Tag |
Content |
WERAM ID |
WERAM-Mum-0021 |
Ensembl Protein ID |
ENSMUSP00000013931.5 |
Uniprot Accession |
Q9Z148; EHMT2_MOUSE; A2CG75; Q6PE08; Q8K4R6; Q8K4R7; Q9Z149 |
Genbank Protein ID |
NP_001273502.1; NP_001273504.1; NP_665829.1; NP_671493.1 |
Protein Name |
Histone-lysine N-methyltransferase EHMT2 |
Genbank Nucleotide ID |
NM_001286573.1; NM_001286575.1; NM_145830.2; NM_147151.2 |
Gene Name |
G9a;EHMT2;Ehmt2;Bat8;Ng36 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HMT |
SUV39 |
SET |
H3K9; H3K27; H3K56 |
K |
25294562 |
Me_Reader |
Ankyrin |
ANK1-7 |
H3K9me1/2 |
K |
18264113 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HMT |
SUV39 |
1.40e-43 |
150 |
354 |
1208 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. |
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
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Domain Profile |
HMT SUV39
SUV39.txt 59 esvenlkegyesdvplssdss.....n 80 e+ e+ +e++e++ + +++ + ENSMUSP00000013931.5 354 EEEEEEEEEEEEEEEEEEEEEeedeeS 380 111111111111111111111111220 PP SUV39.txt 1 vrLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegleegdeyladldske 59 vrLq+++t++ GwGvr+l++i++g+F+c+y+Ge+++d+ea+ + e+d+yl+dld+k+ ENSMUSP00000013931.5 1091 VRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR---EDDSYLFDLDNKD 1146 79***************************************88...**********975 PP SUV39.txt 87 keeseyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdYg 150 k+ ++y+ida+++gn++rf+nH c+pN++ +vf+ ++dlrfpr+afF+s++i++g+EL +dYg ENSMUSP00000013931.5 1145 KDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYG 1208 67899**********************************************************6 PP
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Protein Sequence (Fasta) | MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA SWAPQLPAGL 60 TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHSSLGD TPQSEETLPK ANPDSLEPAG 120 PSSPASVTVT VGDEGADTPV GAASLIGDEP ESLEGDGGRI VLGHATKSFP SSPSKGGACP 180 SRAKMSMTGA GKSPPSVQSL AMRLLSMPGA QGAATAGPEP SPATTAAQEG QPKVHRARKT 240 MSKPSNGQPP IPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLNSGSLSE DLGSAGGSGD 300 IILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL SEEEEEEEEE 360 EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR KDSPWVKPSR KRRKREPPRA 420 KEPRGVNGVG SSGPSEYMEV PLGSLELPSE GTLSPNHAGV SNDTSSLETE RGFEELPLCS 480 CRMEAPKIDR ISERAGHKCM ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR 540 MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT 600 IPRGDGGTPP IGTAAPALPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD PLADTIDSSG 660 PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI 720 LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV 780 NNHLEVARYM VQLGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT 840 PIIWAAEHKH IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV 900 NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV WFALQLNRKL 960 RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN 1020 ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRSC 1080 KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF 1140 DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG 1200 EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE LLPDLSSLPP 1260 INT 1263Protein Fasta Sequence
>ENSMUSP00000013931.5|G9a;EHMT2;Ehmt2;Bat8;Ng36|Mus musculus MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQSEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPINT
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Nucleotide Sequence (Fasta) | GAGATGCGGG GTCTGCCGAG AGGGAGGGGG CTGATGCGGG CCCGGGGGCG GGGGCGTGCG 60 GCCCCCACGG GCGGCCGCGG CCGCGGTCGG GGGGGCGCCC ACCGAGGGCG AGGTAGGCCC 120 CGAAGCCTGC TCTCGCTGCC CAGGGCCCAG GCGTCTTGGG CCCCCCAGCT GCCTGCCGGG 180 CTGACCGGCC CCCCGGTTCC TTGTCTCCCC TCCCAGGGGG AGGCCCCCGC TGAGATGGGG 240 GCGCTGCTGC TGGAGAAGGA GCCCCGAGGA GCCGCCGAGA GAGTTCATAG CTCTTTGGGG 300 GACACCCCTC AGAGTGAGGA GACCCTTCCC AAGGCCAACC CCGACTCCTT GGAGCCTGCC 360 GGCCCCTCCT CTCCGGCCTC TGTCACTGTC ACCGTCGGCG ATGAGGGGGC TGACACCCCT 420 GTCGGGGCCG CATCACTCAT CGGGGACGAA CCCGAGAGCC TGGAGGGAGA TGGGGGTCGC 480 ATCGTGCTGG GCCATGCCAC AAAGTCGTTC CCCTCTTCCC CCAGCAAGGG GGGTGCCTGT 540 CCCAGTCGGG CCAAAATGTC AATGACAGGG GCAGGAAAGT CGCCCCCCTC GGTCCAGAGT 600 TTGGCCATGA GGCTGTTGAG CATGCCCGGG GCCCAGGGAG CTGCAACTGC TGGGCCTGAA 660 CCCTCTCCGG CAACAACTGC CGCCCAGGAG GGGCAGCCCA AAGTGCACCG AGCCCGGAAA 720 ACCATGTCCA AACCTAGCAA CGGACAGCCT CCAATCCCTG AGAAGCGGCC CCCTGAAGTC 780 CAGCATTTCC GCATGAGTGA TGACATGCAT CTGGGGAAGG TGACTTCAGA TGTGGCCAAA 840 AGGAGGAAGC TGAACTCTGG TAGCCTGTCC GAGGACTTGG GCTCTGCCGG GGGCTCAGGA 900 GATATAATCC TGGAGAAGGG AGAGCCCAGG CCCCTGGAGG AGTGGGAGAC GGTGGTGGGC 960 GATGACTTCA GCCTGTACTA TGATGCGTAC TCTGTGGATG AGCGGGTGGA CTCTGACAGC 1020 AAGTCTGAAG TCGAAGCTCT AGCTGAACAG TTGAGTGAGG AGGAGGAGGA GGAAGAGGAG 1080 GAAGAAGAAG AAGAGGAGGA GGAGGAGGAA GAGGAGGAGG AGGAAGAAGA GGACGAGGAG 1140 TCGGGCAATC AGTCAGACAG GAGCGGTTCT AGTGGCCGGC GCAAGGCCAA GAAGAAATGG 1200 CGGAAAGACA GCCCGTGGGT GAAGCCATCT AGAAAACGGC GGAAACGAGA GCCTCCGAGG 1260 