAAACAA 3060
AACAATAAAA CACCAAGAAC GAGAGGACGG AGAAAAGTTC AGCACCCAGA AGAGAAAAAG 3120
GAATTTAAAG CAAACCACAG AGGAGGAAAA CGCCGGAGGG CTTGGCCTTG CAAAAGGGTT 3180
GGACATCATC TCCTGAGTTT TCAATGTTAA CCTTCAGTCC TATCTAAAAA GCAAAATAGG 3240
CCCCTCCCCT TCTTCCCCTC CGGTCCTAGG AGGCGAACTT TTTGTTTTCT ACTCTTTTTC 3300
AGAGGGGTTT TCTGTTTGTT TGGGTTTTTG TTTCTTGCTG TGACTGAAAC AAGAGAGTTA 3360
TTGCAGCAAA ATCAGTAACA ACAAAAAGTA GAAATGCCTT GGAGAGGAAA GGGAGAGAGG 3420
GAAAATTCTA TAAAAACTTA AAATATTGGT TTTTTTTTTT TTCCTTTTCT ATATATCTCT 3480
TTGGTTGTCT CTAGCCTGAT CAGATAGGAG CACAAACAGG AAGAGAATAG AGACCCTCGG 3540
AGGCAGAGTC TCCTCTCCCA CCCCCCGAGC AGTCTCAACA GCACCATTCC TGGTCATGCA 3600
AAACAGAACC CAACTAGCAG CAGGGCGCTG AGAGAACACC ACACCAGACA CTTTTCTACA 3660
GTATTTCAGG TGCCTACCAC ACAGGAAACC TTGAAGAAAA CCAGTTTCTA GAAGCCGCTG 3720
TTACCTCTTG TTTACAGTTT ATATATATAT GATAGATATG AGATATATAT ATATAAAAGG 3780
TACTGTTAAC TACTGTACAT CCCGACTTCA TAATGGTGCT TTCAAAACAG CGAGATGAGC 3840
AAAGACATCA GCTTCCGCCT GGCCCTCTGT GCAAAGGGTT TCAGCCCAGG ATGGGGAGAG 3900
GGGAGCAGCT GGAGGGGGTT TTAACAAACT GAAGGATGAC CCATATCACC CCCCACCCCT 3960
GCCCCATGCC TAGCTTCACC TGCCAAAAAG GGGCTCAGCT GAGGTGGTCG GACCCTGGGG 4020
AAGCTGAGTG TGGAATTTAT CCAGACTCGC GTGCAATAAC CTTAGAATAT GAATCTAAAA 4080
TGACTGCCTC AGAAAAATGG CTTGAGAAAA CATTGTCCCT GATTTTGAAT TCGTCAGCCA 4140
CGTTGAAGGC CCCTTGTGGG ATCAGAAATA TTCCAGAGTG AGGGAAAGTG ACCCGCCATT 4200
AACCCCACCT GGAGCAAATA AAAAAACATA CAAAATGTAC TGGTGCTTTC TGTCTAAGTT 4260
GCCTTTTGTG TGTTCTTTTA TAAGGCCCCA CCATCCCCTC TGCACATGGC AGCTCCGGTC 4320
CTGGAATGTG ATGTTTTTGG TCATCTCTAA AGACTGCAGT TTCATACTTG GGAGGCTGAT 4380
GACACCTTTA TTATAATTAT TCTTATGGTT CTGGCTATAA TTGTTTTAAG ATTTTCTTTC 4440
AGAAAACAAA AACCCAACAC CCTTCCCTTT AGGTTTCAAA CCAAGGTGCG GGGGGGTGGC 4500
AGGTGCTTTT TTAAGGACCA GTGGCTCTGG TGCCCTGGCT CCCACCCCTC AGGCCAGGTG 4560
AGCCACTGGG CAACAAGCTA GGCAGCCAGG GAGTTTGAGG CCCACCCTCC GGGCCAGTCA 4620
CTCTTCTCTT CTTCTTCCCT TCCTCGTGAG TCCGGTGTGT CAGGGCTGGA GGGAGGCCGG 4680
GGCAGCCTCC CTCCTTGTGT GTGTGGTTGG AGTGGCGTGT GTTTCTTTTC TAGTGTTTGC 4740
TCTGATGGCT GTGCTCTCAC TTGAGTCAGC TTCACCTGGG CCATGTGCTC GCACTTTGTT 4800
CCGCTCCCCA GCCAGGGCAG GCAGCCTGGC ATTGGCAGCG GGAAGGGAAG GTGTGCTTGG 4860
CCCCAGGGTG AGGGCTTGCC TGGATGGATG GAGTGTAGAT ATGTGGCATA TAGAGATATA 4920
TATTTTATAA TGGGAGGGGG GACGGCACCT CCTGGGACCA GCAGAGACTG GGAGGTGTGC 4980
TGTCAAGCAC ATGGTCCCAA GACCGCATCC CTAGAAAGAT GGGGCCTATG ATAGGCCCTA 5040
TATAAATACA TAGATAGGGT CATGTATAAG AAATATACAC AGAGGGGGTT GGAGGGAGTG 5100
GGCTCTGTGT TGAGCCTGGG TCCTTCCCGC AGACAGCCCC ACAAACAGTA TATCAGTCTA 5160
ACACATGCAC AGGAATCTAT TTCTGTCTGG ATGCACACCA GGGAGCCCCC AGCACACTTC 5220
TCTGCAGGAT CAGGACGATG GAGTCGGCTA CACAGCTCTC TCTCGTACAT CTGTTGCCCT 5280
GATGACAGGT AGACTCGATC CCAGAAGTTG CTAGGTGCTG AAGTCAGGAA AAGGAGGAGG 5340
TTTGATCCAA GCAGGTGCTT CCTCTAGCAG GTCTGTGTTG TATTCCCTTT GCCTCTGGTG 5400
ATGTCAGCTT CTGTTAGCAG CCTGTGGTTA CTGACCTGCA ACTCTCGGCA CCAGTCAAGT 5460
CAGCCCTCAG CCCCTACCTA TTCTCCCCAA CCAAAGTCGA ACTGAAATCT CTCTTGGCCA 5520
TGGGGCTTCC ATTGGGAAAA TAAAATGTTA AAAAAAAAAT TAAAATGGGA CAGTGAACCT 5580
CACTTTTGGA GTAAAGCAAA TCAGTAATTA GTGCTAAAAC TAGTCAGAGG CTTTGGCCCC 5640
TTGCTCACTG CTCGGGACTA AGCTTGGCTG GTGGCTTGGT ACACTGCTTG GGCTGTGTAG 5700
TCCTGCCCAC CTCTGCTCAT TTTCTCTGGA TAGAGTTTTA AGATCGCAGC TAGTTTCCCC 5760
TGCCATGGCA GGTATGACTA TGGGGCTGGA GCATCCAGGA GAGGGGGATG CTTGCCCTCT 5820
TGGAGTCCCT GTACTAAATG TAACGTCCTC CCTTGCTCCA GCAGGGCTCC ATTCTGACCT 5880
GGAGTCCACC AGCACCATGC AGGAGGACTG GAGGGGAGGA AGGCTGCTTT AGGCAGTCCA 5940
AGGTGCTCCC TCCCCCTCTA GCAATGGCAA GGTCTTCCCA GCTCCTGTCA GGACTGTCTT 6000
CAAAGGCCAT CTCTGCCCAC CGCATATGTG ACGAAGCTAG CCTTTCCCAG GAGCCTAGTG 6060
CCGCCTCAGC TGGGCCTGGT GCTCCCGTGC CTGGGGTTAG TGTGAGGGCT CAGGAGGAGG 6120
AGTTCCCAAG GGACTGAGTA GAGGCTTCCA GGTGGCTGAC CAGTACTGAC CTGACACGGT 6180
CCCTGATGGA CTCCTCATGG GGCGGGCATC GGGTGGCCTT CTCTAGCTTT CCTTCCAGCC 6240
CCATCTGTAG GCTTAGTCTT ACCATAGTGT GAGGGCACCA GGCGAGTTAG CCCCCAATAT 6300
CTTTTGGGGA GGGGTGTCTT TGGGACTGTG CCAATCTGGC TATTCATCCG TCTCTACCCC 6360
AAGTGCGGCT TCTAGGGTCA CCTCTGAGGA GAGCTGCTGG GATGCTGGGG TAGCTGAGGG 6420
GAGGTTGTGG GGAGTTTGCA GTGCATCTAG GAACTAGCTC ACTGCAGGTG GGGCTGAAGC 6480
TGGATTCAGT CATGGGAGGT TCCCTGTGGG CTTTCCTTTC CAAAGACTAG GCTTGTTTTC 6540
CCTAGAAACT AAGGTGCTGG GGACTGGGTG ACAGCCACCT CTCAGCAGGT GCCGTGTAAG 6600
TGTGAAGATT TGTGAAGATC TGTGGCCCTT GCCCAGGGGA GGTAGCTGGT GCTAGCACCA 6660
GGGTCACAGA ACTAAGGCCT CCTGAGGAGG CACACATACC AGCGGGGTCC CAAGCTGGTG 6720
CTAATTCCTC TCATAGGACC CAGTAAGCCC GGGAGCCTGC AGTCGGCTGT TTCTCTGCTG 6780
TGGAATACCC TGTTAGAAAG CTGAGGTCCC CTAAAGAGCC TCCTGGACCG AGTCACTTTT 6840
GTGGCCGGGC TGAGTATGGC AGCAGGTAGA AAGATCCGCA GGCATAAAGA TCCCTGTGGC 6900
TTTTGGCAAA TGACTGAAGT GTGGATGCAG GAGCAATGAG TGGAGGCCAA CATCAACAGC 6960
ATCTACCCTC CCCAATAGTG TCTCTGTTCT GGGGGTGCTG TGGTCCTCAC TTGCTGGCTT 7020