GCCAAGGAGC CAAGAGGAGT GAATGGTGTG GGTTCCTCAG GGCCCAGTGA GTACATGGAG 1320 GTTCCTCTGG GGTCCCTGGA GCTGCCCAGC GAGGGGACCC TCTCCCCCAA CCACGCTGGG 1380 GTCTCCAATG ACACGTCTTC ACTGGAGACA GAACGCGGGT TTGAGGAGCT GCCCCTCTGC 1440 AGCTGCCGCA TGGAGGCTCC CAAGATTGAC CGCATCAGCG AGAGAGCAGG GCACAAGTGC 1500 ATGGCCACAG AGAGTGTGGA TGGAGAGCTC CTGGGCTGCA ATGCTGCCAT CCTTAAGCGG 1560 GAGACCATGC GGCCGTCTAG CCGCGTGGCG CTGATGGTGC TCTGTGAGGC CCATCGAGCC 1620 CGCATGGTCA AGCACCATTG CTGCCCGGGC TGCGGCTACT TCTGCACAGC GGGCACCTTC 1680 CTGGAATGCC ACCCCGACTT TCGTGTAGCT CACCGCTTCC ATAAGGCCTG CGTATCCCAG 1740 CTCAATGGGA TGGTCTTCTG TCCCCACTGT GGAGAGGATG CCTCAGAGGC CCAGGAGGTG 1800 ACCATTCCTC GGGGCGATGG GGGAACACCC CCAATTGGCA CCGCAGCTCC TGCTCTGCCA 1860 CCCCTGGCAC ATGATGCCCC AGGGCGAGCG GATACCTCCC AGCCTAGCGC CCGAATGCGA 1920 GGGCATGGAG AGCCGCGGCG CCCGCCCTGT GATCCCCTGG CTGACACCAT CGACAGCTCA 1980 GGGCCTTCAC TGACTCTGCC TAATGGGGGC TGCCTCTCCG CTGTGGGTCT GCCCCCAGGG 2040 CCGGGCAGGG AAGCCCTGGA AAAAGCCTTG GTCATCCAGG AGTCTGAGAG GCGGAAGAAG 2100 CTGCGATTCC ACCCACGGCA GCTGTACCTG TCGGTGAAGC AGGGGGAGCT GCAGAAGGTG 2160 ATCCTTATGC TGTTAGACAA CCTGGACCCC AACTTCCAGA GCGACCAGCA GAGCAAGCGC 2220 ACGCCCCTGC ACGCGGCCGC CCAGAAGGGG TCGGTAGAGA TCTGTCATGT GCTGCTGCAG 2280 GCAGGAGCCA ACATCAATGC CGTAGATAAG CAACAACGCA CGCCACTAAT GGAGGCCGTG 2340 GTGAACAACC ACCTGGAGGT GGCACGCTAC ATGGTGCAGT TAGGTGGCTG TGTCTACAGC 2400 AAGGAAGAGG ATGGCTCCAC CTGTCTACAT CATGCAGCCA AAATTGGGAA CTTGGAAATG 2460 GTCAGCCTGC TACTGAGCAC AGGACAGGTG GACGTCAATG CCCAGGACAG TGGGGGCTGG 2520 ACGCCCATCA TCTGGGCAGC CGAGCACAAG CACATCGATG TGATTCGTAT GCTGCTGACC 2580 CGGGGTGCCG ATGTCACCCT GACTGACAAT GAGGAAAACA TCTGCCTGCA CTGGGCCTCC 2640 TTCACGGGTA GTGCCGCCAT CGCTGAGGTC CTTCTGAATG CCCAGTGTGA TCTCCATGCT 2700 GTCAACTACC ATGGGGACAC GCCCCTGCAC ATAGCCGCCA GGGAGAGCTA CCATGACTGT 2760 GTTCTGTTGT TCCTGTCTCG TGGAGCCAAC CCTGAGCTTC GGAACAAAGA AGGAGACACG 2820 GCATGGGATC TGACCCCAGA GCGCTCTGAT GTGTGGTTTG CACTGCAGCT CAATCGAAAG 2880 CTTAGGCTTG GGGTAGGGAA CCGGGCTGTC CGCACCGAGA AGATCATCTG CCGGGACGTA 2940 GCCCGAGGCT ATGAGAATGT ACCCATCCCC TGTGTCAATG GTGTGGATGG GGAGCCGTGC 3000 CCGGAGGACT ACAAGTACAT CTCTGAGAAC TGCGAGACAT CGACCATGAA CATCGACCGC 3060 AACATCACCC ATCTGCAGCA CTGCACGTGT GTGGATGACT GCTCCAGCTC CAATTGCCTA 3120 TGTGGTCAGC TCAGTATCCG ATGCTGGTAT GACAAGGACG GGCGGCTGCT CCAGGAGTTT 3180 AACAAGATCG AGCCCCCCCT GATCTTTGAG TGTAACCAGG CATGCTCCTG CTGGAGAAGC 3240 TGCAAGAACC GCGTGGTGCA GAGCGGCATC AAGGTACGGC TGCAGCTCTA CCGGACTGCC 3300 AAGATGGGCT GGGGGGTCCG AGCCTTGCAG ACCATCCCCC AGGGCACGTT CATCTGCGAG 3360 TATGTAGGAG