AGGATTGGAG TTAGGCTGAG CCACTTTGAA GGAGTGTGTT TACAGGAAGA TACAAATTGT 7080
TGGTTTCTCT ATTCTTTACT GTACAGTGTG TCCAGAGAGT AGAAGAAAAT TCCTGGGCCT 7140
GTCTGGTTGG TGCAGAGCTT TTATGGCACT ACAAGGTCTT CAGGAACTGT CACTGTAAGA 7200
GCCCTGGCTG TGAGCTGGGG CTACGTGACC ACTGCAGCTG AGTTTCCAAG CAGGCCTGTG 7260
TTTGGATCTG AGTTTGACGC TTGGCGGCTC CCAGGGCTTG GGATGAGTGG CAGTGCTGAC 7320
TTGTTCACTT GGCAGAGCCA CCCTGTGAGG AGGTGGACTT AGTGGCCCTT TCCAATTGAT 7380
CCTGTCCCAT CCAGGCAGTA TCAGCACTAG GAGCAGTGCT GGGTCAGAAG TCCGAAGGAA 7440
AGGACTCGGT TGATCGGGGT CATTGTGAGC TTGTGTATGT TTGTGTAGAG AAAGCTGAAC 7500
TTTGGGAGGA AAGGCCTTGT CCTTGCAGGC TTCCAAGACA CCGCTAAGGT TAGCCTTTGG 7560
TTGGAGACAA GTCTCTAGCC CAGACACTGG AGTAGGCGCT GAGACCAAGA GGCAGGCCAA 7620
GATGGAGATC TATGGAAGGC CCTTTGCTGG TAGGGATTCA AAGCTTCTCC AGGGGACCCC 7680
AGAACTCTAT TAACTGGCTC CCCTACCGGG ACAAGCTTCG TTTGTGGGCT CATAGAGTGG 7740
CCATAGAGTG GGTTTAACCC AGCACCAAGC CTGAGGGCAT GAGCAGTGGT CTAAAGTCTC 7800
ACATAGTCCC ATTTTACAGA CTAATTTGAT TGCCCGGCCG TAGAATTCTA CAGAAACAAC 7860
AATCACTGAA ATTCCTTAGA ATACGCAGAG GGAGGAGGTG ACTCAACACG GTGCTAAACA 7920
CATTTTATTA AAAATATATA TTGTTAAATT AAGTCTGCTG TCTGGACAAT GATGTTCTGT 7980
TTTGTTTTCT TGTAGTGGAG TTTAAAAGAG ACTATTATTT TACTCTGATA TATTATTATT 8040
AAAAAGGCAT TTTAACTTTG TACTTGAAAA CTAAGTGAGC GATTTCACGT GTTTTAGCTG 8100
AGACATCGAA GTAGCGGGTG CTTACTTGTG GGAAATCATG TATTCATACT ACAACATAAA 8160
CTCCGTAGCT GATTTGGTAA TAACTTTTAC TGTTACAGAC GAATTCGCTT TGACCCCGGT 8220
GGCAGAGCGC TTTGACTCCA CATTCCACGC AGCTAAGTGC AGGACCTTCC AGAACCTTCC 8280
CCGGTCCCCC CTGGTCCTCT TTCGGTTCCT CTTCCTAGCT CTCTCTTTTC CTAATTCTTT 8340
TTTTTAAGAA TTGTCGTTTG TTTTTCCTGG TCCCGGCTTC CTTCTACCAC TGTATTTTTT 8400
GTTAGGGTTG CTTCTCTATT TATTGACAGT AATAATGTAC ATTTCACAGT CTGGTTCTGG 8460
GACAGCCAGG AGGGGTGTGG GGGGCTGCAT ACAGCTTGCT GCACTCTCCG GTGTCCTGTT 8520
GTATCTCTGT GTACGTGATG CTTGTGACAT AGCTGTTGAA GAAATATTAA AAGGTCAATG 8580
CGTACAGCAG GTGTAGAGAG TCCGTCAGTT CCGCTTCATC ACTTTTTTTT TTTTTTTTTG 8640
TGCCCAGAAG AATATAATAA AGCTCCTTTC TAATGTACTT GTGCTGGAGA ACACTTGAAT 8700
AAATGGACTG TTTTTGTGCA AAAAGAAAAA CGGAAAAAAA AAAAAAAGCA CCGTCATAAT 8760
GTCCTTTTGT CCTGCGACTC CTTTCCCCTG ATGTGGCCAC TCACAGTCCT CCAGTGGGCT 8820
GAAGTGGGTG CAGTTTACGT TGGGAGGGTC TGGGAAATGG ATTTCTAAAG TATCTCTCAT 8880
ATGGGTGTTA ACTAGGGGTT GGGACCCAAG GGCAGAGGGA GTTTGGTTCA AGATCAAAAA 8940
CAGGTTAGAC TAAGGTGAAG TTGTCTCGTT TACTTCCCAA ACCAGCAGAT TCTCGAGACC 9000
AGAGCAGGCA ACAGACTGGC ATCCTGGTTA GCTGGCAGTA GGACCAGCAG GGACTTATGG 9060
ATGCCAGAGT CCAGAAGGAA GAAGTCAGCA AAGGAGAGAG GCAGCTGGGG CTGGGGGAAT 9120
CCTGGAAGAA CCTTGCGTTT AAAGGAGATA TTTGCAAACA CTTGACAGGT GACCCAAGGG 9180
CTGGGATCAG TGGCCAATAG GGCTACTGCT GGTCTGAGCA TAGGCTGCCT GGCAGGGCCT 9240
TGCAGCCTGA GGAGTTGTCC ACCGTGTCTC TGCCATACCT ATCTAGAAGG GCCGTCTGTA 9300
TGCGGGGTCT GTCTGTCCTG CATATCTCCG GGAGTAGCCA GCAGGCTTGG CTGGGGTTCC 9360
ACTCCTAAGG ACTGTCCACC CGTTTCTTCC AGCAAACTTT CTGGACGGTT GGATAGGGAG 9420
AGACCGTGTG GCGGTCCTTG AGCAGACTGG GAAAGTTTGG CTAAACAGGT TTTCTCATGG 9480
GCACTTTTTC TTGCTTTTTC TTTGACAAGG TTGTAAATGT GTATTTGGCT TTTACTCTAC 9540
TTTTTTTCTT GATGTTTTTC AATGTTGATG TGGAATCTTA CTTTCAAATG GCTGCATGGC 9600
ATTTTCTTGT TGAATGTTTG TTTATATATA TTTTATTTTC GCTATAAATA GAGCTTCAAT 9660
AAACATCTTT ATGTTTTGGC TTCCC 9686
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0877--Alternative promoter usage
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025766--ADD
IPR018117--C5_DNA_meth_AS
IPR001525--C5_MeTfrase
IPR030487--DNMT3A
IPR000313--PWWP_dom
IPR029063--SAM-dependent_MTases
PROSITE

PS51533--ADD
PS00094--C5_MTASE_1
PS50812--PWWP
PS51679--SAM_MT_C5
Pfam

PF00145--DNA_methylase
PF00855--PWWP
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005737--C:cytoplasm
GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0005720--C:nuclear heterochromatin
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0001741--C:XY body
GO:0003682--F:chromatin binding
GO:0003886--F:DNA (cytosine-5-)-methyltransferase activity
GO:0051718--F:DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0051719--F:DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0008168--F:methyltransferase activity
GO:0045322--F:unmethylated CpG binding
GO:0007568--P:aging
GO:0071230--P:cellular response to amino acid stimulus
GO:0071361--P:cellular response to ethanol
GO:0071456--P:cellular response to hypoxia
GO:0006306--P:DNA methylation
GO:0043045--P:DNA methylation involved in embryo development
GO:0043046--P:DNA methylation involved in gamete generation
GO:0032776--P:DNA methylation on cytosine
GO:0010424--P:DNA methylation on cytosine within a CG sequence
GO:0097284--P:hepatocyte apoptotic process
GO:0044027--P:hypermethylation of CpG island
GO:0010216--P:maintenance of DNA methylation
GO:0006346--P:methylation-dependent chromatin silencing