AGCTGATCTC TGATGCCGAG GCTGATGTGA GAGAGGATGA TTCTTACCTC 3420 TTCGATTTAG ATAACAAGGA TGGCGAGGTT TACTGCATTG ATGCCCGTTA CTATGGCAAC 3480 ATCAGCCGAT TCATTAACCA CCTGTGTGAC CCCAACATCA TCCCTGTCCG GGTTTTCATG 3540 CTGCACCAAG ATCTACGGTT CCCACGCATT GCCTTCTTCA GCTCCAGGGA CATCCGGACT 3600 GGGGAGGAGC TGGGCTTTGA CTACGGTGAC CGATTCTGGG ACATCAAGAG CAAGTATTTC 3660 ACCTGCCAGT GTGGCTCTGA GAAGTGCAAG CATTCAGCGG AGGCCATCGC CCTGGAGCAG 3720 AGCCGCCTGG CCCGGCTGGA CCCCCACCCG GAGCTGCTCC CTGACCTCAG CTCCCTGCCC 3780 CCCATCAACA CCTGAGGACT CTTAAAATCC AGGCCGGGCA CTGCCCTTCA GACATTTCTC 3840 CATCAGAGAC CCCAGTAAGG CCTGGAAGGT CGATGGCCCC TCTCCCAGAG CTGGTTTCTC 3900 ACTGGGAGTG CAAGTGACTT CAGGGCTGGC CTTCCCCACT GAGCCTGGCC TCAGTTAGCT 3960 GATTGAAGTT GGGCCTCTGC CAGCTGATTT TCTGTGTTCT CAATAAATGT TGGGTTTGGT 4020 AATAAA
4027Nucleotide Fasta Sequence
>ENSMUSP00000013931.5|SUV39|Mus musculus GAGATGCGGGGTCTGCCGAGAGGGAGGGGGCTGATGCGGGCCCGGGGGCGGGGGCGTGCGGCCCCCACGGGCGGCCGCGGCCGCGGTCGGGGGGGCGCCCACCGAGGGCGAGGTAGGCCCCGAAGCCTGCTCTCGCTGCCCAGGGCCCAGGCGTCTTGGGCCCCCCAGCTGCCTGCCGGGCTGACCGGCCCCCCGGTTCCTTGTCTCCCCTCCCAGGGGGAGGCCCCCGCTGAGATGGGGGCGCTGCTGCTGGAGAAGGAGCCCCGAGGAGCCGCCGAGAGAGTTCATAGCTCTTTGGGGGACACCCCTCAGAGTGAGGAGACCCTTCCCAAGGCCAACCCCGACTCCTTGGAGCCTGCCGGCCCCTCCTCTCCGGCCTCTGTCACTGTCACCGTCGGCGATGAGGGGGCTGACACCCCTGTCGGGGCCGCATCACTCATCGGGGACGAACCCGAGAGCCTGGAGGGAGATGGGGGTCGCATCGTGCTGGGCCATGCCACAAAGTCGTTCCCCTCTTCCCCCAGCAAGGGGGGTGCCTGTCCCAGTCGGGCCAAAATGTCAATGACAGGGGCAGGAAAGTCGCCCCCCTCGGTCCAGAGTTTGGCCATGAGGCTGTTGAGCATGCCCGGGGCCCAGGGAGCTGCAACTGCTGGGCCTGAACCCTCTCCGGCAACAACTGCCGCCCAGGAGGGGCAGCCCAAAGTGCACCGAGCCCGGAAAACCATGTCCAAACCTAGCAACGGACAGCCTCCAATCCCTGAGAAGCGGCCCCCTGAAGTCCAGCATTTCCGCATGAGTGATGACATGCATCTGGGGAAGGTGACTTCAGATGTGGCCAAAAGGAGGAAGCTGAACTCTGGTAGCCTGTCCGAGGACTTGGGCTCTGCCGGGGGCTCAGGAGATATAATCCTGGAGAAGGGAGAGCCCAGGCCCCTGGAGGAGTGGGAGACGGTGGTGGGCGATGACTTCAGCCTGTACTATGATGCGTACTCTGTGGATGAGCGGGTGGACTCTGACAGCAAGTCTGAAGTCGAAGCTCTAGCTGAACAGTTGAGTGAGGAGGAGGAGGAGGAAGAGGAGGAAGAAGAAGAAGAGGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAAGAGGACGAGGAGTCGGGCAATCAGTCAGACAGGAGCGGTTCTAGTGGCCGGCGCAAGGCCAAGAAGAAATGGCGGAAAGACAGCCCGTGGGTGAAGCCATCTAGAAAACGGCGGAAACGAGAGCCTCCGAGGGCCAAGGAGCCAAGAGGAGTGAATGGTGTGGGTTCCTCAGGGCCCAGTGAGTACATGGAGGTTCCTCTGGGGTCCCTGGAGCTGCCCAGCGAGGGGACCCTCTCCCCCAACCACGCTGGGGTCTCCAATGACACGTCTTCACTGGAGACAGAACGCGGGTTTGAGGAGCTGCCCCTCTGCAGCTGCCGCATGGAGGCTCCCAAGATTGACCGCATCAGCGAGAGAGCAGGGCACAAGTGCATGGCCACAGAGAGTGTGGATGGAGAGCTCCTGGGCTGCAATGCTGCCATCCTTAAGCGGGAGACCATGCGGCCGTCTAGCCGCGTGGCGCTGATGGTGCTCTGTGAGGCCCATCGAGCCCGCATGGTCAAGCACCATTGCTGCCCGGGCTGCGGCTACTTCTGCACAGCGGGCACCTTCCTGGAATGCCACCCCGACTTTCGTGTAGCTCACCGCTTCCATAAGGCCTGCGTATCCCAGCTCAATGGGATGGTCTTCTGTCCCCACTGTGGAGAGGATGCCTCAGAGGCCCAGGAGGTGACCATTCCTCGGGGCGATGGGGGAACACCCCCAATTGGCACCGCAGCTCCTGCTCTGCCACCCCTGGCACATGATGCCCCAGGGCGAGCGGATACCTCCCAGCCTAGCGCCCGAATGCGAGGGCATGGAGAGCCGCGGCGCCCGCCCTGTGATCCCCTGGCTGACACCATCGACAGCTCAGGGCCTTCACTGACTCTGCCTAATGGGGGCTGCCTCTCCGCTGTGGGTCTGCCCCCAGGGCCGGGCAGGGAAGCCCTGGAAAAAGCCTTGGTCATCCAGGAGTCTGAGAGGCGGAAGAAGCTGCGATTCCACCCACGGCAGCTGTACCTGTCGGTGAAGCAGGGGGAGCTGCAGAAGGTGATCCTTATGCTGTTAGACAACCTGGACCCCAACTTCCAGAGCGACCAGCAGAGCAAGCGCACGCCCCTGCACGCGGCCGCCCAGAAGGGGTCGGTAGAGATCTGTCATGTGCTGCTGCAGGCAGGAGCCAACATCAATGCCGTAGATAAGCAACAACGCACGCCACTAATGGAGGCCGTGGTGAACAACCACCTGGAGGTGGCACGCTACATGGTGCAGTTAGGTGGCTGTGTCTACAGCAAGGAAGAGGATGGCTCCACCTGTCTACATCATGCAGCCAAAATTGGGAACTTGGAAATGGTCAGCCTGCTACTGAGCACAGGACAGGTGGACGTCAATGCCCAGGACAGTGGGGGCTGGACGCCCATCATCTGGGCAGCCGAGCACAAGCACATCGATGTGATTCGTATGCTGCTGACCCGGGGTGCCGATGTCACCCTGACTGACAATGAGGAAAACATCTGCCTGCACTGGGCCTCCTTCACGGGTAGTGCCGCCATCGCTGAGGTCCTTCTGAATGCCCAGTGTGATCTCCATGCTGTCAACTACCATGGGGACACGCCCCTGCACATAGCCGCCAGGGAGAGCTACCATGACTGTGTTCTGTTGTTCCTGTCTCGTGGAGCCAACCCTGAGCTTCGGAACAAAGAAGGAGACACGGCATGGGATCTGACCCCAGAGCGCTCTGATGTGTGGTTTGCACTGCAGCTCAATCGAAAGCTTAGGCTTGGGGTAGGGAACCGGGCTGTCCGCACCGAGAAGATCATCTGCCGGGACGTAGCCCGAGGCTATGAGAATGTACCCATCCCCTGTGTCAATGGTGTGGATGGGGAGCCGTGCCCGGAGGACTACAAGTACATCTCTGAGAACTGCGAGACATCGACCATGAACATCGACCGCAACATCACCCATCTGCAGCACTGCACGTGTGTGGATGACTGCTCCAGCTCCAATTGCCTATGTGGTCAGCTCAGTATCCGATGCTGGTATGACAAGGACGGGCGGCTGCTCCAGGAGTTTAACAAGATCGAGCCCCCCCTGATCTTTGAGTGTAACCAGGCATGCTCCTGCTGGAGAAGCTGCAAGAACCGCGTGGTGCAGAGCGGCATCAAGGTACGGCTGCAGCTCTACCGGACTGCCAAGATGGGCTGGGGGGTCCGAGCCTTGCAGACCATCCCCCAGGGCACGTTCATCTGCGAGTATGTAGGAGAGCTGATCTCTGATGCCGAGGCTGATGTGAGAGAGGATGATTCTTACCTCTTCGATTTAGATAACAAGGATGGCGAGGTTTACTGCATTGATGCCCGTTACTATGGCAACATCAGCCGATTCATTAACCACCTGTGTGACCCCAACATCATCCCTGTCCGGGTTTTCATGCTGCACCAAGATCTACGGTTCCCACGCATTGCCTTCTTCAGCTCCAGGGACATCCGGACTGGGGAGGAGCTGGGCTTTGACTACGGTGACCGATTCTGGGACATCAAGAGCAAGTATTTCACCTGCCAGTGTGGCTCTGAGAAGTGCAAGCATTCAGCGGAGGCCATCGCCCTGGAGCAGAGCCGCCTGGCCCGGCTGGACCCCCACCCGGAGCTGCTCCCTGACCTCAGCTCCCTGCCCCCCATCAACACCTGAGGACTCTTAAAATCCAGGCCGGGCACTGCCCTTCAGACATTTCTCCATCAGAGACCCCAGTAAGGCCTGGAAGGTCGATGGCCCCTCTCCCAGAGCTGGTTTCTCACTGGGAGTGCAAGTGACTTCAGGGCTGGCCTTCCCCACTGAGCCTGGCCTCAGTTAGCTGATTGAAGTTGGGCCTCTGCCAGCTGATTTTCTGTGTTCTCAATAAATGTTGGGTTTGGTAATAAA
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Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0040--ANK repeat KW-0156--Chromatin regulator KW-0158--Chromosome KW-0181--Complete proteome KW-0479--Metal-binding KW-0488--Methylation KW-0489--Methyltransferase KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0949--S-adenosyl-L-methionine KW-0808--Transferase KW-0862--Zinc --
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Interpro |
IPR002110--Ankyrin_rpt IPR020683--Ankyrin_rpt-contain_dom IPR007728--Pre-SET_dom IPR001214--SET_dom
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PROSITE |
PS50297--ANK_REP_REGION PS50088--ANK_REPEAT PS50867--PRE_SET PS50280--SET
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Pfam |
PF12796--Ank_2 PF05033--Pre-SET PF00856--SET
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Gene Ontology |
GO:0000790--C:nuclear chromatin GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0070742--F:C2H2 zinc finger domain binding GO:0046976--F:histone methyltransferase activity (H3-K27 specific) GO:0046974--F:histone methyltransferase activity (H3-K9 specific) GO:0018024--F:histone-lysine N-methyltransferase activity GO:0002039--F:p53 binding GO:1990841--F:promoter-specific chromatin binding GO:0016279--F:protein-lysine N-methyltransferase activity GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding GO:0008270--F:zinc ion binding GO:0035690--P:cellular response to drug GO:0009267--P:cellular response to starvation GO:0006306--P:DNA methylation GO:0010424--P:DNA methylation on cytosine within a CG sequence GO:0009566--P:fertilization GO:0007281--P:germ cell development GO:0070734--P:histone H3-K27 methylation GO:0051567--P:histone H3-K9 methylation GO:0034968--P:histone lysine methylation GO:0016571--P:histone methylation GO:0007616--P:long-term memory GO:1902902--P:negative regulation of autophagosome assembly GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0035265--P:organ growth GO:0018027--P:peptidyl-lysine dimethylation GO:0044030--P:regulation of DNA methylation GO:0006275--P:regulation of DNA replication GO:0051569--P:regulation of histone H3-K4 methylation GO:0051570--P:regulation of histone H3-K9 methylation GO:0006357--P:regulation of transcription from RNA polymerase II promoter GO:0045471--P:response to ethanol GO:0060992--P:response to fungicide GO:0007286--P:spermatid development GO:0007130--P:synaptonemal complex assembly
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Orthology |
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Created Date |
25-Jun-2016 |