GO:0000278--P:mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182--P:neuron differentiation
GO:0010942--P:positive regulation of cell death
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0036276--P:response to antidepressant
GO:0042220--P:response to cocaine
GO:0032355--P:response to estradiol
GO:0010212--P:response to ionizing radiation
GO:0010288--P:response to lead ion
GO:0009636--P:response to toxic substance
GO:0033189--P:response to vitamin A
GO:0046498--P:S-adenosylhomocysteine metabolic process
GO:0046499--P:S-adenosylmethioninamine metabolic process
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0163 ENSRNOP00000046524.2 Rattus norvegicus 100 0.0 1614
WERAM-Orc-0186 ENSOCUP00000024004.1 Oryctolagus cuniculus 97 0.0 1584
WERAM-Mup-0162 ENSMPUP00000013938.1 Mustela putorius furo 97 0.0 1583
WERAM-Otg-0159 ENSOGAP00000013597.2 Otolemur garnettii 96 0.0 1575
WERAM-Fec-0041 ENSFCAP00000003373.3 Felis catus 97 0.0 1575
WERAM-Cap-0181 ENSCPOP00000017608.1 Cavia porcellus 97 0.0 1575
WERAM-Dan-0082 ENSDNOP00000008153.3 Dasypus novemcinctus 97 0.0 1575
WERAM-Ova-0194 ENSOARP00000019641.1 Ovis aries 97 0.0 1573
WERAM-Eqc-0213 ENSECAP00000022672.1 Equus caballus 96 0.0 1573
WERAM-Loa-0120 ENSLAFP00000011100.4 Loxodonta africana 97 0.0 1572
WERAM-Myl-0156 ENSMLUP00000012886.2 Myotis lucifugus 97 0.0 1571
WERAM-Hos-0099 ENSP00000324375.5 Homo sapiens 96 0.0 1566
WERAM-Gog-0141 ENSGGOP00000012230.2 Gorilla gorilla 96 0.0 1566
WERAM-Pat-0095 ENSPTRP00000057470.2 Pan troglodytes 96 0.0 1562
WERAM-Mam-0118 ENSMMUP00000017844.2 Macaca mulatta 95 0.0 1560
WERAM-Aim-0037 ENSAMEP00000002620.1 Ailuropoda melanoleuca 96 0.0 1552
WERAM-Caf-0052 ENSCAFP00000006185.3 Canis familiaris 96 0.0 1549
WERAM-Ocp-0080 ENSOPRP00000006902.2 Ochotona princeps 95 0.0 1547
WERAM-Poa-0109 ENSPPYP00000014060.2 Pongo abelii 94 0.0 1508
WERAM-Sah-0072 ENSSHAP00000008668.1 Sarcophilus harrisii 92 0.0 1494
WERAM-Mim-0041 ENSMICP00000003746.1 Microcebus murinus 92 0.0 1489
WERAM-Mod-0141 ENSMODP00000019777.2 Monodelphis domestica 91 0.0 1464
WERAM-Dio-0092 ENSDORP00000009420.1 Dipodomys ordii 92 0.0 1444
WERAM-Tub-0034 ENSTBEP00000004171.1 Tupaia belangeri 88 0.0 1426
WERAM-Gaga-0042 ENSGALP00000006352.4 Gallus gallus 88 0.0 1415
WERAM-Ict-0162 ENSSTOP00000023153.1 Ictidomys tridecemlineatus 99 0.0 1402
WERAM-Bot-0182 ENSBTAP00000032863.4 Bos taurus 85 0.0 1376
WERAM-Anc-0084 ENSACAP00000007951.3 Anolis carolinensis 85 0.0 1364
WERAM-Caj-0093 ENSCJAP00000015223.2 Callithrix jacchus 99 0.0 1357
WERAM-Chs-0100 ENSCSAP00000004839.1 Chlorocebus sabaeus 99 0.0 1348
WERAM-Sus-0200 ENSSSCP00000019203.1 Sus scrofa 99 0.0 1344
WERAM-Paa-0073 ENSPANP00000001180.1 Papio anubis 99 0.0 1343
WERAM-Mae-0014 ENSMEUP00000001177.1 Macropus eugenii 82 0.0 1313
WERAM-Meg-0140 ENSMGAP00000014894.2 Meleagris gallopavo 95 0.0 1304
WERAM-Xet-0006 ENSXETP00000002659.3 Xenopus tropicalis 91 0.0 1298
WERAM-Leo-0170 ENSLOCP00000020139.1 Lepisosteus oculatus 77 0.0 1296
WERAM-Ten-0224 ENSTNIP00000022492.1 Tetraodon nigroviridis 84 0.0 1223
WERAM-Tar-0117 ENSTRUP00000024460.1 Takifugu rubripes 84 0.0 1217
WERAM-Gaa-0116 ENSGACP00000015064.1 Gasterosteus aculeatus 84 0.0 1207
WERAM-Fia-0136 ENSFALP00000011094.1 Ficedula albicollis 97 0.0 1205
WERAM-Xim-0195 ENSXMAP00000015669.1 Xiphophorus maculatus 83 0.0 1201
WERAM-Pof-0221 ENSPFOP00000017990.2 Poecilia formosa 82 0.0 1195
WERAM-Gam-0218 ENSGMOP00000020958.1 Gadus morhua 81 0.0 1171
WERAM-Orn-0015 ENSONIP00000001330.1 Oreochromis niloticus 88 0.0 1170
WERAM-Asm-0010 ENSAMXP00000001710.1 Astyanax mexicanus 78 0.0 1169
WERAM-Dar-0036 ENSDARP00000108609.2 Danio rerio 84 0.0 1120
WERAM-Orla-0195 ENSORLP00000022087.1 Oryzias latipes 77 0.0 1118
WERAM-Lac-0124 ENSLACP00000014690.1 Latimeria chalumnae 83 0.0 1047
WERAM-Nol-0202 ENSNLEP00000024130.1 Nomascus leucogenys 100 0.0 978
WERAM-Prc-0070 ENSPCAP00000006585.1 Procavia capensis 81 0.0 928
WERAM-Ere-0054 ENSEEUP00000004702.1 Erinaceus europaeus 100 0.0 892
WERAM-Ptv-0090 ENSPVAP00000008196.1 Pteropus vampyrus 92 0.0 790
WERAM-Ora-0103 ENSOANP00000019195.2 Ornithorhynchus anatinus 55 0.0 716
WERAM-Tut-0163 ENSTTRP00000014038.1 Tursiops truncatus 70 0.0 685
WERAM-Tas-0015 ENSTSYP00000001852.1 Tarsius syrichta 70 0.0 680
WERAM-Soa-0100 ENSSARP00000009334.1 Sorex araneus 69 0.0 669
WERAM-Tag-0096 ENSTGUP00000006612.1 Taeniopygia guttata 51 0.0 662
WERAM-Ect-0150 ENSETEP00000016503.1 Echinops telfairi 68 0.0 657
WERAM-Anp-0024 ENSAPLP00000003099.1 Anas platyrhynchos 50 3e-158 556
WERAM-Chh-0068 ENSCHOP00000007297.1 Choloepus hoffmanni 97 1e-153 541
WERAM-Vip-0102 ENSVPAP00000009529.1 Vicugna pacos 53 2e-103 374
Created Date 25-Jun-2016